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Overview

ID MAG04023
Name TLS2_bin.66
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Actinomycetota
Class Acidimicrobiia
Order Acidimicrobiales
Family SKKL01
Genus
Species
Assembly information
Completeness (%) 88.43
Contamination (%) 1.21
GC content (%) 70.0
N50 (bp) 19,418
Genome size (bp) 3,154,648

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2924

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1016323_0 dead DEAH box helicase - - - 0.0 1077.0
TLS2_k127_1016323_1 COG2015 Alkyl sulfatase and related hydrolases - - - 1.481e-220 702.0
TLS2_k127_1016323_10 SMART protein phosphatase 2C domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 317.0
TLS2_k127_1016323_11 Acyltransferase, ws dgat mgat K00635 - 2.3.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000003867 277.0
TLS2_k127_1016323_12 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000459 268.0
TLS2_k127_1016323_13 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006568 257.0
TLS2_k127_1016323_14 protein conserved in bacteria K09966 - - 0.00000000000000000000000000000000000000000000000000000000000007125 218.0
TLS2_k127_1016323_15 response regulator, receiver K02485 - - 0.000000000000000000000000000000000000000000000000000000009912 203.0
TLS2_k127_1016323_16 Aminoacyl-tRNA editing domain K03976 - - 0.00000000000000000000000000000000000000000000000000000003571 199.0
TLS2_k127_1016323_17 Sporulation and spore germination - - - 0.00000000000000000000000000000000000000000000000000000006331 209.0
TLS2_k127_1016323_18 Acetyltransferase (GNAT) domain K00657,K00663 - 2.3.1.57,2.3.1.82 0.000000000000000000000000000000000000000000000000001078 188.0
TLS2_k127_1016323_19 Belongs to the phosphoglycerate mutase family K15640 - - 0.000000000000000000000000000000000000000000000000007408 187.0
TLS2_k127_1016323_2 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 609.0
TLS2_k127_1016323_21 HupE / UreJ protein K03192 - - 0.00000000000000000000000000006968 124.0
TLS2_k127_1016323_22 Na H antiporter K05566 - - 0.00000000000000000000000000166 125.0
TLS2_k127_1016323_23 NADH-ubiquinone oxidoreductase, chain 4L K05567 - - 0.0000000000000000000000000123 120.0
TLS2_k127_1016323_24 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000001473 116.0
TLS2_k127_1016323_25 Domain related to MnhB subunit of Na+/H+ antiporter - - - 0.0000000000000000000000126 106.0
TLS2_k127_1016323_26 NUDIX domain - - - 0.0000000000000000000005633 109.0
TLS2_k127_1016323_27 - - - - 0.00000000000000000007608 99.0
TLS2_k127_1016323_28 PFAM cation antiporter K05569 - - 0.000000000000000001407 96.0
TLS2_k127_1016323_29 Mo-molybdopterin cofactor metabolic process K03636,K21142 - 2.8.1.12 0.00000000000000000605 86.0
TLS2_k127_1016323_3 COG2015, Alkyl sulfatase and related hydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 521.0
TLS2_k127_1016323_30 Na+/H+ antiporter subunit K05571 - - 0.000000000008137 74.0
TLS2_k127_1016323_31 Multiple resistance and pH regulation protein F (MrpF / PhaF) - - - 0.00000000003039 74.0
TLS2_k127_1016323_32 Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family K01446 GO:0000270,GO:0002376,GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005539,GO:0005575,GO:0005576,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0016787,GO:0016810,GO:0016811,GO:0030203,GO:0031347,GO:0031348,GO:0042834,GO:0043170,GO:0045087,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0061783,GO:0065007,GO:0071704,GO:0080134,GO:0097367,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - 0.00000000003387 77.0
TLS2_k127_1016323_33 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000007515 61.0
TLS2_k127_1016323_34 STAS domain - - - 0.00000005879 59.0
TLS2_k127_1016323_4 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 486.0
TLS2_k127_1016323_5 PFAM NADH Ubiquinone plastoquinone (complex I) K05568,K12137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 445.0
TLS2_k127_1016323_6 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 419.0
TLS2_k127_1016323_7 PFAM NADH Ubiquinone plastoquinone (complex I) K05568,K12141 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004337 419.0
TLS2_k127_1016323_8 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 354.0
TLS2_k127_1016323_9 CHASE3 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000355 370.0
TLS2_k127_1039710_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 355.0
TLS2_k127_1039710_1 Esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 299.0
TLS2_k127_1039710_2 PFAM YibE F-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003153 284.0
TLS2_k127_1039710_3 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000000003546 202.0
TLS2_k127_1039710_4 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000005707 171.0
TLS2_k127_1039710_5 RibD C-terminal domain K00082 - 1.1.1.193 0.0000000000000000000000000000000000000001646 159.0
TLS2_k127_1039710_6 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000002862 117.0
TLS2_k127_1058342_0 Branched-chain amino acid ATP-binding cassette transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 501.0
TLS2_k127_1058342_1 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 453.0
TLS2_k127_1058342_2 Protein synonym acyl-CoA synthetase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 438.0
TLS2_k127_1058342_3 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 431.0
TLS2_k127_1058342_4 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine K03648 GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006999 318.0
TLS2_k127_1058342_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000422 256.0
TLS2_k127_1058342_6 META domain K03668 - - 0.000006327 51.0
TLS2_k127_1065711_0 Nitrite and sulphite reductase 4Fe-4S domain K00362,K00366,K00381,K00392 - 1.7.1.15,1.7.7.1,1.8.1.2,1.8.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 443.0
TLS2_k127_1065711_1 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000011 287.0
TLS2_k127_1065711_10 YhhN family - - - 0.00000005868 58.0
TLS2_k127_1065711_11 YhhN family - - - 0.000005126 52.0
TLS2_k127_1065711_2 dienelactone hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003759 243.0
TLS2_k127_1065711_3 adenylate kinase activity - - - 0.000000000000000000000000000000000000000000000000000000513 201.0
TLS2_k127_1065711_4 NMT1/THI5 like - - - 0.00000000000000000000000000000000000000000000001255 189.0
TLS2_k127_1065711_5 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000001157 173.0
TLS2_k127_1065711_6 Cell-cycle regulation histidine triad K02503 - - 0.00000000000000000000000000000000000000006802 156.0
TLS2_k127_1065711_7 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000001428 157.0
TLS2_k127_1065711_8 Domain of unknown function (DUF4202) - - - 0.000000000000000000000000000000000000002095 166.0
TLS2_k127_1065711_9 SnoaL-like domain - - - 0.000000000000000000002119 99.0
TLS2_k127_1120425_0 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 7.874e-316 974.0
TLS2_k127_1120425_1 COGs COG3263 NhaP-type Na H and K H antiporter with a unique C-terminal domain K11105 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 341.0
TLS2_k127_1120425_2 Protein of unknown function (DUF3376) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 324.0
TLS2_k127_1120425_3 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003184 263.0
TLS2_k127_1120425_4 Belongs to the BI1 family K06890 - - 0.000000000000000000000000000000000000000007142 174.0
TLS2_k127_1120425_5 Leucine carboxyl methyltransferase - - - 0.000000000000000000000199 111.0
TLS2_k127_1120425_6 Metallo-beta-lactamase superfamily - - - 0.000000000000000007753 94.0
TLS2_k127_1125605_0 ThiF family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 569.0
TLS2_k127_1125605_1 polysaccharide biosynthetic process K01992 GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009987,GO:0044764,GO:0046812,GO:0051704 - 0.0000000000000000000000000000000000000000000000000000000000000000000004529 254.0
TLS2_k127_1125605_2 ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000001513 190.0
TLS2_k127_1125605_3 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.00000000000000000000004347 110.0
TLS2_k127_1125605_4 Glycosyl transferase 4-like domain - - - 0.0000000000000000000001517 108.0
TLS2_k127_1125605_5 peptidase inhibitor activity - - - 0.00000000001045 76.0
TLS2_k127_1159142_0 Zn-dependent hydrolase, glyoxylase - GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002968 337.0
TLS2_k127_1159142_1 Prephenate dehydratase K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008223 334.0
TLS2_k127_1159142_2 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 311.0
TLS2_k127_1159142_3 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 324.0
TLS2_k127_1159142_4 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000008423 216.0
TLS2_k127_1159142_5 Transglycosylase-like domain K21687 - - 0.0003254 48.0
TLS2_k127_1201736_0 B12 binding domain K00548 - 2.1.1.13 0.0 1530.0
TLS2_k127_1201736_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 3.459e-202 665.0
TLS2_k127_1201736_10 A predicted alpha-helical domain with a conserved ER motif. - - - 0.0000000000000000000000000000000000000000000000000000000001396 216.0
TLS2_k127_1201736_11 Membrane - - - 0.000000000000000000000000000000000000000000000000001877 207.0
TLS2_k127_1201736_12 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000005097 205.0
TLS2_k127_1201736_13 Bacterial transglutaminase-like N-terminal region - - - 0.00000000000000000000000000000000000000000000000002952 202.0
TLS2_k127_1201736_14 - - - - 0.000000000000000000000000000000000000001927 155.0
TLS2_k127_1201736_15 PFAM adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000007741 111.0
TLS2_k127_1201736_16 Domain of unknown function (DUF4214) - - - 0.000000000000000007557 97.0
TLS2_k127_1201736_17 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000006183 87.0
TLS2_k127_1201736_19 Major facilitator superfamily - - - 0.00000007362 66.0
TLS2_k127_1201736_2 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 3.666e-198 628.0
TLS2_k127_1201736_20 - - - - 0.000002163 59.0
TLS2_k127_1201736_3 Creatinase/Prolidase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006138 454.0
TLS2_k127_1201736_4 e3 binding domain K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 456.0
TLS2_k127_1201736_5 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003379 434.0
TLS2_k127_1201736_6 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 337.0
TLS2_k127_1201736_7 Sir2 family K12410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 312.0
TLS2_k127_1201736_8 Circularly permuted ATP-grasp type 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002791 268.0
TLS2_k127_1201736_9 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000009809 222.0
TLS2_k127_1210091_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 3.576e-241 762.0
TLS2_k127_1210091_1 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 331.0
TLS2_k127_1210091_2 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000002308 172.0
TLS2_k127_1215778_0 xanthine dehydrogenase activity K03520 - 1.2.5.3 0.0 1483.0
TLS2_k127_1215778_1 Zinc-binding dehydrogenase K17829 - 1.3.1.86 8.117e-212 665.0
TLS2_k127_1215778_10 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.00000000000000000000000000000000000000000000000000000000000000000001179 244.0
TLS2_k127_1215778_11 amine dehydrogenase activity K00504,K12132 - 1.14.17.3,2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000005651 244.0
TLS2_k127_1215778_12 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000001522 226.0
TLS2_k127_1215778_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000006452 218.0
TLS2_k127_1215778_14 Glyoxalase-like domain K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000000006967 209.0
TLS2_k127_1215778_15 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000000000000000001121 212.0
TLS2_k127_1215778_16 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000003504 205.0
TLS2_k127_1215778_17 XdhC Rossmann domain K07402 - - 0.000000000000000000000000000000000000000000001131 177.0
TLS2_k127_1215778_18 - - - - 0.000000000000000000000000000000000000000001059 164.0
TLS2_k127_1215778_19 - - - - 0.0000000000000000000000000000000000000003757 168.0
TLS2_k127_1215778_2 Thiolase, C-terminal domain K00626 GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007045 498.0
TLS2_k127_1215778_20 - - - - 0.0000000000000000000000000000000000005754 156.0
TLS2_k127_1215778_21 Cytochrome c - - - 0.0000000000000000000000000000000002659 136.0
TLS2_k127_1215778_22 - - - - 0.0000000000000000000000000000001377 130.0
TLS2_k127_1215778_23 - - - - 0.0000000000000000000000000000009888 123.0
TLS2_k127_1215778_24 - - - - 0.00000000000000000000000000002205 119.0
TLS2_k127_1215778_25 CoA binding domain - - - 0.000000000000000000000000004147 121.0
TLS2_k127_1215778_27 - - - - 0.000000000000000000007041 98.0
TLS2_k127_1215778_3 DNA primase, small subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 437.0
TLS2_k127_1215778_30 - - - - 0.0000001883 63.0
TLS2_k127_1215778_31 TadE-like protein - - - 0.000008845 55.0
TLS2_k127_1215778_4 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005971 428.0
TLS2_k127_1215778_5 Dehydrogenase K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004375 421.0
TLS2_k127_1215778_6 VWA domain containing CoxE-like protein K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 413.0
TLS2_k127_1215778_7 XdhC Rossmann domain K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 351.0
TLS2_k127_1215778_8 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 334.0
TLS2_k127_1215778_9 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 307.0
TLS2_k127_1258320_0 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 439.0
TLS2_k127_1258320_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 405.0
TLS2_k127_1258320_10 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944 3.6.1.1 0.00000000000000000000000000000000000000000000000000000001207 209.0
TLS2_k127_1258320_11 Major facilitator Superfamily - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000001973 211.0
TLS2_k127_1258320_12 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.000000000000000000000000000000000000000000000002417 190.0
TLS2_k127_1258320_13 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000001362 188.0
TLS2_k127_1258320_14 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000009971 165.0
TLS2_k127_1258320_15 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000002048 122.0
TLS2_k127_1258320_16 peptidase inhibitor activity - - - 0.0000000000000002308 85.0
TLS2_k127_1258320_2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008473 351.0
TLS2_k127_1258320_3 Aminoglycoside phosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 348.0
TLS2_k127_1258320_4 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 339.0
TLS2_k127_1258320_5 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003454 332.0
TLS2_k127_1258320_6 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 312.0
TLS2_k127_1258320_7 N-acetyltransferase Eis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 297.0
TLS2_k127_1258320_8 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001523 284.0
TLS2_k127_1258320_9 pyridoxamine 5-phosphate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001355 258.0
TLS2_k127_1262685_0 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 320.0
TLS2_k127_1262685_1 Exporter of polyketide K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000257 286.0
TLS2_k127_1262685_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000000000000000000000009322 241.0
TLS2_k127_1262685_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000002547 198.0
TLS2_k127_1262685_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904 - 0.000000000000000000000000000000000000000000000262 169.0
TLS2_k127_1262685_5 - - - - 0.00000000000000000000000002523 121.0
TLS2_k127_1262685_6 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 GO:0005575,GO:0005576,GO:0008150,GO:0040007 3.5.4.25,4.1.99.12 0.00000000000000000002505 92.0
TLS2_k127_1262685_7 Ribosomal protein L35 K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000004201 83.0
TLS2_k127_1311529_0 DNA polymerase alpha chain like domain K02337 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 0.0 1691.0
TLS2_k127_1311529_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 593.0
TLS2_k127_1311529_10 Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 293.0
TLS2_k127_1311529_11 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001226 284.0
TLS2_k127_1311529_12 alpha/beta hydrolase fold K08680 - 4.2.99.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005164 279.0
TLS2_k127_1311529_13 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000001324 233.0
TLS2_k127_1311529_14 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000007215 229.0
TLS2_k127_1311529_15 - - - - 0.00000000000000000000000000000000000000000000000000000000000000009355 231.0
TLS2_k127_1311529_16 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000005165 218.0
TLS2_k127_1311529_17 Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol K15520 - 2.3.1.189 0.00000000000000000000000000000000000000000000000000002702 198.0
TLS2_k127_1311529_18 Nucleotidyl transferase K00966,K00992 - 2.7.7.13,2.7.7.99 0.000000000000000000000000000000000000000000000000003886 190.0
TLS2_k127_1311529_19 Protein of unknown function (DUF2587) - - - 0.0000000000000000000000000000000000000000000000008412 179.0
TLS2_k127_1311529_2 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006255 529.0
TLS2_k127_1311529_20 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000003122 156.0
TLS2_k127_1311529_21 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000004571 139.0
TLS2_k127_1311529_22 HNH nucleases - - - 0.0000000000000005805 81.0
TLS2_k127_1311529_23 acetyltransferase - - - 0.000000000007236 75.0
TLS2_k127_1311529_25 zinc ion binding K06204 - - 0.000000000008715 65.0
TLS2_k127_1311529_26 HNH endonuclease - - - 0.00000005899 65.0
TLS2_k127_1311529_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K18688 - 6.2.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003858 482.0
TLS2_k127_1311529_4 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 449.0
TLS2_k127_1311529_5 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009047 434.0
TLS2_k127_1311529_6 AMP-binding enzyme K01911,K02549 GO:0003674,GO:0003824,GO:0008150,GO:0008756,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0040007 4.2.1.113,6.2.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 386.0
TLS2_k127_1311529_7 chorismate binding enzyme K02552 - 5.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006714 331.0
TLS2_k127_1311529_8 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 314.0
TLS2_k127_1311529_9 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 289.0
TLS2_k127_1333524_0 Glycosyl hydrolase family 65, C-terminal domain K01194 GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0030312,GO:0044464,GO:0071944 3.2.1.28 6.774e-321 1009.0
TLS2_k127_1333524_1 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 601.0
TLS2_k127_1333524_2 Oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 589.0
TLS2_k127_1333524_3 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008306 517.0
TLS2_k127_1333524_4 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin K15650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001196 286.0
TLS2_k127_1333524_5 Sensory domain found in PocR K07315 - 3.1.3.3 0.000000000000000000000000000000000000004418 159.0
TLS2_k127_1333524_6 Immunoglobulin-like domain of bacterial spore germination - - - 0.000000000000000000000000002556 124.0
TLS2_k127_1333524_7 Protein of unknown function (DUF1641) - - - 0.0000000000000000000000005653 117.0
TLS2_k127_1333524_8 Domain of unknown function (DUF333) K09712 - - 0.0000001025 63.0
TLS2_k127_1352015_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.117e-207 658.0
TLS2_k127_1352015_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007037 493.0
TLS2_k127_1352015_2 Isocitrate/isopropylmalate dehydrogenase K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005047 452.0
TLS2_k127_1352015_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 436.0
TLS2_k127_1352015_4 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001035 248.0
TLS2_k127_1352015_5 helix_turn_helix isocitrate lyase regulation - - - 0.00000000000000000000000000000000000000000000000000000000000008242 222.0
TLS2_k127_1352015_6 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000007354 190.0
TLS2_k127_1352015_7 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944 - 0.000000000000000000000000000000000000000000000007781 175.0
TLS2_k127_1352015_8 - - - - 0.00000000000000000000000000000000000000000139 164.0
TLS2_k127_1352015_9 Aconitase family (aconitate hydratase) K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000001615 91.0
TLS2_k127_1352255_0 ABC transporter K01990,K09691,K09693 - 3.6.3.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006129 343.0
TLS2_k127_1352255_1 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 308.0
TLS2_k127_1352255_10 Domain of unknown function (DUF4214) - - - 0.000002566 61.0
TLS2_k127_1352255_2 Stage II sporulation protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001199 277.0
TLS2_k127_1352255_3 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000006318 235.0
TLS2_k127_1352255_4 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000006278 199.0
TLS2_k127_1352255_5 PFAM Methyltransferase domain K18827 - 2.1.1.294,2.7.1.181 0.00000000000000000000000000000000000000000004955 178.0
TLS2_k127_1352255_6 LGFP repeat - - - 0.00000000000000000000000000000000000000001961 175.0
TLS2_k127_1352255_7 Transport permease protein K01992 - - 0.0000000000000000000000000000001208 129.0
TLS2_k127_1352255_8 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000001171 104.0
TLS2_k127_1352255_9 N-acetylmuramoyl-L-alanine amidase - - - 0.000000000000001587 78.0
TLS2_k127_1352908_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 1.003e-313 982.0
TLS2_k127_1352908_1 von Willebrand factor (vWF) type A domain - - - 2.8e-287 896.0
TLS2_k127_1352908_10 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 472.0
TLS2_k127_1352908_11 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 453.0
TLS2_k127_1352908_12 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005876 437.0
TLS2_k127_1352908_13 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007557 394.0
TLS2_k127_1352908_14 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 391.0
TLS2_k127_1352908_15 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 388.0
TLS2_k127_1352908_16 succinate dehydrogenase K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 387.0
TLS2_k127_1352908_17 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003621 370.0
TLS2_k127_1352908_18 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 355.0
TLS2_k127_1352908_19 Transcriptional regulatory protein, C terminal K07776 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 331.0
TLS2_k127_1352908_2 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564 2.7.4.1 2.344e-263 828.0
TLS2_k127_1352908_20 Binding-protein-dependent transport system inner membrane component K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008934 327.0
TLS2_k127_1352908_21 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 319.0
TLS2_k127_1352908_22 Binding-protein-dependent transport system inner membrane component K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006171 311.0
TLS2_k127_1352908_23 membrane K08974 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 299.0
TLS2_k127_1352908_24 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 311.0
TLS2_k127_1352908_25 Major facilitator Superfamily - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004591 301.0
TLS2_k127_1352908_26 His Kinase A (phosphoacceptor) domain K07636,K07768 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000001875 278.0
TLS2_k127_1352908_27 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001712 276.0
TLS2_k127_1352908_28 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002007 264.0
TLS2_k127_1352908_29 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007815 253.0
TLS2_k127_1352908_3 Belongs to the isocitrate and isopropylmalate dehydrogenases family K00031 GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.1.1.42 2.565e-233 729.0
TLS2_k127_1352908_30 Formiminotransferase domain, N-terminal subdomain K00603 - 2.1.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000001151 251.0
TLS2_k127_1352908_31 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000002835 216.0
TLS2_k127_1352908_32 PFAM Glyoxalase bleomycin resistance protein dioxygenase - GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 - 0.000000000000000000000000000000000000000000000000001348 187.0
TLS2_k127_1352908_33 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000001011 196.0
TLS2_k127_1352908_34 Glycosyltransferase, MGT family - - - 0.0000000000000000000000000000000000000000004892 171.0
TLS2_k127_1352908_35 GrpB protein - - - 0.000000000000000000000000000000000000000002376 166.0
TLS2_k127_1352908_36 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.000000000000000000000000000000000000005074 148.0
TLS2_k127_1352908_37 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000000007638 139.0
TLS2_k127_1352908_38 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000000000006327 129.0
TLS2_k127_1352908_39 Protein of unknown function (DUF2089) - - - 0.0000000000000000000000000009918 123.0
TLS2_k127_1352908_4 Mg-chelatase subunit ChlI K03405 - 6.6.1.1 2.968e-218 689.0
TLS2_k127_1352908_40 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.000000000000000000000000001194 115.0
TLS2_k127_1352908_41 - - - - 0.00000000000000000000000002628 117.0
TLS2_k127_1352908_43 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000005837 103.0
TLS2_k127_1352908_44 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000002338 97.0
TLS2_k127_1352908_45 Aminoglycoside phosphotransferase - - - 0.000000000000000000711 98.0
TLS2_k127_1352908_46 - - - - 0.000000000004482 76.0
TLS2_k127_1352908_47 Zincin-like metallopeptidase - - - 0.00000000003018 65.0
TLS2_k127_1352908_48 RDD family - - - 0.000000001446 66.0
TLS2_k127_1352908_49 RDD family - - - 0.00000000183 67.0
TLS2_k127_1352908_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02021,K06147,K16786,K16787 - - 2.575e-196 647.0
TLS2_k127_1352908_50 Acyltransferase - GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.00000001776 65.0
TLS2_k127_1352908_51 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000003183 56.0
TLS2_k127_1352908_52 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000006804 55.0
TLS2_k127_1352908_53 RDD domain containing protein - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000001602 63.0
TLS2_k127_1352908_6 beta-mannosidase K01192,K15855 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044238,GO:0071704,GO:1901575 3.2.1.165,3.2.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003749 612.0
TLS2_k127_1352908_7 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008294 550.0
TLS2_k127_1352908_8 ABC transporter transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007016 521.0
TLS2_k127_1352908_9 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009313 506.0
TLS2_k127_1353545_0 SNF2 Helicase protein - - - 1.169e-291 925.0
TLS2_k127_1353545_1 AMP-binding enzyme K01897 - 6.2.1.3 3.112e-222 709.0
TLS2_k127_1353545_10 PFAM AIG2 family protein K00876 - 2.7.1.48 0.00000000000001948 77.0
TLS2_k127_1353545_11 Phosphotransferase enzyme family - - - 0.00000000004494 75.0
TLS2_k127_1353545_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00249 - 1.3.8.7 6.693e-215 685.0
TLS2_k127_1353545_3 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 432.0
TLS2_k127_1353545_4 pfam abc K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004334 400.0
TLS2_k127_1353545_5 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 395.0
TLS2_k127_1353545_6 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 352.0
TLS2_k127_1353545_7 Pentapeptide repeats (8 copies) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 314.0
TLS2_k127_1353545_8 SWIM zinc finger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005535 306.0
TLS2_k127_1353545_9 Regulatory protein tetr - - - 0.0000000000000000000000000000000000000000000000000000000000000002164 227.0
TLS2_k127_1369527_0 Uncharacterised protein family (UPF0182) K09118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 422.0
TLS2_k127_1369527_1 regulation of cell shape K04074 - - 0.0000000000000000000000000000000000000000000000000000003824 218.0
TLS2_k127_1369527_2 Belongs to the peptidase S16 family K07177 - - 0.00000000000000000000000000000000000000000000000002434 194.0
TLS2_k127_1376887_0 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 1.823e-291 902.0
TLS2_k127_1376887_1 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 386.0
TLS2_k127_1376887_2 CarboxypepD_reg-like domain - - - 0.000000000000000000000000000000183 143.0
TLS2_k127_1376887_3 Belongs to the peptidase S1 family K09632 GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005615,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0043170,GO:0044238,GO:0044421,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000208 133.0
TLS2_k127_1377422_0 VWA domain containing CoxE-like protein K07161 - - 1.465e-225 718.0
TLS2_k127_1377422_1 Class-II DAHP synthetase family K01626 - 2.5.1.54 9.33e-215 676.0
TLS2_k127_1377422_2 AAA domain (Cdc48 subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009401 451.0
TLS2_k127_1377422_3 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 464.0
TLS2_k127_1377422_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 367.0
TLS2_k127_1377422_5 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000000000000000007795 199.0
TLS2_k127_1377422_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000001098 175.0
TLS2_k127_1377422_7 Anti-sigma-K factor rskA - - - 0.00000000000000000000000000006837 131.0
TLS2_k127_1377422_8 Beta-lactamase - - - 0.000000000000000000215 102.0
TLS2_k127_1377422_9 - - - - 0.00000000000000005543 91.0
TLS2_k127_1383774_0 Anthranilate synthase component I, N terminal region K01657 - 4.1.3.27 1.65e-212 674.0
TLS2_k127_1383774_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 452.0
TLS2_k127_1383774_10 Glycosyltransferase family 87 - - - 0.00000000000000000000000000000000000004376 166.0
TLS2_k127_1383774_11 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.0000000000000000000000000000000000001361 153.0
TLS2_k127_1383774_12 - K07018 - - 0.000000000000000000000000000000000001118 150.0
TLS2_k127_1383774_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 436.0
TLS2_k127_1383774_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005569 392.0
TLS2_k127_1383774_4 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001103 281.0
TLS2_k127_1383774_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000003758 246.0
TLS2_k127_1383774_6 Protein of unknown function (DUF664) - - - 0.00000000000000000000000000000000000000000000000000000000006495 208.0
TLS2_k127_1383774_7 Histidine biosynthesis protein K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000001983 213.0
TLS2_k127_1383774_8 Belongs to the GcvT family K06980 - - 0.000000000000000000000000000000000000000000000000009161 191.0
TLS2_k127_1383774_9 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000000000005569 158.0
TLS2_k127_143895_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 2.007e-269 837.0
TLS2_k127_143895_1 RmlD substrate binding domain K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 450.0
TLS2_k127_143895_10 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan - - - 0.00000000000000000000000000000000003771 154.0
TLS2_k127_143895_11 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000191 135.0
TLS2_k127_143895_13 Prokaryotic dksA/traR C4-type zinc finger - - - 0.00000000000007929 75.0
TLS2_k127_143895_2 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009578 381.0
TLS2_k127_143895_3 Prephenate dehydrogenase K00210,K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 373.0
TLS2_k127_143895_4 Phage integrase, N-terminal SAM-like domain K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 348.0
TLS2_k127_143895_5 RNA pseudouridylate synthase K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005298 319.0
TLS2_k127_143895_6 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 318.0
TLS2_k127_143895_7 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006716 334.0
TLS2_k127_143895_8 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000000000000000000000000000000004402 243.0
TLS2_k127_143895_9 NUDIX domain K01515 - 3.6.1.13 0.000000000000000000000000000000000001286 157.0
TLS2_k127_1504720_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 397.0
TLS2_k127_1504720_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000409 193.0
TLS2_k127_1504720_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0030312,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.00000000000000000000000000000000000000000000001106 180.0
TLS2_k127_1504720_3 - - - - 0.0000000000005693 78.0
TLS2_k127_1504720_4 - - - - 0.00000000003017 76.0
TLS2_k127_1532438_0 Large extracellular alpha-helical protein K06894 - - 0.0 1767.0
TLS2_k127_1532438_1 serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 1.442e-255 808.0
TLS2_k127_1532438_10 Transcriptional regulator, LacI family K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004113 342.0
TLS2_k127_1532438_11 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000589 338.0
TLS2_k127_1532438_12 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003135 276.0
TLS2_k127_1532438_13 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001056 260.0
TLS2_k127_1532438_14 NADH pyrophosphatase-like rudimentary NUDIX domain K03426 - 3.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000002849 261.0
TLS2_k127_1532438_15 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009661 258.0
TLS2_k127_1532438_16 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000008264 252.0
TLS2_k127_1532438_17 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000001094 233.0
TLS2_k127_1532438_18 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000002966 226.0
TLS2_k127_1532438_19 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000000000000000000000000000001083 193.0
TLS2_k127_1532438_2 Rhodanese Homology Domain - - - 2.756e-197 624.0
TLS2_k127_1532438_20 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000007548 170.0
TLS2_k127_1532438_21 metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000000000000000000002603 164.0
TLS2_k127_1532438_22 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000005488 153.0
TLS2_k127_1532438_23 protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.000000000000000000031 98.0
TLS2_k127_1532438_24 Protein conserved in bacteria K09796 - - 0.000000000000000003565 94.0
TLS2_k127_1532438_25 - - - - 0.000000000003918 74.0
TLS2_k127_1532438_26 Hemerythrin HHE cation binding domain - - - 0.00000000005944 73.0
TLS2_k127_1532438_29 PFAM blue (type 1) copper domain protein - - - 0.0000008032 55.0
TLS2_k127_1532438_3 Flotillin K07192 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 560.0
TLS2_k127_1532438_30 SdpI/YhfL protein family - - - 0.0000009638 58.0
TLS2_k127_1532438_4 diacylglycerol O-acyltransferase K00635 - 2.3.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 465.0
TLS2_k127_1532438_5 N-terminal of TM subunit in PBP-dependent ABC transporters K15771 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 425.0
TLS2_k127_1532438_6 protein conserved in bacteria K09781 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 408.0
TLS2_k127_1532438_7 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003289 392.0
TLS2_k127_1532438_8 ABC transporter K15772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 361.0
TLS2_k127_1532438_9 Bacterial extracellular solute-binding protein K15770 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 361.0
TLS2_k127_1532554_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 2.134e-321 1006.0
TLS2_k127_1532554_1 Domain of unknown function (DUF3367) - - - 7.946e-303 981.0
TLS2_k127_1532554_10 Nitrate and nitrite sensing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 323.0
TLS2_k127_1532554_11 Domain of unknown function (DUF3367) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 308.0
TLS2_k127_1532554_12 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000226 252.0
TLS2_k127_1532554_13 ATP binding protein K06945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006022 247.0
TLS2_k127_1532554_14 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001217 249.0
TLS2_k127_1532554_15 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000001061 228.0
TLS2_k127_1532554_16 Roadblock lc7 family protein K07131 - - 0.000000000000000000000000000000000000000000000002764 177.0
TLS2_k127_1532554_17 Transcriptional regulator K03709 - - 0.00000000000000000000000000000000000001441 154.0
TLS2_k127_1532554_18 Protein of unknown function (DUF742) - - - 0.0000000000000000000000000103 113.0
TLS2_k127_1532554_19 - - - - 0.0000000000006652 74.0
TLS2_k127_1532554_2 PFAM amine oxidase K01854 - 5.4.99.9 2.51e-229 719.0
TLS2_k127_1532554_20 Domain of unknown function (DUF4388) - - - 0.00000002952 64.0
TLS2_k127_1532554_21 DNA-binding transcription factor activity - - - 0.000009512 55.0
TLS2_k127_1532554_3 ABC transporter transmembrane region K06147 - - 4.243e-219 706.0
TLS2_k127_1532554_4 ABC-type multidrug transport system, ATPase and permease K06147 - - 4.115e-201 653.0
TLS2_k127_1532554_5 COG1062 Zn-dependent alcohol dehydrogenases, class III K00121 - 1.1.1.1,1.1.1.284 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 492.0
TLS2_k127_1532554_6 Aminopeptidase I zinc metalloprotease (M18) K01267 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009758 483.0
TLS2_k127_1532554_7 Glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 422.0
TLS2_k127_1532554_8 Acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004878 368.0
TLS2_k127_1532554_9 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 317.0
TLS2_k127_1582455_0 Ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 2.416e-272 850.0
TLS2_k127_1582455_1 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 522.0
TLS2_k127_1582455_10 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000001495 223.0
TLS2_k127_1582455_11 COG NOG14600 non supervised orthologous group - - - 0.00000000000000000000000000001765 117.0
TLS2_k127_1582455_13 single-stranded DNA binding K03111 - - 0.00000000000716 72.0
TLS2_k127_1582455_2 Ferredoxin oxidoreductase K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 496.0
TLS2_k127_1582455_3 fructose-bisphosphate aldolase K01623 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 411.0
TLS2_k127_1582455_4 Thiamine pyrophosphokinase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004963 415.0
TLS2_k127_1582455_5 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K19745 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006844 395.0
TLS2_k127_1582455_6 Protein of unknown function (DUF1015) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003085 362.0
TLS2_k127_1582455_7 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000001256 264.0
TLS2_k127_1582455_8 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000008583 247.0
TLS2_k127_1582455_9 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000001605 220.0
TLS2_k127_1665806_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 439.0
TLS2_k127_1665806_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 444.0
TLS2_k127_1665806_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 411.0
TLS2_k127_1665806_3 Ecdysteroid kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 333.0
TLS2_k127_1665806_4 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000002379 226.0
TLS2_k127_1665806_5 Methyltransferase small domain K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000002801 216.0
TLS2_k127_1665806_6 - - - - 0.00000000000000000000000000000000000003575 156.0
TLS2_k127_1665806_7 cyclic nucleotide binding K10914 - - 0.0000000000000000000000000000008753 126.0
TLS2_k127_1665806_8 Binds the 23S rRNA K02909 - - 0.00000000000000000000000004844 109.0
TLS2_k127_1834522_0 Glycosyltransferase family 28 C-terminal domain - - - 8.102e-240 760.0
TLS2_k127_1834522_1 ABC transporter K02056 - 3.6.3.17 4.325e-215 680.0
TLS2_k127_1834522_10 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007152 336.0
TLS2_k127_1834522_11 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 293.0
TLS2_k127_1834522_12 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005771 287.0
TLS2_k127_1834522_13 Tetrapyrrole (Corrin/Porphyrin) Methylases K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005442 285.0
TLS2_k127_1834522_14 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009874 282.0
TLS2_k127_1834522_15 Multimeric flavodoxin WrbA - - - 0.000000000000000000000000000000000000000000000000000000000004136 211.0
TLS2_k127_1834522_16 Uncharacterized ACR, COG1678 K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000003595 182.0
TLS2_k127_1834522_17 dithiol-disulfide isomerase involved in polyketide biosynthesis - - - 0.000000000000000000000000000000000000000000000003066 181.0
TLS2_k127_1834522_18 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000005862 165.0
TLS2_k127_1834522_19 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000000000001373 148.0
TLS2_k127_1834522_2 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008172 597.0
TLS2_k127_1834522_20 oxidoreductase - - - 0.000000000000000000000000000000006829 140.0
TLS2_k127_1834522_21 heme binding K21471,K21472 - - 0.00000000000000000000000000000004479 140.0
TLS2_k127_1834522_22 Cytidine and deoxycytidylate deaminase zinc-binding region K01489 - 3.5.4.5 0.00000000000000000000000000000009867 136.0
TLS2_k127_1834522_23 oxidoreductase - - - 0.0000000000000000000000000000001871 131.0
TLS2_k127_1834522_24 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000003542 125.0
TLS2_k127_1834522_25 Thioesterase - - - 0.0000000000000000000000000000007431 131.0
TLS2_k127_1834522_3 phosphorylase K00756,K00758 GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 580.0
TLS2_k127_1834522_4 PFAM Adenosine AMP deaminase K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005943 533.0
TLS2_k127_1834522_5 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 486.0
TLS2_k127_1834522_6 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 451.0
TLS2_k127_1834522_7 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005526 387.0
TLS2_k127_1834522_8 Phytanoyl-CoA dioxygenase (PhyH) K00477 - 1.14.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 344.0
TLS2_k127_1834522_9 MviN-like protein K03980 GO:0003674,GO:0005215,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 335.0
TLS2_k127_188733_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1146.0
TLS2_k127_188733_1 Peptidase family M3 K01284 - 3.4.15.5 1.48e-294 916.0
TLS2_k127_188733_10 low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002226 278.0
TLS2_k127_188733_11 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000004131 212.0
TLS2_k127_188733_12 Ferric uptake regulator family K22297 - - 0.00000000000000000000000000000000000000000000000000000000002131 221.0
TLS2_k127_188733_13 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000006499 205.0
TLS2_k127_188733_14 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000005738 202.0
TLS2_k127_188733_15 PFAM NUDIX hydrolase - - - 0.0000000000000000000000000000000000000000000000000000003571 201.0
TLS2_k127_188733_16 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000006909 203.0
TLS2_k127_188733_17 Dienelactone hydrolase - - - 0.0000000000000000000000000000000000000000000000000001388 197.0
TLS2_k127_188733_18 GlcNAc-PI de-N-acetylase K22135 - - 0.0000000000000000000000000000000000000000000000000003159 199.0
TLS2_k127_188733_19 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000001126 193.0
TLS2_k127_188733_2 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 4.425e-214 679.0
TLS2_k127_188733_20 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000001271 168.0
TLS2_k127_188733_21 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000004125 168.0
TLS2_k127_188733_22 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000001159 168.0
TLS2_k127_188733_23 Transcriptional regulator - - - 0.000000000000000000000000000000000000004262 149.0
TLS2_k127_188733_24 transcriptional - - - 0.000000000000000000000000000000000007294 139.0
TLS2_k127_188733_25 Domain of unknown function (DUF1330) - - - 0.000000000000000000000000000002201 125.0
TLS2_k127_188733_26 oxidoreductase activity, acting on CH-OH group of donors - - - 0.00000000000000000000000001367 115.0
TLS2_k127_188733_27 Protein of unknown function (DUF454) K09790 - - 0.00000000000000000000000313 107.0
TLS2_k127_188733_28 membrane K07149 - - 0.000000000000001303 85.0
TLS2_k127_188733_29 ParB-like nuclease domain - - - 0.000000000002626 75.0
TLS2_k127_188733_3 PFAM FMN-dependent alpha-hydroxy acid dehydrogenase K00101,K00104 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 1.1.2.3,1.1.3.15 1.224e-202 638.0
TLS2_k127_188733_30 sigma factor antagonist activity K04757 - 2.7.11.1 0.00004577 51.0
TLS2_k127_188733_4 Carboxylesterase family K03929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009899 527.0
TLS2_k127_188733_5 MmgE/PrpD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 497.0
TLS2_k127_188733_6 Carboxylesterase family K03929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 447.0
TLS2_k127_188733_7 Luciferase-like monooxygenase K15510 - 1.1.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 412.0
TLS2_k127_188733_8 Methyltransferase small domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 380.0
TLS2_k127_188733_9 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007292 374.0
TLS2_k127_1888538_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 0.0 1181.0
TLS2_k127_1888538_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 1.221e-217 683.0
TLS2_k127_1888538_10 Bacterial regulatory helix-turn-helix protein, lysR family K04761 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001406 279.0
TLS2_k127_1888538_11 UTRA K03710 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005053 274.0
TLS2_k127_1888538_12 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006918 268.0
TLS2_k127_1888538_13 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000001374 197.0
TLS2_k127_1888538_14 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000009258 188.0
TLS2_k127_1888538_15 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000000002534 150.0
TLS2_k127_1888538_16 Protein of unknown function (DUF971) - - - 0.0000000000000000000000000000000000003739 145.0
TLS2_k127_1888538_17 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000003773 132.0
TLS2_k127_1888538_2 Acyl-CoA synthetase (NDP forming) - - - 2.846e-216 705.0
TLS2_k127_1888538_3 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 575.0
TLS2_k127_1888538_4 Carboxyl transferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 534.0
TLS2_k127_1888538_5 Binding-protein-dependent transport systems inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006995 537.0
TLS2_k127_1888538_6 Acyl-CoA dehydrogenase, N-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 477.0
TLS2_k127_1888538_7 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000768 395.0
TLS2_k127_1888538_8 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 355.0
TLS2_k127_1888538_9 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003902 328.0
TLS2_k127_1938346_0 GTP-binding protein K06207 - - 1.668e-205 655.0
TLS2_k127_1938346_1 2 iron, 2 sulfur cluster binding K00087,K03518,K07302 - 1.17.1.4,1.2.5.3,1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 588.0
TLS2_k127_1938346_10 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007007 310.0
TLS2_k127_1938346_11 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 307.0
TLS2_k127_1938346_12 Anion-transporting ATPase - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002296 280.0
TLS2_k127_1938346_13 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000004603 226.0
TLS2_k127_1938346_14 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K00219,K01069 - 1.3.1.34,3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000001484 232.0
TLS2_k127_1938346_15 dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000000000000000000000000000002474 220.0
TLS2_k127_1938346_16 Belongs to the peptidase S51 family K13282 - 3.4.15.6 0.000000000000000000000000000000000000000000000000000000003816 210.0
TLS2_k127_1938346_17 Iron-sulphur cluster biosynthesis K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564 - 0.00000000000000000000000000000000000000002444 159.0
TLS2_k127_1938346_18 Phosphoribosyl-ATP pyrophosphohydrolase - - - 0.00000000000000000000000000000000000001063 145.0
TLS2_k127_1938346_19 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000008497 134.0
TLS2_k127_1938346_2 ACT domain K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006919 551.0
TLS2_k127_1938346_20 peptidyl-prolyl cis-trans isomerase K03768 - 5.2.1.8 0.0000000000000000000000000000000008565 141.0
TLS2_k127_1938346_21 STAS domain - - - 0.0000000000000000000000000000004955 135.0
TLS2_k127_1938346_22 oxidation-reduction process K09022 - 3.5.99.10 0.000000000000000000000000000005104 125.0
TLS2_k127_1938346_23 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.0000000000000000000000000001041 119.0
TLS2_k127_1938346_24 FxsA cytoplasmic membrane protein K07113 - - 0.0000000000000000000000000196 114.0
TLS2_k127_1938346_25 Phosphoglycerate mutase family - - - 0.0000000000000000000000000689 120.0
TLS2_k127_1938346_26 Cold shock protein K03704 - - 0.00000000000000000000001958 106.0
TLS2_k127_1938346_27 Metallo-beta-lactamase superfamily - - - 0.00000000003573 76.0
TLS2_k127_1938346_3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 496.0
TLS2_k127_1938346_4 B12 binding domain K14447 - 5.4.99.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 495.0
TLS2_k127_1938346_5 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 447.0
TLS2_k127_1938346_6 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 383.0
TLS2_k127_1938346_7 Anion-transporting ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009183 358.0
TLS2_k127_1938346_8 glutamine synthetase K01915 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008674 332.0
TLS2_k127_1938346_9 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007454 337.0
TLS2_k127_1977535_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 3.862e-312 972.0
TLS2_k127_1977535_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000077 496.0
TLS2_k127_1977535_10 AAA domain K00845 - 2.7.1.2 0.0000000000000000007552 96.0
TLS2_k127_1977535_11 Preprotein translocase subunit K03210 - - 0.000000000000003649 79.0
TLS2_k127_1977535_12 HNH endonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00003612 57.0
TLS2_k127_1977535_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005079 468.0
TLS2_k127_1977535_3 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 365.0
TLS2_k127_1977535_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 347.0
TLS2_k127_1977535_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000001167 265.0
TLS2_k127_1977535_6 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009378,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000002402 212.0
TLS2_k127_1977535_7 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.000000000000000000000000000000000000000000000002008 189.0
TLS2_k127_1977535_8 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000006037 176.0
TLS2_k127_1977535_9 CHAD - - - 0.00000000000000000000000000000000000001255 156.0
TLS2_k127_1998621_0 AMP-binding enzyme C-terminal domain - - - 1.196e-248 775.0
TLS2_k127_1998621_1 ABC transporter - - - 1.902e-194 621.0
TLS2_k127_1998621_2 F420-dependent oxidoreductase, MSMEG_3544 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008975 329.0
TLS2_k127_1998621_3 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 324.0
TLS2_k127_1998621_4 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000003808 181.0
TLS2_k127_1998621_5 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000004059 159.0
TLS2_k127_1998621_6 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000004596 142.0
TLS2_k127_1998621_7 lactoylglutathione lyase activity - - - 0.000000000000000000006104 103.0
TLS2_k127_1998621_8 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000003362 88.0
TLS2_k127_1998621_9 Protein of unknown function (DUF2662) - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.0000000002217 64.0
TLS2_k127_2003718_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 3.6.3.14 4.028e-251 788.0
TLS2_k127_2003718_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 2.778e-233 732.0
TLS2_k127_2003718_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 372.0
TLS2_k127_2003718_3 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000005171 239.0
TLS2_k127_2003718_4 Glycosyl transferase family 4 K02851 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000002049 221.0
TLS2_k127_2003718_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000002323 161.0
TLS2_k127_2003718_6 - - - - 0.00000000000000000000000000000000000005621 153.0
TLS2_k127_2003718_7 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000001518 105.0
TLS2_k127_2003718_8 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000001289 67.0
TLS2_k127_20589_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009752 408.0
TLS2_k127_20589_1 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 331.0
TLS2_k127_20589_2 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003108 256.0
TLS2_k127_20589_3 Lumazine binding domain K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000001098 234.0
TLS2_k127_20589_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000007723 207.0
TLS2_k127_20589_5 ABC transporter permease - - - 0.00000000000000000000000000000000000000000000000003218 198.0
TLS2_k127_20589_6 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - 0.0000000000000000000000000000000000000000000003526 181.0
TLS2_k127_20589_7 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.000000000000000000000000000000001141 133.0
TLS2_k127_2148348_0 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 628.0
TLS2_k127_2148348_1 D-arabinono-1,4-lactone oxidase K00103 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016491,GO:0016627,GO:0016632,GO:0019752,GO:0019852,GO:0019853,GO:0030312,GO:0042364,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046364,GO:0046394,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:0080049,GO:1901576 1.1.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 452.0
TLS2_k127_2148348_10 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004044 280.0
TLS2_k127_2148348_11 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002418 282.0
TLS2_k127_2148348_13 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003995 271.0
TLS2_k127_2148348_14 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000001526 225.0
TLS2_k127_2148348_15 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000009973 211.0
TLS2_k127_2148348_16 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000001429 202.0
TLS2_k127_2148348_17 - - - - 0.00000000000000000000000000000000000000000000001895 179.0
TLS2_k127_2148348_18 Thioredoxin K00384,K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.9 0.0000000000000000000000000000000000000000000003716 180.0
TLS2_k127_2148348_19 PFAM Flavodoxin K03809 - 1.6.5.2 0.000000000000000000000000000000000000000000000873 173.0
TLS2_k127_2148348_2 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004333 427.0
TLS2_k127_2148348_20 PFAM Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000001849 162.0
TLS2_k127_2148348_21 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000003604 150.0
TLS2_k127_2148348_22 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000003232 141.0
TLS2_k127_2148348_23 - - - - 0.0000000000000000000000000007433 132.0
TLS2_k127_2148348_24 COG2335, Secreted and surface protein containing fasciclin-like repeats - - - 0.000000000000001238 87.0
TLS2_k127_2148348_25 - - - - 0.00000000002176 75.0
TLS2_k127_2148348_26 COGs COG0628 permease - - - 0.0002953 53.0
TLS2_k127_2148348_3 ABC transporter K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 432.0
TLS2_k127_2148348_4 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 415.0
TLS2_k127_2148348_5 Putative serine dehydratase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007939 406.0
TLS2_k127_2148348_6 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 378.0
TLS2_k127_2148348_7 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 374.0
TLS2_k127_2148348_8 DNA topoisomerase I K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 325.0
TLS2_k127_2148348_9 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007773 305.0
TLS2_k127_2154523_0 SNF2 family N-terminal domain - - - 0.0 1247.0
TLS2_k127_2154523_1 Pfam Sulfatase - - - 7.635e-202 645.0
TLS2_k127_2154523_10 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000001204 130.0
TLS2_k127_2154523_11 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000008334 116.0
TLS2_k127_2154523_12 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000001625 117.0
TLS2_k127_2154523_14 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000002608 79.0
TLS2_k127_2154523_16 Protein of unknown function (DUF664) - - - 0.00005656 55.0
TLS2_k127_2154523_2 Aminotransferase class-III K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 561.0
TLS2_k127_2154523_3 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 434.0
TLS2_k127_2154523_4 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 404.0
TLS2_k127_2154523_5 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 377.0
TLS2_k127_2154523_6 Protein of unknown function (DUF3089) - - - 0.000000000000000000000000000000000000000000000000000000000000000000005406 250.0
TLS2_k127_2154523_7 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000000000000000000000000000000000000005883 177.0
TLS2_k127_2154523_8 MaoC like domain - - - 0.00000000000000000000000000000000000003134 149.0
TLS2_k127_2154523_9 HDOD domain - - - 0.00000000000000000000000000000000000004161 155.0
TLS2_k127_2179014_0 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006409 445.0
TLS2_k127_2179014_1 ATPase associated with various cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006428 383.0
TLS2_k127_2179014_10 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000000000000002071 146.0
TLS2_k127_2179014_11 HisG, C-terminal domain K00765 - 2.4.2.17 0.00000000000000000000000000000000006629 147.0
TLS2_k127_2179014_12 Metal-sensitive transcriptional repressor - - - 0.00000000000000000189 89.0
TLS2_k127_2179014_13 Phosphoribosyl-ATP K01523 - 3.6.1.31 0.000000000002126 70.0
TLS2_k127_2179014_2 WYL domain K13572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 351.0
TLS2_k127_2179014_3 ABC transporter (Permease) K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 338.0
TLS2_k127_2179014_4 PFAM LmbE family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 298.0
TLS2_k127_2179014_5 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006284 281.0
TLS2_k127_2179014_6 iron dependent repressor - - - 0.00000000000000000000000000000000000000000000000000000001564 202.0
TLS2_k127_2179014_7 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000002172 207.0
TLS2_k127_2179014_8 mannose-6-phosphate isomerase K01809 - 5.3.1.8 0.00000000000000000000000000000000000000000000000006114 201.0
TLS2_k127_2179014_9 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000008954 168.0
TLS2_k127_219391_0 TopoisomeraseII K02470 - 5.99.1.3 1.831e-280 876.0
TLS2_k127_219391_1 tRNA nucleotidyltransferase poly(A) polymerase K00970,K00974 - 2.7.7.19,2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007568 512.0
TLS2_k127_219391_10 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007906 357.0
TLS2_k127_219391_11 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 347.0
TLS2_k127_219391_12 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 338.0
TLS2_k127_219391_13 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004809 336.0
TLS2_k127_219391_14 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 328.0
TLS2_k127_219391_15 Uncharacterised protein, DegV family COG1307 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002986 274.0
TLS2_k127_219391_16 Putative single-stranded nucleic acids-binding domain K06346 - - 0.0000000000000000000000000000000000000000000000000000000321 209.0
TLS2_k127_219391_17 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000001895 201.0
TLS2_k127_219391_18 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000001257 186.0
TLS2_k127_219391_19 60Kd inner membrane protein K03217 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000004615 172.0
TLS2_k127_219391_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008391 481.0
TLS2_k127_219391_20 Ribosomal RNA small subunit methyltransferase G K03501 - 2.1.1.170 0.00000000000000000000000000000000006508 142.0
TLS2_k127_219391_21 Transcriptional regulator - - - 0.0000000000000000000000000000000001897 148.0
TLS2_k127_219391_22 Thioredoxin-like domain K03671 - - 0.000000000000000000000000000000002166 142.0
TLS2_k127_219391_23 FR47-like protein - - - 0.000000000000000000000000000009107 128.0
TLS2_k127_219391_24 Family of unknown function (DUF5318) - - - 0.000000000000000000000000001198 117.0
TLS2_k127_219391_25 extracellular matrix structural constituent - - - 0.0000000000000000000000006771 122.0
TLS2_k127_219391_26 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000005033 99.0
TLS2_k127_219391_27 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000002332 95.0
TLS2_k127_219391_29 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000006405 64.0
TLS2_k127_219391_3 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 470.0
TLS2_k127_219391_30 Belongs to the UPF0232 family - - - 0.000000001164 63.0
TLS2_k127_219391_31 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 GO:0008150,GO:0040007 3.1.26.5 0.0000001858 57.0
TLS2_k127_219391_4 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 449.0
TLS2_k127_219391_5 Cellulose biosynthesis protein BcsQ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 402.0
TLS2_k127_219391_6 penicillin-binding protein - GO:0001666,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0008144,GO:0008150,GO:0008658,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0033554,GO:0036094,GO:0036293,GO:0036294,GO:0042221,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0050896,GO:0051716,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0097159,GO:1901363,GO:1901681 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 425.0
TLS2_k127_219391_7 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 384.0
TLS2_k127_219391_8 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004123 377.0
TLS2_k127_219391_9 dehydrogenase K00001 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 364.0
TLS2_k127_2226987_0 UvrD-like helicase C-terminal domain K03657 GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 1.011e-252 793.0
TLS2_k127_2226987_1 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 589.0
TLS2_k127_2226987_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 500.0
TLS2_k127_2226987_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 494.0
TLS2_k127_2226987_4 Mo-molybdopterin cofactor metabolic process K03636 - - 0.0000000000000000000001007 101.0
TLS2_k127_2226987_6 Protein of unknown function (DUF2510) - - - 0.0007307 51.0
TLS2_k127_2283979_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 3.121e-198 628.0
TLS2_k127_2283979_1 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 485.0
TLS2_k127_2283979_2 ABC transporter, periplasmic binding protein, thiB subfamily K02064 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007368 384.0
TLS2_k127_2283979_3 Aldo/keto reductase family K19265 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 331.0
TLS2_k127_2283979_4 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007392 283.0
TLS2_k127_2283979_5 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003763 285.0
TLS2_k127_2283979_6 THIamine pyrophosphokinase K00949 - 2.7.6.2 0.0000000000000000000000000000002289 133.0
TLS2_k127_2283979_7 NUDIX domain - - - 0.0000000000000000000000000001056 134.0
TLS2_k127_2283979_8 Protein of unknown function (DUF559) - - - 0.00000000000000000000001463 112.0
TLS2_k127_2283979_9 DnaJ-class molecular chaperone with C-terminal Zn finger domain K03686 - - 0.0000000007885 68.0
TLS2_k127_2318556_0 ATP synthase alpha/beta family, nucleotide-binding domain K02412 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008914 539.0
TLS2_k127_2318556_1 FliG N-terminal domain K02410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 357.0
TLS2_k127_2318556_10 Flagellar hook-length control protein FliK K02414 GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 - 0.000002055 61.0
TLS2_k127_2318556_2 The M ring may be actively involved in energy transduction K02409 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 347.0
TLS2_k127_2318556_3 NlpC/P60 family K20742,K21471 - 3.4.14.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 317.0
TLS2_k127_2318556_4 Flagellar basal body rod FlgEFG protein C-terminal K02388 - - 0.000000000000000000000000000000000000008263 149.0
TLS2_k127_2318556_5 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.000000000000000000000000001374 115.0
TLS2_k127_2318556_6 Flagellar hook-basal body complex protein FliE K02408 - - 0.000000000000000001553 91.0
TLS2_k127_2318556_7 Flagellar hook capping protein K02389 - - 0.000000000000000001822 98.0
TLS2_k127_2318556_8 Flagellar assembly protein FliH K02411 - - 0.00000000000000001205 92.0
TLS2_k127_2318556_9 Protein of unknown function (DUF559) - - - 0.0000000000000002062 92.0
TLS2_k127_2338844_0 Alcohol dehydrogenase GroES-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 613.0
TLS2_k127_2338844_1 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 475.0
TLS2_k127_2338844_2 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006374 349.0
TLS2_k127_2338844_3 Aminoglycoside/hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 337.0
TLS2_k127_2338844_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 315.0
TLS2_k127_2338844_5 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000003026 200.0
TLS2_k127_2338844_6 Methyltransferase domain - - - 0.00000000000000000000000000000000000008888 149.0
TLS2_k127_2338844_7 YCII-related domain - - - 0.00000000000000000000000000000005986 136.0
TLS2_k127_2338844_8 Acetyltransferase (GNAT) domain K00663 - 2.3.1.82 0.00000000000000000000000000006233 126.0
TLS2_k127_2338844_9 HNH endonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000001206 64.0
TLS2_k127_2352337_0 helicase K03722 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004645 308.0
TLS2_k127_2352337_1 oxidoreductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000006538 230.0
TLS2_k127_2352337_2 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000005393 209.0
TLS2_k127_2352337_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000004833 64.0
TLS2_k127_2375363_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 1.006e-194 626.0
TLS2_k127_2375363_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 423.0
TLS2_k127_2375363_2 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008317 379.0
TLS2_k127_2375363_3 glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000111 270.0
TLS2_k127_2375363_4 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001147 256.0
TLS2_k127_2375363_5 diguanylate cyclase - - - 0.0000000000000000000000000000000003958 143.0
TLS2_k127_2375363_6 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000003634 112.0
TLS2_k127_2375363_7 cell cycle K05589,K12065,K13052 - - 0.0001491 49.0
TLS2_k127_242535_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 8.099e-226 705.0
TLS2_k127_242535_1 N-4 methylation of cytosine K00571,K00590 - 2.1.1.113,2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 484.0
TLS2_k127_242535_2 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 366.0
TLS2_k127_242535_3 acyl-CoA transferases carnitine dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 341.0
TLS2_k127_242535_4 DNA-binding transcription factor activity K21703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009711 266.0
TLS2_k127_242535_6 iron dependent repressor - - - 0.000000003977 66.0
TLS2_k127_242535_7 - - - - 0.0000001079 64.0
TLS2_k127_242535_8 - - - - 0.00007871 53.0
TLS2_k127_2486001_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004489 552.0
TLS2_k127_2486001_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 454.0
TLS2_k127_2486001_2 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 426.0
TLS2_k127_2486001_3 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006117 394.0
TLS2_k127_2486001_4 GlcNAc-PI de-N-acetylase K18455 GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657 3.5.1.115 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000571 329.0
TLS2_k127_2486001_5 polysaccharide catabolic process K03478 - 3.5.1.105 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005365 318.0
TLS2_k127_2486001_6 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004567 325.0
TLS2_k127_2486001_7 nuclease K01174,K07038 - 3.1.31.1 0.0000000000000000000000000000000007607 139.0
TLS2_k127_2486001_8 cellular response to DNA damage stimulus K07340 - - 0.000000000000000000000000002349 117.0
TLS2_k127_2486001_9 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000005585 83.0
TLS2_k127_2500907_0 Dienelactone hydrolase family - - - 6.153e-214 683.0
TLS2_k127_2500907_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 4.2.1.33,4.2.1.35 1.369e-199 627.0
TLS2_k127_2500907_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 4.963e-198 638.0
TLS2_k127_2500907_3 Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007036 572.0
TLS2_k127_2500907_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002991 271.0
TLS2_k127_2535790_0 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 509.0
TLS2_k127_2535790_1 Pyridoxal-phosphate dependent enzyme K21148 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 475.0
TLS2_k127_2535790_2 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000001526 171.0
TLS2_k127_2535790_3 JAB/MPN domain K21140 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016787,GO:0019344,GO:0019538,GO:0019752,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.13.1.6 0.0000000000000000000000000000000000003793 148.0
TLS2_k127_2535790_4 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000000002404 98.0
TLS2_k127_2535790_5 DNA-binding transcription factor activity - - - 0.00000000000000005183 87.0
TLS2_k127_2535790_6 - - - - 0.0000000000000001254 87.0
TLS2_k127_2535790_7 HNH nucleases - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000001368 58.0
TLS2_k127_2656234_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 519.0
TLS2_k127_2656234_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 384.0
TLS2_k127_2656234_2 transferase activity, transferring alkyl or aryl (other than methyl) groups K22205 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006732 308.0
TLS2_k127_2656234_3 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 294.0
TLS2_k127_2656234_4 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001645 275.0
TLS2_k127_2656234_5 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006969 270.0
TLS2_k127_2656234_6 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000000000000000000001201 224.0
TLS2_k127_2656234_7 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000004388 188.0
TLS2_k127_2656234_8 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.0000000000000000000000000000000000000000003425 161.0
TLS2_k127_2656234_9 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000227 159.0
TLS2_k127_270536_0 domain protein K14475 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 547.0
TLS2_k127_270536_1 PFAM AAA ATPase central domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 478.0
TLS2_k127_270536_10 Diacylglycerol kinase catalytic domain K19302 - 3.6.1.27 0.00000000000000000000000000000000000006607 158.0
TLS2_k127_270536_11 Protein conserved in bacteria - - - 0.00000000002084 72.0
TLS2_k127_270536_12 - - - - 0.00000001158 68.0
TLS2_k127_270536_2 domain protein K14475 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 411.0
TLS2_k127_270536_3 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 319.0
TLS2_k127_270536_4 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004521 270.0
TLS2_k127_270536_5 Belongs to the carbohydrate kinase PfkB family - - - 0.00000000000000000000000000000000000000000000000000000000000000005841 234.0
TLS2_k127_270536_6 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000002163 236.0
TLS2_k127_270536_7 Protein of unknown function (DUF4255) - - - 0.0000000000000000000000000000000000000000001645 173.0
TLS2_k127_270536_8 Methylenetetrahydrofolate reductase - - - 0.000000000000000000000000000000000000000001003 160.0
TLS2_k127_270536_9 Maf-like protein K06287 GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0030428,GO:0032506,GO:0044085,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0090529,GO:1902410,GO:1903047 - 0.000000000000000000000000000000000000001956 166.0
TLS2_k127_2835909_0 MacB-like periplasmic core domain K02004 - - 7.971e-201 654.0
TLS2_k127_2835909_1 Taurine catabolism dioxygenase TauD, TfdA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 404.0
TLS2_k127_2835909_10 regulatory protein TetR - - - 0.0000000000318 67.0
TLS2_k127_2835909_2 Helix-hairpin-helix domain K04477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 395.0
TLS2_k127_2835909_3 D-alanyl-D-alanine carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 315.0
TLS2_k127_2835909_4 Molybdate ABC transporter K02018 - - 0.0000000000000000000000000000000000000000000000000000001017 202.0
TLS2_k127_2835909_5 Molybdenum ABC transporter K02020 - - 0.0000000000000000000000000000000000000000000000000000001397 216.0
TLS2_k127_2835909_6 GnaT family - - - 0.000000000000000000000000000000000000000005737 175.0
TLS2_k127_2835909_7 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 - 3.6.3.29 0.000000000000000000000000000000000000004646 163.0
TLS2_k127_2835909_8 binding domain K03750,K07219 - 2.10.1.1 0.000000000000000000000000000002909 132.0
TLS2_k127_2835909_9 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000001806 122.0
TLS2_k127_2854870_0 Belongs to the argininosuccinate synthase family. Type K01940 - 6.3.4.5 4.017e-223 698.0
TLS2_k127_2854870_1 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 8.204e-201 644.0
TLS2_k127_2854870_10 Belongs to the DNA glycosylase MPG family K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000005297 237.0
TLS2_k127_2854870_11 Arginine repressor, DNA binding domain K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000002823 196.0
TLS2_k127_2854870_12 NUDIX domain - - - 0.0000000000000000000000000000000000000000006256 167.0
TLS2_k127_2854870_13 - - - - 0.000000000000000000000000009198 112.0
TLS2_k127_2854870_14 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.0000000000000000077 94.0
TLS2_k127_2854870_2 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 531.0
TLS2_k127_2854870_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 514.0
TLS2_k127_2854870_4 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 473.0
TLS2_k127_2854870_5 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 439.0
TLS2_k127_2854870_6 Extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000413 433.0
TLS2_k127_2854870_7 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009059 369.0
TLS2_k127_2854870_8 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000588 356.0
TLS2_k127_2854870_9 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K13252 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004139 322.0
TLS2_k127_2886888_0 PFAM Pyridoxal-dependent decarboxylase K01593 - 4.1.1.105,4.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006116 474.0
TLS2_k127_2886888_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 300.0
TLS2_k127_2886888_2 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009682 257.0
TLS2_k127_2886888_3 cAMP biosynthetic process K18672 - 2.7.7.85 0.0000000000000000000000000000000000000000000000000000000000009758 234.0
TLS2_k127_2886888_4 beta-lactamase domain protein K13075 - 3.1.1.81 0.00000000000000000000000000000000000000008104 165.0
TLS2_k127_2886888_5 - - - - 0.000000000000000000000000000002957 139.0
TLS2_k127_2886888_6 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.00000000000000000003663 106.0
TLS2_k127_2886888_7 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000003867 76.0
TLS2_k127_2886888_8 - - - - 0.000000000957 69.0
TLS2_k127_2890460_0 Glycerate kinase family K00865 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009528 353.0
TLS2_k127_2890460_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 289.0
TLS2_k127_2890460_2 Glycosyl transferase family 2 K13693 - 2.4.1.266 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004134 298.0
TLS2_k127_2890460_3 TIGRFAM Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004219 280.0
TLS2_k127_2890460_4 dephospho-CoA kinase activity - - - 0.0000000000000000000000000000000001474 138.0
TLS2_k127_2890460_5 ThiS family K03636 - - 0.0000000000000000000000000000001198 132.0
TLS2_k127_2890460_6 Protein of unknown function (DUF3263) - - - 0.00000000000000000000002277 104.0
TLS2_k127_2890460_7 LytR cell envelope-related transcriptional attenuator - - - 0.00007675 52.0
TLS2_k127_2928665_0 Phosphoadenosine phosphosulfate reductase family K00957 - 2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006178 415.0
TLS2_k127_2928665_1 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 365.0
TLS2_k127_2928665_2 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004013 352.0
TLS2_k127_2928665_3 Belongs to the PAPS reductase family. CysH subfamily K00390 GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000001 240.0
TLS2_k127_2928665_4 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000003296 226.0
TLS2_k127_2928665_5 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00956 - 2.7.7.4 0.00000000008089 74.0
TLS2_k127_2943483_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 9.31e-284 891.0
TLS2_k127_2943483_1 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K03520 - 1.2.5.3 7.354e-216 698.0
TLS2_k127_2943483_2 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 5.971e-195 618.0
TLS2_k127_2943483_3 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 529.0
TLS2_k127_2943483_4 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 400.0
TLS2_k127_2943483_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004271 294.0
TLS2_k127_2943483_6 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000003959 216.0
TLS2_k127_2943483_7 Cation efflux family K16264 - - 0.00000000000000000000000000000000000000000000000000004405 199.0
TLS2_k127_2943483_8 Uncharacterized protein family UPF0016 - - - 0.000000000000000000000000000000000000006926 151.0
TLS2_k127_2943483_9 - - - - 0.00000000000000000000000000000002894 130.0
TLS2_k127_294929_0 AMP-binding enzyme - - - 5.195e-241 760.0
TLS2_k127_294929_1 Dipeptidyl peptidase IV (DPP IV) N-terminal region K01278 - 3.4.14.5 1.483e-226 724.0
TLS2_k127_294929_10 Peptidase C26 K01658,K01664 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000004123 269.0
TLS2_k127_294929_11 Protein of unknown function (DUF2662) - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001452 265.0
TLS2_k127_294929_12 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000002144 276.0
TLS2_k127_294929_13 Forkhead associated domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.000000000000000000000000000000005041 133.0
TLS2_k127_294929_14 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) K02626 - 4.1.1.19 0.000000000000000000000000000111 132.0
TLS2_k127_294929_15 MgtC family K07507 - - 0.00000000000000000000000001078 115.0
TLS2_k127_294929_16 - - - - 0.0000000000000000000003955 98.0
TLS2_k127_294929_17 acetyltransferase - - - 0.000000000000000000001124 104.0
TLS2_k127_294929_18 Helix-turn-helix domain K01647 - 2.3.3.1 0.000000000000000000003341 97.0
TLS2_k127_294929_19 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000005414 106.0
TLS2_k127_294929_2 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 595.0
TLS2_k127_294929_20 SnoaL-like domain K06893 - - 0.00000000000001951 81.0
TLS2_k127_294929_21 Universal stress protein family - - - 0.0000000000001936 76.0
TLS2_k127_294929_22 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000002378 78.0
TLS2_k127_294929_23 Hemerythrin HHE cation binding domain - - - 0.0000008224 59.0
TLS2_k127_294929_24 Sel1-like repeats. K14026 - - 0.00001148 48.0
TLS2_k127_294929_25 PFAM RDD domain containing protein - - - 0.00009831 53.0
TLS2_k127_294929_26 Involved in cell division - - - 0.0001126 50.0
TLS2_k127_294929_3 drug exporters of the RND superfamily K06994 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 574.0
TLS2_k127_294929_4 Penicillin binding protein transpeptidase domain K05364 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 513.0
TLS2_k127_294929_5 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 482.0
TLS2_k127_294929_6 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008172 505.0
TLS2_k127_294929_7 Cell cycle protein K03588 GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007999 467.0
TLS2_k127_294929_8 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 481.0
TLS2_k127_294929_9 Serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009133 444.0
TLS2_k127_2972308_0 Sulfatase - - - 4.151e-270 852.0
TLS2_k127_2972308_1 Elongation factor SelB, winged helix K03833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004513 488.0
TLS2_k127_2972308_10 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10672,K10794 - 1.21.4.1,1.21.4.2 0.00000000000000000000000000000000000000000000000000003815 198.0
TLS2_k127_2972308_11 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000001197 196.0
TLS2_k127_2972308_12 ROK family - - - 0.00000000000000000000000000001551 132.0
TLS2_k127_2972308_13 YCII-related domain - - - 0.0000000000000000000000000001822 121.0
TLS2_k127_2972308_14 Antibiotic biosynthesis monooxygenase - - - 0.00000002186 59.0
TLS2_k127_2972308_2 Belongs to the ABC transporter superfamily K02031,K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 473.0
TLS2_k127_2972308_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 396.0
TLS2_k127_2972308_4 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 402.0
TLS2_k127_2972308_5 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004951 353.0
TLS2_k127_2972308_6 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 341.0
TLS2_k127_2972308_7 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10672,K10794 - 1.21.4.1,1.21.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 312.0
TLS2_k127_2972308_8 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008484 300.0
TLS2_k127_2972308_9 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000002179 247.0
TLS2_k127_297556_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00341 - 1.6.5.3 5.864e-259 815.0
TLS2_k127_297556_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00342 - 1.6.5.3 1.194e-232 730.0
TLS2_k127_297556_10 Belongs to the complex I subunit 6 family K00339,K05578 - 1.6.5.3 0.00000000000000000000000000000000000002105 149.0
TLS2_k127_297556_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000000000000002294 139.0
TLS2_k127_297556_12 hydrolase activity, acting on ester bonds K01286 - 3.4.16.4 0.0000000000000000000000000000001292 128.0
TLS2_k127_297556_13 membrane - - - 0.00000000000000003125 95.0
TLS2_k127_297556_2 Belongs to the complex I 49 kDa subunit family K00333 - 1.6.5.3 6.791e-212 665.0
TLS2_k127_297556_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004661 571.0
TLS2_k127_297556_4 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 565.0
TLS2_k127_297556_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003307 400.0
TLS2_k127_297556_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 299.0
TLS2_k127_297556_7 acr, cog1565 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009482 301.0
TLS2_k127_297556_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000862 267.0
TLS2_k127_297556_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00332 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000003055 235.0
TLS2_k127_2979167_0 Protein of unknown function (DUF455) K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 363.0
TLS2_k127_2979167_2 Domain of unknown function (DUF1996) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 310.0
TLS2_k127_2979167_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086,K03087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001773 252.0
TLS2_k127_2979167_4 Antibiotic biosynthesis monooxygenase K06996,K21481 - 1.14.99.57 0.00000000000000000000000000000000004865 137.0
TLS2_k127_2979167_6 VanW like protein - - - 0.00000000000000000000000000000002909 143.0
TLS2_k127_299408_0 acetyl-coa acetyltransferase K00626 - 2.3.1.9 5.073e-195 615.0
TLS2_k127_299408_1 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 495.0
TLS2_k127_299408_10 Redoxin - - - 0.000000000000000000000000000000003567 144.0
TLS2_k127_299408_11 Belongs to the DsbB family K03611 - - 0.0000000000000000000000000000003959 129.0
TLS2_k127_299408_12 Protein of unknown function (DUF2786) - - - 0.0000000000000000000000000004282 121.0
TLS2_k127_299408_13 Universal stress protein family - - - 0.00000000000000000000000000286 116.0
TLS2_k127_299408_14 Universal stress protein - - - 0.000000002941 69.0
TLS2_k127_299408_15 DNA replication proofreading K02324 GO:0000228,GO:0000278,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006281,GO:0006284,GO:0006287,GO:0006289,GO:0006297,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007049,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008622,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0018130,GO:0019438,GO:0022616,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.000243 54.0
TLS2_k127_299408_2 Extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 472.0
TLS2_k127_299408_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 306.0
TLS2_k127_299408_4 Wax ester synthase-like Acyl-CoA acyltransferase domain K00635 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000001111 252.0
TLS2_k127_299408_5 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.0000000000000000000000000000000000000000000000000000000000000212 217.0
TLS2_k127_299408_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000905 208.0
TLS2_k127_299408_7 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000000007104 193.0
TLS2_k127_299408_8 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0016485,GO:0016540,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564 4.1.1.11 0.0000000000000000000000000000000000000000001355 165.0
TLS2_k127_299408_9 thiolester hydrolase activity - - - 0.000000000000000000000000000000000000000005704 159.0
TLS2_k127_3010319_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.0 1062.0
TLS2_k127_3010319_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 4.812e-213 677.0
TLS2_k127_3010319_10 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000002466 197.0
TLS2_k127_3010319_11 Catalyzes a trans-dehydration via an enolate intermediate K03786,K16021 - 4.2.1.10 0.0000000000000000000000000000000000000000000000001733 188.0
TLS2_k127_3010319_12 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000000000001576 147.0
TLS2_k127_3010319_13 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000000000000002075 144.0
TLS2_k127_3010319_14 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 GO:0008150,GO:0040007 - 0.00000000000000000000000000000004414 131.0
TLS2_k127_3010319_15 Peptidase A24A, prepilin type IV K02654 - 3.4.23.43 0.0000000000000000000000000003396 124.0
TLS2_k127_3010319_16 Universal stress protein - - - 0.000000000000000000009576 108.0
TLS2_k127_3010319_17 Domain of unknown function (DUF4388) - - - 0.00000008086 64.0
TLS2_k127_3010319_18 CHAD - - - 0.0000001274 64.0
TLS2_k127_3010319_2 MgsA AAA+ ATPase C terminal K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 529.0
TLS2_k127_3010319_20 - - - - 0.0001157 47.0
TLS2_k127_3010319_3 Histidyl-tRNA synthetase K01892 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007948 444.0
TLS2_k127_3010319_4 3-dehydroquinate synthase K16020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 402.0
TLS2_k127_3010319_5 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000708 282.0
TLS2_k127_3010319_6 Creatinase Prolidase N-terminal domain K01262,K01271 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000003662 274.0
TLS2_k127_3010319_7 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000003651 245.0
TLS2_k127_3010319_8 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000001874 235.0
TLS2_k127_3010319_9 Phosphoribosyl transferase domain K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000002713 220.0
TLS2_k127_3042892_0 Baseplate J-like protein - - - 1.622e-265 831.0
TLS2_k127_3042892_1 Phage tail sheath C-terminal domain K06907 - - 4.253e-253 791.0
TLS2_k127_3042892_10 - - - - 0.000000000000000000000000000000000000000000003402 168.0
TLS2_k127_3042892_11 Domain of unknown function (DUF4280) - - - 0.0000000000000000000000000000000000000000005212 162.0
TLS2_k127_3042892_12 T4-like virus tail tube protein gp19 - - - 0.000000000000000000000000000000001814 134.0
TLS2_k127_3042892_13 ABC transporter (Permease) K02004 - - 0.000000000000000000000000000000002686 134.0
TLS2_k127_3042892_14 Septum formation - - - 0.000000000000000000000008907 109.0
TLS2_k127_3042892_15 - - - - 0.000000000000000000000533 108.0
TLS2_k127_3042892_16 Domain of unknown function (DUF4157) - - - 0.00000000000000001411 98.0
TLS2_k127_3042892_17 - - - - 0.00000000000000003135 90.0
TLS2_k127_3042892_19 - - - - 0.000007089 57.0
TLS2_k127_3042892_2 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 346.0
TLS2_k127_3042892_3 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 305.0
TLS2_k127_3042892_4 Rhs element Vgr protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009486 319.0
TLS2_k127_3042892_5 PFAM Peptidoglycan-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001688 283.0
TLS2_k127_3042892_6 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006993 279.0
TLS2_k127_3042892_7 Gene 25-like lysozyme K06903 - - 0.00000000000000000000000000000000000000000000000002562 195.0
TLS2_k127_3042892_8 phage tail protein - - - 0.0000000000000000000000000000000000000000000000008785 179.0
TLS2_k127_3042892_9 Phage tail protein (Tail_P2_I) - - - 0.000000000000000000000000000000000000000000000002066 194.0
TLS2_k127_3067651_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1088.0
TLS2_k127_3067651_1 synthase K06044 - 5.4.99.15 3.356e-281 895.0
TLS2_k127_3067651_10 Glycosyl transferases group 1 K16148 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 2.4.1.342 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 466.0
TLS2_k127_3067651_11 Cation transport protein K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006586 396.0
TLS2_k127_3067651_12 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 331.0
TLS2_k127_3067651_13 O-methyltransferase K00588 - 2.1.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002884 270.0
TLS2_k127_3067651_14 TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009931 268.0
TLS2_k127_3067651_15 Fructosamine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000005001 251.0
TLS2_k127_3067651_16 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.00000000000000000000000000000000000000000000000000002891 200.0
TLS2_k127_3067651_17 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000000000001406 187.0
TLS2_k127_3067651_18 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000006385 160.0
TLS2_k127_3067651_19 Anti-sigma regulatory factor (Ser Thr protein kinase) - - - 0.0000000000000000000000000000000001615 146.0
TLS2_k127_3067651_2 Oligopeptidase F K08602 - - 5.777e-252 791.0
TLS2_k127_3067651_20 Cupin domain K11312 - - 0.00000000000000000000003471 103.0
TLS2_k127_3067651_21 - - - - 0.00000000000002366 77.0
TLS2_k127_3067651_3 TIGRFAM malto-oligosyltrehalose trehalohydrolase K01236 - 3.2.1.141 4.423e-218 701.0
TLS2_k127_3067651_4 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.4.1.1 2.237e-200 651.0
TLS2_k127_3067651_5 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004545 554.0
TLS2_k127_3067651_6 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 554.0
TLS2_k127_3067651_7 Aldehyde dehydrogenase family K00128,K22445 - 1.2.1.3,1.2.99.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008456 507.0
TLS2_k127_3067651_8 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008101 485.0
TLS2_k127_3067651_9 Cation transport protein K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 487.0
TLS2_k127_3160363_0 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 464.0
TLS2_k127_3160363_1 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005994 443.0
TLS2_k127_3160363_2 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000776 369.0
TLS2_k127_3160363_3 6-phosphogluconate dehydrogenase (Decarboxylating) K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 340.0
TLS2_k127_3160363_4 Belongs to the dCTP deaminase family K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000003459 262.0
TLS2_k127_3160363_5 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000434 184.0
TLS2_k127_3160363_6 TIGRFAM carbohydrate kinase, thermoresistant glucokinase family K00851 - 2.7.1.12 0.000000000000000000000000000000000000000000001464 171.0
TLS2_k127_3200710_0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944 1.6.5.3 7.839e-240 769.0
TLS2_k127_3200710_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00341 - 1.6.5.3 4.588e-228 724.0
TLS2_k127_3200710_2 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000481 513.0
TLS2_k127_3200710_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 467.0
TLS2_k127_3200710_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 467.0
TLS2_k127_3200710_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K12143 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 326.0
TLS2_k127_3200710_6 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000000000001697 152.0
TLS2_k127_3200710_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 - 1.6.5.3 0.0000000000000000000000000007193 129.0
TLS2_k127_3200710_8 Protein of unknown function (DUF402) K09145 - - 0.0000000000000000000121 102.0
TLS2_k127_3204773_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K15868 - 6.2.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004977 607.0
TLS2_k127_3204773_1 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008119 465.0
TLS2_k127_3204773_2 Ppx GppA phosphatase K01524 GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 451.0
TLS2_k127_3204773_3 aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007433 411.0
TLS2_k127_3204773_4 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006575 383.0
TLS2_k127_3204773_5 Universal stress protein family - - - 0.00000000000000000000000000000000003067 145.0
TLS2_k127_3204773_6 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000007425 138.0
TLS2_k127_3204773_7 Protein of unknown function (DUF983) - - - 0.0000000000000000000000002427 110.0
TLS2_k127_3204773_8 Lysin motif - - - 0.000000001251 69.0
TLS2_k127_3204773_9 Major Facilitator Superfamily - - - 0.0002379 54.0
TLS2_k127_3261884_0 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 4.463e-237 748.0
TLS2_k127_3261884_1 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 552.0
TLS2_k127_3261884_10 lipid kinase activity - - - 0.0000000000000000000000000233 116.0
TLS2_k127_3261884_11 - - - - 0.0000000000001012 80.0
TLS2_k127_3261884_12 HAD-superfamily hydrolase, subfamily IA, variant 1 K01091 - 3.1.3.18 0.0000000007374 69.0
TLS2_k127_3261884_2 DEAD-like helicases superfamily K03727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000583 450.0
TLS2_k127_3261884_3 Peptidase, M20 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 406.0
TLS2_k127_3261884_5 Enoyl-CoA hydratase/isomerase K01692,K08299 - 4.2.1.149,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 304.0
TLS2_k127_3261884_6 PFAM helix-turn-helix- domain containing protein, AraC type - - - 0.000000000000000000000000000000000000000000000000000000000000000008353 229.0
TLS2_k127_3261884_7 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000003994 240.0
TLS2_k127_3261884_8 GDP-mannose mannosyl hydrolase activity - - - 0.0000000000000000000000000000009292 126.0
TLS2_k127_3261884_9 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000001759 120.0
TLS2_k127_326701_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 0.0 1138.0
TLS2_k127_326701_1 Domain of unknown function (DUF1998) K06877 - - 3.76e-234 747.0
TLS2_k127_326701_10 PFAM TadE family protein - - - 0.00000000004922 72.0
TLS2_k127_326701_11 Type II secretion system (T2SS), protein F K12510 - - 0.0000000003512 70.0
TLS2_k127_326701_2 Secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004455 348.0
TLS2_k127_326701_3 haloacid dehalogenase-like hydrolase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000003624 259.0
TLS2_k127_326701_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002237 239.0
TLS2_k127_326701_5 2OG-Fe(II) oxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000002328 203.0
TLS2_k127_326701_6 - - - - 0.000000000000000000000000007373 118.0
TLS2_k127_326701_7 Type II secretion system (T2SS), protein F K12511 - - 0.0000000000000000007085 97.0
TLS2_k127_326701_8 Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B) K04757 GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 2.7.11.1 0.0000000000000002981 88.0
TLS2_k127_326701_9 Belongs to the anti-sigma-factor antagonist family K04749 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000003607 85.0
TLS2_k127_3283290_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 9.799e-243 772.0
TLS2_k127_3283290_1 AMP-binding enzyme C-terminal domain K02182 - 6.2.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004651 581.0
TLS2_k127_3283290_10 Glycerol-3-phosphate ABC transporter permease K02025,K05814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001724 272.0
TLS2_k127_3283290_11 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002288 270.0
TLS2_k127_3283290_12 solute-binding protein K05813 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005825 267.0
TLS2_k127_3283290_13 Phenylacetic acid-responsive transcriptional repressor K02616 - - 0.0000000000000000000000000000000000000000000000000000000000000001258 243.0
TLS2_k127_3283290_14 glyoxalase bleomycin resistance protein dioxygenase K06991 - - 0.0000000000000000000000000000000000000000000000000000000000000009285 220.0
TLS2_k127_3283290_15 Citrate synthase K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000111 234.0
TLS2_k127_3283290_16 carboxylic ester hydrolase activity - GO:0003674,GO:0003824,GO:0016787 - 0.00000000000000000000000000000000000000000000000000003225 210.0
TLS2_k127_3283290_17 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000001667 199.0
TLS2_k127_3283290_18 Domain of unknown function (DUF4395) - - - 0.000000000000000000000000000000000000000000004188 169.0
TLS2_k127_3283290_19 - - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000005234 159.0
TLS2_k127_3283290_2 sulphate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 580.0
TLS2_k127_3283290_20 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000002478 142.0
TLS2_k127_3283290_21 chorismate mutase K04092 - 5.4.99.5 0.0000000000000000000000000000000002802 134.0
TLS2_k127_3283290_22 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000007981 124.0
TLS2_k127_3283290_23 Domain of unknown function (DUF4328) - - - 0.0000000000000004903 89.0
TLS2_k127_3283290_24 - - - - 0.00000000003173 78.0
TLS2_k127_3283290_3 long-chain-fatty-acid--CoA ligase K01897 GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009987,GO:0015645,GO:0016020,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0030312,GO:0032787,GO:0042546,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044464,GO:0071554,GO:0071704,GO:0071766,GO:0071840,GO:0071944,GO:1901576 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 499.0
TLS2_k127_3283290_4 unsaturated fatty acid biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005076 399.0
TLS2_k127_3283290_5 Belongs to the ABC transporter superfamily K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 375.0
TLS2_k127_3283290_6 FAD-binding domain K00529 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003544 378.0
TLS2_k127_3283290_7 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007116 335.0
TLS2_k127_3283290_8 Binding-protein-dependent transport system inner membrane component K05815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006516 278.0
TLS2_k127_3283290_9 PFAM Na Picotransporter K03324 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001068 277.0
TLS2_k127_335563_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 4.38e-302 946.0
TLS2_k127_335563_1 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 589.0
TLS2_k127_335563_10 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000000000000000000002353 191.0
TLS2_k127_335563_11 Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant K06720 - 4.2.1.108 0.00000000000000000000000000000000000000000000004576 180.0
TLS2_k127_335563_12 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.00000000000000000000000000000000000000001896 168.0
TLS2_k127_335563_13 Domain of unknown function (DUF1990) - - - 0.0000000000000000000000000000000000000002915 166.0
TLS2_k127_335563_14 transcriptional - - - 0.00000000000000000000000000000000000008396 152.0
TLS2_k127_335563_15 cyclic-guanylate-specific phosphodiesterase activity K21023 - 2.7.7.65 0.000000000000000000000000000000000000351 161.0
TLS2_k127_335563_16 Acetyltransferase (GNAT) family K06718 GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 2.3.1.178 0.0000000000000000000000000000000003568 140.0
TLS2_k127_335563_17 GGDEF domain - - - 0.00000000000000000000000000000001863 144.0
TLS2_k127_335563_18 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000001176 124.0
TLS2_k127_335563_19 YndJ-like protein - - - 0.000000000000000000000003387 117.0
TLS2_k127_335563_2 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 563.0
TLS2_k127_335563_3 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 578.0
TLS2_k127_335563_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00836 - 2.6.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006998 552.0
TLS2_k127_335563_5 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 546.0
TLS2_k127_335563_6 Ectoine hydroxylase K10674 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016705,GO:0016706,GO:0019752,GO:0032787,GO:0042399,GO:0042400,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.14.11.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009162 349.0
TLS2_k127_335563_7 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002539 273.0
TLS2_k127_335563_8 Cupin superfamily protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000003993 254.0
TLS2_k127_335563_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000211 233.0
TLS2_k127_3466658_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 471.0
TLS2_k127_3466658_1 Glycosyltransferase Family 4 K08256 GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000519 407.0
TLS2_k127_3466658_10 metalloendopeptidase activity K03799 - - 0.000000000000000000000000001685 122.0
TLS2_k127_3466658_11 ABC-2 family transporter protein - - - 0.000000000000000000154 102.0
TLS2_k127_3466658_12 ABC transporter, ATP-binding protein K01990 - - 0.000000000000002819 81.0
TLS2_k127_3466658_13 - - - - 0.000000000001357 80.0
TLS2_k127_3466658_2 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 321.0
TLS2_k127_3466658_3 Bacterial lipid A biosynthesis acyltransferase K22311 - 2.3.1.265 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 291.0
TLS2_k127_3466658_4 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000003717 237.0
TLS2_k127_3466658_5 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000008785 228.0
TLS2_k127_3466658_6 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000001609 221.0
TLS2_k127_3466658_7 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000001153 179.0
TLS2_k127_3466658_8 Protein of unknown function (DUF3048) C-terminal domain - - - 0.000000000000000000000000000000000000000000002365 181.0
TLS2_k127_3466658_9 - - - - 0.0000000000000000000000000000000001254 135.0
TLS2_k127_3513060_0 Thiamine pyrophosphate enzyme, central domain K01652 GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030312,GO:0030976,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 1.22e-300 933.0
TLS2_k127_3513060_1 Dehydratase family K01687 - 4.2.1.9 1.218e-256 816.0
TLS2_k127_3513060_10 abc transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001364 276.0
TLS2_k127_3513060_11 Plays a role in the flagellum-specific transport system K02419 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006707 265.0
TLS2_k127_3513060_12 FlhB HrpN YscU SpaS Family K02401 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007351 257.0
TLS2_k127_3513060_13 Flagellar motor switch protein FliM K02416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008576 254.0
TLS2_k127_3513060_14 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000006148 251.0
TLS2_k127_3513060_15 MotA/TolQ/ExbB proton channel family K02556 - - 0.000000000000000000000000000000000000000000000000000000000000001555 228.0
TLS2_k127_3513060_16 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K02405 - - 0.000000000000000000000000000000000000000000000000000000000000001629 228.0
TLS2_k127_3513060_17 BAAT / Acyl-CoA thioester hydrolase C terminal K03928 - 3.1.1.1 0.0000000000000000000000000000000000000000000000000000000000002752 222.0
TLS2_k127_3513060_18 ACT domain K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000003565 228.0
TLS2_k127_3513060_19 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000428 218.0
TLS2_k127_3513060_2 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 1.887e-236 749.0
TLS2_k127_3513060_20 Diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000371 218.0
TLS2_k127_3513060_21 Bacterial export proteins, family 1 K02421 - - 0.000000000000000000000000000000000000000000000001487 184.0
TLS2_k127_3513060_22 DinB superfamily - - - 0.000000000000000000000000000000000000000000000003078 184.0
TLS2_k127_3513060_23 Membrane MotB of proton-channel complex MotA/MotB K02557 - - 0.00000000000000000000000000000000000000000000000348 184.0
TLS2_k127_3513060_24 4fe-4S ferredoxin, iron-sulfur binding domain protein K03616 - - 0.000000000000000000000000000000000000000000006164 167.0
TLS2_k127_3513060_25 Sterol carrier protein - - - 0.00000000000000000000000000005382 124.0
TLS2_k127_3513060_26 Flagellar motor switch K02417 - - 0.000000000000000000000000001989 124.0
TLS2_k127_3513060_27 bacterial-type flagellum assembly K13626 - - 0.000000000000000000000000009098 114.0
TLS2_k127_3513060_28 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 0.00000000000000000000000001647 112.0
TLS2_k127_3513060_29 Bacterial export proteins, family 3 K02420 - - 0.000000000000000000000004493 104.0
TLS2_k127_3513060_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 6.969e-199 649.0
TLS2_k127_3513060_30 Membrane - - - 0.00000000000000000001851 103.0
TLS2_k127_3513060_31 Flagellar protein (FlbD) K02385 - - 0.000000000000000335 82.0
TLS2_k127_3513060_32 Global regulator protein family K03563 - - 0.00000000000001022 82.0
TLS2_k127_3513060_33 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000002577 76.0
TLS2_k127_3513060_34 Flagellar basal body-associated protein FliL K02415 - - 0.000000000006684 73.0
TLS2_k127_3513060_35 Protein of unknown function (DUF402) - - - 0.00000000149 66.0
TLS2_k127_3513060_36 Flagellar biosynthesis protein, FliO K02418 - - 0.00008969 51.0
TLS2_k127_3513060_4 PFAM Cys Met metabolism K01740 - 2.5.1.49 1.091e-197 625.0
TLS2_k127_3513060_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 614.0
TLS2_k127_3513060_6 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008728 545.0
TLS2_k127_3513060_7 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 495.0
TLS2_k127_3513060_8 Flagellar basal body protein FlaE K02390 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 410.0
TLS2_k127_3513060_9 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 340.0
TLS2_k127_3524588_0 Flavin-binding monooxygenase-like - - - 2.566e-240 755.0
TLS2_k127_3524588_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 4.139e-210 675.0
TLS2_k127_3524588_10 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 316.0
TLS2_k127_3524588_11 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000006929 250.0
TLS2_k127_3524588_12 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000000000000000008618 187.0
TLS2_k127_3524588_13 radical SAM domain protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000001642 177.0
TLS2_k127_3524588_14 EamA-like transporter family - - - 0.000000000000000000000000000000000001985 148.0
TLS2_k127_3524588_15 B12 binding domain K01849 - 5.4.99.2 0.00000000000000000000000000000000004197 154.0
TLS2_k127_3524588_16 Protein of unknown function (DUF1211) - - - 0.000000002379 66.0
TLS2_k127_3524588_17 Glucose-6-phosphate dehydrogenase, NAD binding domain K00036 - 1.1.1.363,1.1.1.49 0.00003002 48.0
TLS2_k127_3524588_2 Aldehyde dehydrogenase family K00128 - 1.2.1.3 3.061e-196 622.0
TLS2_k127_3524588_3 Protein of unknown function (DUF3029) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006957 612.0
TLS2_k127_3524588_4 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 550.0
TLS2_k127_3524588_5 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009942 508.0
TLS2_k127_3524588_6 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006615 496.0
TLS2_k127_3524588_7 protoporphyrinogen oxidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009967 394.0
TLS2_k127_3524588_8 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009831 351.0
TLS2_k127_3524588_9 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005767 312.0
TLS2_k127_3589917_0 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 544.0
TLS2_k127_3589917_1 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009461 419.0
TLS2_k127_3589917_2 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000136 286.0
TLS2_k127_3589917_3 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0000000000000000005988 99.0
TLS2_k127_3589917_4 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.00000001237 66.0
TLS2_k127_364141_0 Aminotransferase K00830,K00839 - 2.6.1.112,2.6.1.44,2.6.1.45,2.6.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004799 434.0
TLS2_k127_364141_1 von Willebrand factor (vWF) type A domain K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 415.0
TLS2_k127_364141_10 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141,K19190 - 1.1.1.328,2.7.7.76 0.00000000000000000000000000000006859 134.0
TLS2_k127_364141_11 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.0000000000000000000000000000004581 138.0
TLS2_k127_364141_2 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007281 407.0
TLS2_k127_364141_3 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 349.0
TLS2_k127_364141_4 Belongs to the pirin family K06911 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002276 271.0
TLS2_k127_364141_5 ANTAR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001402 253.0
TLS2_k127_364141_6 PFAM Ppx GppA phosphatase K01524 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000002525 249.0
TLS2_k127_364141_7 carbon monoxide dehydrogenase subunit G K09386 - - 0.0000000000000000000000000000000000000000000000000000000000000000001884 242.0
TLS2_k127_364141_8 ANTAR - - - 0.00000000000000000000000000000000000000000000000001423 188.0
TLS2_k127_364141_9 Protein of unknown function (DUF501) K09009 - - 0.0000000000000000000000000000000000000000000000001399 181.0
TLS2_k127_3677499_0 Glycosyl transferase 4-like domain K15521 - 2.4.1.250 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 447.0
TLS2_k127_3677499_1 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000002982 218.0
TLS2_k127_3677499_2 Helix-turn-helix XRE-family like proteins - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000005728 156.0
TLS2_k127_3677499_3 Putative bacterial sensory transduction regulator - - - 0.0000000000000000000000000000000000002507 146.0
TLS2_k127_3677499_4 endonuclease activity - - - 0.000000000000000000000009182 114.0
TLS2_k127_3705293_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 454.0
TLS2_k127_3705293_1 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 313.0
TLS2_k127_3705293_2 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006033 279.0
TLS2_k127_3705293_3 acyl-CoA hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000134 247.0
TLS2_k127_3705293_4 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000000000000000000000008982 213.0
TLS2_k127_3705293_5 NUDIX domain - - - 0.000000000000000000000000000000000000313 147.0
TLS2_k127_3705293_6 4-hydroxybenzoate K00481 GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0018659,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.14.13.2 0.000006013 48.0
TLS2_k127_3743405_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 2.556e-229 718.0
TLS2_k127_3743405_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 594.0
TLS2_k127_3743405_2 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 393.0
TLS2_k127_3743405_3 Acetyltransferase (GNAT) domain K00663,K03790 - 2.3.1.128,2.3.1.82 0.00000000000000000000000000000000000000000000000000000000000000000000001386 268.0
TLS2_k127_3743405_4 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000007446 198.0
TLS2_k127_3743405_5 Pentapeptide repeats (9 copies) - - - 0.0000000000000002513 93.0
TLS2_k127_3745155_1 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009014 262.0
TLS2_k127_3745155_2 inositol monophosphate 1-phosphatase activity K01082,K01092 - 3.1.3.25,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000008374 227.0
TLS2_k127_3745155_3 - - - - 0.0000000000000000000000000000000000000000000001154 183.0
TLS2_k127_3745155_4 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000000205 177.0
TLS2_k127_3745155_5 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000001217 171.0
TLS2_k127_3745155_6 C4-type zinc ribbon domain K07164 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000006719 154.0
TLS2_k127_3745155_7 Belongs to the Nudix hydrolase family - - - 0.0000000000000000000000000000003237 128.0
TLS2_k127_3745155_8 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000001153 126.0
TLS2_k127_3759185_0 N-acyl-D-aspartate D-glutamate deacylase - - - 4.688e-240 764.0
TLS2_k127_3759185_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007655 539.0
TLS2_k127_3759185_10 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003691 269.0
TLS2_k127_3759185_11 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001776 233.0
TLS2_k127_3759185_12 D-alanyl-D-alanine carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000007188 226.0
TLS2_k127_3759185_13 RIO1 family K07178 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000001893 206.0
TLS2_k127_3759185_14 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000004873 193.0
TLS2_k127_3759185_15 UTRA domain K02043 - - 0.00000000000000000000000000000000002389 144.0
TLS2_k127_3759185_16 Sigma-70, region 4 - - - 0.0000000000000000000000000000000003659 138.0
TLS2_k127_3759185_17 Esterase PHB depolymerase K03932 - - 0.00000000000000000000000000000001329 143.0
TLS2_k127_3759185_18 arsenate reductase K00537 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 0.00000000000000000000000003912 122.0
TLS2_k127_3759185_19 Protein of unknown function (DUF4031) - - - 0.0000000000000000001258 102.0
TLS2_k127_3759185_2 Sodium:sulfate symporter transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 447.0
TLS2_k127_3759185_20 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.0000000000000000001388 97.0
TLS2_k127_3759185_21 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000000000000004328 91.0
TLS2_k127_3759185_22 Septum formation - - - 0.000000000000001016 89.0
TLS2_k127_3759185_23 Putative adhesin - - - 0.00000000000003252 83.0
TLS2_k127_3759185_24 histone deacetylation - - - 0.000000000000241 82.0
TLS2_k127_3759185_25 Belongs to the glycosyl hydrolase 13 family - - - 0.000006405 56.0
TLS2_k127_3759185_3 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004555 417.0
TLS2_k127_3759185_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003562 359.0
TLS2_k127_3759185_5 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 338.0
TLS2_k127_3759185_6 Neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 327.0
TLS2_k127_3759185_7 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 293.0
TLS2_k127_3759185_8 acetylesterase activity K01066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003994 292.0
TLS2_k127_3759185_9 Catalyzes the synthesis of activated sulfate K00955,K00956 GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234 2.7.1.25,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000003854 258.0
TLS2_k127_3794393_0 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 5.804e-282 887.0
TLS2_k127_3794393_1 MMPL family K07003 - - 1.993e-211 691.0
TLS2_k127_3794393_10 Threonyl alanyl tRNA synthetase SAD K07050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003395 290.0
TLS2_k127_3794393_11 PAC2 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005735 263.0
TLS2_k127_3794393_12 PFAM ExsB family protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001298 259.0
TLS2_k127_3794393_13 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000115 256.0
TLS2_k127_3794393_14 serine-type peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000001191 256.0
TLS2_k127_3794393_15 Acyl-CoA thioesterase K10805 - - 0.00000000000000000000000000000000000000000000000000000000000000004785 234.0
TLS2_k127_3794393_16 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000001173 194.0
TLS2_k127_3794393_17 cell wall organization K10541,K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000005641 188.0
TLS2_k127_3794393_18 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000111 156.0
TLS2_k127_3794393_19 Thiamine-binding protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000004641 134.0
TLS2_k127_3794393_2 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 1.947e-208 654.0
TLS2_k127_3794393_20 GCN5-related N-acetyl-transferase K06975 - - 0.000000000000000000000000001201 114.0
TLS2_k127_3794393_21 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0000000000000000006803 101.0
TLS2_k127_3794393_23 - - - - 0.00003359 51.0
TLS2_k127_3794393_24 - - - - 0.00003926 48.0
TLS2_k127_3794393_3 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096 2.7.7.59 3.473e-201 651.0
TLS2_k127_3794393_4 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 503.0
TLS2_k127_3794393_5 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 487.0
TLS2_k127_3794393_6 ABC-type branched-chain amino acid transport K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 342.0
TLS2_k127_3794393_7 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 340.0
TLS2_k127_3794393_8 ABC transporter, ATP-binding protein K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 302.0
TLS2_k127_3794393_9 GDP-mannose mannosyl hydrolase activity K03574,K06889 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 297.0
TLS2_k127_3797201_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0 1040.0
TLS2_k127_3797201_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 6.759e-221 698.0
TLS2_k127_3797201_10 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000007681 228.0
TLS2_k127_3797201_11 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000000000221 175.0
TLS2_k127_3797201_12 Domain of unknown function (DUF1996) - - - 0.00000000000000000000000000000000000000000000276 182.0
TLS2_k127_3797201_13 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000002158 127.0
TLS2_k127_3797201_14 Two component signalling adaptor domain K03408 - - 0.00000000000000000000000002672 116.0
TLS2_k127_3797201_15 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000009331 97.0
TLS2_k127_3797201_16 Transglycosylase-like domain K21687 - - 0.00000000001025 76.0
TLS2_k127_3797201_17 response regulator K02479,K07684,K07685 - - 0.000000007525 70.0
TLS2_k127_3797201_18 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576 2.7.6.1 0.0008731 44.0
TLS2_k127_3797201_2 Alcohol dehydrogenase GroES-like domain K18369 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005507 580.0
TLS2_k127_3797201_3 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 449.0
TLS2_k127_3797201_4 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 407.0
TLS2_k127_3797201_5 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 396.0
TLS2_k127_3797201_6 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008068 311.0
TLS2_k127_3797201_7 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 308.0
TLS2_k127_3797201_8 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008503 294.0
TLS2_k127_3797201_9 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001146 283.0
TLS2_k127_3799519_0 ABC-type multidrug transport system ATPase and permease K06147,K06148 - - 5.041e-263 822.0
TLS2_k127_3799519_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 4.774e-210 696.0
TLS2_k127_3799519_2 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 663.0
TLS2_k127_3799519_3 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 366.0
TLS2_k127_3799519_4 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 368.0
TLS2_k127_3799519_5 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000003289 241.0
TLS2_k127_3799519_6 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000000000000000000000000000000000000004546 257.0
TLS2_k127_3799519_7 Glyoxalase-like domain K06996 - - 0.000000000000000000000000000000000000000000000001277 176.0
TLS2_k127_3799519_8 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain K07693 - - 0.0000001027 61.0
TLS2_k127_3799519_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000003269 57.0
TLS2_k127_3804362_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1423.0
TLS2_k127_3804362_1 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004482 557.0
TLS2_k127_3804362_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006027 421.0
TLS2_k127_3804362_3 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005354 258.0
TLS2_k127_3804362_4 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.000000000000000005395 88.0
TLS2_k127_3837556_0 trisaccharide binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 610.0
TLS2_k127_3837556_1 Endonuclease Exonuclease Phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006649 556.0
TLS2_k127_3837556_10 Bacterial transcription activator, effector binding domain - - - 0.00000000000000000000000000008675 128.0
TLS2_k127_3837556_11 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000002903 104.0
TLS2_k127_3837556_12 - - - - 0.00000000000000002033 95.0
TLS2_k127_3837556_13 - - - - 0.000000000000008131 87.0
TLS2_k127_3837556_14 Zn-dependent protease - - - 0.00004913 56.0
TLS2_k127_3837556_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 335.0
TLS2_k127_3837556_3 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 295.0
TLS2_k127_3837556_4 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000009042 238.0
TLS2_k127_3837556_5 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000000000000000000001188 186.0
TLS2_k127_3837556_6 PFAM Endonuclease Exonuclease phosphatase K07004 - - 0.00000000000000000000000000000000000000000000000005652 203.0
TLS2_k127_3837556_7 WHG domain - - - 0.0000000000000000000000000000000000000000000000001625 192.0
TLS2_k127_3837556_8 PFAM Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000002669 165.0
TLS2_k127_3837556_9 Predicted membrane protein (DUF2243) - - - 0.00000000000000000000000000000000000000002005 159.0
TLS2_k127_3850262_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1085.0
TLS2_k127_3850262_1 Cytochrome c-type biogenesis protein CcmF K02198 - - 1.372e-251 797.0
TLS2_k127_3850262_10 mechanosensitive ion channel K22044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 331.0
TLS2_k127_3850262_11 Encapsulating protein for peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 322.0
TLS2_k127_3850262_12 lysyltransferase activity K07027,K20468 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005769 290.0
TLS2_k127_3850262_13 Acyl-CoA thioesterase K10805 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003838 280.0
TLS2_k127_3850262_14 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003848 274.0
TLS2_k127_3850262_15 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001234 271.0
TLS2_k127_3850262_16 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000001618 261.0
TLS2_k127_3850262_17 NMT1/THI5 like K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000001409 246.0
TLS2_k127_3850262_18 CcmB protein K02194 - - 0.0000000000000000000000000000000000000000000000000000004542 202.0
TLS2_k127_3850262_19 Cytochrome C assembly protein K02195 - - 0.000000000000000000000000000000000000000000000000002718 195.0
TLS2_k127_3850262_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 5.151e-211 661.0
TLS2_k127_3850262_20 Domain of unknown function (DUF4397) - - - 0.00000000000000000000000000000000000000000000000001017 191.0
TLS2_k127_3850262_21 Evidence 5 No homology to any previously reported sequences K07284 - 3.4.22.70 0.0000000000000000000000000000000000000000000176 176.0
TLS2_k127_3850262_22 cell redox homeostasis - - - 0.000000000000000000000000000000000000000004827 164.0
TLS2_k127_3850262_23 Evidence 4 Homologs of previously reported genes of K09700 - - 0.000000000000000000000000000000000000000005456 171.0
TLS2_k127_3850262_24 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000000000001948 154.0
TLS2_k127_3850262_25 Sortase family - - - 0.0000000000000000000000000000001199 138.0
TLS2_k127_3850262_26 Bacterial transcriptional repressor C-terminal - - - 0.000000000000000000000000007626 123.0
TLS2_k127_3850262_27 PFAM glycosyl transferase group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.0000000000000000000000000188 122.0
TLS2_k127_3850262_28 phosphohistidine phosphatase, SixA K03574,K08296 - 3.6.1.55 0.00000000000000000000000003832 113.0
TLS2_k127_3850262_29 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000082 119.0
TLS2_k127_3850262_3 PFAM AMP-dependent synthetase and ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004754 616.0
TLS2_k127_3850262_31 transcriptional regulator - - - 0.00000000000000000003123 103.0
TLS2_k127_3850262_32 Phospholipase_D-nuclease N-terminal - - - 0.000000000000000005309 89.0
TLS2_k127_3850262_33 Bacterial regulatory proteins, tetR family - - - 0.00000000000000001716 90.0
TLS2_k127_3850262_34 diguanylate cyclase - - - 0.00000000000000004009 93.0
TLS2_k127_3850262_35 Septum formation - - - 0.0000000000002562 83.0
TLS2_k127_3850262_37 subunit of a heme lyase K02200 - - 0.000000000002492 73.0
TLS2_k127_3850262_38 Septum formation - - - 0.0000000001298 73.0
TLS2_k127_3850262_39 CsbD-like - - - 0.000000001457 65.0
TLS2_k127_3850262_4 Transporter associated domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 460.0
TLS2_k127_3850262_40 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000007772 53.0
TLS2_k127_3850262_5 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 446.0
TLS2_k127_3850262_6 Aminotransferase class-V K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 413.0
TLS2_k127_3850262_7 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005205 434.0
TLS2_k127_3850262_8 chorismate binding enzyme K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007347 396.0
TLS2_k127_3850262_9 alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003475 366.0
TLS2_k127_3853028_0 AMP-binding enzyme C-terminal domain K00666 - - 8.942e-258 806.0
TLS2_k127_3853028_1 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 479.0
TLS2_k127_3853028_11 Part of the ABC transporter FtsEX involved in cellular division K09811 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944 - 0.00000000008123 71.0
TLS2_k127_3853028_12 NUDIX domain - - - 0.000729 44.0
TLS2_k127_3853028_2 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 454.0
TLS2_k127_3853028_3 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007026 346.0
TLS2_k127_3853028_4 Bacterial periplasmic substrate-binding proteins K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 340.0
TLS2_k127_3853028_5 PFAM ABC transporter related K02028 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 332.0
TLS2_k127_3853028_6 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 309.0
TLS2_k127_3853028_7 Binding-protein-dependent transport system inner membrane component K01284,K02029 - 3.4.15.5 0.000000000000000000000000000000000000000000000000000000000000000001183 238.0
TLS2_k127_3853028_8 SURF1 family - GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.0000000000000000000000000000000000000000000000005817 193.0
TLS2_k127_3853028_9 OsmC-like protein - - - 0.0000000000000000000000000002941 121.0
TLS2_k127_3865457_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K15408 - 1.9.3.1 1.243e-279 875.0
TLS2_k127_3865457_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 1.014e-245 794.0
TLS2_k127_3865457_10 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 355.0
TLS2_k127_3865457_11 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 341.0
TLS2_k127_3865457_12 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 340.0
TLS2_k127_3865457_13 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 340.0
TLS2_k127_3865457_14 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008333 324.0
TLS2_k127_3865457_15 of an ABC-type transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 311.0
TLS2_k127_3865457_16 peroxidase activity K00435 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005532 291.0
TLS2_k127_3865457_17 Short-chain dehydrogenase reductase sdr - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000175 274.0
TLS2_k127_3865457_18 Cytochrome c oxidase subunit III K02276,K02299 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003188 273.0
TLS2_k127_3865457_19 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001938 249.0
TLS2_k127_3865457_2 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 - 3.4.21.83 2.12e-245 786.0
TLS2_k127_3865457_20 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001523 254.0
TLS2_k127_3865457_21 Pfam:PNPOx_C K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000003519 240.0
TLS2_k127_3865457_22 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000005523 232.0
TLS2_k127_3865457_23 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000001661 226.0
TLS2_k127_3865457_24 Cytochrome c biogenesis protein transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000003759 218.0
TLS2_k127_3865457_25 ABC transporter (Permease) K05846 - - 0.0000000000000000000000000000000000000000000000000000000001993 220.0
TLS2_k127_3865457_26 Binding-protein-dependent transport system inner membrane component K05846 - - 0.0000000000000000000000000000000000000000000000000000000004547 214.0
TLS2_k127_3865457_27 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02298 - 1.10.3.10 0.00000000000000000000000000000000000000000000000000000003182 218.0
TLS2_k127_3865457_28 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000000000000000000000301 192.0
TLS2_k127_3865457_29 Acyl-ACP thioesterase - - - 0.000000000000000000000000000000000000000000000000003397 191.0
TLS2_k127_3865457_3 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 520.0
TLS2_k127_3865457_30 cytochrome oxidase assembly K02259 - - 0.000000000000000000000000000000000000000000000006497 185.0
TLS2_k127_3865457_31 ATP-dependent Clp protease adaptor protein ClpS K06891 - - 0.0000000000000000000000000000000242 139.0
TLS2_k127_3865457_32 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18958 GO:0001101,GO:0008150,GO:0010033,GO:0033993,GO:0042221,GO:0046677,GO:0050896,GO:0070542,GO:1901700 - 0.0000000000000000000000000000004087 132.0
TLS2_k127_3865457_33 - - - - 0.00000000000000000000000003898 124.0
TLS2_k127_3865457_34 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000000000000000001385 117.0
TLS2_k127_3865457_35 Protein conserved in bacteria - - - 0.00000000000000000000002963 113.0
TLS2_k127_3865457_36 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000002658 102.0
TLS2_k127_3865457_37 Zn peptidase - - - 0.000000000000000001341 94.0
TLS2_k127_3865457_38 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.000000000000000001538 96.0
TLS2_k127_3865457_39 Thioredoxin-like - - - 0.00000000000000001223 96.0
TLS2_k127_3865457_4 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K04091 - 1.14.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 478.0
TLS2_k127_3865457_41 Domain of unknown function (DUF2017) - - - 0.000000002011 66.0
TLS2_k127_3865457_42 Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B) K04757 GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 2.7.11.1 0.000006472 55.0
TLS2_k127_3865457_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 395.0
TLS2_k127_3865457_6 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009814 379.0
TLS2_k127_3865457_7 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003944 374.0
TLS2_k127_3865457_8 PFAM Fatty acid desaturase, type 2 K03921 - 1.14.19.11,1.14.19.2,1.14.19.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 357.0
TLS2_k127_3865457_9 ATPases associated with a variety of cellular activities K01995,K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008316 358.0
TLS2_k127_3870656_0 RecF/RecN/SMC N terminal domain K03529 - - 0.0 1177.0
TLS2_k127_3870656_1 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 4.355e-289 897.0
TLS2_k127_3870656_10 Phage integrase, N-terminal SAM-like domain K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 310.0
TLS2_k127_3870656_11 Sigma-70 region 3 K02405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 328.0
TLS2_k127_3870656_12 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001179 274.0
TLS2_k127_3870656_13 competence protein COMEC - - - 0.000000000000000000000000000000000000000000000000000000000000000000012 246.0
TLS2_k127_3870656_14 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000000000005128 234.0
TLS2_k127_3870656_15 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000006457 237.0
TLS2_k127_3870656_17 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000001146 241.0
TLS2_k127_3870656_18 alpha-ribazole phosphatase activity K02226,K15634 - 3.1.3.73,5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000166 233.0
TLS2_k127_3870656_19 Protein of unknown function (DUF1800) - - - 0.0000000000000000000000000000000000000000000000000000000000001008 226.0
TLS2_k127_3870656_2 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 9.302e-266 845.0
TLS2_k127_3870656_20 Protein of unknown function (DUF1501) - - - 0.000000000000000000000000000000000000000000000000000000000001677 233.0
TLS2_k127_3870656_21 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000001057 214.0
TLS2_k127_3870656_22 DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000001513 228.0
TLS2_k127_3870656_23 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000006619 206.0
TLS2_k127_3870656_24 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000000000000000001034 188.0
TLS2_k127_3870656_25 Belongs to the peptidase S1C family K04691,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - 0.0000000000000000000000000000000000000000000000000003379 202.0
TLS2_k127_3870656_26 Antibiotic biosynthesis monooxygenase K21481 - 1.14.99.57 0.0000000000000000000000000000000000000000000000000006903 187.0
TLS2_k127_3870656_27 Di-iron-containing protein involved in the repair of iron-sulfur clusters K07322 - - 0.0000000000000000000000000000000000000000000000002122 188.0
TLS2_k127_3870656_28 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000000000000000000000000000000000002268 180.0
TLS2_k127_3870656_29 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000000000000000000001199 161.0
TLS2_k127_3870656_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 3.298e-196 622.0
TLS2_k127_3870656_30 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000000000008225 148.0
TLS2_k127_3870656_31 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.0000000000000000000000000000000000001348 163.0
TLS2_k127_3870656_32 - - - - 0.0000000000000000000000000000000007985 137.0
TLS2_k127_3870656_33 Belongs to the UPF0102 family K07460 - - 0.0000000000000000000000000000007552 126.0
TLS2_k127_3870656_34 - - - - 0.000000000000000000000000000008135 138.0
TLS2_k127_3870656_35 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000163 127.0
TLS2_k127_3870656_36 Uncharacterized ACR, COG1399 K07040 GO:0008150,GO:0040007 - 0.000000000000000000000000000693 120.0
TLS2_k127_3870656_37 Ribosomal L28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000000000003343 111.0
TLS2_k127_3870656_38 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.0000000000000000000000027 109.0
TLS2_k127_3870656_39 Cold shock K03704 - - 0.000000000000000000000007733 106.0
TLS2_k127_3870656_4 Dak1_2 K07030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 548.0
TLS2_k127_3870656_40 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.0000000000000000001612 96.0
TLS2_k127_3870656_41 - - - - 0.0000000000000000241 83.0
TLS2_k127_3870656_42 Belongs to the UPF0109 family K06960 GO:0008150,GO:0040007 - 0.00000000000000008612 89.0
TLS2_k127_3870656_43 Cytochrome C oxidase, cbb3-type, subunit III K12263 - - 0.000000671 59.0
TLS2_k127_3870656_5 PFAM magnesium chelatase ChlI subunit K07391 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 482.0
TLS2_k127_3870656_6 Multicopper oxidase K00368 - 1.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009295 413.0
TLS2_k127_3870656_7 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 402.0
TLS2_k127_3870656_8 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 370.0
TLS2_k127_3870656_9 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000968 367.0
TLS2_k127_3876560_0 FAD dependent oxidoreductase K15736 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 417.0
TLS2_k127_3876560_1 ABC transporter ATPase permease K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 354.0
TLS2_k127_3876560_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008226 331.0
TLS2_k127_3876560_3 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000000002242 186.0
TLS2_k127_3876560_4 DNA-templated transcription, initiation K03088 - - 0.0000000000000000001107 95.0
TLS2_k127_3893367_0 PFAM AMP-dependent synthetase and ligase K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 591.0
TLS2_k127_3893367_1 carbohydrate transport K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 544.0
TLS2_k127_3893367_10 transcriptional regulator K02616 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008918 314.0
TLS2_k127_3893367_11 ATPases associated with a variety of cellular activities K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004026 316.0
TLS2_k127_3893367_12 ABC-type nitrate sulfonate bicarbonate transport system permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009991 262.0
TLS2_k127_3893367_13 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004764 253.0
TLS2_k127_3893367_14 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000000000000006986 226.0
TLS2_k127_3893367_15 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000005491 227.0
TLS2_k127_3893367_16 phosphatase - - - 0.00000000000000000000002101 109.0
TLS2_k127_3893367_17 heme oxygenase (decyclizing) activity K00799,K03790 - 2.3.1.128,2.5.1.18 0.000000000000000000001563 99.0
TLS2_k127_3893367_18 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000194 56.0
TLS2_k127_3893367_2 methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008628 522.0
TLS2_k127_3893367_3 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 510.0
TLS2_k127_3893367_4 amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008534 492.0
TLS2_k127_3893367_5 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 447.0
TLS2_k127_3893367_6 PrpF protein K16514 - 5.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 431.0
TLS2_k127_3893367_7 PFAM binding-protein-dependent transport systems inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 428.0
TLS2_k127_3893367_8 Rieske [2Fe-2S] domain K19982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004511 427.0
TLS2_k127_3893367_9 Amidohydrolase K10221 - 3.1.1.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 353.0
TLS2_k127_3990952_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.17.4.1 0.0 1207.0
TLS2_k127_3990952_1 PFAM Glycosyl transferase family 2 K00694 - 2.4.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007521 553.0
TLS2_k127_3990952_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 318.0
TLS2_k127_3990952_3 Dolichyl-phosphate-mannose-protein mannosyltransferase K14340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 330.0
TLS2_k127_3990952_4 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001591 272.0
TLS2_k127_3990952_5 Glycosyl hydrolases family 8 K20542 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000009053 267.0
TLS2_k127_3990952_6 Dolichyl-phosphate-mannose-protein mannosyltransferase K14340 - - 0.00000000000000000000000000000000000000000000000003078 190.0
TLS2_k127_3990952_7 Polysaccharide pyruvyl transferase - - - 0.0000000000000001304 93.0
TLS2_k127_3990952_8 membrane transporter protein K07090 - - 0.00000000004025 69.0
TLS2_k127_4017150_0 Beta galactosidase small chain K01190 - 3.2.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006593 567.0
TLS2_k127_4017150_1 PFAM Archaeal ATPase K06921 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 297.0
TLS2_k127_4017150_2 DNA alkylation repair - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001915 274.0
TLS2_k127_4017150_3 - - - - 0.0000016 53.0
TLS2_k127_409385_0 ABC-type dipeptide transport system, periplasmic component K02035 - - 2.92e-224 711.0
TLS2_k127_409385_1 Phosphoglycerate kinase K00927,K01803 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 2.7.2.3,5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008116 560.0
TLS2_k127_409385_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 516.0
TLS2_k127_409385_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007005 367.0
TLS2_k127_409385_4 Displays ATPase and GTPase activities K06958 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004949 312.0
TLS2_k127_4138075_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 2.74e-229 719.0
TLS2_k127_4138075_1 beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005544 554.0
TLS2_k127_4138075_10 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002727 278.0
TLS2_k127_4138075_11 Thioesterase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000002499 230.0
TLS2_k127_4138075_12 ABC-type Na efflux pump, permease K01992 - - 0.0000000000000000000000000000000000000000000000000000000001364 222.0
TLS2_k127_4138075_13 PhoU domain - - - 0.000000000000000000000000000000000000000000000000000000000748 216.0
TLS2_k127_4138075_14 Beta-lactamase K01286 - 3.4.16.4 0.00000000000000000000000000000000000000000003229 176.0
TLS2_k127_4138075_15 - - - - 0.0000000000000000000000000000000001032 137.0
TLS2_k127_4138075_16 Phosphotransferase enzyme family - - - 0.00000000000000000000000000006018 127.0
TLS2_k127_4138075_18 Membrane - - - 0.000000000003564 79.0
TLS2_k127_4138075_19 - - - - 0.00000000000377 70.0
TLS2_k127_4138075_2 Na+/Pi-cotransporter K03324,K14683 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 476.0
TLS2_k127_4138075_20 uridine kinase K00876 - 2.7.1.48 0.000000001887 62.0
TLS2_k127_4138075_3 cytochrome p450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 460.0
TLS2_k127_4138075_4 Sodium:sulfate symporter transmembrane region K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 451.0
TLS2_k127_4138075_5 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004629 411.0
TLS2_k127_4138075_6 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 326.0
TLS2_k127_4138075_7 iron dependent repressor K03709 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 305.0
TLS2_k127_4138075_8 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001629 282.0
TLS2_k127_4138075_9 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002532 278.0
TLS2_k127_4170679_0 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family K00362 - 1.7.1.15 1.356e-294 937.0
TLS2_k127_4170679_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372,K02567 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 606.0
TLS2_k127_4170679_10 TIGRFAM diguanylate cyclase (GGDEF) domain - - - 0.000000000000000000000000000000000000000000000000001762 189.0
TLS2_k127_4170679_11 COGs COG2110 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.000000000000000000000000000000000000000000000000002339 187.0
TLS2_k127_4170679_12 pyridoxamine 5-phosphate - - - 0.00000000000000000000000000000003528 139.0
TLS2_k127_4170679_13 Nitrite reductase NAD(P)H , small subunit K00363 - 1.7.1.15 0.000000000000000000000003887 119.0
TLS2_k127_4170679_14 Domain of unknown function (DUF4349) - - - 0.000000000000000000000217 111.0
TLS2_k127_4170679_15 endonuclease - - - 0.000000002589 62.0
TLS2_k127_4170679_2 COG2223 Nitrate nitrite transporter K02575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004773 492.0
TLS2_k127_4170679_3 F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 406.0
TLS2_k127_4170679_4 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000933 355.0
TLS2_k127_4170679_5 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007308 310.0
TLS2_k127_4170679_6 Uroporphyrinogen III synthase HEM4 K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006396 289.0
TLS2_k127_4170679_7 SMART ATPase, AAA type, core - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009979 268.0
TLS2_k127_4170679_8 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000193 267.0
TLS2_k127_4170679_9 PFAM Enoyl-CoA hydratase isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008349 248.0
TLS2_k127_4197351_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 4.329e-229 727.0
TLS2_k127_4197351_1 Fumarate reductase flavoprotein C-term K00278,K00767 GO:0008150,GO:0040007 1.4.3.16,2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008636 584.0
TLS2_k127_4197351_10 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000153 266.0
TLS2_k127_4197351_11 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000004837 264.0
TLS2_k127_4197351_12 replication factor c K02341,K02343,K09384 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000001068 269.0
TLS2_k127_4197351_13 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000001241 246.0
TLS2_k127_4197351_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000722 220.0
TLS2_k127_4197351_15 Domain of unknown function (DUF2520) - - - 0.000000000000000000000000000000000000000000000000003514 195.0
TLS2_k127_4197351_16 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000003256 189.0
TLS2_k127_4197351_17 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950,K13940 - 2.7.6.3,4.1.2.25 0.000000000000000000000000000000000000000009321 164.0
TLS2_k127_4197351_18 hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000009468 154.0
TLS2_k127_4197351_19 CopC domain K14166 - - 0.000000000000000000000000000000003616 148.0
TLS2_k127_4197351_2 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 510.0
TLS2_k127_4197351_20 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633,K13940 GO:0008150,GO:0040007 1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8 0.00000000000000000000000000003108 123.0
TLS2_k127_4197351_21 Putative zinc-finger - - - 0.0000000000001909 80.0
TLS2_k127_4197351_23 - - - - 0.0007031 47.0
TLS2_k127_4197351_3 Pfam:Zinicin_2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 402.0
TLS2_k127_4197351_4 Transmembrane secretion effector K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 366.0
TLS2_k127_4197351_5 Quinolinate phosphoribosyl transferase, N-terminal domain K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004566 306.0
TLS2_k127_4197351_6 Scramblase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 326.0
TLS2_k127_4197351_7 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009257 304.0
TLS2_k127_4197351_8 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 302.0
TLS2_k127_4197351_9 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009454 277.0
TLS2_k127_4217653_0 trisaccharide binding - - - 3.835e-237 751.0
TLS2_k127_4217653_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 511.0
TLS2_k127_4217653_10 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.0000000000001155 80.0
TLS2_k127_4217653_2 L-lactate permease K03303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 482.0
TLS2_k127_4217653_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K03778 - 1.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 460.0
TLS2_k127_4217653_4 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006737 348.0
TLS2_k127_4217653_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008356 328.0
TLS2_k127_4217653_6 uridine kinase K00876 - 2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001867 291.0
TLS2_k127_4217653_7 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000001504 231.0
TLS2_k127_4217653_8 - - - - 0.0000000000000000000000000000003587 132.0
TLS2_k127_4217653_9 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.17.4.1 0.00000000000006958 71.0
TLS2_k127_4293667_0 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 542.0
TLS2_k127_4293667_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 366.0
TLS2_k127_4293667_2 ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008552 273.0
TLS2_k127_4293667_3 - - - - 0.0000000000000000000000000000008696 130.0
TLS2_k127_4293667_4 Dodecin K09165 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000004305 94.0
TLS2_k127_4293667_5 - - - - 0.000000001394 71.0
TLS2_k127_4293667_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000004553 55.0
TLS2_k127_4293667_7 CoA-transferase family III K07749 - 2.8.3.16 0.00001098 48.0
TLS2_k127_4319860_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008491 535.0
TLS2_k127_4319860_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 401.0
TLS2_k127_4319860_2 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 382.0
TLS2_k127_4319860_3 Formyl transferase, C-terminal domain K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 305.0
TLS2_k127_4319860_4 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000001021 224.0
TLS2_k127_4319860_5 Putative methyltransferase K00564 - 2.1.1.172 0.00000000000000000000000000000000000000000000000000000000000003489 223.0
TLS2_k127_4319860_6 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000001873 192.0
TLS2_k127_4319860_7 Protein of unknown function (DUF402) - - - 0.000000000000000002631 94.0
TLS2_k127_4363626_0 Glutamate-1-semialdehyde aminotransferase K01845 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 569.0
TLS2_k127_4363626_1 Cytochrome b K03887 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 483.0
TLS2_k127_4363626_10 Uroporphyrinogen-III synthase HemD K01719,K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000003735 191.0
TLS2_k127_4363626_11 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K01838 - 5.4.2.6 0.0000000000000000000000000000000000000000000000002768 191.0
TLS2_k127_4363626_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.0000000000000000000000000000000000000000002302 163.0
TLS2_k127_4363626_13 - - - - 0.0000000000000000000000000000000000005436 144.0
TLS2_k127_4363626_14 Cytochrome c - - - 0.0000000000000000000000000000000000008198 149.0
TLS2_k127_4363626_15 - - - - 0.000000000000000000000000000007098 129.0
TLS2_k127_4363626_2 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 468.0
TLS2_k127_4363626_3 Delta-aminolevulinic acid dehydratase K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 451.0
TLS2_k127_4363626_4 Cytochrome b(C-terminal)/b6/petD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 337.0
TLS2_k127_4363626_5 Rieske 2Fe-2S - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005682 295.0
TLS2_k127_4363626_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 293.0
TLS2_k127_4363626_7 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000304 271.0
TLS2_k127_4363626_8 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007255 252.0
TLS2_k127_4363626_9 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000073 264.0
TLS2_k127_4393282_0 acyl-CoA dehydrogenase K00257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 594.0
TLS2_k127_4393282_1 synthase K00697,K16055 GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006651 522.0
TLS2_k127_4393282_10 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.000000000000000000000000000000000000000000000000000000001445 224.0
TLS2_k127_4393282_11 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000401 211.0
TLS2_k127_4393282_12 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000002054 192.0
TLS2_k127_4393282_13 RNA polymerase sigma-70 factor, sigma-B F G subfamily K03090 - - 0.000000000000000000000000000000000000000000000003493 182.0
TLS2_k127_4393282_14 Cbs domain - - - 0.0000000000000000000000000000000000000000001575 165.0
TLS2_k127_4393282_15 Ribosomal RNA methyltransferase RrmJ FtsJ K06442 GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000001016 154.0
TLS2_k127_4393282_16 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000004422 143.0
TLS2_k127_4393282_17 cytidine deaminase activity K01489 - 3.5.4.5 0.000000000000000000000000000001057 125.0
TLS2_k127_4393282_18 ferredoxin K05337 - - 0.00000000000000000000000000001133 128.0
TLS2_k127_4393282_19 Bacterial PH domain K08981 - - 0.000000000000000000000005257 117.0
TLS2_k127_4393282_2 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 337.0
TLS2_k127_4393282_20 membrane K09167 - - 0.0000000000000000189 94.0
TLS2_k127_4393282_21 - - - - 0.000000000000002342 82.0
TLS2_k127_4393282_22 amino acid K02029 - - 0.000000003166 59.0
TLS2_k127_4393282_3 ATPases associated with a variety of cellular activities K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 321.0
TLS2_k127_4393282_4 spore germination - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 319.0
TLS2_k127_4393282_5 Melibiase K07407 - 3.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 305.0
TLS2_k127_4393282_6 Glucose-6-phosphate dehydrogenase, C-terminal domain K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000006298 276.0
TLS2_k127_4393282_7 Haemolysin-III related K11068 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001308 260.0
TLS2_k127_4393282_8 PFAM OsmC-like protein K04063 - - 0.00000000000000000000000000000000000000000000000000000000005184 208.0
TLS2_k127_4393282_9 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000002442 211.0
TLS2_k127_4410725_0 tRNA synthetases class I (C) catalytic domain K01883,K15526 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16,6.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004776 612.0
TLS2_k127_4410725_1 Enoyl- acyl-carrier-protein reductase NADH K00208,K11611 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030312,GO:0030497,GO:0031406,GO:0032787,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 356.0
TLS2_k127_4410725_10 - - - - 0.000000000000000000000000001244 118.0
TLS2_k127_4410725_11 Nad-dependent epimerase dehydratase - - - 0.0000000000000004317 79.0
TLS2_k127_4410725_2 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 304.0
TLS2_k127_4410725_3 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002103 282.0
TLS2_k127_4410725_4 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000006506 216.0
TLS2_k127_4410725_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01576,K01652 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0030312,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.2.1.6,4.1.1.7 0.000000000000000000000000000000000000000000000000000000001092 207.0
TLS2_k127_4410725_6 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000009821 162.0
TLS2_k127_4410725_7 heme binding K21471,K21472 - - 0.00000000000000000000000000000000000004352 160.0
TLS2_k127_4410725_8 Belongs to the Fur family K22297 - - 0.000000000000000000000000000008777 125.0
TLS2_k127_4410725_9 DNA-binding transcription factor activity - - - 0.00000000000000000000000000007101 123.0
TLS2_k127_4423427_0 Glycoside hydrolase 15-related - - - 1.628e-221 702.0
TLS2_k127_4423427_1 Molybdenum Cofactor Synthesis C K03639 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 466.0
TLS2_k127_4423427_10 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004117 248.0
TLS2_k127_4423427_11 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000153 234.0
TLS2_k127_4423427_12 hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000002676 234.0
TLS2_k127_4423427_13 Transcriptional regulator - - - 0.000000000000000000000000000000000000000001095 158.0
TLS2_k127_4423427_14 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000003107 156.0
TLS2_k127_4423427_15 PFAM TspO MBR family K05770 - - 0.00000000000000000000000000000000000001093 150.0
TLS2_k127_4423427_16 ferredoxin K05337 - - 0.000000000000001515 78.0
TLS2_k127_4423427_2 Oxidoreductase molybdopterin binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 456.0
TLS2_k127_4423427_3 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 412.0
TLS2_k127_4423427_4 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 391.0
TLS2_k127_4423427_5 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 374.0
TLS2_k127_4423427_6 Belongs to the SUA5 family K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 326.0
TLS2_k127_4423427_7 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 316.0
TLS2_k127_4423427_8 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001325 281.0
TLS2_k127_4423427_9 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000005156 261.0
TLS2_k127_4446696_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 3.854e-295 935.0
TLS2_k127_4446696_1 Participates in both transcription termination and antitermination K02600 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 533.0
TLS2_k127_4446696_2 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009802 345.0
TLS2_k127_4446696_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006279 284.0
TLS2_k127_4446696_4 Acyl-CoA thioesterase K10805 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001601 261.0
TLS2_k127_4446696_5 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000001614 193.0
TLS2_k127_4446696_6 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000803 191.0
TLS2_k127_4446696_7 Protein of unknown function (DUF503) - - - 0.0000000000000000000003781 98.0
TLS2_k127_4446696_8 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000955 96.0
TLS2_k127_4446696_9 Protein of unknown function (DUF448) K07742 - - 0.0000000004638 67.0
TLS2_k127_4485364_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008557 539.0
TLS2_k127_4485364_1 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 447.0
TLS2_k127_4485364_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000002707 175.0
TLS2_k127_4485364_3 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K07025,K20866 - 3.1.3.10 0.0000000000000000001415 91.0
TLS2_k127_4485364_4 Histidine triad (HIT) protein - - - 0.00000000000000874 79.0
TLS2_k127_4526601_0 TopoisomeraseII K02470 - 5.99.1.3 7.283e-302 949.0
TLS2_k127_4526601_1 DNA Topoisomerase IV K02469 - 5.99.1.3 5.578e-291 923.0
TLS2_k127_4526601_10 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817,K02224,K04720 GO:0008150,GO:0040007 2.6.1.9,4.1.1.81,6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000001262 166.0
TLS2_k127_4526601_11 Domain of unknown function (DUF1905) - - - 0.00000000000000000000000000000000006774 135.0
TLS2_k127_4526601_12 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000000005927 132.0
TLS2_k127_4526601_13 PFAM Cobinamide kinase cobinamide phosphate guanyltransferase K02231 - 2.7.1.156,2.7.7.62 0.000000000000000000000000000001668 138.0
TLS2_k127_4526601_14 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.00000000000000000000000000004764 130.0
TLS2_k127_4526601_15 Protein of unknown function (DUF1679) - - - 0.0000000000000000000000000004351 130.0
TLS2_k127_4526601_2 permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 357.0
TLS2_k127_4526601_3 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 311.0
TLS2_k127_4526601_4 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000261 291.0
TLS2_k127_4526601_5 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000002701 267.0
TLS2_k127_4526601_6 MDMPI C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000003736 239.0
TLS2_k127_4526601_7 Adenosylcobinamide amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000003697 235.0
TLS2_k127_4526601_8 COG1024 Enoyl-CoA hydratase carnithine racemase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000004057 210.0
TLS2_k127_4526601_9 Calcineurin-like phosphoesterase K03651 - 3.1.4.53 0.000000000000000000000000000000000000000000003472 174.0
TLS2_k127_4546826_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 7.58e-199 636.0
TLS2_k127_4546826_1 Acyl transferase domain K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 481.0
TLS2_k127_4546826_10 FabA-like domain K02372 - 4.2.1.59 0.000000000000000000000000000000000000000000000000008944 194.0
TLS2_k127_4546826_11 PFAM globin K06886 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000005082 155.0
TLS2_k127_4546826_12 Sigma-70, region 4 - - - 0.00000000000000000000000000001411 127.0
TLS2_k127_4546826_13 bacterial (prokaryotic) histone like domain K03530 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.0000000000000000000000000003083 118.0
TLS2_k127_4546826_14 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000001674 100.0
TLS2_k127_4546826_15 Antibiotic biosynthesis monooxygenase K11530 - 5.3.1.32 0.00000000000000003831 84.0
TLS2_k127_4546826_16 chaperone cofactor-dependent protein refolding K09527 GO:0001671,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008047,GO:0008150,GO:0009987,GO:0030234,GO:0031072,GO:0031974,GO:0031981,GO:0032781,GO:0043085,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043462,GO:0044093,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0051082,GO:0051084,GO:0051085,GO:0051336,GO:0051345,GO:0060589,GO:0060590,GO:0061077,GO:0065007,GO:0065009,GO:0070013,GO:0080134,GO:0080135,GO:0098772,GO:1900034 - 0.000000001683 65.0
TLS2_k127_4546826_2 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009794 458.0
TLS2_k127_4546826_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 404.0
TLS2_k127_4546826_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 325.0
TLS2_k127_4546826_5 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000996 306.0
TLS2_k127_4546826_6 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 312.0
TLS2_k127_4546826_7 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000003733 260.0
TLS2_k127_4546826_8 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000302 225.0
TLS2_k127_4546826_9 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000004117 201.0
TLS2_k127_4557037_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1193.0
TLS2_k127_4557037_1 Belongs to the 5'-nucleotidase family K11751 - 3.1.3.5,3.6.1.45 8.104e-206 664.0
TLS2_k127_4557037_11 Aminoacyl-tRNA editing domain - - - 0.0000000000000000000000000000000000009927 153.0
TLS2_k127_4557037_12 PIN domain K07064 - - 0.000000000000000000000000000000002661 136.0
TLS2_k127_4557037_13 transcriptional regulator - - - 0.00000000000000000000000000000004058 141.0
TLS2_k127_4557037_15 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.00000000000000007426 91.0
TLS2_k127_4557037_16 positive regulation of growth - - - 0.0000000000000009758 81.0
TLS2_k127_4557037_17 DnaJ molecular chaperone homology domain - - - 0.0000826 55.0
TLS2_k127_4557037_18 DnaJ molecular chaperone homology domain - - - 0.000229 51.0
TLS2_k127_4557037_2 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 585.0
TLS2_k127_4557037_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000737 554.0
TLS2_k127_4557037_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 548.0
TLS2_k127_4557037_5 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 508.0
TLS2_k127_4557037_6 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 317.0
TLS2_k127_4557037_7 thiolester hydrolase activity K01990,K06889 GO:0008150,GO:0009987,GO:0051301 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009536 262.0
TLS2_k127_4557037_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000001735 254.0
TLS2_k127_4557037_9 PFAM HhH-GPD family protein - - - 0.000000000000000000000000000000000000000000000000000000002869 209.0
TLS2_k127_45679_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1133.0
TLS2_k127_45679_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.15 7.179e-240 754.0
TLS2_k127_45679_10 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 379.0
TLS2_k127_45679_11 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 370.0
TLS2_k127_45679_12 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 336.0
TLS2_k127_45679_13 Alanine-glyoxylate amino-transferase K05825 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 334.0
TLS2_k127_45679_14 helix_turn_helix gluconate operon transcriptional repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 339.0
TLS2_k127_45679_15 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 327.0
TLS2_k127_45679_16 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000513 301.0
TLS2_k127_45679_17 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 304.0
TLS2_k127_45679_18 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001312 301.0
TLS2_k127_45679_19 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009015 284.0
TLS2_k127_45679_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 2.411e-216 694.0
TLS2_k127_45679_20 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001213 274.0
TLS2_k127_45679_21 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003364 259.0
TLS2_k127_45679_22 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001816 241.0
TLS2_k127_45679_23 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002079 243.0
TLS2_k127_45679_24 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.0000000000000000000000000000000000000000000000000000000000001004 222.0
TLS2_k127_45679_26 Universal stress protein family - - - 0.0000000000000000000000000004672 119.0
TLS2_k127_45679_27 Zincin-like metallopeptidase - - - 0.0000000000000000000000008348 118.0
TLS2_k127_45679_28 FMN binding - - - 0.000000000000000000000001328 111.0
TLS2_k127_45679_29 PFAM Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000444 108.0
TLS2_k127_45679_3 Belongs to the GPI family K01810 - 5.3.1.9 1.811e-213 683.0
TLS2_k127_45679_30 Stress responsive - - - 0.000000000000000000169 100.0
TLS2_k127_45679_31 Protein of unknown function (DUF2800) K07465 - - 0.0000000000008363 78.0
TLS2_k127_45679_32 Psort location Cytoplasmic, score - - - 0.00000004741 59.0
TLS2_k127_45679_34 - - - - 0.0006382 49.0
TLS2_k127_45679_4 elongation factor Tu domain 2 protein K02355 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - 1.853e-212 681.0
TLS2_k127_45679_5 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 553.0
TLS2_k127_45679_6 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 507.0
TLS2_k127_45679_7 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 439.0
TLS2_k127_45679_8 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 427.0
TLS2_k127_45679_9 helix_turn _helix lactose operon repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 398.0
TLS2_k127_4665222_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K03520 - 1.2.5.3 2.581e-266 840.0
TLS2_k127_4665222_1 C-terminal, D2-small domain, of ClpB protein K03696 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944 - 2.326e-232 726.0
TLS2_k127_4665222_10 Thioesterase - - - 0.00000000000000000000000000000000000000000008462 168.0
TLS2_k127_4665222_11 Transcriptional regulator - - - 0.0000000000000000000000000000000000000006102 155.0
TLS2_k127_4665222_12 AdoMet dependent proline di-methyltransferase - - - 0.0000000000000000000000000002019 125.0
TLS2_k127_4665222_13 D-alanyl-D-alanine carboxypeptidase - - - 0.0000000000000000000000000003862 129.0
TLS2_k127_4665222_14 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000003196 118.0
TLS2_k127_4665222_15 phosphatase activity K07025 - - 0.000000000000000000000000005655 127.0
TLS2_k127_4665222_16 - - - - 0.00000499 57.0
TLS2_k127_4665222_17 40-residue YVTN family beta-propeller repeat - - - 0.0006222 52.0
TLS2_k127_4665222_2 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 473.0
TLS2_k127_4665222_3 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 435.0
TLS2_k127_4665222_4 DisA bacterial checkpoint controller nucleotide-binding K07067 - 2.7.7.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009688 406.0
TLS2_k127_4665222_5 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 384.0
TLS2_k127_4665222_6 aminoglycoside K00662 - 2.3.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 297.0
TLS2_k127_4665222_7 helix_turn_helix, cAMP Regulatory protein K01420,K10914,K21561,K21564 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003539 261.0
TLS2_k127_4665222_8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000001131 190.0
TLS2_k127_4665222_9 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000001964 196.0
TLS2_k127_4692480_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 7.091e-293 908.0
TLS2_k127_4692480_1 Nitrous oxide reductase K00376 - 1.7.2.4 2.666e-241 762.0
TLS2_k127_4692480_10 Pterin binding enzyme K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 297.0
TLS2_k127_4692480_11 Tetratricopeptide repeat K05838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 293.0
TLS2_k127_4692480_12 Methyltransferase type 11 K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 290.0
TLS2_k127_4692480_13 Type II secretion system (T2SS), protein F K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007271 269.0
TLS2_k127_4692480_14 dna polymerase III delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000001015 271.0
TLS2_k127_4692480_15 PAC2 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000489 246.0
TLS2_k127_4692480_16 Type II secretion system (T2SS), protein F K12511 - - 0.00000000000000000000000000000000000000000000000000000000000000001127 242.0
TLS2_k127_4692480_17 ComEC Rec2-related protein K02238 - - 0.0000000000000000000000000000000000000000000000000000003554 221.0
TLS2_k127_4692480_18 PFAM helix-turn-helix domain protein - - - 0.000000000000000000000000000000000000000000000000000009142 196.0
TLS2_k127_4692480_19 Domain present in carbohydrate binding proteins and sugar hydrolses K07218 - - 0.000000000000000000000000000000000000000000002972 187.0
TLS2_k127_4692480_2 PFAM AMP-dependent synthetase and ligase K00666,K01909 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008922,GO:0009058,GO:0009987,GO:0015645,GO:0016020,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016874,GO:0016877,GO:0016878,GO:0017076,GO:0019752,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046394,GO:0051704,GO:0070566,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 6.2.1.20 4.466e-195 626.0
TLS2_k127_4692480_20 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000005326 160.0
TLS2_k127_4692480_21 Competence protein ComEA K02237 - - 0.00000000000000000000000000000000000001298 154.0
TLS2_k127_4692480_22 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000002995 138.0
TLS2_k127_4692480_23 ABC-2 family transporter protein K19341 - - 0.000000000000000000000000415 121.0
TLS2_k127_4692480_24 lipoprotein involved in nitrous oxide reduction K19342 - - 0.000000000000000000000001127 121.0
TLS2_k127_4692480_25 Glyoxalase-like domain - - - 0.0000000000000000002739 102.0
TLS2_k127_4692480_26 Helix-turn-helix domain - - - 0.00000000000000004417 84.0
TLS2_k127_4692480_27 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000005129 80.0
TLS2_k127_4692480_28 Copper binding proteins, plastocyanin/azurin family - - - 0.000000000000003157 80.0
TLS2_k127_4692480_3 DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 537.0
TLS2_k127_4692480_30 Domains in Na-Ca exchangers and integrin-beta4 K01406 - 3.4.24.40 0.000000000001451 79.0
TLS2_k127_4692480_31 SAF - - - 0.00000001111 66.0
TLS2_k127_4692480_33 - - - - 0.000008183 49.0
TLS2_k127_4692480_34 Treponemal membrane protein - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.0005513 51.0
TLS2_k127_4692480_35 Protein tyrosine kinase - - - 0.000814 51.0
TLS2_k127_4692480_4 Type II/IV secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002908 527.0
TLS2_k127_4692480_5 F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 442.0
TLS2_k127_4692480_6 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 408.0
TLS2_k127_4692480_7 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 424.0
TLS2_k127_4692480_8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 349.0
TLS2_k127_4740678_0 Protein synonym acyl-CoA synthetase K01897 - 6.2.1.3 2.48e-239 752.0
TLS2_k127_4740678_1 Thiolase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007848 593.0
TLS2_k127_4740678_10 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 295.0
TLS2_k127_4740678_11 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002738 233.0
TLS2_k127_4740678_12 Hydrolase of the alpha beta-hydrolase K07020 - - 0.00000000000000000000000000000000000000000000000000000000000000003583 238.0
TLS2_k127_4740678_13 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000000000000000000000000000000000000000386 209.0
TLS2_k127_4740678_14 BetI-type transcriptional repressor, C-terminal - - - 0.000000000000000000000000000000000000000000001398 172.0
TLS2_k127_4740678_15 Ferredoxin - - - 0.0000000000000000000000000000000007473 138.0
TLS2_k127_4740678_16 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000006137 132.0
TLS2_k127_4740678_17 NifU-like domain - - - 0.00000000000000000000000005581 110.0
TLS2_k127_4740678_18 proton-transporting ATP synthase activity, rotational mechanism K02114 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000005757 108.0
TLS2_k127_4740678_19 - - - - 0.0000000000000000003328 98.0
TLS2_k127_4740678_2 Fructose-1,6-bisphosphatase K02446 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 452.0
TLS2_k127_4740678_20 2',5' RNA ligase family protein - - - 0.000000000000005078 86.0
TLS2_k127_4740678_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006965 399.0
TLS2_k127_4740678_4 Enoyl-CoA hydratase/isomerase K01692,K08299 - 4.2.1.149,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 370.0
TLS2_k127_4740678_5 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 372.0
TLS2_k127_4740678_6 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 372.0
TLS2_k127_4740678_7 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 357.0
TLS2_k127_4740678_8 PFAM Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 327.0
TLS2_k127_4740678_9 Major facilitator Superfamily K08369 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 310.0
TLS2_k127_4743016_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 3.058e-226 716.0
TLS2_k127_4743016_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K12952 GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 - 4.855e-223 716.0
TLS2_k127_4743016_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K02405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 346.0
TLS2_k127_4743016_3 ABC transporter K11603 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002766 248.0
TLS2_k127_4743016_4 Saccharopine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000002566 212.0
TLS2_k127_4743016_5 methyltransferase - - - 0.000000000000000000000000000000000000004176 156.0
TLS2_k127_4743016_6 MDMPI C-terminal domain - - - 0.00000000000000000000000000000000000008219 166.0
TLS2_k127_4743016_7 domain, Protein - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000002075 111.0
TLS2_k127_4743016_9 HNH endonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000008855 61.0
TLS2_k127_4755639_0 Participates in initiation and elongation during chromosome replication K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 617.0
TLS2_k127_4755639_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 388.0
TLS2_k127_4755639_10 N-4 methylation of cytosine K00571,K00590 - 2.1.1.113,2.1.1.72 0.0000000000000000000001267 100.0
TLS2_k127_4755639_11 - - - - 0.0000000000000000115 96.0
TLS2_k127_4755639_12 - - - - 0.000009409 57.0
TLS2_k127_4755639_2 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005325 336.0
TLS2_k127_4755639_3 ABC-type multidrug transport system, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000137 256.0
TLS2_k127_4755639_4 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000896 243.0
TLS2_k127_4755639_5 Single-strand binding protein family K03111 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000001071 175.0
TLS2_k127_4755639_6 Binds to the 23S rRNA K02939 - - 0.000000000000000000000000000000000000000000000792 170.0
TLS2_k127_4755639_7 acetyltransferase - - - 0.000000000000000000000000000000000000000000002832 171.0
TLS2_k127_4755639_8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000001168 140.0
TLS2_k127_4755639_9 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000005503 124.0
TLS2_k127_4779934_0 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003753 413.0
TLS2_k127_4779934_1 DEAD-like helicases superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 408.0
TLS2_k127_4779934_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000003388 174.0
TLS2_k127_4779934_3 Belongs to the P(II) protein family K04751 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000008447 169.0
TLS2_k127_4779934_4 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000003896 151.0
TLS2_k127_4779934_5 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000001024 136.0
TLS2_k127_4782938_0 pfam fad - - - 1.879e-205 676.0
TLS2_k127_4782938_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003999 557.0
TLS2_k127_4782938_2 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 519.0
TLS2_k127_4782938_3 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 431.0
TLS2_k127_4782938_4 esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005329 400.0
TLS2_k127_4782938_5 acyl-CoA dehydrogenase K22027 - 1.14.13.235 0.00000000000000000000000000000000000000000000000000000000000000000000003654 256.0
TLS2_k127_4782938_6 MDMPI C-terminal domain - - - 0.000000000000000000000000000000000000000000006317 184.0
TLS2_k127_4782938_8 hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000001783 151.0
TLS2_k127_4782938_9 Hep Hag repeat protein - - - 0.0000716 55.0
TLS2_k127_482912_0 Amidohydrolase K10220 - 4.2.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 524.0
TLS2_k127_482912_1 4-hydroxybenzoate K00481 - 1.14.13.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 481.0
TLS2_k127_482912_10 - - - - 0.0008485 51.0
TLS2_k127_482912_2 dehydrogenases and related proteins K10219 - 1.1.1.312 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006751 451.0
TLS2_k127_482912_3 Aldolase/RraA K10218 - 4.1.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000645 293.0
TLS2_k127_482912_4 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009598 257.0
TLS2_k127_482912_5 transcriptional regulator - - - 0.00000000000000000000000000000000000000000001534 182.0
TLS2_k127_482912_6 Acetyltransferase (GNAT) domain K17840 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016020,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0034069,GO:0044237,GO:0044248,GO:0044464,GO:0047921,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658 2.3.1.59 0.000000000000000000000000000000000000002059 154.0
TLS2_k127_482912_7 transcriptional regulator K07979 - - 0.00000000000000000000000000000002469 128.0
TLS2_k127_482912_8 - - - - 0.0000000000000000000000000000003442 135.0
TLS2_k127_482912_9 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000009273 92.0
TLS2_k127_4834307_0 Cation transport ATPase (P-type) K01537 - 3.6.3.8 4.89e-258 824.0
TLS2_k127_4834307_1 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000003428 256.0
TLS2_k127_4834307_2 PFAM DoxX family protein K15977 - - 0.000000000000000000000000000000000000000000000000000001706 196.0
TLS2_k127_4871533_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 1.561e-248 771.0
TLS2_k127_4871533_1 AMP-binding enzyme C-terminal domain - - - 1.908e-206 693.0
TLS2_k127_4871533_10 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 291.0
TLS2_k127_4871533_11 PFAM YCII-related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001124 270.0
TLS2_k127_4871533_12 YceI-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004744 262.0
TLS2_k127_4871533_13 bifunctional deaminase-reductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009511 252.0
TLS2_k127_4871533_14 Pfam Activator of Hsp90 ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001201 246.0
TLS2_k127_4871533_15 Belongs to the low molecular weight phosphotyrosine protein phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000001512 213.0
TLS2_k127_4871533_16 Membrane - - - 0.000000000000000000000000000000000000000000000000000000002901 208.0
TLS2_k127_4871533_17 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000002239 203.0
TLS2_k127_4871533_18 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000001086 175.0
TLS2_k127_4871533_19 transcriptional regulator - - - 0.0000000000000000000000000000000000000000004025 162.0
TLS2_k127_4871533_2 Cystathionine beta-synthase K01697 GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005994 579.0
TLS2_k127_4871533_20 SnoaL-like domain - - - 0.000000000000000001862 90.0
TLS2_k127_4871533_21 Major Facilitator Superfamily - - - 0.0000000004954 70.0
TLS2_k127_4871533_3 TIGRFAM Arsenical-resistance protein K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 544.0
TLS2_k127_4871533_4 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 481.0
TLS2_k127_4871533_5 Cys/Met metabolism PLP-dependent enzyme K01739 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 479.0
TLS2_k127_4871533_6 belongs to the sigma-70 factor family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 357.0
TLS2_k127_4871533_7 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005631 342.0
TLS2_k127_4871533_8 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004153 290.0
TLS2_k127_4871533_9 Enoyl-(Acyl carrier protein) reductase K00038 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016020,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0033764,GO:0044238,GO:0044464,GO:0047044,GO:0055114,GO:0071704,GO:0071944,GO:1901360 1.1.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007479 291.0
TLS2_k127_4876991_0 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007995 345.0
TLS2_k127_4876991_1 Regulatory protein, MerR - - - 0.00000000000000000000000000000000000000000000007536 178.0
TLS2_k127_4876991_2 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.00000000000000000000000000000000000000000000449 170.0
TLS2_k127_4876991_3 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000007662 132.0
TLS2_k127_4876991_4 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000007558 136.0
TLS2_k127_4908356_0 PFAM Transketolase central region K00162 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004534 539.0
TLS2_k127_4908356_1 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008371 444.0
TLS2_k127_4908356_10 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000004674 189.0
TLS2_k127_4908356_11 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000005587 173.0
TLS2_k127_4908356_12 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000000000000000000000003854 162.0
TLS2_k127_4908356_13 heat shock protein K04762 - - 0.00000000000000000000000000000000000001168 155.0
TLS2_k127_4908356_14 Haem-binding domain - - - 0.0000000000000000000000000000004021 127.0
TLS2_k127_4908356_15 endonuclease activity - - - 0.00000000000000000000000000002878 131.0
TLS2_k127_4908356_16 cyclic nucleotide binding K10914 - - 0.0000000000000000000000004148 112.0
TLS2_k127_4908356_17 - - - - 0.00000000000000000000001278 106.0
TLS2_k127_4908356_18 - - - - 0.00000000000000000000008142 102.0
TLS2_k127_4908356_19 - - - - 0.0003634 47.0
TLS2_k127_4908356_2 of components of various dehydrogenase complexes K00627 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009656 438.0
TLS2_k127_4908356_3 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000515 361.0
TLS2_k127_4908356_4 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 323.0
TLS2_k127_4908356_5 A circularly permuted ATPgrasp - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008324 296.0
TLS2_k127_4908356_6 Belongs to the HpcH HpaI aldolase family K01644,K18292 GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046872,GO:0071704 4.1.3.25,4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000004819 252.0
TLS2_k127_4908356_7 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000001156 239.0
TLS2_k127_4908356_8 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000003507 223.0
TLS2_k127_4908356_9 MaoC like domain - - - 0.0000000000000000000000000000000000000000000000000000000000005455 214.0
TLS2_k127_4974709_0 Belongs to the transketolase family K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 594.0
TLS2_k127_4974709_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000434 428.0
TLS2_k127_4974709_2 4Fe-4S dicluster domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 390.0
TLS2_k127_4974709_3 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009486 321.0
TLS2_k127_4974709_4 FIST N domain - GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 301.0
TLS2_k127_4974709_5 FAD binding domain K11472 - - 0.00000000000000000000000000000000000000000000000000000002692 204.0
TLS2_k127_4974709_7 AAA domain - - - 0.000000000000000000000000000000000000857 148.0
TLS2_k127_4974709_8 PFAM Glucosamine-6-phosphate isomerases 6-phosphogluconolactonase K01057 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 0.000000000000000000000000000000006113 136.0
TLS2_k127_503265_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 0.0 1595.0
TLS2_k127_503265_1 ABC transporter - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 1.086e-289 904.0
TLS2_k127_503265_10 Zc3h12a-like Ribonuclease NYN domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 336.0
TLS2_k127_503265_11 diacylglycerol O-acyltransferase K00635 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 328.0
TLS2_k127_503265_12 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 314.0
TLS2_k127_503265_13 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures K07503 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000489 326.0
TLS2_k127_503265_14 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 332.0
TLS2_k127_503265_15 Inositol monophosphatase family K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001003 286.0
TLS2_k127_503265_16 ABC-type Mn2 Zn2 transport systems permease components K02075,K09819 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004552 275.0
TLS2_k127_503265_17 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004798 263.0
TLS2_k127_503265_18 hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000182 247.0
TLS2_k127_503265_19 VanW like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000002636 246.0
TLS2_k127_503265_2 ABC1 family - - - 1.37e-204 657.0
TLS2_k127_503265_20 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.0000000000000000000000000000000000000000000000000000000000000000299 236.0
TLS2_k127_503265_21 methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000007371 221.0
TLS2_k127_503265_22 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000008324 226.0
TLS2_k127_503265_23 transport system, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000009576 225.0
TLS2_k127_503265_24 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000004432 200.0
TLS2_k127_503265_25 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000002059 172.0
TLS2_k127_503265_26 Bacterial PH domain - - - 0.00000000000000000000000000000000000000000001536 172.0
TLS2_k127_503265_27 Zincin-like metallopeptidase - - - 0.000000000000000000000000000000000000000004687 157.0
TLS2_k127_503265_28 Pfam Methyltransferase - - - 0.00000000000000000000000000000000000000001241 169.0
TLS2_k127_503265_29 Thioesterase superfamily - - - 0.00000000000000000000000000000000000003378 159.0
TLS2_k127_503265_3 acyl-CoA dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 564.0
TLS2_k127_503265_30 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000006994 159.0
TLS2_k127_503265_31 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000000000000004783 152.0
TLS2_k127_503265_32 ACT domain K03567 - - 0.0000000000000000000000000000003171 130.0
TLS2_k127_503265_33 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000001343 119.0
TLS2_k127_503265_34 DinB superfamily - - - 0.0000000000000000000000006867 115.0
TLS2_k127_503265_35 ADP-L-glycero-beta-D-manno-heptose biosynthetic process K00980 - 2.7.7.39 0.00000000000000000001704 102.0
TLS2_k127_503265_36 ABC transporter K01990 - - 0.00000000000000003662 87.0
TLS2_k127_503265_38 pyridoxamine 5'-phosphate K07005 - - 0.0000000000002242 80.0
TLS2_k127_503265_4 UvrD-like helicase C-terminal domain K03657 GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008066 576.0
TLS2_k127_503265_41 PFAM Uracil-DNA glycosylase superfamily K03649 - 3.2.2.28 0.000004022 58.0
TLS2_k127_503265_5 F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 469.0
TLS2_k127_503265_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 444.0
TLS2_k127_503265_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000055 422.0
TLS2_k127_503265_8 Dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 374.0
TLS2_k127_503265_9 geranylgeranyl reductase K21401 - 1.3.99.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 385.0
TLS2_k127_5058654_0 carboxylase - - - 0.0 1171.0
TLS2_k127_5058654_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1094.0
TLS2_k127_5058654_10 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007272 300.0
TLS2_k127_5058654_11 histidine kinase HAMP region domain protein K02484 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005117 308.0
TLS2_k127_5058654_12 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006539 279.0
TLS2_k127_5058654_13 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000001016 234.0
TLS2_k127_5058654_14 Domain present in PSD-95, Dlg, and ZO-1/2. K08372 - - 0.0000000000000000000000000000000000000000000000000000000000000000008192 242.0
TLS2_k127_5058654_15 Sigma 54 modulation/S30EA ribosomal protein C terminus - - - 0.0000000000000000000000000000000000000000000000000002199 195.0
TLS2_k127_5058654_16 Belongs to the amidase family K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000002196 167.0
TLS2_k127_5058654_17 PFAM Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000004667 152.0
TLS2_k127_5058654_18 CBS domains - - - 0.0000000000000000000000000000000007387 140.0
TLS2_k127_5058654_19 Belongs to the globin family K05916 - 1.14.12.17 0.000000000000000000002427 110.0
TLS2_k127_5058654_2 N-terminal domain of (some) glycogen debranching enzymes - - - 1.925e-225 730.0
TLS2_k127_5058654_20 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.00000000000000003096 92.0
TLS2_k127_5058654_21 - - - - 0.0000000000000003116 89.0
TLS2_k127_5058654_22 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.00000000000001124 87.0
TLS2_k127_5058654_23 GCN5-related N-acetyl-transferase K06975 - - 0.00000000000001971 76.0
TLS2_k127_5058654_24 Domain of unknown function (DUF1918) - - - 0.0000000000002342 79.0
TLS2_k127_5058654_25 HNH nucleases - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000007545 59.0
TLS2_k127_5058654_27 Aminoglycoside phosphotransferase - - - 0.000149 53.0
TLS2_k127_5058654_3 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005953 503.0
TLS2_k127_5058654_4 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 439.0
TLS2_k127_5058654_5 dioxygenase K11159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000598 437.0
TLS2_k127_5058654_6 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 388.0
TLS2_k127_5058654_7 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006225 369.0
TLS2_k127_5058654_8 WYL domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 332.0
TLS2_k127_5058654_9 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 320.0
TLS2_k127_5079025_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 2.629e-239 749.0
TLS2_k127_5079025_1 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 7.738e-205 653.0
TLS2_k127_5079025_10 Phosphotransferase enzyme family - - - 0.0007788 49.0
TLS2_k127_5079025_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000914 428.0
TLS2_k127_5079025_3 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003144 399.0
TLS2_k127_5079025_5 Pfam:Pyridox_oxidase - - - 0.000000000000000000000000000000001051 134.0
TLS2_k127_5079025_6 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000002941 121.0
TLS2_k127_5079025_7 UvrD-like helicase C-terminal domain K03657 GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.0000000000000000000000623 107.0
TLS2_k127_5079025_8 - - - - 0.000000002502 64.0
TLS2_k127_5079025_9 Pyridoxal-dependent decarboxylase conserved domain - - - 0.0001496 44.0
TLS2_k127_5090297_0 cytochrome P450 K20497 - 1.14.15.14 1.007e-206 659.0
TLS2_k127_5090297_1 Cytochrome C biogenesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 341.0
TLS2_k127_5090297_10 DNA helicase - - - 0.0000000000000000000000000000000000000000000000000000001978 199.0
TLS2_k127_5090297_11 MOSC domain K07140 - - 0.00000000000000000000000000000000000000000000000000000114 201.0
TLS2_k127_5090297_12 - - - - 0.000000000000000000000000000000000000000000000000000001478 200.0
TLS2_k127_5090297_13 YjbR - - - 0.000000000000000000000000000000000000000000000000002071 189.0
TLS2_k127_5090297_14 Lysylphosphatidylglycerol synthase TM region - - - 0.0000000000000000000000000000000000000000000000008057 191.0
TLS2_k127_5090297_15 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.000000000000000000000000000000000000000000000001316 184.0
TLS2_k127_5090297_16 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000001002 183.0
TLS2_k127_5090297_17 glyoxalase bleomycin resistance protein - - - 0.00000000000000000000000000000000000000000002391 164.0
TLS2_k127_5090297_18 Enoyl-CoA hydratase/isomerase K01692,K13766 - 4.2.1.17,4.2.1.18 0.000000000000000000000000000000000000001631 168.0
TLS2_k127_5090297_19 lipopolysaccharide transmembrane transporter activity K07058 - - 0.000000000000000000000000000000000001153 150.0
TLS2_k127_5090297_2 Phytanoyl-CoA dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006454 335.0
TLS2_k127_5090297_20 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000003843 134.0
TLS2_k127_5090297_21 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000001321 114.0
TLS2_k127_5090297_22 Lysylphosphatidylglycerol synthase TM region K19302 - 3.6.1.27 0.000000000000000000000006005 115.0
TLS2_k127_5090297_23 NUDIX domain - - - 0.00000000000000000000001878 107.0
TLS2_k127_5090297_24 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000002641 108.0
TLS2_k127_5090297_25 Ion transport protein - - - 0.000000000000000000004485 103.0
TLS2_k127_5090297_26 YjbR - - - 0.000000000000000000005859 101.0
TLS2_k127_5090297_27 Alpha beta hydrolase - - - 0.0000000000000000002184 104.0
TLS2_k127_5090297_28 Acetyltransferase (GNAT) family - - - 0.000000000000000001167 98.0
TLS2_k127_5090297_29 Sucrose-6F-phosphate phosphohydrolase - - - 0.000000000000000003704 96.0
TLS2_k127_5090297_3 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 311.0
TLS2_k127_5090297_30 lactoylglutathione lyase activity - - - 0.0000000000000008637 82.0
TLS2_k127_5090297_31 YqeY-like protein K09117 - - 0.0000000001938 66.0
TLS2_k127_5090297_32 - - - - 0.000001245 60.0
TLS2_k127_5090297_4 Lysylphosphatidylglycerol synthase TM region K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 323.0
TLS2_k127_5090297_5 AI-2E family transporter K20469 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003965 280.0
TLS2_k127_5090297_6 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000000000000000001123 236.0
TLS2_k127_5090297_7 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000000000000003004 228.0
TLS2_k127_5090297_8 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000005307 232.0
TLS2_k127_5090297_9 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA - - - 0.00000000000000000000000000000000000000000000000000000006167 208.0
TLS2_k127_513688_0 Pyridoxal-dependent decarboxylase conserved domain K01580,K01634 - 4.1.1.15,4.1.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 532.0
TLS2_k127_513688_1 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 474.0
TLS2_k127_513688_2 Sulfate permease family K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 459.0
TLS2_k127_513688_3 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 342.0
TLS2_k127_513688_4 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001953 271.0
TLS2_k127_513688_5 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000000000000000000000000000000000000004072 208.0
TLS2_k127_513688_6 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000002317 136.0
TLS2_k127_513688_7 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000633 96.0
TLS2_k127_513688_8 DinB superfamily - - - 0.0000001214 60.0
TLS2_k127_5161063_0 dienelactone hydrolase K21104 - 3.1.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 402.0
TLS2_k127_5161063_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 381.0
TLS2_k127_5161063_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000002782 152.0
TLS2_k127_5161063_3 F420H(2)-dependent quinone reductase - - - 0.000003578 49.0
TLS2_k127_5223207_0 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 404.0
TLS2_k127_5223207_1 Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA) K00209 - 1.3.1.44,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000076 365.0
TLS2_k127_5223207_3 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000008499 178.0
TLS2_k127_5223207_4 GNAT acetyltransferase - - - 0.00000000004425 67.0
TLS2_k127_52316_0 P-aminobenzoate N-oxygenase AurF - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006695 477.0
TLS2_k127_52316_1 COG0524 Sugar kinases, ribokinase family K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 417.0
TLS2_k127_52316_2 Major Facilitator - - - 0.000000000000000000000000000000000000000000000000000000000000000003466 248.0
TLS2_k127_52316_3 ERAP1-like C-terminal domain K01256,K08776 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000018 232.0
TLS2_k127_52316_4 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000003012 186.0
TLS2_k127_52316_5 Nitroreductase family - - - 0.0000000000000000000005117 106.0
TLS2_k127_52316_6 transferase activity, transferring acyl groups - - - 0.000000000000000000004498 98.0
TLS2_k127_52316_7 Protein of unknown function (DUF559) - - - 0.0000000000000000009941 99.0
TLS2_k127_5305920_0 radical SAM domain protein - - - 3.536e-203 641.0
TLS2_k127_5305920_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 2.373e-195 618.0
TLS2_k127_5305920_10 Methyltransferase domain - - - 0.00000000000000000000000000000009339 134.0
TLS2_k127_5305920_11 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000001232 117.0
TLS2_k127_5305920_12 Tfp pilus assembly protein FimV - - - 0.0000000000000716 81.0
TLS2_k127_5305920_13 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - 0.0000000000009634 76.0
TLS2_k127_5305920_2 Cell division protein FtsA K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 517.0
TLS2_k127_5305920_3 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007549 421.0
TLS2_k127_5305920_4 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 378.0
TLS2_k127_5305920_5 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005469 348.0
TLS2_k127_5305920_6 Cell cycle protein K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009149 288.0
TLS2_k127_5305920_7 polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002135 252.0
TLS2_k127_5305920_8 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000001267 255.0
TLS2_k127_5305920_9 Nucleoside diphosphate kinase K00940 GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564 2.7.4.6 0.0000000000000000000000000000000000000000000000000000002434 202.0
TLS2_k127_5336591_0 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004398 442.0
TLS2_k127_5336591_1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 408.0
TLS2_k127_5336591_10 Activator of Hsp90 ATPase - - - 0.0000000000000000000000000000000000000000000000000000745 210.0
TLS2_k127_5336591_11 ANTAR - - - 0.0000000000000000000000000000000000000000000000001963 188.0
TLS2_k127_5336591_12 DNA synthesis involved in DNA repair - - - 0.00000000000000000000000000000000000000000001007 177.0
TLS2_k127_5336591_13 Domain of unknown function (DUF2383) - - - 0.00000000000000000000000000000000000000000004913 164.0
TLS2_k127_5336591_14 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000312 151.0
TLS2_k127_5336591_15 Protein of Unknown function (DUF2784) - - - 0.0000000000000000000000000000000001958 137.0
TLS2_k127_5336591_16 - - - - 0.000000000000172 70.0
TLS2_k127_5336591_18 antisigma factor binding K04749,K05946,K06378 - 2.4.1.187 0.000008071 55.0
TLS2_k127_5336591_19 Protein conserved in bacteria - - - 0.00002216 53.0
TLS2_k127_5336591_2 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005017 368.0
TLS2_k127_5336591_3 Fumarylacetoacetase N-terminal K01555 - 3.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 344.0
TLS2_k127_5336591_4 Biopterin-dependent aromatic amino acid hydroxylase K00500 - 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 325.0
TLS2_k127_5336591_5 alcohol dehydrogenase K00002,K13953 - 1.1.1.1,1.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000312 270.0
TLS2_k127_5336591_6 ANTAR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000254 263.0
TLS2_k127_5336591_7 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000132 258.0
TLS2_k127_5336591_8 photosystem II stabilization - - - 0.0000000000000000000000000000000000000000000000000000001006 207.0
TLS2_k127_5336591_9 Anabaena sensory rhodopsin transducer - - - 0.000000000000000000000000000000000000000000000000000001613 193.0
TLS2_k127_5401240_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1630.0
TLS2_k127_5401240_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000427 532.0
TLS2_k127_5401240_10 Protein of unknown function (DUF664) - - - 0.00000000000000000000000000000000000006721 151.0
TLS2_k127_5401240_11 Helix-hairpin-helix DNA-binding motif class 1 - - - 0.0000000000000000000000000000003318 130.0
TLS2_k127_5401240_12 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.6 0.00000000000000000000002033 106.0
TLS2_k127_5401240_13 Protein of unknown function (DUF402) - - - 0.000006058 51.0
TLS2_k127_5401240_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 526.0
TLS2_k127_5401240_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 491.0
TLS2_k127_5401240_4 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000908 484.0
TLS2_k127_5401240_5 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 473.0
TLS2_k127_5401240_6 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 332.0
TLS2_k127_5401240_7 Orotidine 5'-phosphate decarboxylase / HUMPS family K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000005333 222.0
TLS2_k127_5401240_8 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000003861 191.0
TLS2_k127_5401240_9 Guanylate kinase homologues. K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000003498 175.0
TLS2_k127_5431004_0 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 370.0
TLS2_k127_5431004_1 Glycosylase K05522 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000006077 248.0
TLS2_k127_5431004_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.00000000000000000000000000000000000000000000000000001022 203.0
TLS2_k127_5431004_3 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000000000000000009465 185.0
TLS2_k127_5431004_4 - - - - 0.00000000000000000000000000000009172 137.0
TLS2_k127_5434359_0 MgtE intracellular N domain K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 534.0
TLS2_k127_5434359_1 Methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 408.0
TLS2_k127_5434359_2 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004411 349.0
TLS2_k127_5434359_3 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000001883 233.0
TLS2_k127_5434359_4 Redoxin - - - 0.0000000000000000000001637 105.0
TLS2_k127_5434359_5 Zn peptidase - - - 0.000000000000452 79.0
TLS2_k127_5509363_0 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005876 588.0
TLS2_k127_5509363_1 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 524.0
TLS2_k127_5509363_10 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000003827 81.0
TLS2_k127_5509363_11 STAS domain - - - 0.0005155 46.0
TLS2_k127_5509363_2 FAD linked K00803 - 2.5.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 518.0
TLS2_k127_5509363_3 GIY-YIG type nucleases (URI domain) K02342 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 506.0
TLS2_k127_5509363_4 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009238 346.0
TLS2_k127_5509363_5 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00991,K21681 - 1.1.1.405,2.7.7.40,2.7.7.60 0.00000000000000000000000000000000000000000002687 179.0
TLS2_k127_5509363_6 enzyme involved in biosynthesis of extracellular polysaccharides - - - 0.0000000000000000000000000000000001242 136.0
TLS2_k127_5509363_7 - - - - 0.0000000000000000000000000000172 120.0
TLS2_k127_5509363_8 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.0000000000000000001743 98.0
TLS2_k127_5509363_9 Immunoglobulin-like domain of bacterial spore germination - - - 0.0000000000000000002646 99.0
TLS2_k127_5587551_0 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779 - 2.5.1.77 0.0 1152.0
TLS2_k127_5587551_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 3.715e-246 775.0
TLS2_k127_5587551_10 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009048 334.0
TLS2_k127_5587551_11 Protein of unknown function (DUF3097) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 324.0
TLS2_k127_5587551_12 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 300.0
TLS2_k127_5587551_13 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004846 301.0
TLS2_k127_5587551_14 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007519 286.0
TLS2_k127_5587551_15 PAP2 superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000005221 248.0
TLS2_k127_5587551_16 iron-sulfur cluster assembly K07400 - - 0.00000000000000000000000000000000000000000000000000000000000000003449 231.0
TLS2_k127_5587551_17 lysyltransferase activity K07027 - - 0.000000000000000000000000000000000000000000000000000002302 209.0
TLS2_k127_5587551_18 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000008667 194.0
TLS2_k127_5587551_19 Protein of unknown function (DUF459) K09795 - - 0.000000000000000000000000000000000000000001336 170.0
TLS2_k127_5587551_2 Na H antiporter K05565,K14086 - - 2.635e-200 652.0
TLS2_k127_5587551_20 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000000000006649 157.0
TLS2_k127_5587551_21 Domain of unknown function (DUF4173) - - - 0.0000000000000000000000000000000000000003603 169.0
TLS2_k127_5587551_22 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K20866 - 3.1.3.10 0.00000000000000000000000000000000001768 142.0
TLS2_k127_5587551_23 Acetyltransferase (GNAT) domain K22441 - 2.3.1.57 0.0000000000000000000000000000000001471 139.0
TLS2_k127_5587551_24 Multisubunit Na H antiporter MnhC subunit K05567 - - 0.000000000000000000000000000000009323 139.0
TLS2_k127_5587551_25 PFAM NADH Ubiquinone plastoquinone (complex I) K05565,K14086 - - 0.00000000000000000000000000000001476 134.0
TLS2_k127_5587551_26 Methylase of polypeptide chain release - - - 0.00000000000000000000000006358 112.0
TLS2_k127_5587551_27 Multisubunit Na H antiporter, MnhE subunit K05569 - - 0.000000000000000000000003484 111.0
TLS2_k127_5587551_28 Multisubunit Na H antiporter, MnhG subunit K05571 - - 0.00000000001058 75.0
TLS2_k127_5587551_29 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.000001601 59.0
TLS2_k127_5587551_3 ATPases associated with a variety of cellular activities K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 616.0
TLS2_k127_5587551_4 Belongs to the aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004883 565.0
TLS2_k127_5587551_5 Proton-conducting membrane transporter K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 505.0
TLS2_k127_5587551_6 Exporter of polyketide K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007828 505.0
TLS2_k127_5587551_7 MBOAT, membrane-bound O-acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008459 458.0
TLS2_k127_5587551_8 ABC transporter ATP-binding K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008254 420.0
TLS2_k127_5587551_9 TAP-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 370.0
TLS2_k127_5627152_0 ABC transporter K06147 - - 0.0 1189.0
TLS2_k127_5627152_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 7.591e-244 767.0
TLS2_k127_5627152_10 stage II sporulation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000358 287.0
TLS2_k127_5627152_11 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K20469 - - 0.000000000000000000000000000000000000000000000000000000000000000000501 243.0
TLS2_k127_5627152_12 Cytidylate kinase K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000003118 229.0
TLS2_k127_5627152_13 Phosphohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000006808 223.0
TLS2_k127_5627152_14 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000007049 189.0
TLS2_k127_5627152_16 - - - - 0.000000000000000000000000000000005247 132.0
TLS2_k127_5627152_17 Transcriptional regulator - - - 0.0000000000000000000000000005881 118.0
TLS2_k127_5627152_19 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000001367 62.0
TLS2_k127_5627152_2 Protein of unknown function (DUF512) - - - 6.913e-196 623.0
TLS2_k127_5627152_3 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 620.0
TLS2_k127_5627152_4 2-Nitropropane dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006617 535.0
TLS2_k127_5627152_5 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 510.0
TLS2_k127_5627152_6 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007086 478.0
TLS2_k127_5627152_7 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 382.0
TLS2_k127_5627152_8 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 321.0
TLS2_k127_5627152_9 SOS response associated peptidase (SRAP) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 299.0
TLS2_k127_5627252_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.4.4.2 0.0 1210.0
TLS2_k127_5627252_1 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 560.0
TLS2_k127_5627252_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000001478 246.0
TLS2_k127_5627252_11 peptidase M15B and M15C DD-carboxypeptidase VanY endolysin K07260 - 3.4.17.14 0.000000000000000000000000000000000000000000000000004439 197.0
TLS2_k127_5627252_12 Nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.000000000000000000000000002727 116.0
TLS2_k127_5627252_13 Protein of unknown function (DUF3499) - - - 0.0000000000001476 73.0
TLS2_k127_5627252_14 Highly conserved protein containing a thioredoxin domain - - - 0.000000000002422 79.0
TLS2_k127_5627252_15 - - - - 0.000000000005518 72.0
TLS2_k127_5627252_2 Acetyl-CoA acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004412 460.0
TLS2_k127_5627252_3 Enoyl-(Acyl carrier protein) reductase - GO:0003674,GO:0003824,GO:0004303,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006066,GO:0006629,GO:0007568,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0014070,GO:0016125,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0018812,GO:0030283,GO:0032502,GO:0033764,GO:0033993,GO:0042221,GO:0042493,GO:0042579,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044594,GO:0046983,GO:0048545,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071407,GO:0071704,GO:1901360,GO:1901615,GO:1902652 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 373.0
TLS2_k127_5627252_4 Glycine cleavage system T protein K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 367.0
TLS2_k127_5627252_5 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 326.0
TLS2_k127_5627252_6 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009125 285.0
TLS2_k127_5627252_7 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001105 256.0
TLS2_k127_5627252_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000008044 258.0
TLS2_k127_5627252_9 Belongs to the IUNH family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000657 246.0
TLS2_k127_5646602_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0 1090.0
TLS2_k127_5646602_1 Signal transducing histidine kinase, homodimeric K02487,K03407,K06596 - 2.7.13.3 1.897e-217 698.0
TLS2_k127_5646602_10 Methyl-accepting chemotaxis protein (MCP) signaling domain K02660,K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007644 283.0
TLS2_k127_5646602_11 CheW domain protein K03408 - - 0.00000000000000000000000000000000000000009141 154.0
TLS2_k127_5646602_12 response regulator receiver K03413 - - 0.0000000000000000000000000000002668 134.0
TLS2_k127_5646602_13 Chemotaxis phosphatase CheX K03409 - - 0.0000000000000000001253 94.0
TLS2_k127_5646602_2 DNA helicase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004451 470.0
TLS2_k127_5646602_3 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 415.0
TLS2_k127_5646602_4 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007384 390.0
TLS2_k127_5646602_5 PFAM MCP methyltransferase CheR-type K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006185 300.0
TLS2_k127_5646602_6 impB/mucB/samB family K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002617 284.0
TLS2_k127_5646602_7 Dienelactone hydrolase family K21104 - 3.1.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004583 287.0
TLS2_k127_5646602_8 Dienelactone hydrolase family K21104 - 3.1.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002664 283.0
TLS2_k127_5646602_9 Belongs to the glycosyl hydrolase family 6 K21104 - 3.1.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000004673 274.0
TLS2_k127_5650083_0 acetyl-CoA hydrolase K18288 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006645 532.0
TLS2_k127_5650083_1 Peptidase family M28 K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000698 395.0
TLS2_k127_5650083_2 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 389.0
TLS2_k127_5650083_3 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009372 313.0
TLS2_k127_5650083_4 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 296.0
TLS2_k127_5650083_5 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 313.0
TLS2_k127_5650083_6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 GO:0008150,GO:0040007 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000004722 225.0
TLS2_k127_5650083_7 Aminotransferase class I and II - - - 0.0000000000858 63.0
TLS2_k127_567273_0 PP-loop family K21947 - 2.8.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003511 449.0
TLS2_k127_567273_1 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 - 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 331.0
TLS2_k127_567273_2 binding-protein-dependent transport systems inner membrane component K10234 - - 0.0000000000000000000000000000000000000000000000000000000007122 220.0
TLS2_k127_567273_3 Trypsin-like serine proteases typically periplasmic contain C-terminal PDZ domain - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944 - 0.00000000000000000000000000000000000000000000000000001529 203.0
TLS2_k127_567273_4 Peptidase S16, lon domain protein K01338,K07157 - 3.4.21.53 0.000000000000000000000000000000000000000000000000007033 188.0
TLS2_k127_567273_5 Binding-protein-dependent transport system inner membrane component K10233 - - 0.000000000000000000000000000000000000000000000002153 183.0
TLS2_k127_567273_6 ferredoxin K05337 - - 0.00000000000000000000000000000000000004909 144.0
TLS2_k127_567273_7 Major facilitator Superfamily K08217 - - 0.000000000000000000000000000000000002196 156.0
TLS2_k127_567273_8 - - - - 0.0000000000000000000001559 115.0
TLS2_k127_567273_9 ThiS family K03154 - - 0.0000000000000002225 80.0
TLS2_k127_5686443_0 Exostosin family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002126 248.0
TLS2_k127_5686443_1 methyltransferase K16215 - 2.1.1.243 0.00000000000000000000000000000000000000000000000000000005002 203.0
TLS2_k127_5686443_2 Acyltransferase - - - 0.000000000000000000000000000000000000000000000000000002927 208.0
TLS2_k127_5686443_3 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000000000000007042 155.0
TLS2_k127_5686443_4 Capsular exopolysaccharide family K08253 - 2.7.10.2 0.00000000000000000005263 106.0
TLS2_k127_5686443_5 glycosyl transferase group 1 - - - 0.000000000000000001034 89.0
TLS2_k127_5686443_6 Domain of unknown function (DUF1996) - - - 0.0000000001269 64.0
TLS2_k127_5712321_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 453.0
TLS2_k127_5712321_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008316 391.0
TLS2_k127_5712321_2 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 349.0
TLS2_k127_5712321_3 BioY family K03523 - - 0.0000000000000000000000000000000000000004194 159.0
TLS2_k127_5712321_4 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000005524 149.0
TLS2_k127_5712321_5 Sortase family K07284 - 3.4.22.70 0.00000000000000000000000000000000005249 145.0
TLS2_k127_5712321_6 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000007701 96.0
TLS2_k127_5712321_7 - - - - 0.0002429 52.0
TLS2_k127_5744020_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 6.611e-295 920.0
TLS2_k127_5744020_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003674 538.0
TLS2_k127_5744020_10 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 319.0
TLS2_k127_5744020_11 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 303.0
TLS2_k127_5744020_12 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000236 304.0
TLS2_k127_5744020_13 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001172 278.0
TLS2_k127_5744020_14 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000004999 215.0
TLS2_k127_5744020_15 PFAM HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000007837 199.0
TLS2_k127_5744020_16 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000007286 198.0
TLS2_k127_5744020_17 Multi-copper polyphenol oxidoreductase laccase K05810 GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944 - 0.0000000000000000000000000000000000000000000005448 174.0
TLS2_k127_5744020_18 Alanine racemase, N-terminal domain K06997 - - 0.00000000000000000000000000000000000000000001742 182.0
TLS2_k127_5744020_19 Lipoate-protein ligase K03800 - 6.3.1.20 0.0000000000000000000000000000000000000000007104 169.0
TLS2_k127_5744020_2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0008150,GO:0040007 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004976 436.0
TLS2_k127_5744020_20 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000002016 162.0
TLS2_k127_5744020_21 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA K09772 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000001443 134.0
TLS2_k127_5744020_22 MraZ protein, putative antitoxin-like K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.00000000000000000000000003387 113.0
TLS2_k127_5744020_23 Protein of unknown function (DUF3040) - - - 0.00000000000000003709 85.0
TLS2_k127_5744020_24 Belongs to the MurCDEF family. MurE subfamily K01928 - 6.3.2.13 0.00000000000000007427 81.0
TLS2_k127_5744020_26 Cell division protein FtsQ K03589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - 0.000000000002015 81.0
TLS2_k127_5744020_28 regulation of cell shape - - - 0.000000004292 68.0
TLS2_k127_5744020_3 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 386.0
TLS2_k127_5744020_4 PFAM ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 362.0
TLS2_k127_5744020_5 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003863 361.0
TLS2_k127_5744020_6 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 354.0
TLS2_k127_5744020_7 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005304 329.0
TLS2_k127_5744020_8 TIGRFAM stage V sporulation protein E, cell division protein FtsW K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 316.0
TLS2_k127_5744020_9 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 330.0
TLS2_k127_5764083_0 ABC transporter transmembrane region K06147 - - 9.194e-230 732.0
TLS2_k127_5764083_1 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 1.165e-218 689.0
TLS2_k127_5764083_11 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002405 285.0
TLS2_k127_5764083_12 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002599 269.0
TLS2_k127_5764083_13 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000002824 226.0
TLS2_k127_5764083_14 translation initiation factor activity - - - 0.00000000000000000000000000000000000000000000000000978 203.0
TLS2_k127_5764083_15 Thioesterase-like superfamily - - - 0.000000000000000000000000000000006662 130.0
TLS2_k127_5764083_16 Domain of unknown function (DUF1992) - - - 0.000000000000000000000000000000008927 131.0
TLS2_k127_5764083_17 Electron transfer DM13 - - - 0.000000000000000000000000000001038 130.0
TLS2_k127_5764083_18 - - - - 0.000000000000002647 88.0
TLS2_k127_5764083_19 heat shock protein binding K03686 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0001788 53.0
TLS2_k127_5764083_2 Belongs to the UPF0061 (SELO) family - - - 6.142e-198 630.0
TLS2_k127_5764083_3 phosphoglucomutase phosphomannomutase alpha beta alpha domain II K01835,K01840 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 520.0
TLS2_k127_5764083_4 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 454.0
TLS2_k127_5764083_5 Sensory domain in DIguanylate Cyclases and Two-component system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000629 396.0
TLS2_k127_5764083_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 354.0
TLS2_k127_5764083_7 Phosphorylase superfamily K03783 GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009242 300.0
TLS2_k127_5764083_8 Potential Queuosine, Q, salvage protein family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 310.0
TLS2_k127_5764083_9 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 290.0
TLS2_k127_586317_0 Glycosyl Transferase - - - 2.121e-243 771.0
TLS2_k127_586317_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 478.0
TLS2_k127_586317_10 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000106 199.0
TLS2_k127_586317_11 Methyltransferase - - - 0.00000000000000000000000000000000106 139.0
TLS2_k127_586317_12 thiolester hydrolase activity - - - 0.000000000000000000000000000000003711 143.0
TLS2_k127_586317_13 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000006911 108.0
TLS2_k127_586317_14 - - - - 0.00000000004823 71.0
TLS2_k127_586317_16 transcriptional regulator - - - 0.00008255 53.0
TLS2_k127_586317_2 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 433.0
TLS2_k127_586317_3 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 399.0
TLS2_k127_586317_4 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 319.0
TLS2_k127_586317_5 transglycosylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000006669 256.0
TLS2_k127_586317_6 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000307 228.0
TLS2_k127_586317_7 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000803 220.0
TLS2_k127_586317_8 Ecdysteroid kinase - - - 0.0000000000000000000000000000000000000000000000000004861 198.0
TLS2_k127_586317_9 PFAM Enoyl-CoA hydratase isomerase - - - 0.0000000000000000000000000000000000000000000000000008482 191.0
TLS2_k127_599173_0 TIGRFAM ATP-dependent helicase HrpA K03578 - 3.6.4.13 0.0 1267.0
TLS2_k127_599173_1 nuclear chromosome segregation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000843 601.0
TLS2_k127_599173_2 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 334.0
TLS2_k127_599173_3 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 294.0
TLS2_k127_599173_4 Predicted membrane protein (DUF2254) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009405,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0051704 - 0.00000000000000000000000000000000000000000000000000000003646 218.0
TLS2_k127_599173_5 Bacterial periplasmic substrate-binding proteins K02030 - - 0.000000000000000000000000000000000000000000000000000000976 207.0
TLS2_k127_599173_6 META domain K03668 - - 0.000000000000000000000000000000000000000000000000001247 190.0
TLS2_k127_599173_7 diguanylate cyclase - - - 0.0000000000000000000000000000018 138.0
TLS2_k127_599173_8 translation release factor activity K02835,K15034 - - 0.0000000000000000000000000001687 121.0
TLS2_k127_599173_9 Heavy metal transport detoxification protein - - - 0.0000001311 58.0
TLS2_k127_6031520_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 2.689e-209 660.0
TLS2_k127_6031520_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006988 552.0
TLS2_k127_6031520_2 Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 434.0
TLS2_k127_6031520_3 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 333.0
TLS2_k127_6031520_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001727 266.0
TLS2_k127_6031520_5 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000008557 219.0
TLS2_k127_6031520_6 Belongs to the aminoglycoside phosphotransferase family K00897 - 2.7.1.95 0.00000000000000000000000000000000000000000009545 175.0
TLS2_k127_6058222_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 2.999e-206 647.0
TLS2_k127_6058222_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005247 603.0
TLS2_k127_6058222_10 heme binding - - - 0.0000000000000000000000005466 121.0
TLS2_k127_6058222_2 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 479.0
TLS2_k127_6058222_3 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 401.0
TLS2_k127_6058222_4 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007357 418.0
TLS2_k127_6058222_5 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007087 361.0
TLS2_k127_6058222_6 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 293.0
TLS2_k127_6058222_7 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001763 259.0
TLS2_k127_6058222_8 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000001919 223.0
TLS2_k127_6058222_9 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000001423 194.0
TLS2_k127_6088871_0 2-nitropropane dioxygenase K02371 - 1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 462.0
TLS2_k127_6088871_1 PFAM Class II Aldolase and Adducin N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007165 383.0
TLS2_k127_6088871_10 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000000002954 168.0
TLS2_k127_6088871_11 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000003438 171.0
TLS2_k127_6088871_12 Histidine triad (Hit) protein K02503 - - 0.00000000000000000000000000000000000000000007067 163.0
TLS2_k127_6088871_13 Psort location Cytoplasmic, score K00760 - 2.4.2.8 0.000000000000000000000000000000003391 137.0
TLS2_k127_6088871_14 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000002911 134.0
TLS2_k127_6088871_15 thioesterase - - - 0.0000000000000000004866 91.0
TLS2_k127_6088871_16 membrane protein (DUF2079) - - - 0.00000000000000003011 93.0
TLS2_k127_6088871_17 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.0000000000007165 81.0
TLS2_k127_6088871_2 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 315.0
TLS2_k127_6088871_3 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009049 277.0
TLS2_k127_6088871_5 D-isomer specific 2-hydroxyacid dehydrogenase family protein - - - 0.0000000000000000000000000000000000000000000000000000000000003541 233.0
TLS2_k127_6088871_6 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000000000005758 203.0
TLS2_k127_6088871_7 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.00000000000000000000000000000000000000000000000001209 187.0
TLS2_k127_6088871_8 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000000000000000000000000000009496 198.0
TLS2_k127_6088871_9 (FHA) domain - - - 0.00000000000000000000000000000000000000000000001822 175.0
TLS2_k127_6128364_0 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 426.0
TLS2_k127_6128364_1 Phosphate acyltransferases - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 381.0
TLS2_k127_6128364_2 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009425 268.0
TLS2_k127_6128364_3 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.0000000000000000000000000000000000000000000000000000000000000000000002018 244.0
TLS2_k127_6128364_4 - - - - 0.0000000000000000000000000000002349 138.0
TLS2_k127_6128364_5 - - - - 0.00000000000000002398 86.0
TLS2_k127_6176152_0 Zn-dependent metallo-hydrolase RNA specificity domain K12574 - - 2.98e-233 734.0
TLS2_k127_6176152_1 Ftsk_gamma K03466 - - 2.065e-223 719.0
TLS2_k127_6176152_10 PFAM GCN5-related N-acetyltransferase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006104,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000002336 228.0
TLS2_k127_6176152_11 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000001985 219.0
TLS2_k127_6176152_12 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000004711 200.0
TLS2_k127_6176152_13 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000001841 181.0
TLS2_k127_6176152_14 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000005781 173.0
TLS2_k127_6176152_15 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000001558 98.0
TLS2_k127_6176152_16 Putative adhesin - - - 0.000000000002179 76.0
TLS2_k127_6176152_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K14441 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007302 584.0
TLS2_k127_6176152_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 571.0
TLS2_k127_6176152_4 Belongs to the CinA family K03742 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005346 537.0
TLS2_k127_6176152_5 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 368.0
TLS2_k127_6176152_6 F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 360.0
TLS2_k127_6176152_7 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003948 312.0
TLS2_k127_6176152_8 PFAM sodium calcium exchanger K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000003472 246.0
TLS2_k127_6176152_9 Glutamine amidotransferase class-I - - - 0.00000000000000000000000000000000000000000000000000000000000000000003601 239.0
TLS2_k127_6274347_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 5.047e-204 651.0
TLS2_k127_6274347_1 PFAM Aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006197 489.0
TLS2_k127_6274347_10 Ubiquinol-cytochrome C reductase K03890 - - 0.0000000000000000000000000000000000000006223 161.0
TLS2_k127_6274347_11 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000001391 159.0
TLS2_k127_6274347_12 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139,K01752,K01754 - 2.7.6.5,3.1.7.2,4.3.1.17,4.3.1.19 0.000000000000000000000000000000000000004119 157.0
TLS2_k127_6274347_13 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000418 137.0
TLS2_k127_6274347_14 translation release factor activity K03265 GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.00000000000000000000000000000006473 143.0
TLS2_k127_6274347_15 MASE1 - - - 0.000000000000000000000227 113.0
TLS2_k127_6274347_16 - - - - 0.0000000000000000004672 91.0
TLS2_k127_6274347_17 - - - - 0.00000000002739 74.0
TLS2_k127_6274347_18 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K15408 - 1.9.3.1 0.000000152 55.0
TLS2_k127_6274347_19 - - - - 0.0001879 47.0
TLS2_k127_6274347_2 Glycosyl transferases group 1 K13668 - 2.4.1.346 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004001 455.0
TLS2_k127_6274347_3 Cytochrome b K03891 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 411.0
TLS2_k127_6274347_4 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 368.0
TLS2_k127_6274347_5 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 352.0
TLS2_k127_6274347_6 ROK family K00845,K00886 - 2.7.1.2,2.7.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000008531 276.0
TLS2_k127_6274347_7 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000004155 270.0
TLS2_k127_6274347_8 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000000000000000000000000000003184 231.0
TLS2_k127_6274347_9 cytochrome C K03889 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000004663 166.0
TLS2_k127_6287847_0 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 509.0
TLS2_k127_6287847_1 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 473.0
TLS2_k127_6287847_2 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004642 288.0
TLS2_k127_6287847_3 lipopolysaccharide transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000001014 233.0
TLS2_k127_6287847_4 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000006401 169.0
TLS2_k127_6287847_5 - - - - 0.000000003803 64.0
TLS2_k127_6329932_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 5.456e-281 873.0
TLS2_k127_6329932_1 ABC-2 type transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 532.0
TLS2_k127_6329932_10 Putative zinc-finger - - - 0.00000000000000000003322 99.0
TLS2_k127_6329932_11 major facilitator superfamily MFS_1 - - - 0.0000000000000000001497 102.0
TLS2_k127_6329932_12 PFAM blue (type 1) copper domain protein - - - 0.0000000000000001814 85.0
TLS2_k127_6329932_13 - - - - 0.000000001529 69.0
TLS2_k127_6329932_2 L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004287 456.0
TLS2_k127_6329932_3 ATP dependent DNA ligase C terminal region - GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 427.0
TLS2_k127_6329932_4 Calcineurin-like phosphoesterase K03651 - 3.1.4.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 368.0
TLS2_k127_6329932_5 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 301.0
TLS2_k127_6329932_6 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000692 274.0
TLS2_k127_6329932_7 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000004025 233.0
TLS2_k127_6329932_8 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000007177 185.0
TLS2_k127_6329932_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000006071 151.0
TLS2_k127_6341244_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006214 318.0
TLS2_k127_6341244_1 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000003629 223.0
TLS2_k127_6341244_2 lysyltransferase activity K07027,K20468 - - 0.000000000000000000000000000000000000000000000000000202 205.0
TLS2_k127_6341244_3 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000008093 191.0
TLS2_k127_6341244_4 lysyltransferase activity K07027,K20468 - - 0.000000009645 66.0
TLS2_k127_6341244_5 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000003511 63.0
TLS2_k127_6347081_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1043.0
TLS2_k127_6347081_1 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 384.0
TLS2_k127_6347081_10 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000003129 177.0
TLS2_k127_6347081_11 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000301 165.0
TLS2_k127_6347081_12 - - - - 0.00000000000000000000000000000000000000007289 157.0
TLS2_k127_6347081_13 diguanylate cyclase activity - - - 0.0000000000000000000000000000000000001413 159.0
TLS2_k127_6347081_14 - - - - 0.0000000000000000000000000000006151 130.0
TLS2_k127_6347081_15 Uncharacterized conserved protein (DUF2277) - - - 0.000000000000000000000000000004592 121.0
TLS2_k127_6347081_16 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000003938 124.0
TLS2_k127_6347081_17 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.00000000000000000000000003111 127.0
TLS2_k127_6347081_18 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.000000000000000000000002096 108.0
TLS2_k127_6347081_19 helix_turn_helix, Lux Regulon - - - 0.000001734 56.0
TLS2_k127_6347081_2 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 396.0
TLS2_k127_6347081_3 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006514 330.0
TLS2_k127_6347081_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000105 287.0
TLS2_k127_6347081_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004693 258.0
TLS2_k127_6347081_6 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001324 247.0
TLS2_k127_6347081_7 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000009306 199.0
TLS2_k127_6347081_8 transmembrane transport K01992 - - 0.00000000000000000000000000000000000000000000000004481 190.0
TLS2_k127_6347081_9 Acetyltransferase (GNAT) family K03824,K09964 - - 0.000000000000000000000000000000000000000000000001029 180.0
TLS2_k127_638792_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 5.139e-275 863.0
TLS2_k127_638792_1 Glucose-6-phosphate dehydrogenase, C-terminal domain K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 533.0
TLS2_k127_638792_2 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009126 323.0
TLS2_k127_638792_3 Protein of unknown function (DUF1385) - - - 0.0000000000000000000000000000000000000000000000005067 188.0
TLS2_k127_638792_4 transcriptional regulator - - - 0.0000000000000000000000000003505 121.0
TLS2_k127_6443800_0 AMP-binding enzyme C-terminal domain K12429 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 541.0
TLS2_k127_6443800_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 455.0
TLS2_k127_6443800_2 Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) K00059,K18335 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 380.0
TLS2_k127_6443800_3 Enoyl-CoA hydratase/isomerase K13766 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000002805 241.0
TLS2_k127_6443800_4 LemA family K03744 - - 0.00000000000000000000004489 115.0
TLS2_k127_6448499_0 UvrD/REP helicase N-terminal domain - - - 8.46e-321 1028.0
TLS2_k127_6448499_1 PD-(D/E)XK nuclease superfamily - - - 6.558e-231 759.0
TLS2_k127_6448499_2 L,D-transpeptidase catalytic domain K21470 - - 0.0000000000000000000000000000000000000000000000001063 205.0
TLS2_k127_6451634_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 2.009e-221 692.0
TLS2_k127_6451634_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 534.0
TLS2_k127_6451634_10 sequence-specific DNA binding K15773 - - 0.00000000005044 71.0
TLS2_k127_6451634_2 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 359.0
TLS2_k127_6451634_3 HELICc2 K03722 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005752 353.0
TLS2_k127_6451634_4 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004181 282.0
TLS2_k127_6451634_5 Methyl-accepting chemotaxis protein (MCP) signaling domain K02660,K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003141 266.0
TLS2_k127_6451634_6 AzlC protein - - - 0.000000000000000000000000000000000000000000000000000000000000000002184 234.0
TLS2_k127_6451634_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001183 230.0
TLS2_k127_6451634_8 branched-chain amino acid - - - 0.0000000000000000000000000000000000000002075 153.0
TLS2_k127_6451634_9 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000001423 84.0
TLS2_k127_6458455_0 serine-type aminopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 488.0
TLS2_k127_6458455_1 Iron-containing redox enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 334.0
TLS2_k127_6458455_2 3'-5' exonuclease activity K03547 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008152 251.0
TLS2_k127_6458455_3 Domain of unknown function (DUF4214) - - - 0.000000000000000000004123 106.0
TLS2_k127_6458455_4 protein import - - - 0.0000000000001071 83.0
TLS2_k127_659569_0 DNA polymerase LigD polymerase domain K01971,K10747 GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007239 323.0
TLS2_k127_659569_1 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004312 265.0
TLS2_k127_659569_10 antisigma factor binding K04749,K17763 - - 0.0001056 49.0
TLS2_k127_659569_11 Heat induced stress protein YflT - - - 0.0004635 51.0
TLS2_k127_659569_2 Ku70/Ku80 beta-barrel domain K10979 GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000001283 261.0
TLS2_k127_659569_3 RNA polymerase sigma factor, sigma-70 family K03090 GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000000000000000000000009955 201.0
TLS2_k127_659569_4 diguanylate cyclase K21088 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000007049 208.0
TLS2_k127_659569_5 Belongs to the 'phage' integrase family - - - 0.0000000000002844 74.0
TLS2_k127_659569_7 anti-sigma regulatory factor K04757 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 2.7.11.1 0.000000004491 63.0
TLS2_k127_659569_8 Histidine kinase-like ATPase domain - - - 0.0000001289 62.0
TLS2_k127_6599681_0 Thiolase, C-terminal domain K00626 GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005454 520.0
TLS2_k127_6599681_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008258 458.0
TLS2_k127_6599681_2 Voltage gated chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 373.0
TLS2_k127_6599681_3 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 303.0
TLS2_k127_6599681_4 ANTAR - - - 0.000000000000000000000000000000000000000000000003155 187.0
TLS2_k127_6599681_5 HWE histidine kinase - - - 0.0000000000000000000000000000003544 128.0
TLS2_k127_6599681_6 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000009552 92.0
TLS2_k127_6602154_0 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005403 397.0
TLS2_k127_6602154_1 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 398.0
TLS2_k127_6602154_2 Polyprenyl synthetase K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000583 374.0
TLS2_k127_6602154_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000116 269.0
TLS2_k127_6602154_4 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 0.000000000000000000000000000000000000000000000007785 178.0
TLS2_k127_6602154_5 protein phosphatase 2C domain protein - - - 0.0000000000000000000000000000000106 136.0
TLS2_k127_6602154_6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000002573 64.0
TLS2_k127_660523_0 E1-E2 ATPase K01533,K12956 - 3.6.3.4,3.6.3.54 8.386e-288 904.0
TLS2_k127_660523_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 563.0
TLS2_k127_660523_10 redox protein regulator of disulfide bond formation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002133 269.0
TLS2_k127_660523_11 GlcNAc-PI de-N-acetylase K22135 - - 0.0000000000000000000000000000000000000000000000000000000000004565 225.0
TLS2_k127_660523_12 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000002113 203.0
TLS2_k127_660523_13 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000008557 184.0
TLS2_k127_660523_14 glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000299 180.0
TLS2_k127_660523_15 - - - - 0.0000000000000000000000000000000002676 138.0
TLS2_k127_660523_16 Metal-sensitive transcriptional repressor K21600 - - 0.000000000000000000000000000000003685 130.0
TLS2_k127_660523_17 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000001621 141.0
TLS2_k127_660523_18 Diguanylate cyclase - - - 0.00000000000000000000000001707 129.0
TLS2_k127_660523_19 branched-chain amino acid permease (azaleucine resistance) - - - 0.000000000000000000000004158 112.0
TLS2_k127_660523_2 Acyl-CoA dehydrogenase, middle domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 440.0
TLS2_k127_660523_20 cyclic nucleotide-binding - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000007147 90.0
TLS2_k127_660523_21 Belongs to the globin family - - - 0.0000000000000001077 86.0
TLS2_k127_660523_22 Protein of unknown function (DUF2568) - - - 0.000000000001181 74.0
TLS2_k127_660523_23 Bacterial regulatory proteins, tetR family - - - 0.0000000005671 68.0
TLS2_k127_660523_24 Histidine kinase K07675 - 2.7.13.3 0.000000419 63.0
TLS2_k127_660523_3 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 418.0
TLS2_k127_660523_4 Periplasmic binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004995 371.0
TLS2_k127_660523_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009478 364.0
TLS2_k127_660523_6 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 356.0
TLS2_k127_660523_7 NAD(P)-binding Rossmann-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 375.0
TLS2_k127_660523_8 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 342.0
TLS2_k127_660523_9 FAD binding domain K21401 - 1.3.99.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007581 321.0
TLS2_k127_662569_0 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 322.0
TLS2_k127_662569_1 Na+-dependent bicarbonate transporter superfamily K07086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 319.0
TLS2_k127_662569_2 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000002605 188.0
TLS2_k127_662569_3 Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family K00561 - 2.1.1.184 0.0000000000000000000000000000000000000000000000001205 183.0
TLS2_k127_662569_4 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000000000008531 159.0
TLS2_k127_662569_5 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000005884 150.0
TLS2_k127_662569_6 F420-dependent oxidoreductase - - - 0.000000000000000000000000000000206 124.0
TLS2_k127_662569_7 Transcriptional regulator - - - 0.0000000000000000000000000001805 117.0
TLS2_k127_662569_8 - - - - 0.00001192 52.0
TLS2_k127_6650982_0 Acyl-CoA dehydrogenase, C-terminal domain K00248,K14448 - 1.3.8.1,1.3.8.12 1.957e-247 780.0
TLS2_k127_6650982_1 Uncharacterized protein family (UPF0051) K09014 - - 8.871e-243 759.0
TLS2_k127_6650982_10 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 295.0
TLS2_k127_6650982_11 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008819 284.0
TLS2_k127_6650982_12 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005308 276.0
TLS2_k127_6650982_13 Cache 3/Cache 2 fusion domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001883 276.0
TLS2_k127_6650982_14 TIGRFAM FeS assembly ATPase SufC K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001173 257.0
TLS2_k127_6650982_15 Bacterial transferase hexapeptide (six repeats) K02617 - - 0.0000000000000000000000000000000000000000000000000000000000000000002285 233.0
TLS2_k127_6650982_16 FeS assembly protein SufD K07033,K09015 GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136 - 0.0000000000000000000000000000000000000000000000000000000000000000005651 244.0
TLS2_k127_6650982_17 DNA repair protein - - - 0.000000000000000000000000000000000000000000000000000000000000000003476 232.0
TLS2_k127_6650982_18 NifU-like N terminal domain K04488 - - 0.000000000000000000000000000000000000000000000000000000000008062 213.0
TLS2_k127_6650982_19 DIM6 NTAB family - - - 0.000000000000000000000000000000000000000000000001901 178.0
TLS2_k127_6650982_2 ABC transporter transmembrane region K06147 - - 2.541e-200 641.0
TLS2_k127_6650982_20 - - - - 0.0000000000000000000000000000000000000000003854 162.0
TLS2_k127_6650982_21 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000001145 173.0
TLS2_k127_6650982_22 Rieske-like [2Fe-2S] domain K05710 - - 0.00000000000000000001151 106.0
TLS2_k127_6650982_23 Sigma-70 region 2 - - - 0.000000000000000345 86.0
TLS2_k127_6650982_24 - - - - 0.000000004342 63.0
TLS2_k127_6650982_3 Aminotransferase class-V K11717 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 543.0
TLS2_k127_6650982_4 GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 411.0
TLS2_k127_6650982_5 ABC transporter transmembrane region K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 419.0
TLS2_k127_6650982_6 F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 345.0
TLS2_k127_6650982_7 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005415 333.0
TLS2_k127_6650982_8 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009117 317.0
TLS2_k127_6650982_9 endonuclease III K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 316.0
TLS2_k127_667090_0 Proteasomal ATPase OB/ID domain K13527 GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 - 7.192e-267 835.0
TLS2_k127_667090_1 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K13571 - 6.3.1.19 1.989e-255 791.0
TLS2_k127_667090_10 Dienelactone hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000004858 222.0
TLS2_k127_667090_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000002165 218.0
TLS2_k127_667090_12 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000001812 166.0
TLS2_k127_667090_13 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000069 143.0
TLS2_k127_667090_14 Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation K13570 - - 0.000000000000000002259 86.0
TLS2_k127_667090_16 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03116,K03117 - - 0.000000294 55.0
TLS2_k127_667090_2 Pup-ligase protein K20814 - 3.5.1.119 1.327e-197 627.0
TLS2_k127_667090_3 helicase K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 433.0
TLS2_k127_667090_4 Proteasome subunit K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 381.0
TLS2_k127_667090_5 Protein of unknown function (DUF3866) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 361.0
TLS2_k127_667090_6 Proteasome subunit K03432 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005969 294.0
TLS2_k127_667090_7 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000001529 255.0
TLS2_k127_667090_8 WYL domain K13573 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000007898 265.0
TLS2_k127_667090_9 WYL domain K13572,K13573 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000324 234.0
TLS2_k127_6675878_0 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 459.0
TLS2_k127_6675878_1 Belongs to the DegT DnrJ EryC1 family K21328 - 2.6.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 436.0
TLS2_k127_6675878_10 Male sterility protein - - - 0.0000000000000000000000000000000000000000000000000000000009617 222.0
TLS2_k127_6675878_11 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000007776 215.0
TLS2_k127_6675878_12 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.0000000000000000000000000003705 130.0
TLS2_k127_6675878_13 Pfam Glycosyl transferase family 2 K16556 - - 0.00000000000000000000000002755 121.0
TLS2_k127_6675878_14 O-Antigen ligase - - - 0.00000000000000000000006007 115.0
TLS2_k127_6675878_15 Belongs to the glycosyltransferase 26 family K05946,K13660 - 2.4.1.187 0.000000000000000000004666 94.0
TLS2_k127_6675878_16 - - - - 0.0000000000000000001805 104.0
TLS2_k127_6675878_2 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007829 369.0
TLS2_k127_6675878_3 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005378 363.0
TLS2_k127_6675878_4 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 328.0
TLS2_k127_6675878_5 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009835 287.0
TLS2_k127_6675878_6 Domain of unknown function (DUF1996) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007305 268.0
TLS2_k127_6675878_7 Hexapeptide repeat of succinyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002328 249.0
TLS2_k127_6675878_8 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003176 264.0
TLS2_k127_6675878_9 Semialdehyde dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004624 239.0
TLS2_k127_6688161_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000905 581.0
TLS2_k127_6688161_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 556.0
TLS2_k127_6688161_10 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000101 177.0
TLS2_k127_6688161_11 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000000000000000000000000003997 162.0
TLS2_k127_6688161_12 Protein of unknown function (DUF952) K00799,K01560,K21420 - 2.3.2.29,2.5.1.18,3.8.1.2 0.0000000000000000000000000000000001129 139.0
TLS2_k127_6688161_13 YjbR - - - 0.0000000000000000000000000000000006627 134.0
TLS2_k127_6688161_15 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000001561 95.0
TLS2_k127_6688161_16 GtrA-like protein - - - 0.00000000000000000001952 98.0
TLS2_k127_6688161_2 ATPase component of ABC transporters with duplicated ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007963 534.0
TLS2_k127_6688161_3 PFAM Glycoside hydrolase 15-related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 440.0
TLS2_k127_6688161_4 Thioesterase-like superfamily K10805 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 362.0
TLS2_k127_6688161_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 360.0
TLS2_k127_6688161_6 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007586 331.0
TLS2_k127_6688161_7 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003444 316.0
TLS2_k127_6688161_8 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 295.0
TLS2_k127_6688161_9 stress protein (general stress protein 26) - - - 0.000000000000000000000000000000000000000000000000000000000002638 220.0
TLS2_k127_669702_0 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 481.0
TLS2_k127_669702_1 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 427.0
TLS2_k127_669702_2 haloacid dehalogenase-like hydrolase K02203 - 2.7.1.39,3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004916 278.0
TLS2_k127_669702_3 FMN binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002181 261.0
TLS2_k127_669702_4 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000003033 192.0
TLS2_k127_669702_5 Ferredoxin K05337 - - 0.0000000000002485 81.0
TLS2_k127_669702_6 Periplasmic component of the Tol biopolymer transport system - - - 0.000003084 59.0
TLS2_k127_6721244_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 3.004e-195 617.0
TLS2_k127_6721244_1 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K11263 GO:0003674,GO:0003824,GO:0004658,GO:0016421,GO:0016874,GO:0016885 6.3.4.14,6.4.1.2,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 584.0
TLS2_k127_6721244_10 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 345.0
TLS2_k127_6721244_11 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 331.0
TLS2_k127_6721244_12 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007083 325.0
TLS2_k127_6721244_13 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006742 301.0
TLS2_k127_6721244_14 F420-0:Gamma-glutamyl ligase K12234 GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 291.0
TLS2_k127_6721244_15 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002494 284.0
TLS2_k127_6721244_16 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001313 274.0
TLS2_k127_6721244_17 GDP-mannose 4,6 dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000118 273.0
TLS2_k127_6721244_18 Cell envelope-related transcriptional attenuator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004063 246.0
TLS2_k127_6721244_19 functions in conversion of succinate to propionate K01847 - 5.4.99.2 0.00000000000000000000000000000000000000000000001162 193.0
TLS2_k127_6721244_2 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 541.0
TLS2_k127_6721244_20 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000001317 175.0
TLS2_k127_6721244_21 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000001191 170.0
TLS2_k127_6721244_22 Helix-turn-helix - - - 0.0000000000000000000000000000001059 131.0
TLS2_k127_6721244_23 Protein of unknown function (DUF559) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000002054 120.0
TLS2_k127_6721244_3 UDP binding domain K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005478 536.0
TLS2_k127_6721244_4 Exporter of polyketide K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 475.0
TLS2_k127_6721244_5 Male sterility protein K12454 - 5.1.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008341 438.0
TLS2_k127_6721244_6 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 447.0
TLS2_k127_6721244_7 PFAM NAD-dependent epimerase dehydratase K01710,K08678 - 4.1.1.35,4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 435.0
TLS2_k127_6721244_8 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 350.0
TLS2_k127_6721244_9 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K15856 - 1.1.1.281 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 348.0
TLS2_k127_6731515_0 ATPase P-type (Transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1021.0
TLS2_k127_6731515_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 578.0
TLS2_k127_6731515_10 Thioesterase-like superfamily - - - 0.00000000000000000000000000000000000009236 149.0
TLS2_k127_6731515_11 - - - - 0.00000000000000000000000000000000001924 146.0
TLS2_k127_6731515_2 Homoserine dehydrogenase K00003,K12524 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.3,2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000982 541.0
TLS2_k127_6731515_3 Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 470.0
TLS2_k127_6731515_4 Threonine synthase K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 372.0
TLS2_k127_6731515_5 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008733 277.0
TLS2_k127_6731515_6 cyclic-guanylate-specific phosphodiesterase activity - - - 0.00000000000000000000000000000000000000000000000000000000000001804 232.0
TLS2_k127_6731515_7 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000000000000002125 192.0
TLS2_k127_6731515_8 PFAM Rhomboid family - - - 0.000000000000000000000000000000000000000000000009881 183.0
TLS2_k127_6731515_9 Protein of unknown function, DUF480 K09915 - - 0.000000000000000000000000000000000000000000003522 173.0
TLS2_k127_6743257_0 trisaccharide binding - - - 9.872e-200 645.0
TLS2_k127_6743257_1 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004326 432.0
TLS2_k127_6743257_10 - - - - 0.00000000000000000000000000000000000000000000004592 179.0
TLS2_k127_6743257_11 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.00000000000000000000000000000000000000000002883 166.0
TLS2_k127_6743257_12 PFAM MazG nucleotide pyrophosphohydrolase - - - 0.0000000000000000000000000000000000001042 144.0
TLS2_k127_6743257_13 Domain of unknown function (DUF1905) - - - 0.0000000000000000000000000000006012 133.0
TLS2_k127_6743257_14 - - - - 0.0000000000000005364 80.0
TLS2_k127_6743257_2 Pfam Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 431.0
TLS2_k127_6743257_3 Protein of unknown function (DUF2855) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 406.0
TLS2_k127_6743257_4 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 355.0
TLS2_k127_6743257_5 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000466 289.0
TLS2_k127_6743257_6 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002765 254.0
TLS2_k127_6743257_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000005616 222.0
TLS2_k127_6743257_8 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000005968 179.0
TLS2_k127_6743257_9 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000002993 177.0
TLS2_k127_6780156_0 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 437.0
TLS2_k127_6780156_1 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 391.0
TLS2_k127_6780156_10 - - - - 0.000000000000000006561 85.0
TLS2_k127_6780156_11 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000001019 93.0
TLS2_k127_6780156_12 COG1520 FOG WD40-like repeat - - - 0.0000000429 66.0
TLS2_k127_6780156_13 Multicopper oxidase - - - 0.00000009483 63.0
TLS2_k127_6780156_2 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002684 262.0
TLS2_k127_6780156_3 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004308 258.0
TLS2_k127_6780156_4 Activator of Hsp90 ATPase 1 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000008757 228.0
TLS2_k127_6780156_6 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000001185 209.0
TLS2_k127_6780156_7 transcriptional regulator, ArsR family - - - 0.000000000000000000000000000000000000000000000000004757 183.0
TLS2_k127_6780156_8 Protein conserved in bacteria - - - 0.0000000000000000000000000000000003388 138.0
TLS2_k127_6780156_9 methyltransferase - - - 0.0000000000000000001142 97.0
TLS2_k127_6812747_0 PFAM acyl-CoA dehydrogenase domain protein - - - 0.0 1020.0
TLS2_k127_6812747_1 drug exporters of the RND superfamily K06994 - - 3.972e-273 861.0
TLS2_k127_6812747_2 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000387 316.0
TLS2_k127_6812747_3 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003935 310.0
TLS2_k127_6812747_4 FCD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007381 329.0
TLS2_k127_6812747_5 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008027 260.0
TLS2_k127_6812747_6 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) - - - 0.000000000000000000000000000000000000000000000000000000001095 220.0
TLS2_k127_6812747_7 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000001123 144.0
TLS2_k127_6812747_8 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000006643 104.0
TLS2_k127_6841404_0 Belongs to the ABC transporter superfamily K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005214 525.0
TLS2_k127_6841404_1 carboxylic ester hydrolase activity K03929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009516 442.0
TLS2_k127_6841404_2 PFAM Binding-protein-dependent transport system inner membrane component K10119,K10234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 353.0
TLS2_k127_6841404_3 ABC-type sugar transport system periplasmic component K10232 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 343.0
TLS2_k127_6841404_4 COG1175 ABC-type sugar transport systems permease components K10233 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 321.0
TLS2_k127_6942395_0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term K00441 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000991 610.0
TLS2_k127_6942395_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 599.0
TLS2_k127_6942395_10 Cell envelope-related transcriptional attenuator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 308.0
TLS2_k127_6942395_11 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001058 278.0
TLS2_k127_6942395_12 Phosphatidylinositol - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001015 267.0
TLS2_k127_6942395_13 Histidine phosphatase superfamily (branch 1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001405 256.0
TLS2_k127_6942395_14 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000000000000000000000000000000000001019 212.0
TLS2_k127_6942395_15 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000001771 167.0
TLS2_k127_6942395_16 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000000000000000000000008204 154.0
TLS2_k127_6942395_17 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000001706 143.0
TLS2_k127_6942395_18 Protein of unknown function (DUF3090) - - - 0.000000000000000000000000000000008646 134.0
TLS2_k127_6942395_19 ECF sigma factor - - - 0.0000000000000000000000007858 120.0
TLS2_k127_6942395_2 anion-transporting ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 470.0
TLS2_k127_6942395_20 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000002595 100.0
TLS2_k127_6942395_21 Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes K04487 GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840 2.8.1.7 0.0000000000000000009299 94.0
TLS2_k127_6942395_22 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000001051 95.0
TLS2_k127_6942395_3 Histidine kinase K00936 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 441.0
TLS2_k127_6942395_4 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008753 407.0
TLS2_k127_6942395_5 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 393.0
TLS2_k127_6942395_6 Pfam Anion-transporting ATPase - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 374.0
TLS2_k127_6942395_7 Elongation factor Tu GTP binding domain K00956 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 358.0
TLS2_k127_6942395_8 Diacylglycerol kinase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 325.0
TLS2_k127_6942395_9 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 304.0
TLS2_k127_6944494_0 Cell division protein FtsA K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 469.0
TLS2_k127_6944494_1 Pfam:Zinicin_2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006879 298.0
TLS2_k127_6944494_2 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000005363 236.0
TLS2_k127_6944494_3 Epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000001132 226.0
TLS2_k127_6944494_4 PBS lyase HEAT-like repeat - - - 0.000000000000000000000000000000000000000000000000007331 188.0
TLS2_k127_6944494_5 MoaE protein K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000001766 169.0
TLS2_k127_6944494_6 PDZ domain (Also known as DHR or GLGF) K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000000000000000000000000000004729 150.0
TLS2_k127_700313_0 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K03817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004395 336.0
TLS2_k127_700313_1 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 314.0
TLS2_k127_700313_10 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876,K09759 - 6.1.1.12,6.1.1.23 0.00000000000000000001342 97.0
TLS2_k127_700313_11 Hydrolase of X-linked nucleoside diphosphate N terminal - - - 0.00000001214 63.0
TLS2_k127_700313_12 YhhN family - - - 0.0001658 50.0
TLS2_k127_700313_2 N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001969 259.0
TLS2_k127_700313_3 EamA-like transporter family K15269 - - 0.00000000000000000000000000000000000000000000000000000000000000000002576 246.0
TLS2_k127_700313_4 homoserine kinase activity K02204 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000004084 220.0
TLS2_k127_700313_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000000005477 168.0
TLS2_k127_700313_6 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000005455 163.0
TLS2_k127_700313_7 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000002582 158.0
TLS2_k127_700313_8 2-phosphosulpholactate phosphatase K05979 - 3.1.3.71 0.0000000000000000000000000000000000001678 152.0
TLS2_k127_700313_9 helix_turn_helix, mercury resistance - - - 0.000000000000000000008431 97.0
TLS2_k127_7015507_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 8.244e-243 776.0
TLS2_k127_7015507_1 tRNA methyl transferase K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 413.0
TLS2_k127_7015507_10 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000006067 208.0
TLS2_k127_7015507_11 Bacterial flagellin C-terminal helical region K02397 - - 0.0000000000000000000000000000000000000000000000002451 193.0
TLS2_k127_7015507_13 - - - - 0.00000000000000000000000000000000000006692 158.0
TLS2_k127_7015507_14 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000002804 144.0
TLS2_k127_7015507_15 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.00000000000000000000000000000001293 128.0
TLS2_k127_7015507_16 FlgN protein - - - 0.0000000000000000000000007653 116.0
TLS2_k127_7015507_17 RESPONSE REGULATOR receiver - - - 0.0000000000000002757 87.0
TLS2_k127_7015507_2 Aminotransferase class-V K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000471 388.0
TLS2_k127_7015507_3 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 368.0
TLS2_k127_7015507_4 flagellar hook-associated protein K02396 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 338.0
TLS2_k127_7015507_5 Iron/manganese superoxide dismutases, alpha-hairpin domain K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004344 287.0
TLS2_k127_7015507_6 PFAM Serine threonine-protein kinase-like domain K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002637 291.0
TLS2_k127_7015507_7 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000612 236.0
TLS2_k127_7015507_8 Rhomboid family K19225 - 3.4.21.105 0.0000000000000000000000000000000000000000000000000000000000000000001155 240.0
TLS2_k127_7015507_9 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000001364 228.0
TLS2_k127_70456_0 Pirin C-terminal cupin domain K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 571.0
TLS2_k127_70456_1 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004213 265.0
TLS2_k127_70456_2 Domain of unknown function (DUF427) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002486 237.0
TLS2_k127_70456_3 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000000001205 122.0
TLS2_k127_7115501_0 ABC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009146 524.0
TLS2_k127_7115501_1 serine-type aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003736 481.0
TLS2_k127_7115501_10 DNA segregation ATPase FtsK SpoIIIE and related proteins K03466 - - 0.0000000000000000000000000000000000000001411 159.0
TLS2_k127_7115501_11 Uncharacterized protein conserved in bacteria (DUF2087) - - - 0.00000000000000000000000000000000000004373 158.0
TLS2_k127_7115501_12 Cbs domain - - - 0.0000000000000000000669 95.0
TLS2_k127_7115501_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 391.0
TLS2_k127_7115501_3 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 361.0
TLS2_k127_7115501_4 chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 294.0
TLS2_k127_7115501_5 GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005611 262.0
TLS2_k127_7115501_6 3'-5' exonuclease activity K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000001035 253.0
TLS2_k127_7115501_7 PFAM isochorismatase hydrolase K08281 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 0.000000000000000000000000000000000000000000000000000000003468 209.0
TLS2_k127_7115501_8 COG2335, Secreted and surface protein containing fasciclin-like repeats K19519 - - 0.00000000000000000000000000000000000000000031 171.0
TLS2_k127_717782_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1265.0
TLS2_k127_717782_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657 3.3.1.1 2.749e-255 795.0
TLS2_k127_717782_10 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001462 250.0
TLS2_k127_717782_11 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000003117 233.0
TLS2_k127_717782_12 membrane K07149 - - 0.00000000000000000000000000000000000000000000000000000000002336 222.0
TLS2_k127_717782_13 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000146 212.0
TLS2_k127_717782_14 branched-chain amino acid - - - 0.00000000000000000000000000000000000000000000000000004867 197.0
TLS2_k127_717782_15 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000004776 130.0
TLS2_k127_717782_16 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000001566 128.0
TLS2_k127_717782_17 tetraacyldisaccharide 4'-kinase activity K09791 - - 0.0000000000000000000001735 110.0
TLS2_k127_717782_18 competence protein K03654 - 3.6.4.12 0.0000000000000000000008345 110.0
TLS2_k127_717782_19 CAAX protease self-immunity K07052 - - 0.0000000000000000001794 101.0
TLS2_k127_717782_2 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 579.0
TLS2_k127_717782_21 Branched-chain amino acid transport protein (AzlD) - - - 0.000000005697 61.0
TLS2_k127_717782_3 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 552.0
TLS2_k127_717782_4 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 414.0
TLS2_k127_717782_5 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 427.0
TLS2_k127_717782_6 COG1024 Enoyl-CoA hydratase carnithine racemase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 396.0
TLS2_k127_717782_7 ATPases associated with a variety of cellular activities K09812 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006337 373.0
TLS2_k127_717782_8 Redoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000272 261.0
TLS2_k127_717782_9 Bacterial phospho-glucose isomerase C-terminal SIS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001076 255.0
TLS2_k127_7202801_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.0 1237.0
TLS2_k127_7202801_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 3.548e-234 737.0
TLS2_k127_7202801_10 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008741 278.0
TLS2_k127_7202801_11 peptidase S58, DmpA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000781 273.0
TLS2_k127_7202801_12 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000005386 248.0
TLS2_k127_7202801_13 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000007634 229.0
TLS2_k127_7202801_14 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000001201 231.0
TLS2_k127_7202801_15 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000009276 221.0
TLS2_k127_7202801_16 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000001166 202.0
TLS2_k127_7202801_17 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000187 211.0
TLS2_k127_7202801_18 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000006614 190.0
TLS2_k127_7202801_19 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000004761 189.0
TLS2_k127_7202801_2 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 547.0
TLS2_k127_7202801_20 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.000000000000000000000000000000000000000000005605 167.0
TLS2_k127_7202801_21 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000000279 162.0
TLS2_k127_7202801_22 FR47-like protein K03789 GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 0.000000000000000000000000000000000000001483 155.0
TLS2_k127_7202801_23 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000001618 140.0
TLS2_k127_7202801_24 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000002665 145.0
TLS2_k127_7202801_25 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.0000000000000000000000000000001871 131.0
TLS2_k127_7202801_26 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000000128 120.0
TLS2_k127_7202801_27 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000001342 118.0
TLS2_k127_7202801_28 Ribosomal protein L30p/L7e K02907 - - 0.00000000000000000000001402 100.0
TLS2_k127_7202801_29 CbiX - - - 0.00000000000000000000256 103.0
TLS2_k127_7202801_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003899 457.0
TLS2_k127_7202801_30 Bacterial regulatory proteins, tetR family - - - 0.00000000000001322 82.0
TLS2_k127_7202801_31 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000002301 72.0
TLS2_k127_7202801_32 - - - - 0.00002156 51.0
TLS2_k127_7202801_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 446.0
TLS2_k127_7202801_5 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 GO:0008150,GO:0040007 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 406.0
TLS2_k127_7202801_6 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009543 372.0
TLS2_k127_7202801_7 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005979 334.0
TLS2_k127_7202801_8 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002876 331.0
TLS2_k127_7202801_9 tRNA threonylcarbamoyladenosine modification K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001843 279.0
TLS2_k127_7243430_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1060.0
TLS2_k127_7243430_1 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000006261 131.0
TLS2_k127_7243430_2 LytR cell envelope-related transcriptional attenuator - - - 0.0006445 51.0
TLS2_k127_7343162_0 Heat shock 70 kDa protein K04043 GO:0000302,GO:0000303,GO:0000305,GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016310,GO:0019222,GO:0019538,GO:0019899,GO:0030112,GO:0030162,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031975,GO:0031982,GO:0032268,GO:0032270,GO:0033554,GO:0034599,GO:0034614,GO:0035375,GO:0036211,GO:0040007,GO:0042221,GO:0042603,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043388,GO:0043412,GO:0044044,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0046688,GO:0046777,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070613,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0071944,GO:0080090,GO:0097691,GO:1901564,GO:1901700,GO:1901701,GO:1903317,GO:1903319,GO:1903561,GO:2000677,GO:2000679 - 1.941e-304 950.0
TLS2_k127_7343162_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005011 411.0
TLS2_k127_7343162_2 Sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000759 369.0
TLS2_k127_7343162_3 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 332.0
TLS2_k127_7343162_4 DNA-templated transcription, initiation K02945,K03527 - 1.17.7.4 0.0000000000000000000000000000000007734 137.0
TLS2_k127_7343162_5 helix_turn_helix, mercury resistance K13640 - - 0.0000000000000000000000000000004702 139.0
TLS2_k127_7343162_6 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000000000003224 119.0
TLS2_k127_7343323_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 2.158e-277 880.0
TLS2_k127_7343323_1 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K09972,K10041 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 372.0
TLS2_k127_7343323_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 334.0
TLS2_k127_7343323_3 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009356 327.0
TLS2_k127_7343323_4 Aminotransferase class I and II K00817,K04720 GO:0008150,GO:0040007 2.6.1.9,4.1.1.81 0.000000000000000000000000000000000000000000000000009938 185.0
TLS2_k127_7343323_5 peptidase M15B and M15C DD-carboxypeptidase VanY endolysin K07260 - 3.4.17.14 0.000000000000000000000000000000000000003972 160.0
TLS2_k127_7343323_6 - - - - 0.0000000000001027 81.0
TLS2_k127_7345539_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 1.164e-300 951.0
TLS2_k127_7345539_1 synthetase K01895 - 6.2.1.1 8.88e-261 818.0
TLS2_k127_7345539_10 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004152 294.0
TLS2_k127_7345539_11 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000152 276.0
TLS2_k127_7345539_12 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000006143 266.0
TLS2_k127_7345539_13 Protein of unknown function (DUF664) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001455 233.0
TLS2_k127_7345539_14 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000006258 226.0
TLS2_k127_7345539_15 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000001606 212.0
TLS2_k127_7345539_16 carboxylic ester hydrolase activity K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000008138 199.0
TLS2_k127_7345539_17 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000002012 180.0
TLS2_k127_7345539_18 Membrane - - - 0.000000000000000000000000000000000656 138.0
TLS2_k127_7345539_19 diguanylate cyclase - - - 0.000000000000000000000000000001468 137.0
TLS2_k127_7345539_2 hydrolase, family 3 K05349 - 3.2.1.21 8.834e-251 798.0
TLS2_k127_7345539_20 Glyoxalase-like domain K01759 - 4.4.1.5 0.00000000000000000000000001508 113.0
TLS2_k127_7345539_21 DUF167 - - - 0.0000000000000000006234 92.0
TLS2_k127_7345539_22 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000004075 91.0
TLS2_k127_7345539_23 Phosphopantetheine attachment site - - - 0.0000000000000003512 84.0
TLS2_k127_7345539_24 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000007232 85.0
TLS2_k127_7345539_25 HesB YadR YfhF-family protein - - - 0.0000001494 57.0
TLS2_k127_7345539_26 CoA binding domain - - - 0.00006864 54.0
TLS2_k127_7345539_27 PFAM Ankyrin K06867 - - 0.0001414 46.0
TLS2_k127_7345539_3 Zn-dependent metallo-hydrolase RNA specificity domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006459 527.0
TLS2_k127_7345539_4 Transketolase, C-terminal domain K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 509.0
TLS2_k127_7345539_5 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008289 507.0
TLS2_k127_7345539_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 449.0
TLS2_k127_7345539_7 acetyltransferase component of pyruvate dehydrogenase complex K00627,K00658 - 2.3.1.12,2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 405.0
TLS2_k127_7345539_8 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 376.0
TLS2_k127_7345539_9 Mur ligase family, glutamate ligase domain K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 340.0
TLS2_k127_7368351_0 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 413.0
TLS2_k127_7368351_1 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006763 258.0
TLS2_k127_7368351_2 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004913 236.0
TLS2_k127_7368351_3 Domain of unknown function (DUF1932) - - - 0.0000000000000000000000000000000000000000000000000000113 196.0
TLS2_k127_7368351_4 DsrC like protein K11179 - - 0.0000000000000000000000000000000000000109 154.0
TLS2_k127_7368351_5 Protein of unknown function (DUF1641) - - - 0.0000000000000000000000007026 109.0
TLS2_k127_7398458_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00262 - 1.4.1.4 1.194e-228 715.0
TLS2_k127_7398458_1 ABC transporter K06147 - - 1.814e-219 728.0
TLS2_k127_7398458_2 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 573.0
TLS2_k127_7398458_3 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003454 369.0
TLS2_k127_7398458_4 Thioesterase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006077 339.0
TLS2_k127_7398458_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009437 285.0
TLS2_k127_7398458_6 - - - - 0.00000000000000000000000000000000000000000000000000008599 203.0
TLS2_k127_7398458_7 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000004242 130.0
TLS2_k127_7398458_8 Helix-turn-helix XRE-family like proteins - - - 0.000000000000002244 79.0
TLS2_k127_740597_0 AMP-binding enzyme - - - 2.394e-202 643.0
TLS2_k127_740597_1 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 544.0
TLS2_k127_740597_10 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 317.0
TLS2_k127_740597_11 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000001692 193.0
TLS2_k127_740597_12 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000005792 205.0
TLS2_k127_740597_13 Phosphoglycerate mutase - - - 0.000000000000000000000000000000000000000000002511 185.0
TLS2_k127_740597_14 Protein of unknown function (DUF3151) - - - 0.000000000000000000000000000000000000000000006119 167.0
TLS2_k127_740597_15 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000000004881 183.0
TLS2_k127_740597_16 Rhodanese-related sulfurtransferase - - - 0.000000000000000001448 93.0
TLS2_k127_740597_17 membrane transporter protein K07090 - - 0.000000000000000006344 94.0
TLS2_k127_740597_19 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03753,K13818 - 2.7.7.77 0.000000000396 70.0
TLS2_k127_740597_2 synthetase K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 552.0
TLS2_k127_740597_20 Bacterial regulatory proteins, tetR family - - - 0.0000000007454 71.0
TLS2_k127_740597_22 ubiquitin specific peptidase 8 K11839 GO:0000278,GO:0000281,GO:0000910,GO:0002009,GO:0002165,GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004843,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006996,GO:0007032,GO:0007049,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007399,GO:0007444,GO:0007472,GO:0007476,GO:0007552,GO:0007560,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008283,GO:0008587,GO:0008589,GO:0009653,GO:0009719,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009966,GO:0009967,GO:0009987,GO:0010008,GO:0010033,GO:0010256,GO:0010646,GO:0010647,GO:0012505,GO:0014069,GO:0016020,GO:0016043,GO:0016050,GO:0016322,GO:0016579,GO:0016787,GO:0019538,GO:0019783,GO:0019897,GO:0019898,GO:0021700,GO:0022008,GO:0022402,GO:0023051,GO:0023052,GO:0023056,GO:0030111,GO:0030154,GO:0030177,GO:0030182,GO:0030425,GO:0030496,GO:0031090,GO:0031312,GO:0031313,GO:0031410,GO:0031982,GO:0032279,GO:0032501,GO:0032502,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0035556,GO:0036211,GO:0036459,GO:0036477,GO:0042221,GO:0042551,GO:0042995,GO:0043005,GO:0043170,GO:0043197,GO:0043226,GO:0043227,GO:0043229,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044309,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0045202,GO:0045880,GO:0048468,GO:0048469,GO:0048513,GO:0048518,GO:0048522,GO:0048563,GO:0048569,GO:0048583,GO:0048584,GO:0048666,GO:0048699,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051301,GO:0051716,GO:0060429,GO:0060562,GO:0060828,GO:0061640,GO:0065007,GO:0070011,GO:0070536,GO:0070646,GO:0070647,GO:0070848,GO:0070887,GO:0071108,GO:0071310,GO:0071363,GO:0071495,GO:0071695,GO:0071704,GO:0071840,GO:0071944,GO:0090263,GO:0097447,GO:0097458,GO:0097708,GO:0098588,GO:0098794,GO:0098805,GO:0098984,GO:0099572,GO:0101005,GO:0120025,GO:0120038,GO:0140096,GO:1901564,GO:1903047,GO:1990089,GO:1990090 3.4.19.12 0.0007497 46.0
TLS2_k127_740597_3 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 533.0
TLS2_k127_740597_4 Belongs to the ABC transporter superfamily K02031,K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 482.0
TLS2_k127_740597_5 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 474.0
TLS2_k127_740597_6 Domain of unknown function (DUF3367) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006391 503.0
TLS2_k127_740597_7 PFAM FAD linked oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 395.0
TLS2_k127_740597_8 3'-5' exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 374.0
TLS2_k127_740597_9 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 319.0
TLS2_k127_7408871_0 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 541.0
TLS2_k127_7408871_1 Ammonium Transporter Family K03320 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003496 483.0
TLS2_k127_7408871_10 Cold shock protein K03704 - - 0.000000000000000000000000007338 111.0
TLS2_k127_7408871_11 - - - - 0.0000000000000000009455 93.0
TLS2_k127_7408871_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 477.0
TLS2_k127_7408871_3 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000002871 238.0
TLS2_k127_7408871_4 Carboxylesterase family - - - 0.0000000000000000000000000000000000000000000000000000001372 206.0
TLS2_k127_7408871_5 - - - - 0.000000000000000000000000000000000000000000000668 180.0
TLS2_k127_7408871_6 nitrogen regulatory protein P-II K04751 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000003877 168.0
TLS2_k127_7408871_7 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000004484 131.0
TLS2_k127_7408871_8 LysR family - - - 0.0000000000000000000000000000007578 134.0
TLS2_k127_7408871_9 Carboxylesterase family K03929 - - 0.000000000000000000000000000202 119.0
TLS2_k127_764546_0 AMP-binding enzyme C-terminal domain K18688 - 6.2.1.42 5.409e-206 654.0
TLS2_k127_764546_1 Acyl-CoA dehydrogenase N terminal K20035 - - 3.418e-200 641.0
TLS2_k127_764546_10 synthase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004776 395.0
TLS2_k127_764546_11 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 391.0
TLS2_k127_764546_12 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006758 326.0
TLS2_k127_764546_13 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009379 336.0
TLS2_k127_764546_14 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003306 343.0
TLS2_k127_764546_15 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 324.0
TLS2_k127_764546_16 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007582 300.0
TLS2_k127_764546_17 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009651 274.0
TLS2_k127_764546_18 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000108 273.0
TLS2_k127_764546_19 N-6 DNA Methylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001511 278.0
TLS2_k127_764546_2 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 602.0
TLS2_k127_764546_20 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004066 262.0
TLS2_k127_764546_21 formamidopyrimidine-DNA glycosylase K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000001045 256.0
TLS2_k127_764546_22 Thymidine kinase K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000008787 251.0
TLS2_k127_764546_23 ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003005 263.0
TLS2_k127_764546_24 Glutathione peroxidase K00432 - 1.11.1.9 0.00000000000000000000000000000000000000000000000000000000000000000001765 239.0
TLS2_k127_764546_25 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003553 226.0
TLS2_k127_764546_26 transcriptional regulator K07736 - - 0.000000000000000000000000000000000000000000000000000000000000001948 222.0
TLS2_k127_764546_27 pyridoxamine 5-phosphate K07006 - - 0.000000000000000000000000000000000000000000000000000000000004869 214.0
TLS2_k127_764546_28 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000001458 229.0
TLS2_k127_764546_29 thiolester hydrolase activity K06889 - - 0.00000000000000000000000000000000000000000000000000000000005109 213.0
TLS2_k127_764546_3 Cys/Met metabolism PLP-dependent enzyme K01739,K01740,K01761 - 2.5.1.48,2.5.1.49,4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 540.0
TLS2_k127_764546_30 ABC-2 type transporter K09694 - - 0.00000000000000000000000000000000000000000000000000000002154 210.0
TLS2_k127_764546_31 Protein of unknown function (DUF1365) K09701 - - 0.0000000000000000000000000000000000000000000000001821 192.0
TLS2_k127_764546_32 Protein of unknown function (DUF3048) C-terminal domain - - - 0.00000000000000000000000000000000000000000000001111 192.0
TLS2_k127_764546_33 Mycothiol maleylpyruvate isomerase N-terminal domain K16163 - 5.2.1.4 0.000000000000000000000000000000000000000009438 167.0
TLS2_k127_764546_34 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000006822 164.0
TLS2_k127_764546_35 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000001085 139.0
TLS2_k127_764546_36 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000002121 145.0
TLS2_k127_764546_37 membrane K07058 - - 0.0000000000000000000000000000000002749 143.0
TLS2_k127_764546_38 Phosphate acyltransferases - - - 0.00000000000000000000000000000000162 147.0
TLS2_k127_764546_39 Rhodanese Homology Domain - - - 0.0000000000000000000000000000001242 132.0
TLS2_k127_764546_4 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 509.0
TLS2_k127_764546_40 Protein of unknown function (DUF3237) - - - 0.00000000000000000000000000000339 130.0
TLS2_k127_764546_41 efflux transmembrane transporter activity K02004,K09813 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000002432 119.0
TLS2_k127_764546_42 - - - - 0.000000000000000000000004576 103.0
TLS2_k127_764546_43 Protein of unknown function (DUF3039) - - - 0.0000000000000000005488 96.0
TLS2_k127_764546_44 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.00000000000000001964 87.0
TLS2_k127_764546_45 - - - - 0.0000003234 59.0
TLS2_k127_764546_46 - - - - 0.0000006181 61.0
TLS2_k127_764546_47 TadE-like protein - - - 0.00007975 52.0
TLS2_k127_764546_5 helicase superfamily c-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 481.0
TLS2_k127_764546_6 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K20940 - 1.14.13.218 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008083 468.0
TLS2_k127_764546_7 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003108 462.0
TLS2_k127_764546_8 Flavin containing amine oxidoreductase K06954 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 425.0
TLS2_k127_764546_9 ABC transporter K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006346 411.0
TLS2_k127_80215_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.0 1283.0
TLS2_k127_80215_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 6.215e-308 970.0
TLS2_k127_80215_10 nUDIX hydrolase K01515,K15634 - 3.6.1.13,5.4.2.12 0.00000000000000000000000000000000000000001455 161.0
TLS2_k127_80215_11 phosphatase activity K01560,K07025,K08723,K20862 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008655,GO:0009058,GO:0009112,GO:0009410,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019856,GO:0019859,GO:0030145,GO:0034641,GO:0034654,GO:0042221,GO:0042578,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.3.102,3.1.3.104,3.1.3.5,3.8.1.2 0.00000000000000000000000000000000000001106 158.0
TLS2_k127_80215_12 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000003325 110.0
TLS2_k127_80215_13 Histidine kinase - - - 0.00000000000000000003198 100.0
TLS2_k127_80215_14 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000004457 100.0
TLS2_k127_80215_15 Copper chaperone PCu(A)C K09796 - - 0.000000000000000002349 93.0
TLS2_k127_80215_16 Protein of unknown function (DUF1269) - - - 0.0000000000000001708 87.0
TLS2_k127_80215_17 Hemerythrin HHE cation binding domain protein - - - 0.00000000000007088 79.0
TLS2_k127_80215_2 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 3.232e-278 888.0
TLS2_k127_80215_3 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 7.929e-245 773.0
TLS2_k127_80215_4 Aminotransferase K00812,K14260,K14267 - 2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 506.0
TLS2_k127_80215_5 PFAM glycoside hydrolase family 77 K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005135 387.0
TLS2_k127_80215_6 cytochrome c oxidase K02351,K02862 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001014 254.0
TLS2_k127_80215_7 Acetyltransferase (GNAT) family K06976 - - 0.000000000000000000000000000000000000000000000000000000000000002155 227.0
TLS2_k127_80215_8 SCO1 SenC K07152 - - 0.0000000000000000000000000000000000000000000000000001638 195.0
TLS2_k127_80215_9 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000000000000000000000000000000006441 198.0
TLS2_k127_89763_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007114 584.0
TLS2_k127_89763_1 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 572.0
TLS2_k127_89763_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 334.0
TLS2_k127_89763_3 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 326.0
TLS2_k127_89763_4 nUDIX hydrolase - GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818 - 0.0000000000000000000000000000000000000008835 158.0
TLS2_k127_93898_0 ABC-type Fe3 transport system, permease component K02011 - - 3.696e-201 644.0
TLS2_k127_93898_1 Glycosyl hydrolase family 1 K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 584.0
TLS2_k127_93898_10 nitric oxide reductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000159 275.0
TLS2_k127_93898_11 iron ion homeostasis K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000001193 235.0
TLS2_k127_93898_12 PaaX-like protein K02616 - - 0.0000000000000000000000000000000000000000000000000000005205 206.0
TLS2_k127_93898_13 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000003067 171.0
TLS2_k127_93898_14 Uncharacterized protein conserved in bacteria (DUF2199) - - - 0.00000000000000000000004077 114.0
TLS2_k127_93898_2 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008196 537.0
TLS2_k127_93898_3 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 496.0
TLS2_k127_93898_4 cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 472.0
TLS2_k127_93898_5 ATPases associated with a variety of cellular activities K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 442.0
TLS2_k127_93898_6 ABC transporter K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 413.0
TLS2_k127_93898_7 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 402.0
TLS2_k127_93898_8 helix_turn _helix lactose operon repressor K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000705 343.0
TLS2_k127_93898_9 cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 309.0
TLS2_k127_942381_0 transcriptional activator domain - - - 9.641e-231 750.0
TLS2_k127_942381_1 Transport of potassium into the cell K03549 - - 4.554e-227 719.0
TLS2_k127_942381_2 PFAM FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 532.0
TLS2_k127_942381_3 tryptophan 2,3-dioxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 395.0
TLS2_k127_947242_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 1.335e-240 760.0
TLS2_k127_947242_1 Nad-dependent epimerase dehydratase - - - 5.691e-214 675.0
TLS2_k127_947242_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008054 317.0
TLS2_k127_947242_3 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008682 280.0
TLS2_k127_947242_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002426 261.0
TLS2_k127_947242_5 HIT domain K19710 - 2.7.7.53 0.00000000000000000000000000000000000000000000000000000001266 203.0
TLS2_k127_947242_6 tRNA synthetases class I (C) catalytic domain K01883,K15526 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16,6.3.1.13 0.0000000000000000003889 88.0
TLS2_k127_947242_7 - - - - 0.000000000000001501 79.0
TLS2_k127_967096_0 Transcriptional regulatory protein, C terminal K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 381.0
TLS2_k127_967096_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009803 375.0
TLS2_k127_967096_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000002328 267.0
TLS2_k127_967096_3 Inositol monophosphatase family K01092 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000002346 254.0
TLS2_k127_967096_4 GDP-mannose mannosyl hydrolase activity K08310 - 3.6.1.67 0.00000000000000000000000000000000000000000000000008315 186.0