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Overview

ID MAG04026
Name TLS2_bin.69
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Actinomycetota
Class Actinomycetes
Order Jiangellales
Family Jiangellaceae
Genus DASTQL01
Species DASTQL01 sp035462375
Assembly information
Completeness (%) 81.4
Contamination (%) 1.46
GC content (%) 73.0
N50 (bp) 11,539
Genome size (bp) 3,249,986

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3159

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_100452_0 Phosphoglucomutase K01835 - 5.4.2.2 1.937e-288 893.0
TLS2_k127_100452_1 ABC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005987 416.0
TLS2_k127_100452_2 alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 315.0
TLS2_k127_100452_3 Protein of unknown function (DUF3145) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003078 271.0
TLS2_k127_1013275_0 DNA-directed DNA polymerase K02337 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 0.0 1747.0
TLS2_k127_1013275_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 0.0 1383.0
TLS2_k127_1013275_10 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.0000000000000000000000000000000000000000000000000000000000000001501 225.0
TLS2_k127_1013275_11 Peptidase S16, lon domain protein K01338,K07157 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000001843 211.0
TLS2_k127_1013275_12 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000000000000000000000000000000001275 194.0
TLS2_k127_1013275_13 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000007419 181.0
TLS2_k127_1013275_14 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.4.23.36 0.000000000000000000000000000000000000000001154 166.0
TLS2_k127_1013275_15 - - - - 0.00000000000000000000000000000000000006391 145.0
TLS2_k127_1013275_16 Belongs to the UPF0235 family K09131 - - 0.0000000000000000000001036 101.0
TLS2_k127_1013275_17 - - - - 0.000000000000001029 86.0
TLS2_k127_1013275_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 7.86e-202 637.0
TLS2_k127_1013275_3 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 519.0
TLS2_k127_1013275_4 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 479.0
TLS2_k127_1013275_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01657,K02500 GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 396.0
TLS2_k127_1013275_6 imidazole-4-carboxamide isomerase K01814,K01817 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16,5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008427 391.0
TLS2_k127_1013275_7 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008897 323.0
TLS2_k127_1013275_8 Imidazoleglycerol-phosphate dehydratase K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 318.0
TLS2_k127_1013275_9 Chorismate mutase type II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000703 246.0
TLS2_k127_1016008_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 552.0
TLS2_k127_1016008_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K14215,K21273 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 434.0
TLS2_k127_1016008_10 Protein of unknown function (Hypoth_ymh) - - - 0.00000001217 62.0
TLS2_k127_1016008_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821,K09251 - 2.6.1.11,2.6.1.17,2.6.1.82 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 420.0
TLS2_k127_1016008_3 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006302 443.0
TLS2_k127_1016008_4 permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 388.0
TLS2_k127_1016008_5 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 365.0
TLS2_k127_1016008_6 epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001138 256.0
TLS2_k127_1016008_7 TIGRFAM TIGR03943 family protein - - - 0.000000000000000000000000000000000000000000000000000000001153 211.0
TLS2_k127_1016008_8 Protein of unknown function (Hypoth_ymh) - - - 0.0000000000000000000000001343 110.0
TLS2_k127_1016008_9 Evidence 2b Function of strongly homologous gene - - - 0.000000000002467 70.0
TLS2_k127_1019127_0 asparagine K01953 - 6.3.5.4 1.42e-204 646.0
TLS2_k127_1019127_1 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00895 - 2.7.1.90 2.22e-198 625.0
TLS2_k127_1019127_2 Belongs to the class-II DAHP synthase family K01626,K16019 GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0022607,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.5.1.54 0.00000000000000000004843 93.0
TLS2_k127_1021237_0 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 630.0
TLS2_k127_1021237_1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 580.0
TLS2_k127_1021237_2 Proton-conducting membrane transporter K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000561 471.0
TLS2_k127_1021237_3 Cupin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005947 454.0
TLS2_k127_1021237_4 NADH dehydrogenase K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 422.0
TLS2_k127_1021237_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 297.0
TLS2_k127_1021237_6 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339,K05578 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000001579 202.0
TLS2_k127_1021237_7 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000000000000001525 161.0
TLS2_k127_1021237_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000000000000000006719 144.0
TLS2_k127_1021237_9 epimerase - - - 0.00000000003877 75.0
TLS2_k127_1029944_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 0.0 1506.0
TLS2_k127_1029944_1 Amino acid permease - - - 2.855e-248 783.0
TLS2_k127_1029944_10 Protein of unknown function (DUF3159) - - - 0.000000000000000000000000000000000000000000000000000000002827 214.0
TLS2_k127_1029944_11 Protein of unknown function (DUF3710) - - - 0.0000000000000000000000000000000000000000000000000803 191.0
TLS2_k127_1029944_12 Nucleic acid binding, OB-fold, tRNA - - - 0.00000000000000000000000000000000000000006421 154.0
TLS2_k127_1029944_13 - - - - 0.000000000000000000000000000000000001575 141.0
TLS2_k127_1029944_14 Protein of unknown function (DUF3093) - - - 0.000000049 59.0
TLS2_k127_1029944_2 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 476.0
TLS2_k127_1029944_3 ABC transporter substrate-binding protein K10543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 447.0
TLS2_k127_1029944_4 ABC transporter K10545 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 386.0
TLS2_k127_1029944_5 TrkA-C domain K03499 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000401 361.0
TLS2_k127_1029944_6 TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 327.0
TLS2_k127_1029944_7 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000004966 222.0
TLS2_k127_1029944_8 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000000000000000000000000009582 227.0
TLS2_k127_1029944_9 Belongs to the binding-protein-dependent transport system permease family K10544 - - 0.00000000000000000000000000000000000000000000000000000000006021 211.0
TLS2_k127_1030135_0 Ftsk_gamma K03466 GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0 1034.0
TLS2_k127_1030135_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 6.495e-277 864.0
TLS2_k127_1030135_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009646 370.0
TLS2_k127_1030135_3 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000119 145.0
TLS2_k127_103279_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370 GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008940,GO:0009056,GO:0009628,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016491,GO:0016661,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036293,GO:0036294,GO:0042126,GO:0042128,GO:0042221,GO:0042493,GO:0043436,GO:0043602,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070482,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071453,GO:0071704,GO:0071731,GO:0071732,GO:0071941,GO:0071944,GO:0097366,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:2001057 1.7.5.1 4.69e-291 909.0
TLS2_k127_103279_1 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 543.0
TLS2_k127_103279_10 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway K15525 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016137,GO:0016138,GO:0016787,GO:0016810,GO:0016811,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 3.5.1.103 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 314.0
TLS2_k127_103279_11 Redoxin K03564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000001359 251.0
TLS2_k127_103279_12 EamA-like transporter family K03298 - - 0.00000000000000000000000000000000000000000000000000000000000000001574 248.0
TLS2_k127_103279_13 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000003585 221.0
TLS2_k127_103279_14 Domain of unknown function (DUF427) - - - 0.000000000000000000000000000000000000000000000000000000002748 212.0
TLS2_k127_103279_15 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000000000000000003887 175.0
TLS2_k127_103279_16 FCD - - - 0.0000000000000000000000000000000000007499 147.0
TLS2_k127_103279_17 family transcriptional regulator K13652 - - 0.000000000000000000001113 100.0
TLS2_k127_103279_18 Transcriptional regulator - - - 0.0000000000000000001815 101.0
TLS2_k127_103279_19 Domain of unknown function (DUF4870) - - - 0.00000000000000006929 90.0
TLS2_k127_103279_2 PFAM Major Facilitator Superfamily K02575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 539.0
TLS2_k127_103279_20 antisigma factor binding K04749 - - 0.00000000002847 69.0
TLS2_k127_103279_21 Protein of unknown function (DUF3618) - - - 0.000000004304 62.0
TLS2_k127_103279_3 Oxidoreductase molybdopterin binding domain K00387 - 1.8.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 437.0
TLS2_k127_103279_4 cytochrome P450 K21164 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 413.0
TLS2_k127_103279_5 ATPases associated with a variety of cellular activities K02006,K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000547 396.0
TLS2_k127_103279_6 DNA polymerase LigD, polymerase domain K01971,K10747 GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008556 364.0
TLS2_k127_103279_7 Cobalt ABC transporter K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 325.0
TLS2_k127_103279_8 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 338.0
TLS2_k127_103279_9 Fusaric acid resistance protein-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004289 330.0
TLS2_k127_1062015_0 Elongation factor G, domain IV K02355 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - 0.0 1059.0
TLS2_k127_1062015_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.0 1049.0
TLS2_k127_1062015_10 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000034 281.0
TLS2_k127_1062015_11 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K00999 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001878 276.0
TLS2_k127_1062015_12 HIT family hydrolase, diadenosine tetraphosphate hydrolase K19710 GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.7.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000201 256.0
TLS2_k127_1062015_13 Putative stress-induced transcription regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000003681 237.0
TLS2_k127_1062015_14 nUDIX hydrolase - - - 0.0000000000000000000000000000000000000000000000007779 190.0
TLS2_k127_1062015_15 Streptomyces sporulation and cell division protein, SsgA - GO:0000003,GO:0000910,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006725,GO:0006732,GO:0007049,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009653,GO:0009987,GO:0010564,GO:0010927,GO:0016043,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0018958,GO:0019438,GO:0019748,GO:0019752,GO:0019954,GO:0022402,GO:0022607,GO:0030154,GO:0030312,GO:0030428,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0030638,GO:0030639,GO:0031160,GO:0032465,GO:0032467,GO:0032502,GO:0032506,GO:0032989,GO:0032991,GO:0040007,GO:0042180,GO:0042181,GO:0042221,GO:0042244,GO:0042546,GO:0043436,GO:0043648,GO:0043650,GO:0043934,GO:0043936,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044457,GO:0044464,GO:0044550,GO:0045229,GO:0045787,GO:0046189,GO:0046394,GO:0046483,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051301,GO:0051302,GO:0051716,GO:0051726,GO:0051781,GO:0065007,GO:0070590,GO:0070726,GO:0070887,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0090068,GO:0090529,GO:1901110,GO:1901112,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1902074,GO:1902075,GO:1903664,GO:1903666,GO:1990586,GO:2000241,GO:2000243,GO:2000244,GO:2000246 - 0.00000000000000000000000000001575 130.0
TLS2_k127_1062015_16 calcium, potassium:sodium antiporter activity K07301 - - 0.000000000000000000000001374 117.0
TLS2_k127_1062015_17 - - - - 0.00000000000000000003285 104.0
TLS2_k127_1062015_18 - - - - 0.0000001288 54.0
TLS2_k127_1062015_2 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007086 511.0
TLS2_k127_1062015_3 Glycosyltransferase Family 4 K08256 GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006072 495.0
TLS2_k127_1062015_4 chorismate binding enzyme K01665,K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 433.0
TLS2_k127_1062015_5 Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005879 410.0
TLS2_k127_1062015_6 Glycoside hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002174 385.0
TLS2_k127_1062015_7 Bacterial lipid A biosynthesis acyltransferase K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 328.0
TLS2_k127_1062015_8 carbamate kinase K00926 - 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 304.0
TLS2_k127_1062015_9 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 320.0
TLS2_k127_110011_0 Alpha/beta-hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 390.0
TLS2_k127_110011_1 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 302.0
TLS2_k127_110011_10 Transcriptional regulator PadR-like family - - - 0.00001203 57.0
TLS2_k127_110011_11 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00001908 57.0
TLS2_k127_110011_2 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007924 273.0
TLS2_k127_110011_3 ATP-binding protein K00876 - 2.7.1.48 0.000000000000000000000000000000000000000000000000000000004638 207.0
TLS2_k127_110011_4 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000000000000000001222 196.0
TLS2_k127_110011_5 Histidine kinase - - - 0.00000000000000000000000000000000000379 153.0
TLS2_k127_110011_6 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000005319 121.0
TLS2_k127_110011_7 Transcriptional regulator - - - 0.000000000000000000000000000144 124.0
TLS2_k127_110011_9 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000005438 59.0
TLS2_k127_1126811_0 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.0 1005.0
TLS2_k127_1126811_1 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 4.625e-316 989.0
TLS2_k127_1126811_2 Glycosyl transferases group 1 K15521 - 2.4.1.250 2.961e-255 806.0
TLS2_k127_1126811_3 UDP-glucoronosyl and UDP-glucosyl transferase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0020012,GO:0030682,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 559.0
TLS2_k127_1126811_4 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004339 469.0
TLS2_k127_1157344_0 Bacterial transcriptional activator domain - - - 7.971e-315 1004.0
TLS2_k127_1157344_1 glutamine synthetase K01915 GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 3.874e-281 869.0
TLS2_k127_1157344_10 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007897 316.0
TLS2_k127_1157344_11 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009058 257.0
TLS2_k127_1157344_12 Domain of unknown function (DUF4191) - GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000001352 250.0
TLS2_k127_1157344_13 metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001057 244.0
TLS2_k127_1157344_14 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000001265 170.0
TLS2_k127_1157344_15 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000001744 140.0
TLS2_k127_1157344_16 OHCU decarboxylase K16840 - 4.1.1.97 0.0000000000000000000000000000000001087 139.0
TLS2_k127_1157344_17 RDD family - - - 0.00000000000000000000000000000004617 130.0
TLS2_k127_1157344_18 Transthyretin K07127 - 3.5.2.17 0.0000000000000000000000000000008335 133.0
TLS2_k127_1157344_19 protoporphyrinogen oxidase activity - - - 0.000000000002084 67.0
TLS2_k127_1157344_2 MMPL family K06994 - - 2.936e-230 733.0
TLS2_k127_1157344_20 methyltransferase - - - 0.00000008827 63.0
TLS2_k127_1157344_3 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 1.063e-214 693.0
TLS2_k127_1157344_4 Amidohydrolase family K01466 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 601.0
TLS2_k127_1157344_5 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 542.0
TLS2_k127_1157344_6 Belongs to the allantoicase family K01477 - 3.5.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004372 535.0
TLS2_k127_1157344_7 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 449.0
TLS2_k127_1157344_8 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 396.0
TLS2_k127_1157344_9 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 363.0
TLS2_k127_1157619_0 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003219 501.0
TLS2_k127_1157619_1 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 330.0
TLS2_k127_1157619_2 PFAM Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000208 223.0
TLS2_k127_1157619_3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000000000000000003981 201.0
TLS2_k127_1157619_4 dehydratase - - - 0.000000000000000000000000000000000000000000006027 174.0
TLS2_k127_1157619_5 L-valine transmembrane transporter activity - - - 0.000000000000000000000000000000002007 139.0
TLS2_k127_1157619_6 SnoaL-like domain - - - 0.0000009684 56.0
TLS2_k127_1191705_0 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 463.0
TLS2_k127_1191705_1 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 448.0
TLS2_k127_1191705_2 Flavin containing amine oxidoreductase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 407.0
TLS2_k127_1191705_3 homocysteine S-methyltransferase K00547,K21169 - 2.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 343.0
TLS2_k127_1191705_4 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000002145 218.0
TLS2_k127_1191705_5 cellular response to heat K09807 - - 0.00000000000000000000000000000000006061 142.0
TLS2_k127_1201040_0 Large subunit K06281 - 1.12.99.6 0.0 1180.0
TLS2_k127_1201040_1 Binding-protein-dependent transport systems inner membrane component K02011 - - 1.274e-233 734.0
TLS2_k127_1201040_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 314.0
TLS2_k127_1201040_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 313.0
TLS2_k127_1201040_12 TIGRFAM hydrogenase maturation protease K03605 - - 0.00000000000000000000000000000000000000000000000000000000004535 213.0
TLS2_k127_1201040_13 Archease protein family (MTH1598/TM1083) - - - 0.00000000000000000000000000000000000000001651 160.0
TLS2_k127_1201040_14 Hydrogenase nickel incorporation protein hypA K04651 - - 0.000000000000000000000000000000002404 136.0
TLS2_k127_1201040_15 HupF/HypC family K04653 - - 0.000000000000000000000000001369 114.0
TLS2_k127_1201040_16 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 0.000000000000000000000008531 116.0
TLS2_k127_1201040_19 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000002316 89.0
TLS2_k127_1201040_2 NADH ubiquinone oxidoreductase, 20 K06282 - 1.12.99.6 7.327e-227 704.0
TLS2_k127_1201040_3 Initiates the rapid degradation of small, acid-soluble proteins during spore germination - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 529.0
TLS2_k127_1201040_4 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005872 509.0
TLS2_k127_1201040_5 ATPase P-type (Transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008658 458.0
TLS2_k127_1201040_6 iron ion homeostasis K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009543 458.0
TLS2_k127_1201040_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 428.0
TLS2_k127_1201040_8 PFAM nitrogen-fixing NifU domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 358.0
TLS2_k127_1201040_9 Hydrogenase accessory protein HypB K04652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 329.0
TLS2_k127_1227251_0 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 1.47e-288 903.0
TLS2_k127_1227251_1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 608.0
TLS2_k127_1227251_2 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 543.0
TLS2_k127_1227251_3 Sulfurtransferase K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 522.0
TLS2_k127_1227251_4 Fe-S metabolism associated domain K02426 - - 0.0000000000000000000000000000000000000000000000000000002776 199.0
TLS2_k127_1227251_5 Protein of unknown function (DUF1232) - - - 0.0000000000000000000000000004516 119.0
TLS2_k127_1234121_0 O-acetylhomoserine K01740 - 2.5.1.49 1.846e-222 701.0
TLS2_k127_1234121_1 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006759 522.0
TLS2_k127_1266041_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0 1027.0
TLS2_k127_1266041_1 AMP-dependent synthetase K01897 - 6.2.1.3 9.248e-236 743.0
TLS2_k127_1266041_10 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000004098 109.0
TLS2_k127_1266041_11 Domain of unknown function (DUF4870) K09940 - - 0.0000000000000000000001318 106.0
TLS2_k127_1266041_12 Helix-hairpin-helix motif K02237 - - 0.000000000000000000001051 96.0
TLS2_k127_1266041_13 Protein of unknown function (DUF3097) - - - 0.0000004287 56.0
TLS2_k127_1266041_2 ComEC Rec2-related protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 602.0
TLS2_k127_1266041_3 Involved in the biosynthesis of porphyrin-containing compound - GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008672 588.0
TLS2_k127_1266041_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000552 537.0
TLS2_k127_1266041_5 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009557 492.0
TLS2_k127_1266041_6 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 320.0
TLS2_k127_1266041_7 MOSC domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009745 246.0
TLS2_k127_1266041_8 PemK-like, MazF-like toxin of type II toxin-antitoxin system - - - 0.000000000000000000000000000000000000000000000000000006443 215.0
TLS2_k127_1266041_9 RDD family - - - 0.00000000000000000000000000000000002197 145.0
TLS2_k127_1294736_0 Dehydrogenase K15371 - 1.4.1.2 0.0 1517.0
TLS2_k127_1294736_1 Dehydrogenase K00294 - 1.2.1.88 1.961e-275 858.0
TLS2_k127_1294736_2 Belongs to the long-chain O-acyltransferase family K00635 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 516.0
TLS2_k127_1294736_3 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 405.0
TLS2_k127_1294736_4 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 304.0
TLS2_k127_1294736_5 - - - - 0.00000000000000000000000000000000000000004841 170.0
TLS2_k127_1294736_6 Protein of unknown function (DUF2505) - - - 0.00000000000000000000000000003091 124.0
TLS2_k127_1315456_0 Uncharacterized protein conserved in bacteria (DUF2252) - - - 1.002e-216 683.0
TLS2_k127_1315456_1 Nucleotidyl transferase K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 498.0
TLS2_k127_1315456_2 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 435.0
TLS2_k127_1315456_3 - - - - 0.00000000000000000000000000000000000000000000000002139 188.0
TLS2_k127_1315456_4 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000008787 160.0
TLS2_k127_132179_0 Transcriptional regulator, CarD family K07736 GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 294.0
TLS2_k127_132179_1 Pfam UbiA prenyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000001205 234.0
TLS2_k127_132179_2 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000009848 197.0
TLS2_k127_132179_3 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576 2.7.7.60 0.00000000003912 72.0
TLS2_k127_1354820_0 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000747 338.0
TLS2_k127_1354820_1 Involved in the tonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000006539 232.0
TLS2_k127_1354820_2 - - - - 0.00000000000000000000000000000000006433 146.0
TLS2_k127_1354820_3 Tricorn protease homolog K08676 - - 0.00000000000008806 85.0
TLS2_k127_1354820_4 Peptidase family M23 - - - 0.00007121 54.0
TLS2_k127_1372596_0 Flavin-binding monooxygenase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 296.0
TLS2_k127_1372596_1 Bacterial transcriptional repressor C-terminal - - - 0.0000000000000000000000002481 111.0
TLS2_k127_1372596_2 Protein of unknown function (DUF1269) - - - 0.0000000000000000006716 94.0
TLS2_k127_1401970_0 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 604.0
TLS2_k127_1401970_1 50S ribosome-binding GTPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000308 483.0
TLS2_k127_1401970_12 Phage integrase family - - - 0.000004869 49.0
TLS2_k127_1401970_2 Protease prsW family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 317.0
TLS2_k127_1401970_3 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 284.0
TLS2_k127_1401970_4 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003149 249.0
TLS2_k127_1401970_5 PFAM YbaK prolyl-tRNA synthetases associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001477 229.0
TLS2_k127_1401970_6 Protein of unknown function (DUF3152) - - - 0.00000000000000000000000000000000000000000000000000000000546 210.0
TLS2_k127_1401970_7 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000003407 165.0
TLS2_k127_1401970_8 Phage integrase, N-terminal SAM-like domain - - - 0.0000000000000000000000000000000000000002289 156.0
TLS2_k127_1401970_9 single-stranded DNA-binding protein K03111 - - 0.000000000000000000000000000000000228 143.0
TLS2_k127_1419803_0 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 388.0
TLS2_k127_1419803_1 TIGRFAM 6-phosphogluconolactonase K01057 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 295.0
TLS2_k127_1419803_2 Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters - - - 0.0000000000000000000000000000000000000000000000000001737 187.0
TLS2_k127_1419803_3 Preprotein translocase SecG subunit K03075 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000004081 113.0
TLS2_k127_1419803_4 Belongs to the phosphoglycerate kinase family K00927,K01803 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 2.7.2.3,5.3.1.1 0.000000000000000000001581 94.0
TLS2_k127_1437184_0 hydrolase family 65, central catalytic - - - 9.861e-319 1003.0
TLS2_k127_1437184_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 1.484e-270 867.0
TLS2_k127_1437184_11 Belongs to the universal stress protein A family - - - 0.0009868 47.0
TLS2_k127_1437184_2 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003433 599.0
TLS2_k127_1437184_3 PFAM Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004248 583.0
TLS2_k127_1437184_4 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 478.0
TLS2_k127_1437184_5 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 428.0
TLS2_k127_1437184_6 Histidine kinase-like ATPases K01768,K02488,K17763 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65,4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 360.0
TLS2_k127_1437184_7 - - - - 0.00000000000000000000000000000000000000000000001528 175.0
TLS2_k127_1437184_9 Domain of unknown function (DUF1918) - - - 0.000000000000000000000001264 109.0
TLS2_k127_147401_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K01848 - 5.4.99.2 5.497e-307 947.0
TLS2_k127_147401_1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 2.003e-298 925.0
TLS2_k127_147401_10 methylmalonyl-CoA epimerase K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000000000003998 221.0
TLS2_k127_147401_11 ANTAR - - - 0.0000000000000000000000000000000000000000000000000005686 203.0
TLS2_k127_147401_12 ATP- GTP-binding protein - - - 0.0000000000000000000000000000000001643 135.0
TLS2_k127_147401_13 YCII-related domain K09780 - - 0.0000000000000000000000000003004 115.0
TLS2_k127_147401_14 Bacterial PH domain - - - 0.0000000000000000000005428 105.0
TLS2_k127_147401_15 - - - - 0.00009159 48.0
TLS2_k127_147401_2 TIGRFAM crotonyl-CoA reductase K17829 - 1.3.1.86 2.188e-254 790.0
TLS2_k127_147401_3 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 600.0
TLS2_k127_147401_4 LAO AO transport system ATPase K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009991 474.0
TLS2_k127_147401_5 hydrolase of the alpha beta K07018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 400.0
TLS2_k127_147401_6 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures K07503 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 374.0
TLS2_k127_147401_7 DivIVA protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000002311 248.0
TLS2_k127_147401_8 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000005859 247.0
TLS2_k127_147401_9 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000006039 237.0
TLS2_k127_1482356_0 Caspase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 522.0
TLS2_k127_1482356_1 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 420.0
TLS2_k127_1482356_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004402 404.0
TLS2_k127_1482356_3 Glycosyl hydrolases family 16 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005531 339.0
TLS2_k127_1482356_4 COG0569 K transport systems, NAD-binding component K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 289.0
TLS2_k127_1482356_5 Cation transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003034 252.0
TLS2_k127_1482356_6 transport, permease protein K01990,K01992 - - 0.0000000000000000000000000000000000000000000001599 170.0
TLS2_k127_1482356_7 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000001161 149.0
TLS2_k127_1482356_8 - - - - 0.00000000000000000000000000000004325 130.0
TLS2_k127_1487756_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0 1239.0
TLS2_k127_1487756_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002506 252.0
TLS2_k127_1493276_0 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008912 495.0
TLS2_k127_1493276_1 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 424.0
TLS2_k127_1493276_2 VWA containing CoxE family protein K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 374.0
TLS2_k127_1493276_3 ATP phosphoribosyltransferase K00765,K02502 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000001812 252.0
TLS2_k127_1493276_4 MobA-like NTP transferase domain K07141,K19190 - 1.1.1.328,2.7.7.76 0.0000000000000000000000000000000000000000000000000000000006324 215.0
TLS2_k127_1493276_5 - - - - 0.00000000000000000000006396 114.0
TLS2_k127_1501331_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 6.359e-251 787.0
TLS2_k127_1501331_1 Belongs to the aldehyde dehydrogenase family K00130 - 1.2.1.8 9.731e-238 744.0
TLS2_k127_1501331_10 Domain present in PSD-95, Dlg, and ZO-1/2. K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 514.0
TLS2_k127_1501331_11 COG0687 Spermidine putrescine-binding periplasmic protein K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007787 422.0
TLS2_k127_1501331_12 PFAM GCN5-related N-acetyltransferase K06976 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 385.0
TLS2_k127_1501331_13 ABC-type spermidine putrescine transport system, permease component I K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007938 397.0
TLS2_k127_1501331_14 COG1177 ABC-type spermidine putrescine transport system, permease component II K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009503 356.0
TLS2_k127_1501331_15 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 328.0
TLS2_k127_1501331_16 AsnC family K03718 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002901 241.0
TLS2_k127_1501331_17 homoserine transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000002068 188.0
TLS2_k127_1501331_18 - - - - 0.00000000002331 74.0
TLS2_k127_1501331_2 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.171e-223 702.0
TLS2_k127_1501331_3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 1.94e-218 682.0
TLS2_k127_1501331_4 Saccharopine dehydrogenase K00290 - 1.5.1.7 6.859e-213 666.0
TLS2_k127_1501331_5 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 614.0
TLS2_k127_1501331_6 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007736 594.0
TLS2_k127_1501331_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 621.0
TLS2_k127_1501331_8 Arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 563.0
TLS2_k127_1501331_9 Belongs to the ABC transporter superfamily K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 523.0
TLS2_k127_1571983_0 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 331.0
TLS2_k127_1571983_1 PFAM peptidase S1 and S6 chymotrypsin Hap - - - 0.00000000000000000000000000000000000000000000000000000000000007188 226.0
TLS2_k127_1571983_2 Predicted membrane protein (DUF2157) - - - 0.00000000000000000000000000000000000000000000000000000007971 210.0
TLS2_k127_1571983_3 - - - - 0.0000000000000000000000000000000000000000000001135 175.0
TLS2_k127_1571983_4 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000001733 169.0
TLS2_k127_1571983_5 pyridoxamine 5-phosphate - - - 0.0000000000000000000000000004593 118.0
TLS2_k127_1571983_6 - - - - 0.0000000000000000003138 101.0
TLS2_k127_1571983_7 CsbD-like - - - 0.0008703 43.0
TLS2_k127_1600756_0 Fibronectin type III-like domain K05349 - 3.2.1.21 7.009e-308 960.0
TLS2_k127_1600756_1 major facilitator superfamily - - - 4.404e-210 666.0
TLS2_k127_1600756_2 Gluconate K03299 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 614.0
TLS2_k127_1600756_3 FGGY family of carbohydrate kinases, N-terminal domain K00851,K00854 - 2.7.1.12,2.7.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 550.0
TLS2_k127_1600756_4 Dihydrofolate reductase - - - 0.00000000000000000000000000000005533 132.0
TLS2_k127_1600756_5 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000008916 126.0
TLS2_k127_1600756_6 - - - - 0.0000000000000001161 87.0
TLS2_k127_1641362_0 DNA polymerase LigD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 552.0
TLS2_k127_1641362_1 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 475.0
TLS2_k127_1641362_2 chlorite dismutase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 379.0
TLS2_k127_1641362_3 Peptide-methionine (R)-S-oxide reductase K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000002731 219.0
TLS2_k127_1641362_5 Domain of unknown function (DUF4349) - - - 0.000000007603 59.0
TLS2_k127_1673604_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1861.0
TLS2_k127_1673604_1 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 495.0
TLS2_k127_1673604_2 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 394.0
TLS2_k127_1673604_3 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000005502 224.0
TLS2_k127_1673604_4 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000002465 214.0
TLS2_k127_1706354_0 Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 460.0
TLS2_k127_1706354_1 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004986 351.0
TLS2_k127_1706354_2 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004441 332.0
TLS2_k127_1706354_3 EamA-like transporter family K11939 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 306.0
TLS2_k127_1706354_4 Putative adhesin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002064 265.0
TLS2_k127_1706354_5 protein encoded in hypervariable junctions of pilus gene clusters - - - 0.000000000000000000000000000000000000000000000000003453 194.0
TLS2_k127_1706354_6 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000000000000000000000000000000000000000009077 176.0
TLS2_k127_1706354_8 alpha/beta hydrolase fold - - - 0.00005418 46.0
TLS2_k127_1707833_0 ABC transporter transmembrane region K02021,K06147,K16786,K16787 - - 2.419e-246 781.0
TLS2_k127_1707833_1 ABC transporter transmembrane region - - - 2.796e-213 674.0
TLS2_k127_1707833_2 - - - - 0.000000000000000000000000000000001684 135.0
TLS2_k127_17153_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 366.0
TLS2_k127_17153_1 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001423 292.0
TLS2_k127_17153_2 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A - - - 0.000000000000000000000000000000000000000000000006694 188.0
TLS2_k127_17153_3 AAA ATPase domain - - - 0.00000000000000000000000000000000005153 140.0
TLS2_k127_17153_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000009309 149.0
TLS2_k127_17153_5 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000003504 139.0
TLS2_k127_17153_6 - - - - 0.00000000000001554 79.0
TLS2_k127_17153_7 Metallo-beta-lactamase superfamily - - - 0.000000001071 61.0
TLS2_k127_1726962_0 Mur ligase middle domain K03802 - 6.3.2.29,6.3.2.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005927 558.0
TLS2_k127_1726962_1 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 413.0
TLS2_k127_1726962_2 reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 355.0
TLS2_k127_1726962_3 Dodecin K09165 - - 0.000000000000000000000000000001571 123.0
TLS2_k127_1726962_4 Protein of unknown function (DUF3099) - - - 0.000000000000000003776 89.0
TLS2_k127_1791708_0 response regulator - - - 3.201e-234 740.0
TLS2_k127_1791708_1 Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005709 515.0
TLS2_k127_1791708_10 Peptide ABC transporter permease K02034,K15582 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002319 281.0
TLS2_k127_1791708_11 Belongs to the LOG family K06966 GO:0003674,GO:0003824,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009308,GO:0009690,GO:0009691,GO:0009987,GO:0010817,GO:0016787,GO:0016798,GO:0016799,GO:0034754,GO:0042445,GO:0042446,GO:0044237,GO:0044249,GO:0046483,GO:0065007,GO:0065008,GO:0071704,GO:1901564 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000266 238.0
TLS2_k127_1791708_12 Binding-protein-dependent transport system inner membrane component K02033,K15581 - - 0.000000000000000000000000000000000000000000000002134 185.0
TLS2_k127_1791708_13 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000000000000000001768 152.0
TLS2_k127_1791708_14 Putative mono-oxygenase ydhR - - - 0.000000000000000000000000000000002998 134.0
TLS2_k127_1791708_15 regulation of cell shape - - - 0.00000000000001955 81.0
TLS2_k127_1791708_2 Peptidase dimerisation domain K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 469.0
TLS2_k127_1791708_3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA K00674 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008928 435.0
TLS2_k127_1791708_4 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 423.0
TLS2_k127_1791708_5 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 381.0
TLS2_k127_1791708_6 heme binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 361.0
TLS2_k127_1791708_7 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 355.0
TLS2_k127_1791708_8 Flavodoxin-like fold K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 295.0
TLS2_k127_1791708_9 Glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 289.0
TLS2_k127_1810009_0 MazG nucleotide pyrophosphohydrolase domain K02428,K02499 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008244 285.0
TLS2_k127_1810009_1 SurA N-terminal domain - - - 0.00000000000007208 83.0
TLS2_k127_1845880_0 4Fe-4S dicluster domain - - - 0.0 1035.0
TLS2_k127_1845880_1 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 379.0
TLS2_k127_1845880_2 Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 310.0
TLS2_k127_1845880_3 Phospholipase_D-nuclease N-terminal - - - 0.0000000000000000000000000000000000000000000005535 171.0
TLS2_k127_1871461_0 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 1.518e-291 910.0
TLS2_k127_1871461_1 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 3.136e-261 827.0
TLS2_k127_1871461_10 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 419.0
TLS2_k127_1871461_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 353.0
TLS2_k127_1871461_12 Acyl-CoA thioesterase K10805 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 334.0
TLS2_k127_1871461_13 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005323 288.0
TLS2_k127_1871461_14 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002489 285.0
TLS2_k127_1871461_15 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003085 284.0
TLS2_k127_1871461_16 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001081 280.0
TLS2_k127_1871461_17 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 K02768,K02798,K11183 - 2.7.1.197,2.7.1.202 0.00000000000000000000000000000000000000000000000000000000000000000002584 234.0
TLS2_k127_1871461_18 - - - - 0.00000000000000000000000000000000000006802 151.0
TLS2_k127_1871461_19 Protein of unknown function (DUF3263) - - - 0.000000000000000000000000000000000000721 141.0
TLS2_k127_1871461_2 Aldehyde dehydrogenase family K22187 - - 2.053e-250 796.0
TLS2_k127_1871461_20 membrane K00389 - - 0.000000000000000000000000000000000004431 140.0
TLS2_k127_1871461_21 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000000000000000000000000000000000007963 152.0
TLS2_k127_1871461_22 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000006265 115.0
TLS2_k127_1871461_23 - - - - 0.00000000000000000007229 105.0
TLS2_k127_1871461_24 - - - - 0.0000000000000000005438 91.0
TLS2_k127_1871461_25 PFAM Glycosyl transferase family 2 K13693 - 2.4.1.266 0.00000000000000009077 83.0
TLS2_k127_1871461_26 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.0000000000000006238 77.0
TLS2_k127_1871461_27 Phospholipase_D-nuclease N-terminal - - - 0.0000000000003191 76.0
TLS2_k127_1871461_28 - - - - 0.0000000004126 68.0
TLS2_k127_1871461_29 - - - - 0.0000001315 56.0
TLS2_k127_1871461_3 TIGRFAM PTS system, mannitol-specific IIC subunit K02798,K02799,K02800 - 2.7.1.197 3.191e-236 740.0
TLS2_k127_1871461_30 LytR cell envelope-related transcriptional attenuator - - - 0.00001848 54.0
TLS2_k127_1871461_4 Glycosyltransferase family 20 K00697,K16055 GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 3.216e-199 634.0
TLS2_k127_1871461_5 Zinc-binding dehydrogenase K00008 - 1.1.1.14 1.712e-196 624.0
TLS2_k127_1871461_6 transporter mgtE K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006917 571.0
TLS2_k127_1871461_7 FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006366 565.0
TLS2_k127_1871461_8 Cyclopropane-fatty-acyl-phospholipid synthase K00574 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005888 514.0
TLS2_k127_1871461_9 PFAM Glycosyl transferase, family 20 K00697 - 2.4.1.15,2.4.1.347 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 509.0
TLS2_k127_1893472_0 transporter K14445 - - 5.485e-215 691.0
TLS2_k127_1893472_1 alpha amylase, catalytic K01176 - 3.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003831 524.0
TLS2_k127_1893472_2 PAS domain containing protein K02476 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 497.0
TLS2_k127_1893472_3 Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 310.0
TLS2_k127_1893472_4 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 300.0
TLS2_k127_1893472_5 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001044 274.0
TLS2_k127_1893472_6 OsmC-like protein - - - 0.00000000006575 68.0
TLS2_k127_1919388_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 4.2.1.33,4.2.1.35 1.85e-243 793.0
TLS2_k127_1919388_1 MMPL family K06994 - - 2.492e-217 697.0
TLS2_k127_1919388_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 526.0
TLS2_k127_1919388_3 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 389.0
TLS2_k127_1919388_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 294.0
TLS2_k127_1919388_5 Belongs to the bacterial histone-like protein family K03530 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010106,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019725,GO:0030003,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0040007,GO:0042262,GO:0042592,GO:0042594,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046916,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060255,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090143,GO:0090304,GO:0097100,GO:0097159,GO:0098771,GO:0140110,GO:1901360,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000003238 156.0
TLS2_k127_1920478_0 Glycoside hydrolase - - - 4.123e-257 804.0
TLS2_k127_1920478_1 ABC transporter transmembrane region K06147 - - 2.166e-255 803.0
TLS2_k127_1920478_2 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 518.0
TLS2_k127_1920478_3 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 326.0
TLS2_k127_1920478_4 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007495 295.0
TLS2_k127_1920478_5 LD-carboxypeptidase K01297 - 3.4.17.13 0.000000000000000000000000000000000000000000000000000000000000000000000000001945 270.0
TLS2_k127_1920478_6 SURF1 family - GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.0000000000000000000000000000000000000000000000001185 186.0
TLS2_k127_1920478_7 PFAM peptidase C60 sortase A and B - - - 0.00000000000000000000000000009347 121.0
TLS2_k127_1920478_8 transcriptional regulator - - - 0.000000000000000000000003515 107.0
TLS2_k127_1922940_0 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008107 391.0
TLS2_k127_1922940_1 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 301.0
TLS2_k127_1922940_2 NlpC/P60 family K21471,K21473 - - 0.0001061 54.0
TLS2_k127_1940107_0 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 413.0
TLS2_k127_1940107_1 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000666 245.0
TLS2_k127_1940107_2 OsmC-like protein - - - 0.000000000000000000000000000000000000000009122 158.0
TLS2_k127_1940107_3 PFAM Acetyltransferase (GNAT) family - - - 0.00001884 48.0
TLS2_k127_1940784_0 RimK-like ATP-grasp domain K03802 - 6.3.2.29,6.3.2.30 0.0 1443.0
TLS2_k127_1940784_1 Mur ligase middle domain K03802 - 6.3.2.29,6.3.2.30 1.119e-203 646.0
TLS2_k127_1940784_2 Peptidase family S51 K13282 - 3.4.15.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 376.0
TLS2_k127_1940784_3 HNH endonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000005006 73.0
TLS2_k127_1948002_0 Catalyzes the formation of phosphoenolpyruvate from pyruvate K00873 GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 2.258e-209 660.0
TLS2_k127_1948002_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 606.0
TLS2_k127_1948002_2 ANTAR K22010 GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000134 284.0
TLS2_k127_1948002_3 Intracellular protease K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000000000000002616 260.0
TLS2_k127_1948002_4 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000001063 173.0
TLS2_k127_1950528_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006807 531.0
TLS2_k127_1950528_1 Belongs to the LDH MDH superfamily. LDH family K00016,K00024 - 1.1.1.27,1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 414.0
TLS2_k127_1950528_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07032 - - 0.000000000000000000000000000000000000000000001519 169.0
TLS2_k127_1950528_3 Protein of unknown function (DUF998) - - - 0.000000000000000000000001819 106.0
TLS2_k127_1950528_4 Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor K00845,K00886 - 2.7.1.2,2.7.1.63 0.0000000000000000000002508 97.0
TLS2_k127_1950528_6 - - - - 0.00001355 48.0
TLS2_k127_1959276_0 AMP-dependent synthetase - - - 7.859e-284 902.0
TLS2_k127_1959276_1 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 438.0
TLS2_k127_1959276_10 Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000000000000000000006504 184.0
TLS2_k127_1959276_11 Chlorophyllase enzyme - - - 0.0000000000000000000000000000000000000000000000003356 187.0
TLS2_k127_1959276_12 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0035335,GO:0035821,GO:0036211,GO:0042578,GO:0043170,GO:0043207,GO:0043412,GO:0044003,GO:0044046,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052046,GO:0052047,GO:0052048,GO:0052083,GO:0052155,GO:0052173,GO:0052200,GO:0052212,GO:0052255,GO:0052278,GO:0052294,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:0140096,GO:1901564 3.1.3.48 0.000000000000000000000000000000000000000007182 173.0
TLS2_k127_1959276_13 membrane K08972 - - 0.0000000000000000000000000000000000005835 142.0
TLS2_k127_1959276_14 Glyoxalase-like domain - - - 0.000000000000000000005543 93.0
TLS2_k127_1959276_15 - - - - 0.0000000000000000159 92.0
TLS2_k127_1959276_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005098 398.0
TLS2_k127_1959276_3 Glutamate decarboxylase and related PLP-dependent K01580 - 4.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008449 368.0
TLS2_k127_1959276_4 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 327.0
TLS2_k127_1959276_5 Fructosamine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005994 295.0
TLS2_k127_1959276_6 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004201 251.0
TLS2_k127_1959276_7 Saccharopine dehydrogenase NADP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000008071 231.0
TLS2_k127_1959276_8 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000000000000000000000000000009155 236.0
TLS2_k127_1959276_9 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000009789 226.0
TLS2_k127_1961976_0 Aminotransferase K00812 - 2.6.1.1 2.289e-209 664.0
TLS2_k127_1961976_1 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 434.0
TLS2_k127_1961976_2 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005431 381.0
TLS2_k127_1961976_3 Participates in transcription elongation, termination and antitermination K02601 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009037 324.0
TLS2_k127_1961976_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001371 264.0
TLS2_k127_1961976_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000007941 139.0
TLS2_k127_1961976_6 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000001469 96.0
TLS2_k127_1961976_7 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000002405 92.0
TLS2_k127_1962881_0 DNA Topoisomerase IV K02469 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 539.0
TLS2_k127_1962881_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 526.0
TLS2_k127_1962881_2 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000423 194.0
TLS2_k127_1962881_3 LppX_LprAFG lipoprotein K14954 - - 0.000000000000000000000000000000000000000000772 173.0
TLS2_k127_1986433_0 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000003371 260.0
TLS2_k127_1986433_1 PFAM Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000004326 169.0
TLS2_k127_1988069_0 Malonate decarboxylase gamma subunit (MdcE) K18472 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009317,GO:0009987,GO:0016042,GO:0016053,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019367,GO:0019752,GO:0030312,GO:0030497,GO:0032787,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:1901575,GO:1901576,GO:1902494 2.1.3.15,6.4.1.2,6.4.1.3 7.878e-221 694.0
TLS2_k127_1988069_1 Acyl transferase domain K00645 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008519 571.0
TLS2_k127_1988069_10 Polyphosphate kinase 2 (PPK2) K22468 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.1 0.00000004988 54.0
TLS2_k127_1988069_11 cheY-homologous receiver domain - - - 0.00000115 55.0
TLS2_k127_1988069_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009477 550.0
TLS2_k127_1988069_3 Helix-hairpin-helix domain K04477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008715 492.0
TLS2_k127_1988069_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 456.0
TLS2_k127_1988069_5 PucR C-terminal helix-turn-helix domain - GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 437.0
TLS2_k127_1988069_6 Belongs to the pirin family K06911 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000006985 214.0
TLS2_k127_1988069_7 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.00000000000000000000000000000000000000000000001825 176.0
TLS2_k127_1988069_8 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006643,GO:0006644,GO:0006664,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009245,GO:0009247,GO:0009259,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0019637,GO:0019693,GO:0019752,GO:0019842,GO:0030312,GO:0031177,GO:0032787,GO:0033218,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046483,GO:0046493,GO:0048037,GO:0051186,GO:0051192,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072341,GO:0072521,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901360,GO:1901564,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000397 138.0
TLS2_k127_1988069_9 Methyltransferase domain - - - 0.0000000000000000000000000000000004257 148.0
TLS2_k127_1992562_0 ERAP1-like C-terminal domain K01256,K08776 - 3.4.11.2 0.0 1080.0
TLS2_k127_1992562_1 4-alpha-glucanotransferase K00705 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.4.1.25 5.679e-289 903.0
TLS2_k127_1992562_2 AAA ATPase domain - - - 2.779e-198 666.0
TLS2_k127_1992562_3 peptidase S9A, prolyl oligopeptidase domain protein beta-propeller K01322 - 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008152 528.0
TLS2_k127_1992562_4 Belongs to the amidase family K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005632 506.0
TLS2_k127_1992562_5 Formamidopyrimidine-DNA glycosylase H2TH domain K05522,K10563 GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0003906,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0090304,GO:0097159,GO:0097506,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 317.0
TLS2_k127_1992562_6 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 329.0
TLS2_k127_1992562_7 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000517 235.0
TLS2_k127_1992562_8 PFAM FAD linked oxidase domain protein - - - 0.0000000000000000000000007634 107.0
TLS2_k127_201414_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.0 1183.0
TLS2_k127_201414_1 MgsA AAA+ ATPase C terminal K07478 - - 2.045e-194 618.0
TLS2_k127_201414_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007985 608.0
TLS2_k127_201414_3 Shikimate dehydrogenase K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000243 293.0
TLS2_k127_201414_4 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004533 285.0
TLS2_k127_201414_5 Type IV leader peptidase family K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000002389 184.0
TLS2_k127_201414_6 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000000003175 171.0
TLS2_k127_201414_7 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000003131 112.0
TLS2_k127_201414_8 Bacterial protein of unknown function (DUF948) - - - 0.000000000000000000000003938 106.0
TLS2_k127_201414_9 - - - - 0.00000000001531 74.0
TLS2_k127_2017436_0 Putative glucoamylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 506.0
TLS2_k127_2017436_1 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 494.0
TLS2_k127_2017436_2 PFAM binding-protein-dependent transport systems inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 413.0
TLS2_k127_2017436_3 ABC transporter (Permease) K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 404.0
TLS2_k127_2017436_4 Periplasmic binding protein LacI transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 376.0
TLS2_k127_2017436_5 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000008789 228.0
TLS2_k127_2026341_0 Belongs to the DEAD box helicase family K05592,K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 2.676e-261 819.0
TLS2_k127_2026341_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 2.835e-234 732.0
TLS2_k127_2026341_10 HNH nucleases - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000009226 61.0
TLS2_k127_2026341_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 4.976e-220 691.0
TLS2_k127_2026341_3 Belongs to the GARS family K01945,K11788 GO:0008150,GO:0040007 6.3.3.1,6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006471 582.0
TLS2_k127_2026341_4 PFAM Peptidase S10, serine carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 518.0
TLS2_k127_2026341_5 Belongs to the amidase family K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006322 415.0
TLS2_k127_2026341_6 F420-dependent oxidoreductase, MSMEG_2906 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002427 421.0
TLS2_k127_2026341_7 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002205 280.0
TLS2_k127_2026341_8 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000006959 133.0
TLS2_k127_2026341_9 lactoylglutathione lyase activity - - - 0.000000000000000000000008235 107.0
TLS2_k127_2033033_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 313.0
TLS2_k127_2033033_1 Major facilitator superfamily K03762 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001835 261.0
TLS2_k127_2033033_2 - - - - 0.00000000000000000000000000000000000000000001043 167.0
TLS2_k127_2033033_3 - - - - 0.000002738 50.0
TLS2_k127_2041292_0 PFAM glycoside hydrolase family 39 K01198 - 3.2.1.37 2.384e-229 728.0
TLS2_k127_2041292_1 Putative glucoamylase - - - 0.0000000000000000001733 89.0
TLS2_k127_2041292_2 helix_turn_helix gluconate operon transcriptional repressor - - - 0.000000000001128 70.0
TLS2_k127_20494_0 Bacterial protein of unknown function (DUF853) K06915 - - 2.854e-214 680.0
TLS2_k127_20494_1 Transcription regulator of the Arc MetJ class - - - 0.00000000000000000000000000000000000000000001104 163.0
TLS2_k127_20494_2 LytR cell envelope-related transcriptional attenuator - - - 0.000000000000000000002177 101.0
TLS2_k127_2055128_0 alcohol dehydrogenase K18382 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 581.0
TLS2_k127_2055128_1 Domain of unknown function (DUF4389) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 532.0
TLS2_k127_2055128_2 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001556 275.0
TLS2_k127_2055128_3 - - - - 0.000000000000000000000000000000000000001567 160.0
TLS2_k127_2055128_4 RDD family - - - 0.000000000000000000000000000000000003325 142.0
TLS2_k127_2055128_5 Cold shock protein K03704 - - 0.0000000000000000000000000000000009889 130.0
TLS2_k127_2060086_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1428.0
TLS2_k127_2060086_1 Uncharacterised protein, DegV family COG1307 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 334.0
TLS2_k127_2060086_2 Helix-hairpin-helix motif K02237 - - 0.00000000000000000003428 102.0
TLS2_k127_2071475_0 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 595.0
TLS2_k127_2071475_1 epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 359.0
TLS2_k127_2071475_2 - - - - 0.000008332 52.0
TLS2_k127_2109750_0 TPP binding domain protein K01652 GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 6.219e-254 793.0
TLS2_k127_2109750_1 Histidine kinase K00936 GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008561 598.0
TLS2_k127_2109750_2 belongs to the sigma-70 factor family K03090 GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 385.0
TLS2_k127_2109750_3 Protein of unknown function (DUF2785) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 297.0
TLS2_k127_2109750_4 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000169 164.0
TLS2_k127_2109750_5 - - - - 0.00000001078 63.0
TLS2_k127_2118172_0 Cysteine-rich domain - - - 6.322e-318 989.0
TLS2_k127_2118172_1 Histidine ammonia-lyase K01745 - 4.3.1.3 1.514e-238 762.0
TLS2_k127_2118172_2 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000001009 255.0
TLS2_k127_2118172_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000001806 265.0
TLS2_k127_2122236_0 Carbamoyl-phosphate synthase L chain, ATP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 557.0
TLS2_k127_2122236_1 Belongs to the peptidase S51 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001597 275.0
TLS2_k127_2122236_2 Putative esterase K07214 - - 0.000000000000000000000000000000000000000000264 175.0
TLS2_k127_2126477_0 Metallopeptidase family M24 K01265 GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 444.0
TLS2_k127_2126477_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 353.0
TLS2_k127_2126477_2 Transcriptional regulator sugar kinase K00845,K00886 - 2.7.1.2,2.7.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000592 304.0
TLS2_k127_2126477_3 - - - - 0.000000005121 62.0
TLS2_k127_2126477_4 - - - - 0.0000001201 61.0
TLS2_k127_2139765_0 NAD(P)H quinone oxidoreductase, PIG3 family K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008556 442.0
TLS2_k127_2139765_1 Ion channel K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009816 430.0
TLS2_k127_2139765_2 Transposase - - - 0.0000000001619 61.0
TLS2_k127_2151068_0 Adenosyl cobinamide kinase adenosyl cobinamide phosphate guanylyltransferase K02231 - 2.7.1.156,2.7.7.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004037 484.0
TLS2_k127_2151068_1 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 391.0
TLS2_k127_2151068_2 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000000000008839 192.0
TLS2_k127_2151068_3 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000002283 170.0
TLS2_k127_2151068_4 ECF transporter, substrate-specific component K16927 - - 0.00000000000000008817 81.0
TLS2_k127_2173611_0 Carboxyl transferase domain - - - 1.327e-267 840.0
TLS2_k127_2173611_1 acyl-CoA dehydrogenase K00248,K11410 GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681 1.3.8.1,1.3.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 594.0
TLS2_k127_2173611_2 Berberine and berberine like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 542.0
TLS2_k127_2173611_3 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004637 518.0
TLS2_k127_2173611_4 Hydroxymethylglutaryl-CoA lyase K01640,K18314 - 4.1.3.4,4.1.3.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 402.0
TLS2_k127_2173611_5 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 363.0
TLS2_k127_2173611_6 MerR, DNA binding - - - 0.000000000000000000000000000000000000000000000888 169.0
TLS2_k127_2173611_7 ThiS family K03636 - - 0.00000000000000000003389 98.0
TLS2_k127_2173611_8 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0000000000008375 69.0
TLS2_k127_2173611_9 Biotin carboxylase C-terminal domain - - - 0.00003284 48.0
TLS2_k127_2255071_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.7.8 0.0 1154.0
TLS2_k127_2255071_1 Insulinase (Peptidase family M16) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 5.922e-196 621.0
TLS2_k127_2255071_10 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000000000000775 166.0
TLS2_k127_2255071_11 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000002642 157.0
TLS2_k127_2255071_12 Protein of unknown function (DUF503) K09764 - - 0.00000000000000000000000000000000006146 139.0
TLS2_k127_2255071_13 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000001576 107.0
TLS2_k127_2255071_14 branched-chain amino acid - - - 0.00000000000000002777 93.0
TLS2_k127_2255071_2 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005022 494.0
TLS2_k127_2255071_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003632 383.0
TLS2_k127_2255071_4 Belongs to the ribF family K11753 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 345.0
TLS2_k127_2255071_5 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 336.0
TLS2_k127_2255071_6 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 332.0
TLS2_k127_2255071_7 Conserved hypothetical protein (DUF2461) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005393 248.0
TLS2_k127_2255071_8 Ribosome-binding factor A K02834 - - 0.0000000000000000000000000000000000000000000000000000000000004358 214.0
TLS2_k127_2255071_9 AzlC protein - - - 0.0000000000000000000000000000000000000000000000000000009203 204.0
TLS2_k127_2285741_0 choline dehydrogenase activity - - - 5.774e-253 791.0
TLS2_k127_2285741_1 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008488 323.0
TLS2_k127_2395019_0 DNA topoisomerase (ATP-hydrolyzing) K02470 - 5.99.1.3 0.0 1022.0
TLS2_k127_2395019_1 Amidohydrolase family - - - 1.136e-237 741.0
TLS2_k127_2395019_10 - - - - 0.0000000000000000008072 93.0
TLS2_k127_2395019_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00819 - 2.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 592.0
TLS2_k127_2395019_3 Belongs to the HpcH HpaI aldolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003853 439.0
TLS2_k127_2395019_4 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 416.0
TLS2_k127_2395019_5 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 361.0
TLS2_k127_2395019_6 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000003995 267.0
TLS2_k127_2395019_7 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000008503 202.0
TLS2_k127_2395019_8 Protein of unknown function (DUF456) K09793 - - 0.000000000000000000000000000000000000000000000121 177.0
TLS2_k127_2395019_9 - - - - 0.00000000000000000000000000322 124.0
TLS2_k127_2416187_0 Helicase associated domain (HA2) Add an annotation K03578 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 435.0
TLS2_k127_2416187_1 - - - - 0.000000000000000000000000000000000000000000000000002444 185.0
TLS2_k127_2416187_2 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000004678 171.0
TLS2_k127_2416187_3 YjbR - - - 0.00000000000000000000000000000000000000000008858 163.0
TLS2_k127_2416187_4 Flavodoxin domain K00230 - 1.3.5.3 0.000000000000000000000000000000000000001695 155.0
TLS2_k127_2416187_5 Transglycosylase associated protein - - - 0.00000000000000000000000000000003969 134.0
TLS2_k127_2426662_0 Ferric reductase like transmembrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005756 492.0
TLS2_k127_2426662_1 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005566 431.0
TLS2_k127_2426662_10 Formamidopyrimidine-DNA glycosylase N-terminal domain K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000002483 94.0
TLS2_k127_2426662_11 - - - - 0.00000000000003686 78.0
TLS2_k127_2426662_12 - - - - 0.0000000000001124 77.0
TLS2_k127_2426662_2 TIGRFAM phenazine biosynthesis protein PhzF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 316.0
TLS2_k127_2426662_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06889 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003167 310.0
TLS2_k127_2426662_4 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001686 293.0
TLS2_k127_2426662_5 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001162 295.0
TLS2_k127_2426662_6 glyoxalase bleomycin resistance protein K07032 - - 0.00000000000000000000000000000000000000000001509 166.0
TLS2_k127_2426662_7 EcsC protein family - - - 0.0000000000000000000000000000000000000000000553 181.0
TLS2_k127_2426662_8 - - - - 0.00000000000000000000000000000000000002814 144.0
TLS2_k127_2426662_9 KAP family P-loop domain - - - 0.00000000000000000000198 110.0
TLS2_k127_2462243_0 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006949 618.0
TLS2_k127_2462243_1 Cobyrinic acid ac-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 332.0
TLS2_k127_2462243_2 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001504 300.0
TLS2_k127_2462243_3 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000003988 168.0
TLS2_k127_2488955_0 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 347.0
TLS2_k127_2488955_1 PFAM iron-containing alcohol dehydrogenase K00217 - 1.3.1.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 315.0
TLS2_k127_2488955_2 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 308.0
TLS2_k127_2488955_3 glyoxalase bleomycin resistance protein dioxygenase K08234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002054 276.0
TLS2_k127_2488955_4 permease, DMT superfamily K11939 - - 0.00000000000000000000000000000000000000000009647 167.0
TLS2_k127_2488955_5 RibD C-terminal domain - - - 0.00000000000000000000006806 102.0
TLS2_k127_2488955_6 - - - - 0.000000000002672 78.0
TLS2_k127_2488955_7 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.0000000002504 69.0
TLS2_k127_2488955_8 HNH endonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00005258 49.0
TLS2_k127_25001_0 anion-transporting ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 426.0
TLS2_k127_25001_1 Transglycosylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 311.0
TLS2_k127_25001_2 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.000000000000000000000000000000000000000000197 176.0
TLS2_k127_2503336_0 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009622 344.0
TLS2_k127_2503336_1 PFAM FAD linked oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 346.0
TLS2_k127_2503336_2 Histidine kinase-like ATPase domain - - - 0.00000000000000000000000007625 113.0
TLS2_k127_2503336_3 SEC-C motif - - - 0.00001569 47.0
TLS2_k127_250967_0 Acetyl-CoA carboxylase, central region - - - 0.0 1154.0
TLS2_k127_250967_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 541.0
TLS2_k127_250967_2 Capsule synthesis protein K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 406.0
TLS2_k127_250967_3 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004518 325.0
TLS2_k127_250967_4 Flavodoxin domain K00230 - 1.3.5.3 0.000000000000000000000000000000000000000004809 164.0
TLS2_k127_250967_5 4'-phosphopantetheinyl transferase superfamily K06133 - - 0.00000000000000000000000000000008135 141.0
TLS2_k127_250967_6 - - - - 0.00000000000000000000000000002372 127.0
TLS2_k127_250967_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000018 117.0
TLS2_k127_250967_8 - - - - 0.000000000000000000456 100.0
TLS2_k127_2511809_0 von Willebrand factor type A domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007992 566.0
TLS2_k127_2511809_1 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006386 374.0
TLS2_k127_2511809_2 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 331.0
TLS2_k127_2511809_3 - - - - 0.0000000000007395 78.0
TLS2_k127_2515916_0 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.0 1207.0
TLS2_k127_2515916_1 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00239,K00278 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4,1.4.3.16 0.0 1020.0
TLS2_k127_2515916_10 succinate dehydrogenase K00242 - - 0.00000000000000000000000000000000000000000000000000000000004129 215.0
TLS2_k127_2515916_11 succinate dehydrogenase K00241 - - 0.000000000000000000000000000000000000000000000000000000001821 204.0
TLS2_k127_2515916_12 acyl-CoA-binding protein - - - 0.000000000000000000000000000005384 120.0
TLS2_k127_2515916_2 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K01848 - 5.4.99.2 1.034e-270 844.0
TLS2_k127_2515916_3 Peptidase family M20/M25/M40 K01436,K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009449 516.0
TLS2_k127_2515916_4 Luciferase-like monooxygenase K15510 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0019725,GO:0030312,GO:0031406,GO:0036094,GO:0042592,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0046983,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0055114,GO:0065007,GO:0065008,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 1.1.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 482.0
TLS2_k127_2515916_5 ABC transporter K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 432.0
TLS2_k127_2515916_6 Succinate dehydrogenase fumarate reductase K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 424.0
TLS2_k127_2515916_7 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 401.0
TLS2_k127_2515916_8 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009283 323.0
TLS2_k127_2515916_9 D-alanyl-D-alanine carboxypeptidase K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000008231 247.0
TLS2_k127_252624_0 helix_turn_helix, Lux Regulon K03556 - - 1e-323 1017.0
TLS2_k127_252624_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 452.0
TLS2_k127_252624_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005265 311.0
TLS2_k127_252624_3 Predicted membrane protein (DUF2306) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 298.0
TLS2_k127_252624_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003615 274.0
TLS2_k127_252624_5 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001895 270.0
TLS2_k127_252624_6 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000000000001571 80.0
TLS2_k127_2568972_0 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 539.0
TLS2_k127_2568972_1 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000005635 207.0
TLS2_k127_2568972_2 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.0000000000003226 83.0
TLS2_k127_2568972_3 anaphase-promoting complex binding - - - 0.000001003 53.0
TLS2_k127_2581129_0 Protein of unknown function (DUF3417) K00688 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.4.1.1 0.0 1257.0
TLS2_k127_2581129_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576 2.4.1.18 0.0 1182.0
TLS2_k127_2581129_10 Aminotransferase class-V K04487 GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007385 547.0
TLS2_k127_2581129_11 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007287 541.0
TLS2_k127_2581129_12 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 481.0
TLS2_k127_2581129_13 protein probably involved in trehalose biosynthesis K16146 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.7.1.175 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008313 465.0
TLS2_k127_2581129_14 DeoC/LacD family aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007016 461.0
TLS2_k127_2581129_15 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002593 420.0
TLS2_k127_2581129_16 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 393.0
TLS2_k127_2581129_17 Belongs to the enoyl-CoA hydratase isomerase family K01692 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 381.0
TLS2_k127_2581129_18 Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 367.0
TLS2_k127_2581129_19 Methionine synthase, vitamin-B12 independent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 348.0
TLS2_k127_2581129_2 Trehalose synthase K05343 GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576 3.2.1.1,5.4.99.16 0.0 1029.0
TLS2_k127_2581129_20 Bacterial transferase hexapeptide (six repeats) K00661 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.3.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 321.0
TLS2_k127_2581129_21 ACT domain - - - 0.000000000000000000000000000000000000000000000000000000001032 208.0
TLS2_k127_2581129_22 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000005947 183.0
TLS2_k127_2581129_23 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000001881 146.0
TLS2_k127_2581129_24 Putative adhesin - - - 0.0000000000000000000001964 108.0
TLS2_k127_2581129_25 Cbs domain - - - 0.000000000000000000008567 94.0
TLS2_k127_2581129_26 Putative esterase - - - 0.00001326 55.0
TLS2_k127_2581129_27 - - - - 0.0005849 51.0
TLS2_k127_2581129_3 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 4.88e-314 990.0
TLS2_k127_2581129_4 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 7.876e-305 949.0
TLS2_k127_2581129_5 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 1.594e-289 901.0
TLS2_k127_2581129_6 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 1.89e-264 826.0
TLS2_k127_2581129_7 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 6.054e-238 746.0
TLS2_k127_2581129_8 Belongs to the D-alanine--D-alanine ligase family - - - 3.266e-204 648.0
TLS2_k127_2581129_9 Belongs to the glycosyl hydrolase 57 family K16149 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 588.0
TLS2_k127_2597283_0 glutamine synthetase K01915 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 1.893e-258 801.0
TLS2_k127_2597283_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 1.109e-252 791.0
TLS2_k127_2597283_2 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000001086 172.0
TLS2_k127_2597283_4 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.1.2.11 0.0000000000000000000000001182 110.0
TLS2_k127_2603629_0 ABC-type multidrug transport system, ATPase and permease K06147,K06148 - - 4.85e-282 878.0
TLS2_k127_2603629_1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 616.0
TLS2_k127_2603629_10 - - - - 0.0000000000000000000000000000000000000000000001185 169.0
TLS2_k127_2603629_11 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000324 181.0
TLS2_k127_2603629_12 Abortive infection protein K07052 - - 0.000000000000000000000000000000000002829 149.0
TLS2_k127_2603629_13 Na+/H+ ion antiporter subunit K05569 - - 0.00000000000000000000000000000000002179 143.0
TLS2_k127_2603629_14 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.0000000000000000000000001372 110.0
TLS2_k127_2603629_15 monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.000000000000000000001301 101.0
TLS2_k127_2603629_16 Cupin domain - - - 0.000000000000000008269 93.0
TLS2_k127_2603629_19 Cupin domain - - - 0.00001138 54.0
TLS2_k127_2603629_2 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 600.0
TLS2_k127_2603629_3 Flavin-binding monooxygenase-like K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 499.0
TLS2_k127_2603629_4 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004757 461.0
TLS2_k127_2603629_5 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004445 382.0
TLS2_k127_2603629_6 Nodulation protein S (NodS) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001167 260.0
TLS2_k127_2603629_7 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000000000001282 233.0
TLS2_k127_2603629_8 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000002451 223.0
TLS2_k127_2603629_9 Na H antiporter - - - 0.0000000000000000000000000000000000000000000000000000000000002257 230.0
TLS2_k127_2606090_0 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 589.0
TLS2_k127_2606090_1 Alanine racemase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 464.0
TLS2_k127_2606090_2 Protein of unknown function (DUF445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008681 242.0
TLS2_k127_2606090_3 belongs to the nudix hydrolase family - - - 0.000000000000000000000000000000000000000000000003702 185.0
TLS2_k127_2607906_0 von Willebrand factor (vWF) type A domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 1.654e-292 928.0
TLS2_k127_2607906_1 Mg-chelatase subunit ChlI K03405 - 6.6.1.1 1.263e-222 699.0
TLS2_k127_2607906_10 2OG-Fe(II) oxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 316.0
TLS2_k127_2607906_11 Peptidase M50B-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 302.0
TLS2_k127_2607906_12 LURP-one-related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006335 266.0
TLS2_k127_2607906_13 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 0.00000000000000000000000000000000000000000000000000001127 190.0
TLS2_k127_2607906_14 Domain of unknown function (DUF4442) - - - 0.00000000000000000000000000000000000000000000000003112 201.0
TLS2_k127_2607906_15 FMN binding - - - 0.0000000000000000000000000000000000000000000001534 174.0
TLS2_k127_2607906_16 YCII-related domain - - - 0.00000000000000000000000000000000000000000008402 172.0
TLS2_k127_2607906_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005057 592.0
TLS2_k127_2607906_3 belongs to the sigma-70 factor family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 515.0
TLS2_k127_2607906_4 F420-dependent oxidoreductase K04091 - 1.14.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004771 467.0
TLS2_k127_2607906_5 ubiE/COQ5 methyltransferase family K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 449.0
TLS2_k127_2607906_6 MutL protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003697 460.0
TLS2_k127_2607906_7 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003932 403.0
TLS2_k127_2607906_8 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008187 373.0
TLS2_k127_2607906_9 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005515 351.0
TLS2_k127_2613378_0 4-alpha-D-((1- 4)-alpha-D-glucano)trehalose trehalohydrolase K01236 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0033942,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0071704,GO:1901575,GO:1901576 3.2.1.141 1.619e-235 742.0
TLS2_k127_2613378_1 dna ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 499.0
TLS2_k127_2613378_2 PFAM AFG1-family ATPase K06916 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003667 486.0
TLS2_k127_2613378_3 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 404.0
TLS2_k127_2613378_4 Cytochrome C biogenesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000193 287.0
TLS2_k127_2613378_5 MGS-like domain K01734 - 4.2.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000002029 242.0
TLS2_k127_2613378_6 Pyrimidine reductase, riboflavin biosynthesis K00082 - 1.1.1.193 0.000000000000000000000000000000000000000000000000000000000000002023 225.0
TLS2_k127_2613378_7 - - - - 0.0000000000000000000000000000000000000000000007804 171.0
TLS2_k127_2687673_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 555.0
TLS2_k127_2687673_1 glycine cleavage system K00605 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000057 510.0
TLS2_k127_2687673_2 - - - - 0.000000000000001897 76.0
TLS2_k127_2729294_0 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 8.053e-238 747.0
TLS2_k127_2729294_1 Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 499.0
TLS2_k127_2729294_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 361.0
TLS2_k127_2729294_3 PFAM bifunctional deaminase-reductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001008 279.0
TLS2_k127_2736338_0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 398.0
TLS2_k127_2736338_1 Glucose Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 391.0
TLS2_k127_2736338_2 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005452 270.0
TLS2_k127_2736338_3 cobalamin (vitamin B12) biosynthesis CbiX protein - - - 0.00001719 46.0
TLS2_k127_2805541_0 Glycine betaine K05845 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 342.0
TLS2_k127_2805541_1 PFAM binding-protein-dependent transport systems inner membrane component K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002108 288.0
TLS2_k127_2805541_2 ABC transporter K05847 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002818 276.0
TLS2_k127_2805541_3 Binding-protein-dependent transport system inner membrane component K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008654 265.0
TLS2_k127_2805541_4 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001449 254.0
TLS2_k127_2806944_0 COGs COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004597 318.0
TLS2_k127_2806944_1 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000003977 224.0
TLS2_k127_2806944_2 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000000000000000000000000000000000003315 220.0
TLS2_k127_2806944_3 PFAM regulatory protein AsnC Lrp family K03719 - - 0.00000000000000000000000000165 115.0
TLS2_k127_2813216_0 D-ala D-ala ligase C-terminus K03802 - 6.3.2.29,6.3.2.30 2.4e-242 766.0
TLS2_k127_2813216_1 Bacterial transcriptional activator domain - - - 1.069e-236 793.0
TLS2_k127_2813216_2 asparagine K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 286.0
TLS2_k127_2813216_3 DNA-binding transcriptional activator of the SARP family - - - 0.00000000000000000000000000000000000000000000000000000003086 217.0
TLS2_k127_2813216_4 Histidine kinase K07653 GO:0000160,GO:0003674,GO:0003824,GO:0004721,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023052,GO:0035556,GO:0036211,GO:0040007,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 0.00000000000000000000001133 105.0
TLS2_k127_2845396_0 Ammonium Transporter Family K03320 - - 5.066e-211 664.0
TLS2_k127_2845396_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 497.0
TLS2_k127_2845396_2 ABC transporter transmembrane region K16013,K16014 - - 0.0000000000000000000000000000000000000000000000000000000000000000007729 236.0
TLS2_k127_2845396_3 Belongs to the P(II) protein family K04751 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000005361 189.0
TLS2_k127_2859418_0 Thioredoxin-like - - - 1.591e-255 802.0
TLS2_k127_2859418_1 Acyl-CoA dehydrogenase N terminal - - - 8.455e-231 722.0
TLS2_k127_2859418_2 Glycosyl hydrolase family 1 K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 550.0
TLS2_k127_2859418_3 Binding-protein-dependent transport system inner membrane component K10233 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 493.0
TLS2_k127_2859418_4 PFAM binding-protein-dependent transport systems inner membrane component K10234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 488.0
TLS2_k127_2859418_5 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000000003654 198.0
TLS2_k127_2859418_6 - - - - 0.000000000000000001491 88.0
TLS2_k127_2862732_0 carboxylase K11263 - 6.3.4.14,6.4.1.2,6.4.1.3 2.828e-291 903.0
TLS2_k127_2862732_1 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 7.278e-267 827.0
TLS2_k127_2862732_10 - - - - 0.000000000000000000000000000000000000000000000009302 188.0
TLS2_k127_2862732_11 ABC-2 family transporter protein K01992 - - 0.00000000000001742 86.0
TLS2_k127_2862732_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain II K01835,K01840 - 5.4.2.2,5.4.2.8 4.307e-223 704.0
TLS2_k127_2862732_3 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.8.1.4 3.55e-204 654.0
TLS2_k127_2862732_4 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006565 498.0
TLS2_k127_2862732_5 Aldehyde dehydrogenase K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 437.0
TLS2_k127_2862732_6 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007913 404.0
TLS2_k127_2862732_7 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009347 346.0
TLS2_k127_2862732_8 AIG2-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000001791 247.0
TLS2_k127_2862732_9 ABC transporter, ATP-binding protein K01990 - - 0.000000000000000000000000000000000000000000000000000000000001113 214.0
TLS2_k127_2876967_0 MMPL family K06994,K20470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004635 575.0
TLS2_k127_2876967_1 TetR Family - - - 0.000000000000000000000000000000233 131.0
TLS2_k127_2878525_0 Evidence 2b Function of strongly homologous gene K00612 - - 5.697e-275 854.0
TLS2_k127_2878525_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 4.889e-213 682.0
TLS2_k127_2878525_10 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005077 334.0
TLS2_k127_2878525_11 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000054 314.0
TLS2_k127_2878525_12 SIS domain K03271,K15669 - 2.7.7.71,5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000001657 270.0
TLS2_k127_2878525_13 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007917 246.0
TLS2_k127_2878525_14 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002835 271.0
TLS2_k127_2878525_15 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000006096 171.0
TLS2_k127_2878525_16 TrkA C-terminal domain protein K07085 - - 0.000000000000000000000000005198 111.0
TLS2_k127_2878525_17 - - - - 0.0000000000000000000001426 98.0
TLS2_k127_2878525_18 DNA-binding transcription factor activity - - - 0.0000005588 59.0
TLS2_k127_2878525_2 Alcohol dehydrogenase GroES-associated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 595.0
TLS2_k127_2878525_3 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005703 493.0
TLS2_k127_2878525_4 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008012 490.0
TLS2_k127_2878525_5 Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005453 483.0
TLS2_k127_2878525_6 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 476.0
TLS2_k127_2878525_7 cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004544 438.0
TLS2_k127_2878525_8 PFAM glycosyl transferase family 9 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008307 432.0
TLS2_k127_2878525_9 Sigma factor PP2C-like phosphatases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 411.0
TLS2_k127_287910_0 Glycosyl transferase family 2 - - - 7.628e-235 746.0
TLS2_k127_287910_1 1-aminocyclopropane-1-carboxylate deaminase K01505,K05396 - 3.5.99.7,4.4.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003725 551.0
TLS2_k127_287910_2 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00322,K00382 - 1.6.1.1,1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008671 543.0
TLS2_k127_287910_3 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008504 257.0
TLS2_k127_287910_4 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002609 254.0
TLS2_k127_287910_5 Thioredoxin K00384,K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.9 0.0000000000000000000000000000000000000000000006959 187.0
TLS2_k127_2908640_0 Alpha/beta-hydrolase family - - - 1.129e-232 748.0
TLS2_k127_2908640_1 trisaccharide binding K03556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071 604.0
TLS2_k127_2908640_2 Sulfate permease family K03321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007683 439.0
TLS2_k127_2908640_3 ABC1 family K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000003346 244.0
TLS2_k127_2908640_4 - - - - 0.00000000000000000000000000000000000000000000000000000000003781 209.0
TLS2_k127_2908640_5 Short C-terminal domain - - - 0.00000000000000000000001067 111.0
TLS2_k127_2908640_6 - - - - 0.0000000000216 74.0
TLS2_k127_2908640_7 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0004705 50.0
TLS2_k127_2925461_0 Protein of unknown function (DUF3618) - - - 0.00000000000000000000000000000000000000007484 162.0
TLS2_k127_2925461_1 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000000000000000000000000000007332 135.0
TLS2_k127_2925461_2 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.00000000000000000000001732 111.0
TLS2_k127_2973551_0 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 439.0
TLS2_k127_2973551_1 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 298.0
TLS2_k127_2973551_2 COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002572 247.0
TLS2_k127_2973551_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000005496 187.0
TLS2_k127_2973551_4 luxR family - - - 0.00000000000000000000000001774 120.0
TLS2_k127_2973551_5 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000000000002547 98.0
TLS2_k127_2973551_6 CAAX protease self-immunity - - - 0.000000000000000000423 102.0
TLS2_k127_2973551_7 Domain of unknown function (DUF5122) beta-propeller - - - 0.000002909 51.0
TLS2_k127_2973551_8 Winged helix DNA-binding domain K09927 - - 0.0009916 48.0
TLS2_k127_2980337_0 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004741 552.0
TLS2_k127_2980337_1 Maf-like protein K06287 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000007854 262.0
TLS2_k127_2980337_2 Pfam:DUF385 - - - 0.00000000000000000000000000000000000000000000000000000001143 200.0
TLS2_k127_2980337_3 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000008448 211.0
TLS2_k127_2980337_4 SnoaL-like domain - - - 0.00000000000000000000000000000000000001084 149.0
TLS2_k127_2985137_0 Peptidase dimerisation domain K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007848 406.0
TLS2_k127_2985137_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 364.0
TLS2_k127_2985137_2 CutC family K06201 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001256 277.0
TLS2_k127_2985137_3 nUDIX hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000003849 230.0
TLS2_k127_2985137_4 - - - - 0.00000000000000000000000000000000000000001046 166.0
TLS2_k127_2985137_5 Protein of unknown function (DUF4031) - - - 0.0000000000000000000000000000005391 126.0
TLS2_k127_301034_0 NIF3 (NGG1p interacting factor 3) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 469.0
TLS2_k127_301034_1 oxidoreductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009715 462.0
TLS2_k127_301034_2 phosphoglycerate mutase K02226,K22316 - 3.1.26.4,3.1.3.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007955 413.0
TLS2_k127_301034_3 Zn-ribbon protein, possibly nucleic acid-binding K07164 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000007802 252.0
TLS2_k127_301034_4 Pfam Uncharacterised protein family UPF0047 - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000001813 214.0
TLS2_k127_301034_5 Protein of unknown function (DUF3052) - - - 0.00000000000000000000000000000000000000000000000001483 185.0
TLS2_k127_301034_6 Protein of unknown function (DUF998) - - - 0.000000000000000000000000000000000000000000002326 172.0
TLS2_k127_301034_7 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.00000000000000000000000000000000000000002899 160.0
TLS2_k127_301034_8 Domain of unknown function (DUF1918) - - - 0.00000000000000000000003533 102.0
TLS2_k127_301034_9 pyruvate dehydrogenase (acetyl-transferring) activity K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204 1.2.4.1 0.0009671 50.0
TLS2_k127_3031857_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 7.472e-220 696.0
TLS2_k127_3031857_1 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00658 - 2.3.1.61 1.574e-199 667.0
TLS2_k127_3031857_2 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 309.0
TLS2_k127_3031857_3 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000004336 213.0
TLS2_k127_3031857_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000007326 155.0
TLS2_k127_3031857_5 - - - - 0.000000000000000004762 87.0
TLS2_k127_3031857_6 Serine threonine protein kinase - - - 0.00000000000975 75.0
TLS2_k127_3043370_0 Belongs to the complex I 49 kDa subunit family K00333 - 1.6.5.3 1.814e-209 660.0
TLS2_k127_3043370_1 overlaps another CDS with the same product name K08981 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000823 427.0
TLS2_k127_3043370_2 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000465 356.0
TLS2_k127_3043370_3 Bacterial PH domain K09167 - - 0.00000000000000000000000000000000000000000000000000002386 196.0
TLS2_k127_3043370_4 - - - - 0.000000000000000000000002373 113.0
TLS2_k127_3043370_5 Protein of unknown function (DUF1684) K09164 - - 0.000000000000001798 76.0
TLS2_k127_3043370_6 Domain of unknown function (DUF2520) - - - 0.0005555 44.0
TLS2_k127_304505_0 TIGRFAM Carbon-monoxide dehydrogenase, large subunit K03520 - 1.2.5.3 0.0 1364.0
TLS2_k127_304505_1 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 304.0
TLS2_k127_304505_2 PFAM ATPase associated with various cellular activities, AAA_5 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001138 295.0
TLS2_k127_304505_3 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005547 273.0
TLS2_k127_304505_4 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000001487 219.0
TLS2_k127_309827_0 phytoene K01854 - 5.4.99.9 1.993e-207 659.0
TLS2_k127_309827_1 alcohol dehydrogenase K00001,K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 467.0
TLS2_k127_309827_10 - - - - 0.000000000000000000001114 102.0
TLS2_k127_309827_11 Domain of unknown function (DUF3817) - GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000002044 104.0
TLS2_k127_309827_12 Diguanylate cyclase - - - 0.000000297 59.0
TLS2_k127_309827_13 Glucose / Sorbosone dehydrogenase - - - 0.00004872 46.0
TLS2_k127_309827_2 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 415.0
TLS2_k127_309827_3 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 327.0
TLS2_k127_309827_4 Carotenoid biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001503 244.0
TLS2_k127_309827_5 Cyclase dehydrase - - - 0.00000000000000000000000000000000000000000000000000000000000123 213.0
TLS2_k127_309827_6 Domain of unknown function (DUF4126) - - - 0.0000000000000000000000000000000000000000000000000001143 192.0
TLS2_k127_309827_7 SURF1 family - - - 0.00000000000000000000000000000000000002181 153.0
TLS2_k127_309827_8 RF-1 domain K15034 - - 0.0000000000000000000000000000000000009872 152.0
TLS2_k127_309827_9 spheroidene monooxygenase - - - 0.0000000000000000000000000002434 118.0
TLS2_k127_3117484_0 PFAM NmrA family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 366.0
TLS2_k127_3117484_1 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 327.0
TLS2_k127_3117484_2 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001216 288.0
TLS2_k127_3117484_3 Peptidase M28 - - - 0.00000000000000000000000000000000000000000001396 177.0
TLS2_k127_3117484_4 - - - - 0.000000000000007697 85.0
TLS2_k127_3126707_0 Sigma-70 region 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004828 535.0
TLS2_k127_3126707_1 PhoD-like phosphatase K01113 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006645 431.0
TLS2_k127_3126707_2 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000001226 210.0
TLS2_k127_3126707_3 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0000000000000000000000000007302 116.0
TLS2_k127_3126707_4 - - - - 0.0000001204 63.0
TLS2_k127_3137641_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 4.2.1.9 2.49e-309 953.0
TLS2_k127_3137641_1 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 1.349e-308 956.0
TLS2_k127_3137641_10 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000001011 177.0
TLS2_k127_3137641_11 glyoxalase III activity - - - 0.0000000000000000000000000000001191 137.0
TLS2_k127_3137641_12 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.000000000000000000000000001068 113.0
TLS2_k127_3137641_13 DJ-1/PfpI family - - - 0.000000000000000000003443 95.0
TLS2_k127_3137641_14 Lysyl oxidase - - - 0.00000000000000005503 91.0
TLS2_k127_3137641_15 Domain of unknown function (DUF1707) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000004123 74.0
TLS2_k127_3137641_16 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000049 59.0
TLS2_k127_3137641_17 Pyridoxamine 5'-phosphate oxidase - - - 0.000001111 59.0
TLS2_k127_3137641_2 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 1.212e-255 797.0
TLS2_k127_3137641_3 Multicopper oxidase - - - 2.201e-202 648.0
TLS2_k127_3137641_4 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 601.0
TLS2_k127_3137641_5 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 570.0
TLS2_k127_3137641_6 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006796 471.0
TLS2_k127_3137641_7 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 376.0
TLS2_k127_3137641_8 Small subunit of acetolactate synthase K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008698 283.0
TLS2_k127_3137641_9 cobalamin (vitamin B12) biosynthesis CbiX protein - - - 0.0000000000000000000000000000000000000000000000000000000003918 213.0
TLS2_k127_316697_0 Uroporphyrinogen-III synthase HemD K01719,K13542 - 2.1.1.107,4.2.1.75 5.523e-222 712.0
TLS2_k127_316697_1 belongs to the sigma-70 factor family K03088 - - 7.714e-206 646.0
TLS2_k127_316697_10 Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily K01661 - 4.1.3.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 519.0
TLS2_k127_316697_11 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000612 501.0
TLS2_k127_316697_12 GDP-mannose 4,6 dehydratase K01784 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 474.0
TLS2_k127_316697_13 Belongs to the ALAD family K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 473.0
TLS2_k127_316697_14 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 GO:0008150,GO:0040007 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006145 475.0
TLS2_k127_316697_15 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 443.0
TLS2_k127_316697_16 Phosphate acyltransferases - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008658 445.0
TLS2_k127_316697_17 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 GO:0008150,GO:0040007 4.2.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 388.0
TLS2_k127_316697_18 haloacid dehalogenase-like hydrolase - GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009059 363.0
TLS2_k127_316697_19 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009066 352.0
TLS2_k127_316697_2 Aminotransferase K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 617.0
TLS2_k127_316697_20 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 336.0
TLS2_k127_316697_21 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 359.0
TLS2_k127_316697_22 Belongs to the MenA family. Type 1 subfamily K02548 GO:0003674,GO:0003824,GO:0004659,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 334.0
TLS2_k127_316697_23 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01911,K02549 GO:0003674,GO:0003824,GO:0008150,GO:0008756,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0040007 4.2.1.113,6.2.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 331.0
TLS2_k127_316697_24 Cytochrome c biogenesis protein K06196 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 333.0
TLS2_k127_316697_25 phosphoglycerate mutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004545 313.0
TLS2_k127_316697_26 Cytochrome c-type biogenesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005303 308.0
TLS2_k127_316697_27 Uncharacterised BCR, YnfA/UPF0060 family K09771 GO:0005575,GO:0005576 - 0.00000000000000000000000000000000000000000000000000000008533 202.0
TLS2_k127_316697_28 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000003797 189.0
TLS2_k127_316697_29 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000000000000009727 182.0
TLS2_k127_316697_3 DEAD DEAH box helicase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 551.0
TLS2_k127_316697_30 Redoxin - - - 0.00000000000000000000000000000000000000000000000001053 192.0
TLS2_k127_316697_31 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000000000000000003417 158.0
TLS2_k127_316697_32 Acetyltransferase (GNAT) family K03824,K09964 - - 0.0000000000000000000000000000000001073 147.0
TLS2_k127_316697_33 Glutaredoxin-like domain (DUF836) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000007599 138.0
TLS2_k127_316697_34 Helix-turn-helix domain - - - 0.000000000000000000000000009198 112.0
TLS2_k127_316697_35 Esterase PHB depolymerase K03932 - - 0.00000000000000000000000002675 119.0
TLS2_k127_316697_36 Phospholipase_D-nuclease N-terminal - - - 0.0000000000000000000000003837 109.0
TLS2_k127_316697_37 Alpha beta hydrolase - - - 0.000000000000000000001608 104.0
TLS2_k127_316697_38 - - - - 0.000000000000001096 81.0
TLS2_k127_316697_39 Protein of unknown function (DUF4229) - - - 0.00000000005807 70.0
TLS2_k127_316697_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007483 557.0
TLS2_k127_316697_40 Mitochondrial domain of unknown function (DUF1713) - - - 0.000000002484 59.0
TLS2_k127_316697_41 Glyoxalase-like domain - - - 0.00006128 51.0
TLS2_k127_316697_5 Histone deacetylase domain K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008028 546.0
TLS2_k127_316697_6 ResB-like family K07399 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 568.0
TLS2_k127_316697_7 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 570.0
TLS2_k127_316697_8 Peptidase inhibitor I9 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003446 551.0
TLS2_k127_316697_9 Secretory lipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 546.0
TLS2_k127_318984_0 Domain of unknown function (DUF4032) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007556 574.0
TLS2_k127_318984_1 Belongs to the ABC transporter superfamily K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 308.0
TLS2_k127_318984_2 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000000000333 189.0
TLS2_k127_3240024_0 Pregnancy-associated plasma protein-A - - - 1.57e-285 897.0
TLS2_k127_3240024_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005193 436.0
TLS2_k127_3240024_2 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004203 364.0
TLS2_k127_3240024_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000003661 174.0
TLS2_k127_3240024_4 Pregnancy-associated plasma protein-A - - - 0.0000000000000000000000000000003314 126.0
TLS2_k127_3240024_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07171 - - 0.000000000000000000000005385 104.0
TLS2_k127_3240024_6 endonuclease exonuclease phosphatase - - - 0.000000002025 60.0
TLS2_k127_3240024_7 FCD - - - 0.00000002854 62.0
TLS2_k127_3267548_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 1.564e-214 670.0
TLS2_k127_3267548_1 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 506.0
TLS2_k127_3267548_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002271 445.0
TLS2_k127_3267548_3 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000009781 225.0
TLS2_k127_3267548_4 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000000000000000000000000000000007574 140.0
TLS2_k127_3273753_0 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 550.0
TLS2_k127_3273753_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005873 493.0
TLS2_k127_3273753_10 membrane - - - 0.00000000000000000000000000000000000000000000000000004833 193.0
TLS2_k127_3273753_11 - - - - 0.000000000000000000000000000000000000005584 156.0
TLS2_k127_3273753_12 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000000984 151.0
TLS2_k127_3273753_13 alpha beta hydrolase fold - - - 0.00000000000000000000000000000000001171 150.0
TLS2_k127_3273753_14 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000002604 98.0
TLS2_k127_3273753_2 Beta propeller domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009893 466.0
TLS2_k127_3273753_3 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005571 429.0
TLS2_k127_3273753_4 Glycosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 295.0
TLS2_k127_3273753_5 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000985 290.0
TLS2_k127_3273753_6 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001079 273.0
TLS2_k127_3273753_7 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002801 247.0
TLS2_k127_3273753_9 DNA repair - - - 0.00000000000000000000000000000000000000000000000000000000004279 216.0
TLS2_k127_3302795_0 Required for chromosome condensation and partitioning K03529 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0 1368.0
TLS2_k127_3302795_1 PFAM cytochrome bd ubiquinol oxidase subunit I K00425 - 1.10.3.14 1.888e-217 683.0
TLS2_k127_3302795_2 ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD K06148,K16013,K16014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 552.0
TLS2_k127_3302795_3 cytochrome d ubiquinol oxidase, subunit K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 490.0
TLS2_k127_3302795_4 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 395.0
TLS2_k127_3302795_5 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 335.0
TLS2_k127_3302795_6 ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC K16012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 318.0
TLS2_k127_3302795_7 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.000000000000000000000000007658 112.0
TLS2_k127_3302795_8 - - - - 0.0000000000000001142 83.0
TLS2_k127_3302795_9 structural constituent of ribosome K02911 - - 0.00000000000001134 74.0
TLS2_k127_330991_0 Acetyl propionyl-CoA carboxylase, alpha subunit - - - 6.848e-208 651.0
TLS2_k127_330991_1 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000008533 253.0
TLS2_k127_3310298_0 2-oxoglutarate dehydrogenase K00164,K01616 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 0.0 1745.0
TLS2_k127_3310298_1 PFAM malic K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005861 544.0
TLS2_k127_3310298_10 - - - - 0.00000000000000000000000001395 109.0
TLS2_k127_3310298_2 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005754 471.0
TLS2_k127_3310298_3 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 358.0
TLS2_k127_3310298_4 belongs to the sigma-70 factor family K03090 GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009085 304.0
TLS2_k127_3310298_5 Nickel-containing superoxide dismutase K00518 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000004322 237.0
TLS2_k127_3310298_6 FR47-like protein - - - 0.000000000000000000000000000000000000000000000000000000101 200.0
TLS2_k127_3310298_7 G-D-S-L family lipolytic protein - - - 0.00000000000000000000000000000000000000000000395 183.0
TLS2_k127_3310298_8 anti-sigma regulatory factor K04757 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 2.7.11.1 0.0000000000000000000000000000000000000002332 154.0
TLS2_k127_3310298_9 signal peptide processing - - - 0.000000000000000000000000007595 126.0
TLS2_k127_3347766_0 assembly protein sufB K09014 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 503.0
TLS2_k127_3347766_1 FeS assembly protein SufD K09015 GO:0008150,GO:0009605,GO:0009607,GO:0040007,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007147 467.0
TLS2_k127_3347766_2 ATPases associated with a variety of cellular activities K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 417.0
TLS2_k127_3347766_3 Rieske-like [2Fe-2S] domain K05710 - - 0.00000000000000000000000000000000000000004116 157.0
TLS2_k127_3353468_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.6.5,3.1.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 559.0
TLS2_k127_3353468_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009525 520.0
TLS2_k127_3353468_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 514.0
TLS2_k127_3353468_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 356.0
TLS2_k127_3353468_4 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.7 0.000000000000000000000000000000000000000000000000000001156 198.0
TLS2_k127_3353468_5 Preprotein translocase, YajC subunit K03210 - - 0.00000000000000000000003688 102.0
TLS2_k127_338345_0 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 602.0
TLS2_k127_338345_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 539.0
TLS2_k127_338345_2 Fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 428.0
TLS2_k127_338345_3 Transposase - - - 0.00000000000000000000000000000000000000000000000000000002607 209.0
TLS2_k127_338345_4 Protein of unknown function (DUF3037) - - - 0.00000000000000000000000000000000000001253 151.0
TLS2_k127_338345_5 Serine threonine protein kinase involved in cell cycle control - - - 0.000000000000000001058 87.0
TLS2_k127_340587_0 helicase K10843 - 3.6.4.12 9.187e-309 954.0
TLS2_k127_341612_0 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007221 597.0
TLS2_k127_341612_1 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 490.0
TLS2_k127_341612_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 418.0
TLS2_k127_341612_3 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 399.0
TLS2_k127_341612_4 Pfam Sulfatase K01130 GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004065,GO:0004098,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005783,GO:0005788,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0008484,GO:0009987,GO:0012505,GO:0016192,GO:0016787,GO:0016788,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034774,GO:0035578,GO:0036230,GO:0042119,GO:0042582,GO:0043167,GO:0043169,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044255,GO:0044422,GO:0044424,GO:0044432,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0097708,GO:0099503,GO:1901135,GO:1901564,GO:1903509 3.1.6.1 0.000000000000000000000000000000000000004547 151.0
TLS2_k127_341612_5 regulation of translation - - - 0.0000000000000000000000001043 113.0
TLS2_k127_343171_0 Exporter of polyketide K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002689 468.0
TLS2_k127_343171_1 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 423.0
TLS2_k127_343171_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008819 400.0
TLS2_k127_343171_3 Histidine kinase K02478 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 339.0
TLS2_k127_343171_4 Filamentation induced by cAMP protein fic - - - 0.0000000000000000000000000000000000000000000000000000000003329 212.0
TLS2_k127_343171_5 transcriptional regulator - - - 0.0000000000000000001455 104.0
TLS2_k127_343171_6 Bacterial regulatory proteins, tetR family - - - 0.0000608 53.0
TLS2_k127_3468833_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 5.461e-214 672.0
TLS2_k127_3468833_1 PTS system, Lactose/Cellobiose specific IIB subunit K02768,K02769,K02770 - 2.7.1.202 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 499.0
TLS2_k127_3513326_0 GXGXG motif K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.0 2381.0
TLS2_k127_3513326_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 1.207e-197 632.0
TLS2_k127_3513326_10 Protein of unknown function (DUF2752) - - - 0.00009106 46.0
TLS2_k127_3513326_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009477 550.0
TLS2_k127_3513326_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 440.0
TLS2_k127_3513326_4 Indole-3-glycerol phosphate synthase K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 407.0
TLS2_k127_3513326_5 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 347.0
TLS2_k127_3513326_6 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 292.0
TLS2_k127_3513326_7 DoxX family - - - 0.0000000000000000000000000000000000000000002917 167.0
TLS2_k127_3513326_8 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000001853 137.0
TLS2_k127_3513326_9 - - - - 0.00001034 56.0
TLS2_k127_3519175_0 Anthranilate synthase component I, N terminal region K01657 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 6.825e-236 739.0
TLS2_k127_3519175_1 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 GO:0008150,GO:0040007 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000000000000002103 214.0
TLS2_k127_3519175_2 Tryptophan-associated transmembrane protein (Trp_oprn_chp) - - - 0.00000000000000001973 95.0
TLS2_k127_3519175_3 - - - - 0.000000000009533 74.0
TLS2_k127_3519175_4 Protein of unknown function (DUF2752) - - - 0.0000000006682 67.0
TLS2_k127_3534639_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 3.27e-265 826.0
TLS2_k127_3534639_1 Branched-chain amino acid aminotransferase K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008199 566.0
TLS2_k127_3534639_2 Evidence 2b Function of strongly homologous gene - - - 0.0000000000000000000000000000009789 126.0
TLS2_k127_3537474_0 Acetyl-CoA carboxylase, central region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 523.0
TLS2_k127_3551906_0 Flavin containing amine oxidoreductase K06955 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 323.0
TLS2_k127_3551906_1 N-acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003344 286.0
TLS2_k127_3551906_2 Hydrolase of X-linked nucleoside diphosphate N terminal - - - 0.000000000000000000000000000000000000199 158.0
TLS2_k127_3551906_3 - - - - 0.0000000000000000000000000000001188 128.0
TLS2_k127_3551906_4 Acetyltransferase (GNAT) domain K17840 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016020,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0034069,GO:0044237,GO:0044248,GO:0044464,GO:0047921,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658 2.3.1.59 0.0000000000000000000000000000001774 139.0
TLS2_k127_3555993_0 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0 1114.0
TLS2_k127_3555993_1 ABC1 family - - - 2.513e-198 628.0
TLS2_k127_3555993_10 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003913 314.0
TLS2_k127_3555993_11 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002819 264.0
TLS2_k127_3555993_12 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000109 248.0
TLS2_k127_3555993_13 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000176 242.0
TLS2_k127_3555993_14 PFAM Glutamine cyclotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001988 240.0
TLS2_k127_3555993_15 helix_turn_helix ASNC type - - - 0.00000000000000000000000000000000000000000000000000000000000000001126 229.0
TLS2_k127_3555993_16 - - - - 0.000000000000000000000000000000000000000000000000000000000001082 220.0
TLS2_k127_3555993_17 Molybdopterin K03635,K21142 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 0.00000000000000000000000000000000000000000000000000006333 194.0
TLS2_k127_3555993_18 - - - - 0.0000000000000000000000000000000000000000000000001134 184.0
TLS2_k127_3555993_19 UBA THIF-type NAD FAD binding - - - 0.0000000000000000000000000000000000000000000000003094 194.0
TLS2_k127_3555993_2 mannose-ethanolamine phosphotransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000978 556.0
TLS2_k127_3555993_21 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000000000001543 166.0
TLS2_k127_3555993_22 TfoX N-terminal domain - - - 0.0000000000000000000000000000000000000003864 151.0
TLS2_k127_3555993_23 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000001481 142.0
TLS2_k127_3555993_24 YCII-related domain - - - 0.000000000000000000000000000000001826 135.0
TLS2_k127_3555993_25 - - - - 0.000000000000000000000007793 105.0
TLS2_k127_3555993_26 light absorption K06893 - - 0.00000000000001111 79.0
TLS2_k127_3555993_27 FAD binding domain K14672,K15972 - 1.14.13.200 0.00000000000001701 77.0
TLS2_k127_3555993_28 - - - - 0.000000000001637 68.0
TLS2_k127_3555993_29 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.00000000563 60.0
TLS2_k127_3555993_3 Cys/Met metabolism PLP-dependent enzyme K01739,K01761 - 2.5.1.48,4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002616 539.0
TLS2_k127_3555993_4 hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 475.0
TLS2_k127_3555993_5 PFAM CoA-transferase family III K01796 - 5.1.99.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008058 407.0
TLS2_k127_3555993_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 390.0
TLS2_k127_3555993_7 Epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007058 407.0
TLS2_k127_3555993_8 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005794 366.0
TLS2_k127_3555993_9 Domain present in PSD-95, Dlg, and ZO-1/2. K07177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000813 323.0
TLS2_k127_3556949_0 Type II secretion system K12511 - - 0.00000000000000000000000000000002356 127.0
TLS2_k127_3556949_1 TadE-like protein - - - 0.00000000000000000000004279 103.0
TLS2_k127_3556949_2 - - - - 0.00000000000000000000357 103.0
TLS2_k127_3556949_3 - - - - 0.0000000000001077 73.0
TLS2_k127_3556949_4 Putative Flp pilus-assembly TadE/G-like - - - 0.000003416 57.0
TLS2_k127_3594128_0 Cell envelope-related transcriptional attenuator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009201 329.0
TLS2_k127_3594128_1 May play a role in the intracellular transport of hydrophobic ligands - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000002024 232.0
TLS2_k127_3594128_2 Ferric uptake regulator family K03711,K09825 - - 0.000000000000000000000000000000000000000000000000000002911 195.0
TLS2_k127_3594128_3 DsrE/DsrF-like family - - - 0.000000000000000000000000000000000000000000000000000003083 193.0
TLS2_k127_3594128_4 Belongs to the GcvT family K06980 - - 0.00000000000000000000971 95.0
TLS2_k127_3594128_5 exo-alpha-(2->6)-sialidase activity - - - 0.0003691 51.0
TLS2_k127_3614697_0 tRNA synthetase class II core domain (G, H, P, S and T) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 3.858e-262 818.0
TLS2_k127_3614697_1 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007195 583.0
TLS2_k127_3614697_10 transcriptional K22298 GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0044212,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000001619 128.0
TLS2_k127_3614697_11 Bacterial regulatory proteins, tetR family - - - 0.000000000005066 70.0
TLS2_k127_3614697_12 - - - - 0.0000000008439 67.0
TLS2_k127_3614697_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 382.0
TLS2_k127_3614697_3 PFAM YibE F-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 342.0
TLS2_k127_3614697_4 PFAM ABC-3 protein K09816,K09819 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 314.0
TLS2_k127_3614697_5 Belongs to the bacterial solute-binding protein 9 family K02077,K09815,K09818 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 320.0
TLS2_k127_3614697_6 ATPases associated with a variety of cellular activities K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007323 269.0
TLS2_k127_3614697_7 spheroidene monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000956 254.0
TLS2_k127_3614697_8 Ferric uptake regulator family K03711 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000004457 218.0
TLS2_k127_3614697_9 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000003806 220.0
TLS2_k127_3650412_0 Argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 2.331e-228 717.0
TLS2_k127_3650412_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 7.09e-213 679.0
TLS2_k127_3650412_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 607.0
TLS2_k127_3650412_3 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006427 516.0
TLS2_k127_3650412_4 acetylornithine aminotransferase K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 504.0
TLS2_k127_3650412_5 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 441.0
TLS2_k127_3650412_6 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 449.0
TLS2_k127_3650412_7 Belongs to the DNA glycosylase MPG family K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000005833 248.0
TLS2_k127_3650412_8 Regulates arginine biosynthesis genes K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000001119 215.0
TLS2_k127_3659040_0 Type ii secretion system protein e K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 464.0
TLS2_k127_3659040_1 bacterial-type flagellum organization - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 366.0
TLS2_k127_3659040_2 Type ii secretion system K12510 - - 0.000000000000000000000000000000000006796 155.0
TLS2_k127_3679636_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 9.718e-207 647.0
TLS2_k127_3679636_1 Belongs to the glycerate kinase type-1 family K00865 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 452.0
TLS2_k127_3679636_10 - - - - 0.0000000000000000000000000839 109.0
TLS2_k127_3679636_11 Aldo/keto reductase family - - - 0.000000000000000000000002495 105.0
TLS2_k127_3679636_2 PspA/IM30 family K03969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004092 358.0
TLS2_k127_3679636_3 Peptidase family M48 K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 356.0
TLS2_k127_3679636_4 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 295.0
TLS2_k127_3679636_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006536 265.0
TLS2_k127_3679636_6 Iron-sulphur cluster biosynthesis K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564 - 0.000000000000000000000000000000000000000000000000009647 203.0
TLS2_k127_3679636_7 Protein of unknown function (DUF3043) - GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 - 0.000000000000000000000000000000000000000000000006413 181.0
TLS2_k127_3679636_8 PFAM Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000003452 162.0
TLS2_k127_3679636_9 - - - - 0.000000000000000000000000003856 122.0
TLS2_k127_3713324_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 504.0
TLS2_k127_3713324_1 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 336.0
TLS2_k127_3713324_2 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003624 259.0
TLS2_k127_3713324_3 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000009053 219.0
TLS2_k127_3713324_4 permease, DMT superfamily K11939 - - 0.0000000000000000000000000000000000000000000004861 171.0
TLS2_k127_3719733_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1191.0
TLS2_k127_3719733_1 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 6.724e-305 940.0
TLS2_k127_3719733_2 Catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 563.0
TLS2_k127_3719733_3 Formiminoglutamate deiminase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 556.0
TLS2_k127_3719733_4 Peptidase family M28 K02083,K06016 - 3.5.1.6,3.5.1.87,3.5.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 492.0
TLS2_k127_3719733_5 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007463 265.0
TLS2_k127_3719733_6 Family of unknown function (DUF695) - - - 0.00000000000000000000000000000000000000000000000000000000000000001716 245.0
TLS2_k127_3719733_7 Protein of unknown function (DUF3467) - - - 0.0000000000000000000001575 101.0
TLS2_k127_3719733_8 Protein of unknown function (DUF4235) - - - 0.00000000000000000001161 96.0
TLS2_k127_3737211_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009839 601.0
TLS2_k127_3737211_1 Cysteine synthase K21148 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 539.0
TLS2_k127_3737211_10 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000000000000000003433 166.0
TLS2_k127_3737211_11 ThiS family K03636 GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.00000000000000000000000000000000000001723 147.0
TLS2_k127_3737211_12 Oxidoreductase molybdopterin binding - - - 0.00000000000000000000002693 108.0
TLS2_k127_3737211_2 Provides the (R)-glutamate required for cell wall biosynthesis K01776 GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 403.0
TLS2_k127_3737211_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007155 385.0
TLS2_k127_3737211_4 Beta-lactamase superfamily domain - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005845 322.0
TLS2_k127_3737211_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000003425 280.0
TLS2_k127_3737211_6 Isochorismatase family K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000001107 286.0
TLS2_k127_3737211_7 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.00000000000000000000000000000000000000000000000000000000000000004051 226.0
TLS2_k127_3737211_8 JAB/MPN domain K21140 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016787,GO:0019344,GO:0019538,GO:0019752,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.13.1.6 0.000000000000000000000000000000000000000000000000000000000001265 222.0
TLS2_k127_3737211_9 Domain of unknown function (DUF2017) - - - 0.000000000000000000000000000000000000000000000000908 180.0
TLS2_k127_3750655_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.0 1146.0
TLS2_k127_3750655_1 Metallopeptidase family M24 - - - 1.216e-261 809.0
TLS2_k127_3750655_10 - - - - 0.0000000000000000000001672 111.0
TLS2_k127_3750655_11 - - - - 0.000000000004851 77.0
TLS2_k127_3750655_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 606.0
TLS2_k127_3750655_3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 501.0
TLS2_k127_3750655_4 CO dehydrogenase flavoprotein C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000393 399.0
TLS2_k127_3750655_5 geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 373.0
TLS2_k127_3750655_6 Cro/C1-type HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006469 275.0
TLS2_k127_3750655_7 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000003734 257.0
TLS2_k127_3750655_8 Transketolase, pyrimidine binding domain K21417 - - 0.00000000000000000000000000000000000000000000000000000000007786 212.0
TLS2_k127_3750655_9 Thiamine-binding protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000008045 164.0
TLS2_k127_3751448_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.93e-322 1002.0
TLS2_k127_3751448_1 C-terminal four TMM region of protein-O-mannosyltransferase K00728 GO:0000030,GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006493,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0034645,GO:0035268,GO:0035269,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.109 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 539.0
TLS2_k127_3751448_2 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000654 404.0
TLS2_k127_3751448_3 TatD related DNase K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 344.0
TLS2_k127_3751448_4 G5 K21688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 327.0
TLS2_k127_3751448_5 Putative esterase - - - 0.00000000000000000000000000000000000000000000009158 169.0
TLS2_k127_3751448_6 CGNR zinc finger - - - 0.00000000000000000000000000000000001135 147.0
TLS2_k127_3751448_7 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.00000001079 66.0
TLS2_k127_3779716_0 DEAD DEAH box helicase K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.0 1190.0
TLS2_k127_3779716_1 lysine 2,3-aminomutase K01843 - 5.4.3.2 4.057e-253 786.0
TLS2_k127_3779716_10 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 - 2.3.1.51 0.000000000000000000001051 96.0
TLS2_k127_3779716_2 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 614.0
TLS2_k127_3779716_3 Dehydrogenase K18012 - 1.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 494.0
TLS2_k127_3779716_4 Belongs to the peptidase M24B family K01271,K01274 - 3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008352 487.0
TLS2_k127_3779716_5 aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003802 481.0
TLS2_k127_3779716_6 5'-3' exonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000718 409.0
TLS2_k127_3779716_7 Diacylglycerol kinase K07029 GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 341.0
TLS2_k127_3779716_8 Regulator K03719 - - 0.000000000000000000000000000000000000000000000000000000000002023 228.0
TLS2_k127_3779716_9 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000000000005792 149.0
TLS2_k127_3798967_0 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.1.11.5 0.0 1221.0
TLS2_k127_3798967_1 Helix-turn-helix domain - - - 6.608e-241 775.0
TLS2_k127_3798967_10 response to pH - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001201 260.0
TLS2_k127_3798967_11 protein conserved in cyanobacteria - - - 0.000000000000000000000000000000000000000000000000000000000000001363 224.0
TLS2_k127_3798967_13 - - - - 0.00000000000000000000000000000000003142 139.0
TLS2_k127_3798967_14 - - - - 0.000000000000000000000000004458 113.0
TLS2_k127_3798967_15 Phospholipid methyltransferase - - - 0.000000000000000000000002 115.0
TLS2_k127_3798967_16 - - - - 0.000000000000000000001336 100.0
TLS2_k127_3798967_17 Multicopper oxidase K06324 - 1.16.3.3 0.00005114 50.0
TLS2_k127_3798967_18 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00383 - 1.8.1.7 0.0006003 48.0
TLS2_k127_3798967_2 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 7.134e-196 635.0
TLS2_k127_3798967_3 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 584.0
TLS2_k127_3798967_4 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 582.0
TLS2_k127_3798967_5 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006995 441.0
TLS2_k127_3798967_6 Diacylglycerol kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 380.0
TLS2_k127_3798967_7 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004645 344.0
TLS2_k127_3798967_8 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 312.0
TLS2_k127_3798967_9 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000743 279.0
TLS2_k127_3800076_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 GO:0008150,GO:0040007 5.4.2.10 1.571e-201 639.0
TLS2_k127_3800076_1 Pantothenic acid kinase K00867 GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 458.0
TLS2_k127_3800076_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 314.0
TLS2_k127_3800076_3 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000002088 252.0
TLS2_k127_3800076_4 Ribosomal protein S9/S16 K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000007493 217.0
TLS2_k127_3826153_0 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 538.0
TLS2_k127_3826153_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006032 405.0
TLS2_k127_3826153_10 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000004481 217.0
TLS2_k127_3826153_11 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000001487 175.0
TLS2_k127_3826153_12 Transcriptional regulator PadR-like family K10947 - - 0.00000000000000000000000000000000000000002435 159.0
TLS2_k127_3826153_13 DNA binding domain - - - 0.0000000000000000000000000000000000000001031 155.0
TLS2_k127_3826153_14 Peptidase family S41 - - - 0.00000000000000000000000000351 114.0
TLS2_k127_3826153_2 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 411.0
TLS2_k127_3826153_3 Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 393.0
TLS2_k127_3826153_4 ABC transporter K02017,K02018 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 398.0
TLS2_k127_3826153_5 Molybdate ABC transporter K02017,K02018 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000785 330.0
TLS2_k127_3826153_6 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 295.0
TLS2_k127_3826153_7 Bacterial extracellular solute-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000000001391 249.0
TLS2_k127_3826153_8 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000005349 243.0
TLS2_k127_3826153_9 glyoxalase - - - 0.0000000000000000000000000000000000000000000000000000000000000005613 225.0
TLS2_k127_3830486_0 AlkA N-terminal domain K01247,K13529 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005293 567.0
TLS2_k127_3830486_1 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 425.0
TLS2_k127_3830486_10 Involved in cell division - - - 0.0000000000000000001518 101.0
TLS2_k127_3830486_11 - - - - 0.0000000008987 62.0
TLS2_k127_3830486_2 Glutamine amidotransferase of anthranilate synthase K01658,K01664 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 331.0
TLS2_k127_3830486_3 Glycosyl transferase family group 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 294.0
TLS2_k127_3830486_4 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004377 271.0
TLS2_k127_3830486_5 Rhomboid family K19225 - 3.4.21.105 0.000000000000000000000000000000000000000000000000000000000000000000006805 244.0
TLS2_k127_3830486_6 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000000000000001456 214.0
TLS2_k127_3830486_7 Bacterial protein of unknown function (DUF881) - - - 0.00000000000000000000000000000000000000000000000000000000001456 214.0
TLS2_k127_3830486_8 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000000005343 176.0
TLS2_k127_3830486_9 Transmembrane domain of unknown function (DUF3566) - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000724 157.0
TLS2_k127_387029_0 ABC transporter K15738 - - 2.281e-227 719.0
TLS2_k127_387029_1 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003236 411.0
TLS2_k127_387029_2 GHMP kinases C terminal K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 336.0
TLS2_k127_3916047_0 Aminotransferase class-V - - - 4.711e-283 881.0
TLS2_k127_3916047_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 1.8e-227 752.0
TLS2_k127_3916047_2 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 604.0
TLS2_k127_3916047_3 Uncharacterized conserved protein (DUF2183) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 386.0
TLS2_k127_3916047_4 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000001749 185.0
TLS2_k127_3916047_5 Amino acid-binding act domain protein - - - 0.0000000000000000000000000000000000000000004393 168.0
TLS2_k127_399174_0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit K01844 - 5.4.3.3 1.056e-278 872.0
TLS2_k127_399174_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 512.0
TLS2_k127_399174_2 Dimerisation domain of d-ornithine 4,5-aminomutase K18011 - 5.4.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008193 414.0
TLS2_k127_399174_3 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 365.0
TLS2_k127_399174_4 3-aminobutyryl-CoA ammonia lyase K18014 - 4.3.1.14 0.0000000000000000000000000000000000000000000000000005356 189.0
TLS2_k127_399174_5 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000212 172.0
TLS2_k127_399174_6 FxsA cytoplasmic membrane protein K07113 - - 0.00000000000000000000000000000000000000004481 156.0
TLS2_k127_4024545_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 0.0 1208.0
TLS2_k127_4024545_1 Carboxyl transferase domain K01966 GO:0003674,GO:0003824,GO:0003989,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009317,GO:0009987,GO:0015977,GO:0016020,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0030312,GO:0032787,GO:0032991,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:1901575,GO:1902494 2.1.3.15,6.4.1.3 3.946e-287 888.0
TLS2_k127_4024545_2 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 462.0
TLS2_k127_4024545_3 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003757 371.0
TLS2_k127_4024545_4 Adenylate cyclase regulatory domain K01768 GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005504,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009268,GO:0009628,GO:0009975,GO:0009987,GO:0010851,GO:0010854,GO:0010855,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0030234,GO:0031279,GO:0031406,GO:0033293,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098772,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000004959 271.0
TLS2_k127_4024545_5 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000007124 243.0
TLS2_k127_4024545_6 PFAM GtrA family protein - - - 0.0000000000000000000000000000000000000000001489 172.0
TLS2_k127_4024545_7 Bacterial PH domain - - - 0.0000000000000000000000000000000000008153 154.0
TLS2_k127_4024545_8 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000007348 144.0
TLS2_k127_4024545_9 Acyl-CoA carboxylase epsilon subunit - - - 0.000000000000001004 79.0
TLS2_k127_4030913_0 Phosphopantetheine attachment site - - - 0.0 1454.0
TLS2_k127_4030913_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 1.263e-272 844.0
TLS2_k127_4030913_2 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 433.0
TLS2_k127_4030913_3 Biotin-protein ligase, N terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001215 276.0
TLS2_k127_4030913_4 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008125 274.0
TLS2_k127_4030913_5 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001891 251.0
TLS2_k127_4030913_6 Belongs to the cytochrome c oxidase bacterial subunit CtaF family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000001243 190.0
TLS2_k127_4030913_7 Belongs to the P-Pant transferase superfamily K06133 - - 0.00000000000000000000000000000000000000001621 168.0
TLS2_k127_4037242_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 4.693e-318 998.0
TLS2_k127_4037242_1 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K05565,K14086 - - 4.764e-275 873.0
TLS2_k127_4037242_10 PFAM Sodium calcium exchanger membrane region K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 401.0
TLS2_k127_4037242_11 Nodulation protein S (NodS) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 331.0
TLS2_k127_4037242_12 cheY-homologous receiver domain K02485 - - 0.00000000000000000000000000000000000000000000000000000000000000000844 233.0
TLS2_k127_4037242_13 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000001518 234.0
TLS2_k127_4037242_14 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000019 203.0
TLS2_k127_4037242_15 Isochorismatase family - - - 0.00000000000000000000000000000000000000148 148.0
TLS2_k127_4037242_16 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K21600 - - 0.0000000000000000000000000000000000005439 151.0
TLS2_k127_4037242_17 Multisubunit Na H antiporter MnhC subunit K05567 - - 0.000000000000000000000000000003844 123.0
TLS2_k127_4037242_18 multisubunit Na H antiporter MnhE subunit K05569 - - 0.000000000000000000000000001606 120.0
TLS2_k127_4037242_19 monovalent cation:proton antiporter activity K05571 - - 0.000000000000000000002071 103.0
TLS2_k127_4037242_2 Sulfate permease family K03321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 605.0
TLS2_k127_4037242_20 Heavy-metal-associated domain - - - 0.0000000000000000001602 90.0
TLS2_k127_4037242_21 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.0000000000001004 77.0
TLS2_k127_4037242_22 Sigma factor PP2C-like phosphatases - - - 0.00000000001205 67.0
TLS2_k127_4037242_23 Peptidase family M23 - - - 0.0000000008817 66.0
TLS2_k127_4037242_3 acetyl-CoA hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 533.0
TLS2_k127_4037242_4 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 519.0
TLS2_k127_4037242_5 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006195 497.0
TLS2_k127_4037242_6 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 482.0
TLS2_k127_4037242_7 Belongs to the GarS family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000032 457.0
TLS2_k127_4037242_8 Short-chain dehydrogenase reductase sdr - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 437.0
TLS2_k127_4037242_9 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 426.0
TLS2_k127_4043335_0 acyl-CoA dehydrogenase - - - 6.057e-214 670.0
TLS2_k127_4043335_1 Belongs to the HpcH HpaI aldolase family K01644,K14447 - 4.1.3.34,5.4.99.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 550.0
TLS2_k127_4043335_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001654 275.0
TLS2_k127_4043335_3 - - - - 0.000000000000000000003089 94.0
TLS2_k127_405574_0 involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000001146 254.0
TLS2_k127_4057129_0 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 548.0
TLS2_k127_4057129_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000626 455.0
TLS2_k127_4057129_2 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 449.0
TLS2_k127_4057129_3 Domain of unknown function (DUF4389) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009333 345.0
TLS2_k127_4057129_4 sequence-specific DNA binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 316.0
TLS2_k127_4057129_5 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000005571 226.0
TLS2_k127_4057129_6 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000000005366 228.0
TLS2_k127_4057129_7 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000001905 223.0
TLS2_k127_4057129_8 Bacterial low temperature requirement A protein (LtrA) - - - 0.0000000000000000000000000000000000000003638 153.0
TLS2_k127_4057129_9 - - - - 0.0000000000000000000000002067 110.0
TLS2_k127_409276_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370 GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008940,GO:0009056,GO:0009628,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016491,GO:0016661,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036293,GO:0036294,GO:0042126,GO:0042128,GO:0042221,GO:0042493,GO:0043436,GO:0043602,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070482,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071453,GO:0071704,GO:0071731,GO:0071732,GO:0071941,GO:0071944,GO:0097366,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:2001057 1.7.5.1 0.0 1194.0
TLS2_k127_409276_1 Nitrate reductase beta subunit K00371 - 1.7.5.1 1.053e-289 932.0
TLS2_k127_409276_10 IstB-like ATP binding protein - - - 0.0000004909 56.0
TLS2_k127_409276_11 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000002613 56.0
TLS2_k127_409276_12 Transposase IS116 IS110 IS902 - - - 0.0003457 48.0
TLS2_k127_409276_2 Belongs to the arginase family K01476 - 3.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 436.0
TLS2_k127_409276_3 Nitrate reductase gamma subunit K00370,K00374 GO:0001666,GO:0006950,GO:0008150,GO:0009628,GO:0036293,GO:0050896,GO:0070482 1.7.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 369.0
TLS2_k127_409276_4 Nitrate reductase, delta subunit K00373 - - 0.00000000000000000000000000000000000000000000000000000000004093 231.0
TLS2_k127_409276_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.0000000000000000000000000000000000000000000000000007839 191.0
TLS2_k127_409276_6 - - - - 0.000000000000000000000000000000000000000000000008932 175.0
TLS2_k127_409276_7 helix_turn_helix, mercury resistance - - - 0.0000000008884 59.0
TLS2_k127_409276_8 Integrase core domain - - - 0.000000001 63.0
TLS2_k127_409276_9 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000001966 58.0
TLS2_k127_4160471_0 Glutamine amidotransferase domain K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.081e-242 754.0
TLS2_k127_4160471_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 553.0
TLS2_k127_4160471_10 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000000000000000000003887 175.0
TLS2_k127_4160471_11 Methyltransferase domain - - - 0.00000000000000000000000000000000000001657 160.0
TLS2_k127_4160471_12 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 0.00000000000000000000000000000000005582 153.0
TLS2_k127_4160471_13 Inosine-uridine preferring nucleoside hydrolase K01239,K01250,K10213,K12700 - 3.2.2.1,3.2.2.8 0.00000000000000000000003015 116.0
TLS2_k127_4160471_14 SAM-dependent - - - 0.00000002131 60.0
TLS2_k127_4160471_2 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 539.0
TLS2_k127_4160471_3 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008777 496.0
TLS2_k127_4160471_4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006781 483.0
TLS2_k127_4160471_5 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 387.0
TLS2_k127_4160471_6 Glycoprotease family K14742 GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000002874 218.0
TLS2_k127_4160471_7 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000038 212.0
TLS2_k127_4160471_8 ATPase or kinase K06925 GO:0008150,GO:0040007 - 0.000000000000000000000000000000000000000000000000001672 199.0
TLS2_k127_4160471_9 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000001613 177.0
TLS2_k127_419006_0 trisaccharide binding - - - 8.361e-256 809.0
TLS2_k127_419006_1 AAA domain - - - 4.778e-234 750.0
TLS2_k127_419006_10 Hydrolase of the alpha beta-hydrolase K07020 - - 0.000000000000000000000000000000000000000000000000000000000000000000002232 241.0
TLS2_k127_419006_11 PFAM UbiA prenyltransferase K09833 GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009987,GO:0010189,GO:0018130,GO:0042360,GO:0042362,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617 2.5.1.115,2.5.1.116 0.00000000000000000000000000000000000000000000000002111 194.0
TLS2_k127_419006_12 - - - - 0.00000000000000000000000000000000000000000000008949 184.0
TLS2_k127_419006_13 DoxX - - - 0.0000000000000000000000000000000000000000005774 163.0
TLS2_k127_419006_14 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000000000000000001817 158.0
TLS2_k127_419006_16 PFAM Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000009149 133.0
TLS2_k127_419006_17 Thioesterase - - - 0.0000000000000000000000000000004508 139.0
TLS2_k127_419006_18 Putative zinc-finger - GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - 0.000000000000000000000000158 108.0
TLS2_k127_419006_19 Biotin-requiring enzyme K02160 - - 0.00000000000000000005573 94.0
TLS2_k127_419006_2 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004473 564.0
TLS2_k127_419006_20 Family of unknown function (DUF5317) - - - 0.0001457 54.0
TLS2_k127_419006_3 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007988 555.0
TLS2_k127_419006_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 452.0
TLS2_k127_419006_5 Inositol monophosphatase family K01092,K05602 GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 377.0
TLS2_k127_419006_6 Sigma-70, region 4 K03088 GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 339.0
TLS2_k127_419006_7 Belongs to the SOS response-associated peptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 334.0
TLS2_k127_419006_8 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 323.0
TLS2_k127_419006_9 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005972 302.0
TLS2_k127_4193347_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 1.338e-205 659.0
TLS2_k127_4193347_1 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004284 524.0
TLS2_k127_4193347_2 RNA 2'-O ribose methyltransferase substrate binding K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003031 391.0
TLS2_k127_4193347_3 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000006709 201.0
TLS2_k127_4193347_4 Phosphotransferase enzyme family - - - 0.0000000000000000002793 90.0
TLS2_k127_4194430_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008667 374.0
TLS2_k127_4194430_1 ABC transporter K05847 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 330.0
TLS2_k127_4194430_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 304.0
TLS2_k127_4194430_3 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 308.0
TLS2_k127_4194430_4 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950,K13940 - 2.7.6.3,4.1.2.25 0.0000000000000000000000000000000000000000000000000000000000003971 222.0
TLS2_k127_4194430_5 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633,K13940 GO:0008150,GO:0040007 1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8 0.0000000000000000000000000000000000000000000003952 169.0
TLS2_k127_4194430_6 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000001727 171.0
TLS2_k127_4194430_8 regulation of cell shape - - - 0.00002335 56.0
TLS2_k127_4204121_0 ATP-dependent DNA helicase K03657 GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 1.35e-311 972.0
TLS2_k127_4204121_1 Bifunctional purine biosynthesis protein PurH K00602 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.2.3,3.5.4.10 2.54e-242 759.0
TLS2_k127_4204121_10 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004951 338.0
TLS2_k127_4204121_11 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000747 338.0
TLS2_k127_4204121_12 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007979 277.0
TLS2_k127_4204121_13 PFAM cobalamin B12-binding domain protein K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000009283 234.0
TLS2_k127_4204121_14 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000008603 251.0
TLS2_k127_4204121_15 PspC domain - - - 0.000000000000000000000000000000000000000000000000000000000000001082 239.0
TLS2_k127_4204121_16 Peptidase family M23 K21471 - - 0.00000000000000000000000000000000000000000004172 171.0
TLS2_k127_4204121_17 CHRD domain - - - 0.000000000000000000000000000000000000001077 171.0
TLS2_k127_4204121_18 Membrane - - - 0.00000000000000000000000000000000000001267 166.0
TLS2_k127_4204121_19 - - - - 0.00000000000000000000000000000005455 130.0
TLS2_k127_4204121_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 560.0
TLS2_k127_4204121_20 - - - - 0.00000000000000000000000000000008672 129.0
TLS2_k127_4204121_21 RDD family - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000006312 136.0
TLS2_k127_4204121_22 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000001699 126.0
TLS2_k127_4204121_23 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000000000003588 113.0
TLS2_k127_4204121_24 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000006264 104.0
TLS2_k127_4204121_26 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000002074 66.0
TLS2_k127_4204121_27 - - - - 0.0005883 50.0
TLS2_k127_4204121_28 - - - - 0.0009972 45.0
TLS2_k127_4204121_3 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003034 527.0
TLS2_k127_4204121_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000603 489.0
TLS2_k127_4204121_5 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 459.0
TLS2_k127_4204121_6 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007997 428.0
TLS2_k127_4204121_7 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 412.0
TLS2_k127_4204121_8 PspC domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 404.0
TLS2_k127_4204121_9 with the alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 349.0
TLS2_k127_420658_0 homogentisate 12-dioxygenase K00451 - 1.13.11.5 2.794e-233 726.0
TLS2_k127_420658_1 Fumarylacetoacetase K01555 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000389 573.0
TLS2_k127_420658_2 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 380.0
TLS2_k127_420658_3 histidyl-tRNA synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000332 237.0
TLS2_k127_420658_4 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000007955 133.0
TLS2_k127_4217178_0 PFAM FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000646 504.0
TLS2_k127_4217178_1 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004545 459.0
TLS2_k127_4217178_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005341 319.0
TLS2_k127_4232030_0 phenylacetate-CoA oxygenase K02609 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007436 540.0
TLS2_k127_4232030_1 Oxidoreductase FAD-binding domain K02613 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008222 470.0
TLS2_k127_4232030_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 GO:0000166,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0036094,GO:0040007,GO:0042083,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050797,GO:0070402,GO:0097159,GO:1901265,GO:1901363 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007137 394.0
TLS2_k127_4232030_3 Phenylacetate-CoA oxygenase, PaaI subunit K02611 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008461 354.0
TLS2_k127_4232030_4 Iron-sulfur cluster assembly protein K02612 - - 0.0000000000000000000000000000000000000000000000000000000000004071 221.0
TLS2_k127_4232030_5 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000001098 207.0
TLS2_k127_4232030_6 PFAM Phenylacetic acid degradation B K02610 - - 0.0000000000000000000000000000000000000000000005017 183.0
TLS2_k127_4232030_7 CGNR zinc finger - - - 0.0000000000000000000000000000000000000005427 155.0
TLS2_k127_4234963_0 Diacylglycerol kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 442.0
TLS2_k127_4234963_1 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 422.0
TLS2_k127_4234963_2 Helicase conserved C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 307.0
TLS2_k127_4234963_3 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 319.0
TLS2_k127_4234963_4 PFAM phosphoesterase, PA-phosphatase related K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000002044 213.0
TLS2_k127_42397_0 glucose sorbosone - - - 0.0 1038.0
TLS2_k127_42397_1 Alpha amylase, catalytic domain K05341 - 2.4.1.4 7.663e-282 879.0
TLS2_k127_42397_10 Bacterial-like globin K06886 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000002617 215.0
TLS2_k127_42397_11 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000007008 201.0
TLS2_k127_42397_12 Thioesterase K07107 - - 0.00000000000000000000000000000000000000000000000005012 181.0
TLS2_k127_42397_13 OsmC-like protein K04063 - - 0.000000000000000000000000000000000000000000000017 195.0
TLS2_k127_42397_14 - - - - 0.0000000000000000000000000000000008632 147.0
TLS2_k127_42397_15 transcriptional regulator, XRE family - - - 0.00000000000000000000000000000003977 134.0
TLS2_k127_42397_16 ABC transporter - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000006981 118.0
TLS2_k127_42397_17 Thioesterase K07107 - - 0.00000000000000000000000000002663 134.0
TLS2_k127_42397_18 - - - - 0.000000000000000000003625 99.0
TLS2_k127_42397_2 PFAM Alpha amylase, catalytic K01187 - 3.2.1.20 6.77e-238 747.0
TLS2_k127_42397_3 IMP dehydrogenase / GMP reductase domain K00088 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.1.1.205 9.406e-228 713.0
TLS2_k127_42397_4 NmrA-like family - - - 1.291e-225 713.0
TLS2_k127_42397_5 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004722 517.0
TLS2_k127_42397_6 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 458.0
TLS2_k127_42397_7 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 441.0
TLS2_k127_42397_8 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 431.0
TLS2_k127_42397_9 mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 362.0
TLS2_k127_424704_0 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 7.741e-197 627.0
TLS2_k127_424704_1 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000004092 247.0
TLS2_k127_4278338_0 Dihydroxyacetone kinase K00863 - 2.7.1.28,2.7.1.29,4.6.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004233 493.0
TLS2_k127_4278338_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 GO:0000988,GO:0000990,GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043254,GO:0044087,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000742 466.0
TLS2_k127_4278338_10 - - - - 0.000005686 53.0
TLS2_k127_4278338_11 Glycosyl hydrolases family 16 - - - 0.00002981 54.0
TLS2_k127_4278338_2 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 360.0
TLS2_k127_4278338_3 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 346.0
TLS2_k127_4278338_4 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 325.0
TLS2_k127_4278338_5 Putative sugar-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000008063 236.0
TLS2_k127_4278338_6 Dak2 K05879 - 2.7.1.121 0.0000000000000000000000000000000000000000000000000000000000000001481 227.0
TLS2_k127_4278338_7 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000007006 148.0
TLS2_k127_4278338_8 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.0000000000000002663 87.0
TLS2_k127_4278338_9 - - - - 0.000005297 53.0
TLS2_k127_4292839_0 Peptidase family S49 K04773,K04774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 539.0
TLS2_k127_4292839_1 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000002044 206.0
TLS2_k127_4326193_0 pyruvate phosphate dikinase, PEP K01006 - 2.7.9.1 0.0 1090.0
TLS2_k127_4326193_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 1.474e-230 729.0
TLS2_k127_4326193_2 ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 592.0
TLS2_k127_4326193_3 Phosphohydrolase-associated domain K01129 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 530.0
TLS2_k127_4326193_4 Reductase C-terminal K00529 - 1.18.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006761 511.0
TLS2_k127_4326193_5 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000000001652 209.0
TLS2_k127_4326193_6 glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000004042 199.0
TLS2_k127_4328921_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.1.1.12 1.461e-292 926.0
TLS2_k127_4328921_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.6.5,3.1.7.2 3.2e-242 754.0
TLS2_k127_4328921_2 MMPL family K06994 - - 7.84e-219 700.0
TLS2_k127_4328921_3 histidyl-tRNA synthetase K01892 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 584.0
TLS2_k127_4328921_4 Domain of Unknown Function (DUF349) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006647 433.0
TLS2_k127_4328921_5 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008253 316.0
TLS2_k127_4328921_6 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000002992 211.0
TLS2_k127_4354216_0 oxidoreductase activity - - - 0.0 1071.0
TLS2_k127_4354216_1 Tachylectin K03418 - 3.5.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006271 591.0
TLS2_k127_4354216_2 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 529.0
TLS2_k127_4354216_3 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005409 516.0
TLS2_k127_4354216_4 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 507.0
TLS2_k127_4354216_5 Helix-turn-helix diphteria tox regulatory element K03709 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000629 330.0
TLS2_k127_4354216_6 Sulfite exporter TauE/SafE - - - 0.00000000000000000000000000000000000001773 153.0
TLS2_k127_4354216_7 Metal-sensitive transcriptional repressor - - - 0.00000000000000000000001687 113.0
TLS2_k127_4354216_8 Rhodanese Homology Domain - - - 0.0000000000000000000003247 103.0
TLS2_k127_4446421_0 dehydrogenase subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 361.0
TLS2_k127_4446421_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000002541 259.0
TLS2_k127_4446421_2 6-phosphogluconolactonase K01057 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 0.00000000000000000000000000000004117 142.0
TLS2_k127_4452045_0 domain protein K01421 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 633.0
TLS2_k127_4452045_1 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 419.0
TLS2_k127_4452045_2 - - - - 0.0000000000000000000000000000000000000000005871 164.0
TLS2_k127_4465130_0 helix_turn_helix, Lux Regulon - - - 2.11e-213 695.0
TLS2_k127_4481402_0 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008448 441.0
TLS2_k127_4481402_1 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009899 275.0
TLS2_k127_4481402_2 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000004056 265.0
TLS2_k127_4481402_3 Bax inhibitor 1 like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007398 260.0
TLS2_k127_4481402_4 ACT domain K03567 - - 0.000000000000000000000000000000000000000000000000000000000001654 221.0
TLS2_k127_4481402_5 FR47-like protein - - - 0.0000000000000000000000000000000000000000003369 163.0
TLS2_k127_4481402_6 Domain of unknown function (DUF4287) - - - 0.00000000000000000000000000000007171 129.0
TLS2_k127_4481402_7 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.0000000000000000000000004558 110.0
TLS2_k127_4504707_0 Putative peptidoglycan binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 458.0
TLS2_k127_4504707_1 Belongs to the ABC transporter superfamily K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 440.0
TLS2_k127_4504707_2 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway K15525 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016137,GO:0016138,GO:0016787,GO:0016810,GO:0016811,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 3.5.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 339.0
TLS2_k127_4504707_3 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000462 264.0
TLS2_k127_4504707_4 Ferredoxin K05524 - - 0.00000000000000000000000000000000000000000000000000000000000001619 218.0
TLS2_k127_4504707_5 FR47-like protein K22476 - 2.3.1.1 0.0000000000000000000000000000000000000000000000000000000000001338 226.0
TLS2_k127_4504707_6 - - - - 0.0002874 51.0
TLS2_k127_4516363_0 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 521.0
TLS2_k127_4516363_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 293.0
TLS2_k127_4516363_2 - - - - 0.0000000000000000000000000000000000000000006431 166.0
TLS2_k127_4516363_3 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000538 131.0
TLS2_k127_4516363_4 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.00000000001048 78.0
TLS2_k127_4524643_0 alpha-glucosidase K01187 - 3.2.1.20 2.737e-232 740.0
TLS2_k127_4524643_1 DNA helicase - - - 3.223e-216 679.0
TLS2_k127_4524643_10 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000003037 201.0
TLS2_k127_4524643_11 DNA helicase - - - 0.000000000000000002537 99.0
TLS2_k127_4524643_12 Methyltransferase K00587 - 2.1.1.100 0.00000000000002394 81.0
TLS2_k127_4524643_13 Transposase - - - 0.0000000000002003 73.0
TLS2_k127_4524643_14 DegT/DnrJ/EryC1/StrS aminotransferase family K10907 - - 0.0004832 49.0
TLS2_k127_4524643_2 Bacterial extracellular solute-binding protein K10232 - - 1.042e-198 628.0
TLS2_k127_4524643_3 RmlD substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 521.0
TLS2_k127_4524643_4 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004397 518.0
TLS2_k127_4524643_5 lacI family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 447.0
TLS2_k127_4524643_6 epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 422.0
TLS2_k127_4524643_7 InterPro IPR014922 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005442 245.0
TLS2_k127_4524643_8 Rifampin ADP-ribosyl transferase K19062 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000572 251.0
TLS2_k127_4524643_9 Thiopurine S-methyltransferase (TPMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002994 242.0
TLS2_k127_4555843_0 SNF2 Helicase protein - - - 2.985e-220 706.0
TLS2_k127_4555843_1 Bacterial low temperature requirement A protein (LtrA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 429.0
TLS2_k127_4555843_2 ROK family K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000005681 268.0
TLS2_k127_4555843_3 F420H(2)-dependent quinone reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000009376 227.0
TLS2_k127_4555843_4 - - - - 0.0000000000000000000000004558 110.0
TLS2_k127_4555843_5 Belongs to the 'phage' integrase family - - - 0.0001164 46.0
TLS2_k127_4557494_0 CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 498.0
TLS2_k127_4557494_1 Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) K00010 - 1.1.1.18,1.1.1.369 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006395 440.0
TLS2_k127_4557494_10 - - - - 0.000000000000000000000000002763 125.0
TLS2_k127_4557494_11 - - - - 0.00000000000000000000000008194 124.0
TLS2_k127_4557494_12 COG1413 FOG HEAT repeat K22221 - - 0.0003849 51.0
TLS2_k127_4557494_13 Ribbon-helix-helix protein, copG family - - - 0.0004547 51.0
TLS2_k127_4557494_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 428.0
TLS2_k127_4557494_3 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 412.0
TLS2_k127_4557494_4 Domain of unknown function DUF21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 409.0
TLS2_k127_4557494_5 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 382.0
TLS2_k127_4557494_6 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 343.0
TLS2_k127_4557494_7 metallopeptidase activity K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000001281 268.0
TLS2_k127_4557494_8 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002387 237.0
TLS2_k127_4557494_9 - - - - 0.000000000000000000000000000000000000003251 149.0
TLS2_k127_4580653_0 FAD binding domain K14672,K15972 - 1.14.13.200 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 501.0
TLS2_k127_4580653_1 Two component transcriptional regulator, winged helix family K07776 - - 0.0000000000000006785 83.0
TLS2_k127_4604681_0 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.5.3 4.339e-278 866.0
TLS2_k127_4604681_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 4.971e-243 760.0
TLS2_k127_4604681_2 Beta-lactamase K01286 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 558.0
TLS2_k127_4604681_3 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 514.0
TLS2_k127_4604681_4 Belongs to the MIP aquaporin (TC 1.A.8) family K02440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 354.0
TLS2_k127_4604681_5 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.00000000000000000000000002592 108.0
TLS2_k127_462337_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.3.4.2 7.021e-300 927.0
TLS2_k127_462337_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 3.375e-216 681.0
TLS2_k127_462337_10 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004758 284.0
TLS2_k127_462337_11 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002882 263.0
TLS2_k127_462337_12 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005271 263.0
TLS2_k127_462337_13 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000007968 259.0
TLS2_k127_462337_14 Chorismate mutase K06208 - 5.4.99.5 0.000000000000000000000000000000000000000000000001121 178.0
TLS2_k127_462337_15 - - - - 0.00000000000000000000000000000000001546 148.0
TLS2_k127_462337_16 Copper transport outer membrane protein, MctB - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796 - 0.00000000000000000000000003271 113.0
TLS2_k127_462337_17 - - - - 0.00000000000000002164 97.0
TLS2_k127_462337_18 HNH endonuclease - - - 0.000000938 57.0
TLS2_k127_462337_2 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 590.0
TLS2_k127_462337_3 tyrosine recombinase K04763 GO:0008150,GO:0040007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007126 442.0
TLS2_k127_462337_4 virulence factor MVIN family protein K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 455.0
TLS2_k127_462337_5 PFAM Cobyrinic acid a,c-diamide synthase K03496 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 431.0
TLS2_k127_462337_6 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000315 358.0
TLS2_k127_462337_7 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 334.0
TLS2_k127_462337_8 Belongs to the pseudouridine synthase RsuA family K06178,K06183 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 323.0
TLS2_k127_462337_9 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 321.0
TLS2_k127_4645017_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 7.744e-269 835.0
TLS2_k127_4645017_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 1.321e-243 767.0
TLS2_k127_4645017_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 454.0
TLS2_k127_4645017_3 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 333.0
TLS2_k127_4645017_4 Histidine kinase K02478 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000001205 265.0
TLS2_k127_4645017_5 membrane - - - 0.00000000000000000000000000000000000000000001015 165.0
TLS2_k127_4645017_6 - - - - 0.000000000000000000000000000000002645 140.0
TLS2_k127_4675276_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0 1200.0
TLS2_k127_468678_0 Heavy metal translocating P-type atpase K01533,K17686 - 3.6.3.4,3.6.3.54 0.0 1277.0
TLS2_k127_468678_1 Belongs to the glutamate synthase family K00284 - 1.4.7.1 1.38e-276 857.0
TLS2_k127_468678_10 Chagasin family peptidase inhibitor I42 K14475 - - 0.0000006359 56.0
TLS2_k127_468678_2 Predicted membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009242 260.0
TLS2_k127_468678_3 PFAM zinc finger SWIM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001247 251.0
TLS2_k127_468678_4 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000002259 241.0
TLS2_k127_468678_5 Protein of unknown function (DUF3159) - - - 0.000000000000000000000000000000000000000000000000000000000005195 224.0
TLS2_k127_468678_6 Domain of unknown function (DUF1992) - - - 0.000000000000000000000000000000000001921 154.0
TLS2_k127_468678_7 Peptidase family M48 - - - 0.0000000000000000000000000000000001294 155.0
TLS2_k127_468678_8 - - - - 0.000000000000000002199 91.0
TLS2_k127_468678_9 Papain family cysteine protease - - - 0.000000000000004669 87.0
TLS2_k127_4688788_0 Belongs to the TPP enzyme family K03336 - 3.7.1.22 1.325e-290 915.0
TLS2_k127_4688788_1 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 7.863e-255 800.0
TLS2_k127_4688788_10 UTRA K03710 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 303.0
TLS2_k127_4688788_11 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007979 277.0
TLS2_k127_4688788_12 O-methyltransferase activity - - - 0.00000000000000000001659 93.0
TLS2_k127_4688788_2 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002688 489.0
TLS2_k127_4688788_3 PFAM PfkB domain protein K03338 - 2.7.1.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 445.0
TLS2_k127_4688788_4 PFAM Myo-inositol catabolism IolB domain protein K03337 - 5.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003236 431.0
TLS2_k127_4688788_5 Xylose isomerase-like TIM barrel K03335 - 4.2.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 420.0
TLS2_k127_4688788_6 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 419.0
TLS2_k127_4688788_7 Oxidoreductase family, C-terminal alpha/beta domain K00010 - 1.1.1.18,1.1.1.369 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 400.0
TLS2_k127_4688788_8 deoxyribose-phosphate aldolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000923 397.0
TLS2_k127_4688788_9 Orn/Lys/Arg decarboxylase, C-terminal domain K01582 - 4.1.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 376.0
TLS2_k127_4689425_0 Multicopper oxidase K04753 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 398.0
TLS2_k127_4689425_1 Protein of unknown function (DUF664) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005293 248.0
TLS2_k127_4689425_2 Belongs to the 'phage' integrase family K04763 - - 0.00000000000000000000000000006975 117.0
TLS2_k127_4689425_3 Phosphoenolpyruvate phosphomutase - - - 0.0000000000000007507 81.0
TLS2_k127_4689425_4 Multicopper oxidase K04753 - - 0.00000000002257 67.0
TLS2_k127_4713539_0 LOR/SDH bifunctional enzyme conserved region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 603.0
TLS2_k127_4713539_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008475 511.0
TLS2_k127_4713539_10 Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000000000000427 126.0
TLS2_k127_4713539_11 YCII-related domain - - - 0.00000000000000000000000001446 113.0
TLS2_k127_4713539_12 N-acetylmuramoyl-L-alanine amidase - - - 0.00000000000000000000000704 111.0
TLS2_k127_4713539_13 YCII-related domain - - - 0.0000000000000000000001575 101.0
TLS2_k127_4713539_14 - - - - 0.0000000000000000001112 103.0
TLS2_k127_4713539_16 SMART Rhodanese domain protein - - - 0.0000000004294 66.0
TLS2_k127_4713539_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 413.0
TLS2_k127_4713539_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 413.0
TLS2_k127_4713539_4 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 348.0
TLS2_k127_4713539_5 Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 332.0
TLS2_k127_4713539_6 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007781 324.0
TLS2_k127_4713539_7 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008723 294.0
TLS2_k127_4713539_8 Esterase K03928 - 3.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000611 286.0
TLS2_k127_4713539_9 - - - - 0.000000000000000000000000000000000000004919 155.0
TLS2_k127_4724374_0 TIGRFAM methionine aminopeptidase, type I K01265 GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009598 338.0
TLS2_k127_4724374_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 288.0
TLS2_k127_4724374_2 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000001215 260.0
TLS2_k127_4724374_3 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000001783 220.0
TLS2_k127_4724374_4 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000002365 168.0
TLS2_k127_4724374_5 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944 - 0.0000000000000000000000000000000000001239 153.0
TLS2_k127_4724374_6 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000000003374 79.0
TLS2_k127_473461_0 PA domain - - - 1.488e-227 719.0
TLS2_k127_473461_1 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007768 511.0
TLS2_k127_473461_2 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 374.0
TLS2_k127_4753104_0 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 415.0
TLS2_k127_4753104_1 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006275 244.0
TLS2_k127_4753104_2 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000000000000004864 226.0
TLS2_k127_4753104_3 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000000000000000000000000000000000000001583 198.0
TLS2_k127_4761585_0 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 351.0
TLS2_k127_4768951_0 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 328.0
TLS2_k127_4768951_1 Maoc domain protein dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 295.0
TLS2_k127_4768951_2 Uncharacterized protein conserved in bacteria (DUF2332) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 296.0
TLS2_k127_4768951_3 Phosphoglycerate mutase family K02226 GO:0003674,GO:0003824,GO:0003993,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0042802,GO:0042803,GO:0044237,GO:0046983 3.1.3.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000003144 259.0
TLS2_k127_4768951_4 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000168 258.0
TLS2_k127_4768951_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000002825 239.0
TLS2_k127_4768951_6 NUDIX domain - - - 0.0000000000000000000000000000000000000001261 156.0
TLS2_k127_4768951_7 - - - - 0.0000000001173 63.0
TLS2_k127_4789827_0 Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway K15521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 2.4.1.250 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 580.0
TLS2_k127_4789827_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007432 551.0
TLS2_k127_4789827_10 Glycine cleavage T-protein C-terminal barrel domain K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 376.0
TLS2_k127_4789827_11 Threonyl alanyl tRNA synthetase SAD K07050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 369.0
TLS2_k127_4789827_12 ATPase associated with various cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 364.0
TLS2_k127_4789827_13 von Willebrand factor, type A K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 351.0
TLS2_k127_4789827_14 alpha beta - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001032 281.0
TLS2_k127_4789827_15 Appr-1'-p processing enzyme - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000004292 237.0
TLS2_k127_4789827_16 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000000000000000003073 224.0
TLS2_k127_4789827_17 Putative bacterial sensory transduction regulator - - - 0.00000000000000000000000000000000000000000000000000000000000331 212.0
TLS2_k127_4789827_18 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000005899 210.0
TLS2_k127_4789827_19 Helix-turn-helix domain - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000003395 160.0
TLS2_k127_4789827_2 RmlD substrate binding domain K01710,K01784 - 4.2.1.46,5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 531.0
TLS2_k127_4789827_20 Protein of unknown function (DUF2516) - - - 0.0000000000000000000005594 108.0
TLS2_k127_4789827_21 regulator - - - 0.0000000000000002415 90.0
TLS2_k127_4789827_22 - - - - 0.00000001153 63.0
TLS2_k127_4789827_23 - - - - 0.0001124 53.0
TLS2_k127_4789827_24 - K16645 - - 0.0003862 51.0
TLS2_k127_4789827_3 beta-keto acid cleavage enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 427.0
TLS2_k127_4789827_4 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 421.0
TLS2_k127_4789827_5 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007189 423.0
TLS2_k127_4789827_6 Histidine kinase K07768 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 418.0
TLS2_k127_4789827_7 response regulator, receiver K07776 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004557 395.0
TLS2_k127_4789827_8 L-asparaginase II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006944 394.0
TLS2_k127_4789827_9 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 397.0
TLS2_k127_4800626_0 Glycine radical K00656 - 2.3.1.54 0.0 1156.0
TLS2_k127_4800626_1 belongs to the sigma-70 factor family - - - 3.66e-218 682.0
TLS2_k127_4800626_10 Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 293.0
TLS2_k127_4800626_11 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006362 276.0
TLS2_k127_4800626_12 spermidine synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000429 276.0
TLS2_k127_4800626_13 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009794 275.0
TLS2_k127_4800626_14 WHG domain - - - 0.000000000000000000000000000000000000000000000000000000000009917 214.0
TLS2_k127_4800626_15 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000001652 188.0
TLS2_k127_4800626_16 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000395 183.0
TLS2_k127_4800626_17 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000003121 158.0
TLS2_k127_4800626_18 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000000001015 160.0
TLS2_k127_4800626_19 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000002034 156.0
TLS2_k127_4800626_2 MMPL family K06994 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 556.0
TLS2_k127_4800626_20 Transposase IS116 IS110 IS902 family protein - - - 0.0000000000000000000000000000000000002756 148.0
TLS2_k127_4800626_21 phosphoribosyltransferase K07100 - - 0.000000000000000000000000004467 113.0
TLS2_k127_4800626_22 lactoylglutathione lyase activity - - - 0.0000000000000000000000001043 111.0
TLS2_k127_4800626_23 Transposase IS116 IS110 IS902 family protein - - - 0.000000000000000000000000166 108.0
TLS2_k127_4800626_24 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000003724 91.0
TLS2_k127_4800626_25 Lipopolysaccharide assembly protein A domain - - - 0.00000000000000004703 85.0
TLS2_k127_4800626_26 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000001787 80.0
TLS2_k127_4800626_27 Belongs to the 'phage' integrase family - - - 0.00000000000004861 81.0
TLS2_k127_4800626_28 Belongs to the 'phage' integrase family - - - 0.00000000001104 68.0
TLS2_k127_4800626_3 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005213 477.0
TLS2_k127_4800626_4 involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 427.0
TLS2_k127_4800626_5 cell envelope-related transcriptional attenuator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007695 384.0
TLS2_k127_4800626_6 ANTAR domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 350.0
TLS2_k127_4800626_7 ANTAR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007192 344.0
TLS2_k127_4800626_8 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 334.0
TLS2_k127_4800626_9 'Phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 317.0
TLS2_k127_4822005_0 (4Fe-4S) cluster-containing protein K18929 - - 1.985e-238 753.0
TLS2_k127_4822005_1 Trypsin-like peptidase domain K01173 - - 1.201e-212 685.0
TLS2_k127_4822005_10 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004647 260.0
TLS2_k127_4822005_11 Pfam Uncharacterised ACR, YkgG family COG1556 K00782 - - 0.0000000000000000000000000000000000000000000000000000000000000006256 233.0
TLS2_k127_4822005_12 Ion channel - - - 0.000000000000000000000000000000000000000000000000000826 197.0
TLS2_k127_4822005_13 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000001439 188.0
TLS2_k127_4822005_14 Protein of unknown function (DUF421) - - - 0.0000000000000000000000000000000000000000002247 164.0
TLS2_k127_4822005_15 Protein of unknown function (DUF3618) - - - 0.000000000000000000000000000000000000006402 153.0
TLS2_k127_4822005_16 Redoxin - - - 0.0000000000000000000000000000000002967 139.0
TLS2_k127_4822005_17 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000000000000000000000000001459 135.0
TLS2_k127_4822005_18 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.00000000000000000000003277 109.0
TLS2_k127_4822005_19 Histidine kinase-like ATPases - - - 0.0000000000000005467 86.0
TLS2_k127_4822005_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003012 440.0
TLS2_k127_4822005_20 Histidine kinase-like ATPases - - - 0.000000001287 69.0
TLS2_k127_4822005_21 - - - - 0.000001047 59.0
TLS2_k127_4822005_3 Cysteine-rich domain K18928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 411.0
TLS2_k127_4822005_4 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009342 372.0
TLS2_k127_4822005_5 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007175 343.0
TLS2_k127_4822005_6 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 314.0
TLS2_k127_4822005_7 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007255 307.0
TLS2_k127_4822005_8 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 295.0
TLS2_k127_4822005_9 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001918 288.0
TLS2_k127_4854723_0 Protein of unknown function (DUF3866) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006905 481.0
TLS2_k127_4854723_1 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K13571 GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006928 462.0
TLS2_k127_4854723_2 WYL domain K13573 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004455 401.0
TLS2_k127_4854723_3 WYL domain K13572,K13573 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 368.0
TLS2_k127_4854723_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001264 281.0
TLS2_k127_4854723_5 Peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000004861 190.0
TLS2_k127_4854723_6 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000006257 190.0
TLS2_k127_4854723_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0008150,GO:0040007 - 0.000000000000008802 83.0
TLS2_k127_4859312_0 Orn/Lys/Arg decarboxylase, C-terminal domain K01585 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 608.0
TLS2_k127_4859312_1 Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 551.0
TLS2_k127_4859312_2 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 512.0
TLS2_k127_4859312_3 Carbon-nitrogen hydrolase K01501 - 3.5.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 437.0
TLS2_k127_4859312_4 Peptidase dimerisation domain K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003837 376.0
TLS2_k127_4859312_5 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 329.0
TLS2_k127_4859312_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000009137 196.0
TLS2_k127_4859312_7 - - - - 0.0000000000000000000000164 107.0
TLS2_k127_4859312_8 PFAM Ion - - - 0.0000000000000000005039 95.0
TLS2_k127_4859312_9 transcriptional regulator K02529 - - 0.00008055 46.0
TLS2_k127_4859313_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 1.256e-258 805.0
TLS2_k127_4859313_1 Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) K00010 - 1.1.1.18,1.1.1.369 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005194 487.0
TLS2_k127_4859313_10 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001058 281.0
TLS2_k127_4859313_11 Tautomerase enzyme K01821 - 5.3.2.6 0.00000000000000000000000000000000000000000000000000003623 189.0
TLS2_k127_4859313_2 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009134 489.0
TLS2_k127_4859313_3 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005408 476.0
TLS2_k127_4859313_4 PFAM Xylose isomerase domain protein TIM barrel K06605 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009205 455.0
TLS2_k127_4859313_5 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 411.0
TLS2_k127_4859313_6 Xylose isomerase-like TIM barrel K03335 - 4.2.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008351 404.0
TLS2_k127_4859313_7 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 398.0
TLS2_k127_4859313_8 Monosaccharide ABC transporter substrate-binding protein, CUT2 family K02058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 387.0
TLS2_k127_4859313_9 Oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 325.0
TLS2_k127_4874434_0 Transcriptional regulator, LacI family K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002932 472.0
TLS2_k127_4874434_1 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006724 314.0
TLS2_k127_4874434_2 Belongs to the ABC transporter superfamily K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000002967 231.0
TLS2_k127_4874434_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000000000000005974 185.0
TLS2_k127_4874434_5 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000001285 59.0
TLS2_k127_4892183_0 Mo-co oxidoreductase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007914 551.0
TLS2_k127_4892183_1 Binding-protein-dependent transport systems inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 546.0
TLS2_k127_4892183_10 PFAM regulatory protein LuxR - - - 0.000000002412 69.0
TLS2_k127_4892183_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008354 419.0
TLS2_k127_4892183_3 TOBE domain K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 378.0
TLS2_k127_4892183_4 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001778 290.0
TLS2_k127_4892183_5 Belongs to the UPF0301 (AlgH) family K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000001103 227.0
TLS2_k127_4892183_6 extracellular solute-binding protein, family 1 K02012 - - 0.00000000000000000000000000000000000000000000000001818 193.0
TLS2_k127_4892183_7 Protein of unknown function (DUF3039) - - - 0.00000000000000000000000000000000004328 148.0
TLS2_k127_4892183_8 Vitamin K epoxide reductase - - - 0.000000000000000002631 93.0
TLS2_k127_4892183_9 - - - - 0.00000000000003883 85.0
TLS2_k127_4905003_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204 1.2.4.1 0.0 1501.0
TLS2_k127_4905003_1 transcriptional - - - 0.000000000000000000000000001496 123.0
TLS2_k127_4907659_0 Malto-oligosyl trehalose synthase K06044 GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 5.4.99.15 2e-323 1009.0
TLS2_k127_4907659_1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 1.462e-254 791.0
TLS2_k127_4907659_2 Radical SAM - - - 0.000000000000000000000000000000000000000000000000006941 196.0
TLS2_k127_4907659_3 HNH endonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000002819 59.0
TLS2_k127_490977_0 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008575 526.0
TLS2_k127_490977_1 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 526.0
TLS2_k127_490977_10 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000001001 252.0
TLS2_k127_490977_11 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000001501 230.0
TLS2_k127_490977_12 phytoene K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.000000000000000000000000000000000000000000000000000000000008398 209.0
TLS2_k127_490977_13 lycopene cyclase domain - - - 0.000000000000000000000000000000000007313 146.0
TLS2_k127_490977_14 lycopene cyclase - - - 0.0000000000000000000000000000002408 135.0
TLS2_k127_490977_2 Beta-eliminating lyase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 454.0
TLS2_k127_490977_3 Reductase C-terminal K00529 - 1.18.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 423.0
TLS2_k127_490977_4 Squalene/phytoene synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 370.0
TLS2_k127_490977_5 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006499 369.0
TLS2_k127_490977_6 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 362.0
TLS2_k127_490977_7 Serine phosphatase RsbU, regulator of sigma subunit K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 374.0
TLS2_k127_490977_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007643 274.0
TLS2_k127_490977_9 cobalamin binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000008299 244.0
TLS2_k127_4913761_0 ABC transporter, ATP-binding protein K10441 - 3.6.3.17 1.446e-233 738.0
TLS2_k127_4913761_1 ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006061 274.0
TLS2_k127_4922369_0 Alcohol dehydrogenase GroES-like domain K00001,K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 559.0
TLS2_k127_4922369_1 dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 501.0
TLS2_k127_4922369_2 Belongs to the long-chain O-acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 357.0
TLS2_k127_4922369_3 Domain of unknown function (DUF389) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 304.0
TLS2_k127_4922369_4 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000303 284.0
TLS2_k127_4922369_5 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.00000000000000000000000000000000000000000000000000000000000001056 228.0
TLS2_k127_4922369_6 Region found in RelA / SpoT proteins - - - 0.000000000000000000000000001928 123.0
TLS2_k127_4924829_0 Sulfate transporter K03321 GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 - 1.545e-204 659.0
TLS2_k127_4924829_1 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008918 549.0
TLS2_k127_4924829_10 Binding-protein-dependent transport system inner membrane component K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 329.0
TLS2_k127_4924829_11 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 313.0
TLS2_k127_4924829_12 PAC2 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006654 300.0
TLS2_k127_4924829_13 serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006247 309.0
TLS2_k127_4924829_14 Belongs to the low molecular weight phosphotyrosine protein phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001609 268.0
TLS2_k127_4924829_15 Phosphoglycerate mutase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000002166 251.0
TLS2_k127_4924829_16 PFAM YbaK prolyl-tRNA synthetase associated region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000289 239.0
TLS2_k127_4924829_17 PFAM regulatory protein, ArsR K03892 - - 0.00000000000000000000000000002018 123.0
TLS2_k127_4924829_18 - - - - 0.0000000000000000000000000005073 124.0
TLS2_k127_4924829_19 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.0000000000000000000000001929 119.0
TLS2_k127_4924829_2 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 515.0
TLS2_k127_4924829_20 redox-active disulfide protein 2 - - - 0.000000000000000000000004021 115.0
TLS2_k127_4924829_3 phosphate binding protein K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 413.0
TLS2_k127_4924829_4 Flavin-binding monooxygenase-like K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000313 409.0
TLS2_k127_4924829_5 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 400.0
TLS2_k127_4924829_6 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 405.0
TLS2_k127_4924829_7 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 352.0
TLS2_k127_4924829_8 Phospholipid glycerol acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 338.0
TLS2_k127_4924829_9 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006154 326.0
TLS2_k127_4938876_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006587 526.0
TLS2_k127_4938876_1 ATPases associated with a variety of cellular activities K16785,K16786,K16787 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009171 532.0
TLS2_k127_4938876_2 Peptidase s1 and s6 chymotrypsin hap K08372 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008317 357.0
TLS2_k127_4938876_3 RNA polymerase sigma factor, sigma-70 family K03088 GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000001638 237.0
TLS2_k127_4938876_4 cobalt transport K16785 - - 0.00000000000000000000000000000000000000000000000000000000000000002147 245.0
TLS2_k127_4938876_5 ABC-type cobalt transport system, permease component K16925 - - 0.000000000000000000000000000000000000000000000000007049 188.0
TLS2_k127_4938876_6 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000002493 166.0
TLS2_k127_4938876_7 antisigma factor binding K03598 - - 0.0000000000000000000000000000000000005092 159.0
TLS2_k127_4938876_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 GO:0008150,GO:0040007 - 0.00000000000000000003302 98.0
TLS2_k127_4938876_9 Putative zinc-finger - - - 0.00000000000000006038 91.0
TLS2_k127_4954880_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 7.284e-229 715.0
TLS2_k127_4954880_1 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002825 297.0
TLS2_k127_4954880_2 Diacylglycerol kinase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001334 270.0
TLS2_k127_4977247_0 Sulfatase K01130 GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004065,GO:0004098,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005783,GO:0005788,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0008484,GO:0009987,GO:0012505,GO:0016192,GO:0016787,GO:0016788,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034774,GO:0035578,GO:0036230,GO:0042119,GO:0042582,GO:0043167,GO:0043169,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044255,GO:0044422,GO:0044424,GO:0044432,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0097708,GO:0099503,GO:1901135,GO:1901564,GO:1903509 3.1.6.1 0.0 1200.0
TLS2_k127_4977247_1 FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008275 603.0
TLS2_k127_4977247_2 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 459.0
TLS2_k127_4977247_3 Belongs to the GarS family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 398.0
TLS2_k127_4977247_4 Uncharacterised protein family UPF0066 - - - 0.00000000000000000000000000000000000000000000000000000008455 207.0
TLS2_k127_4977247_5 alcohol dehydrogenase - - - 0.000000000000000000000000000000000014 141.0
TLS2_k127_4977247_6 - - - - 0.0001595 51.0
TLS2_k127_4984986_0 2-Nitropropane dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 499.0
TLS2_k127_4984986_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 426.0
TLS2_k127_4984986_10 ABC-type amino acid transport signal transduction systems, periplasmic component domain K02030,K02424,K17073 - - 0.000000000000000000000000000000000000000000000001172 177.0
TLS2_k127_4984986_11 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000002839 183.0
TLS2_k127_4984986_12 NADP oxidoreductase coenzyme F420-dependent - - - 0.0000000000000000000000000000000000005094 141.0
TLS2_k127_4984986_2 Binding-protein-dependent transport system inner membrane component K02029,K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 354.0
TLS2_k127_4984986_3 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007668 366.0
TLS2_k127_4984986_4 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K02029 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 367.0
TLS2_k127_4984986_5 TipAS antibiotic-recognition domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 329.0
TLS2_k127_4984986_6 Aldo/keto reductase family - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004907 276.0
TLS2_k127_4984986_7 MafB19-like deaminase K01487 - 3.5.4.3 0.0000000000000000000000000000000000000000000000000000000000000155 219.0
TLS2_k127_4984986_8 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000007152 209.0
TLS2_k127_4984986_9 response to pH - - - 0.000000000000000000000000000000000000000000000000000001153 201.0
TLS2_k127_5002047_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00271 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.4.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 519.0
TLS2_k127_5002047_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001377 254.0
TLS2_k127_5002047_2 Copper resistance K02351,K07245 - - 0.0000000000000000000000000000000000000001559 154.0
TLS2_k127_5002047_3 TIGRFAM DNA binding domain protein, excisionase family - - - 0.000000000000000000000000000004623 123.0
TLS2_k127_5002047_4 Protein of unknown function (DUF3073) - - - 0.00000000008467 65.0
TLS2_k127_5040331_0 MoeA domain protein domain I and II K00963,K03750 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1,2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 524.0
TLS2_k127_5040331_1 Utp--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 467.0
TLS2_k127_5040331_2 PFAM Acetyltransferase (GNAT) family K03790 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000000000000000000000000008172 265.0
TLS2_k127_5040331_3 Molybdenum cofactor synthesis K03635 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000181 248.0
TLS2_k127_5040331_4 Penicillin amidase K01434 - 3.5.1.11 0.00000000000000000000000000000000000000000000000000000000000000009946 226.0
TLS2_k127_5040331_5 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000000000000000000003091 216.0
TLS2_k127_5040331_6 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000004321 227.0
TLS2_k127_5040331_7 - - - - 0.000000000000005222 87.0
TLS2_k127_5064447_0 GlcNAc-PI de-N-acetylase K22135 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 322.0
TLS2_k127_5064447_1 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 304.0
TLS2_k127_5064447_2 Fructose transport system kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006227 237.0
TLS2_k127_5064447_3 Secreted and surface protein containing fasciclin-like repeats - - - 0.0000000000000002046 93.0
TLS2_k127_5117391_0 Sodium hydrogen exchanger K03316 GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042592,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098719,GO:0098739,GO:0098771,GO:0099516,GO:0099587,GO:1902600 - 2.054e-265 833.0
TLS2_k127_5117391_1 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 562.0
TLS2_k127_5117391_2 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000292 549.0
TLS2_k127_5117391_3 Bacterial transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 298.0
TLS2_k127_5117391_4 PFAM CoA-binding domain protein K06929 - - 0.000000000000000000000000000000000000000000000000000000000000000006421 233.0
TLS2_k127_5117391_5 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000001432 185.0
TLS2_k127_5117391_6 AbiEi antitoxin C-terminal domain - - - 0.00000000000000000000000000000000000000000000008626 176.0
TLS2_k127_5117391_7 ACT domain K09964 - - 0.00000000000000000000000000000000000000000007719 162.0
TLS2_k127_5117391_8 PFAM Biotin lipoyl attachment - - - 0.000000000000000000008792 106.0
TLS2_k127_5139891_0 - K16214 - 2.7.1.176 0.000000000000000000000000000000000000000000000000000000000000000002904 260.0
TLS2_k127_5139891_1 Calpain family cysteine protease - - - 0.000000000000000000000000000000000000000000000000000000000000000003826 260.0
TLS2_k127_5139891_2 domain, Protein - - - 0.0000000000000000003543 105.0
TLS2_k127_5139891_3 domain, Protein - - - 0.000000000000001346 93.0
TLS2_k127_5139891_4 Zeta toxin - - - 0.000000000001294 83.0
TLS2_k127_517986_0 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family K00366,K00392 GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.7.7.1,1.8.7.1 1.36e-260 813.0
TLS2_k127_517986_1 acyl-CoA dehydrogenase K09456 - - 6.041e-206 655.0
TLS2_k127_517986_2 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 502.0
TLS2_k127_517986_3 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 372.0
TLS2_k127_517986_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 336.0
TLS2_k127_517986_5 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006298 276.0
TLS2_k127_517986_6 - - - - 0.000000001222 59.0
TLS2_k127_5212429_0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944 1.6.5.3 0.0 1129.0
TLS2_k127_5212429_1 Pyruvate:ferredoxin oxidoreductase core domain II K00174 - 1.2.7.11,1.2.7.3 0.0 1023.0
TLS2_k127_5212429_10 Belongs to the FPP GGPP synthase family K00805 - 2.5.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006892 441.0
TLS2_k127_5212429_11 EamA-like transporter family K05786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 372.0
TLS2_k127_5212429_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 333.0
TLS2_k127_5212429_13 Thioredoxin-like [2Fe-2S] ferredoxin K00334 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 321.0
TLS2_k127_5212429_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K12143 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 314.0
TLS2_k127_5212429_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 289.0
TLS2_k127_5212429_16 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000003353 258.0
TLS2_k127_5212429_17 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000004281 221.0
TLS2_k127_5212429_18 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339,K05578 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000001616 197.0
TLS2_k127_5212429_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000000000000000001059 146.0
TLS2_k127_5212429_2 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 1.677e-271 849.0
TLS2_k127_5212429_20 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000001947 108.0
TLS2_k127_5212429_21 NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient K05574,K05582 - 1.6.5.3 0.0000000000000001485 86.0
TLS2_k127_5212429_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 2.571e-232 741.0
TLS2_k127_5212429_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 3.41e-204 654.0
TLS2_k127_5212429_5 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005501 560.0
TLS2_k127_5212429_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008634 521.0
TLS2_k127_5212429_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 548.0
TLS2_k127_5212429_8 Ferredoxin oxidoreductase K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 533.0
TLS2_k127_5212429_9 NADH dehydrogenase K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 491.0
TLS2_k127_5233132_0 TIGRFAM molybdenum cofactor synthesis domain K03750,K07219 - 2.10.1.1 1.51e-260 814.0
TLS2_k127_5233132_1 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 477.0
TLS2_k127_5233132_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00122,K00335 - 1.17.1.9,1.6.5.3 0.000000000000001203 78.0
TLS2_k127_5249005_0 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 561.0
TLS2_k127_5249005_1 involved in chromosome partitioning - - - 0.0000000000000000000000000000000000000000000000000000000000000000004698 237.0
TLS2_k127_5249005_2 Protein conserved in bacteria - - - 0.0000000001021 74.0
TLS2_k127_5305779_0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02351,K07245 GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 520.0
TLS2_k127_5305779_1 PFAM Metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 432.0
TLS2_k127_5305779_2 nuclease activity - GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000002121 142.0
TLS2_k127_5305779_3 Bacterial antitoxin of type II TA system, VapB - GO:0006417,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0040008,GO:0043207,GO:0044403,GO:0044419,GO:0045727,GO:0045927,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:2000112 - 0.000000000000000000000000000103 116.0
TLS2_k127_5305779_4 copper resistance protein K07156,K14166 - - 0.000000000000000000003211 106.0
TLS2_k127_5305779_5 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000008412 79.0
TLS2_k127_5305779_6 - - - - 0.00000000674 64.0
TLS2_k127_5305779_7 - - - - 0.00000695 52.0
TLS2_k127_5361852_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1071.0
TLS2_k127_5361852_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.15 1.164e-303 942.0
TLS2_k127_5361852_10 Domain of unknown function (DUF4439) - - - 0.000000000000000000000001085 113.0
TLS2_k127_5361852_2 Participates in both transcription termination and antitermination K02600 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 532.0
TLS2_k127_5361852_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007367 381.0
TLS2_k127_5361852_4 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 362.0
TLS2_k127_5361852_5 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000006671 247.0
TLS2_k127_5361852_6 carbon monoxide dehydrogenase subunit G - - - 0.00000000000000000000000000000000000000000000000000000173 212.0
TLS2_k127_5361852_7 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000007929 175.0
TLS2_k127_5361852_8 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000000057 119.0
TLS2_k127_5361852_9 nucleic-acid-binding protein implicated in transcription termination K07742 - - 0.000000000000000000000000001555 116.0
TLS2_k127_5369001_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006521 509.0
TLS2_k127_5369001_1 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006578 507.0
TLS2_k127_5369001_2 Belongs to the peptidase M24B family K01262,K01271 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 391.0
TLS2_k127_5369001_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 315.0
TLS2_k127_5369001_4 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000004169 265.0
TLS2_k127_5369001_5 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000007332 222.0
TLS2_k127_5369001_6 Catalyzes a trans-dehydration via an enolate intermediate K03786 GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000001422 220.0
TLS2_k127_5369001_7 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000000000006616 195.0
TLS2_k127_5369001_8 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000005412 108.0
TLS2_k127_5384375_0 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 6.3.2.9 9.5e-199 634.0
TLS2_k127_5384375_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008502 614.0
TLS2_k127_5384375_10 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 432.0
TLS2_k127_5384375_11 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 412.0
TLS2_k127_5384375_12 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000001195 235.0
TLS2_k127_5384375_13 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000005837 199.0
TLS2_k127_5384375_14 Cell division protein FtsQ K03589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000003209 140.0
TLS2_k127_5384375_15 Protein of unknown function (DUF3040) - - - 0.00000000000000000000000000000001447 132.0
TLS2_k127_5384375_16 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.000000000000000000000006194 115.0
TLS2_k127_5384375_2 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 GO:0008150,GO:0040007 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 550.0
TLS2_k127_5384375_3 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0008150,GO:0040007 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 507.0
TLS2_k127_5384375_4 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 525.0
TLS2_k127_5384375_5 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 469.0
TLS2_k127_5384375_6 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006434 494.0
TLS2_k127_5384375_7 Belongs to the SEDS family K02563,K03588 GO:0008150,GO:0040007 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004795 475.0
TLS2_k127_5384375_8 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009589 467.0
TLS2_k127_5384375_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007289 457.0
TLS2_k127_5441183_0 GAF domain - - - 7.992e-265 843.0
TLS2_k127_5441183_1 ATP-grasp domain - - - 5.034e-212 685.0
TLS2_k127_5441183_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000588 523.0
TLS2_k127_5441183_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 308.0
TLS2_k127_5441183_4 Adenylyl- / guanylyl cyclase, catalytic domain K07814 - - 0.000000000000000000000000000000001958 142.0
TLS2_k127_5441183_5 Periplasmic binding protein LacI transcriptional regulator K02529 - - 0.000539 43.0
TLS2_k127_5530937_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 2e-227 713.0
TLS2_k127_5530937_1 Zincin-like metallopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005656 436.0
TLS2_k127_5530937_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K00760,K04075 GO:0008150,GO:0040007 2.4.2.8,6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 334.0
TLS2_k127_5530937_3 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 298.0
TLS2_k127_5530937_4 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 291.0
TLS2_k127_5530937_5 D-alanyl-D-alanine carboxypeptidase K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000138 291.0
TLS2_k127_5530937_6 NlpC/P60 family K21471,K21473 - - 0.0000000000000000000000000000000000000000003774 164.0
TLS2_k127_5593580_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 316.0
TLS2_k127_5593580_1 CHAT domain - - - 0.0000000000000000000001323 100.0
TLS2_k127_5593580_2 - - - - 0.00000000000000003413 94.0
TLS2_k127_5593580_3 - - - - 0.00000000000000005129 89.0
TLS2_k127_5593580_4 - - - - 0.000000000003028 79.0
TLS2_k127_5618370_0 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003697 474.0
TLS2_k127_5618370_1 Belongs to the D-alanine--D-alanine ligase family K01921 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004654 467.0
TLS2_k127_5618370_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 GO:0008150,GO:0040007 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 397.0
TLS2_k127_5618370_3 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 411.0
TLS2_k127_5618370_4 Acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000142 277.0
TLS2_k127_5618370_5 Lrp/AsnC ligand binding domain - - - 0.00000000000000000000000000000000009459 137.0
TLS2_k127_5618370_6 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000000000000000003807 128.0
TLS2_k127_5618370_7 Protein of unknown function (DUF3515) - - - 0.0000000000000000000000000001141 121.0
TLS2_k127_5618370_8 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568 2.7.7.68 0.00000000000000000000003855 104.0
TLS2_k127_5623293_0 Glucose Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 550.0
TLS2_k127_5623293_1 Peptidase family M3 K01392 - 3.4.24.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 487.0
TLS2_k127_5623293_2 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007613 441.0
TLS2_k127_5623293_3 CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000992 420.0
TLS2_k127_5623293_4 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 397.0
TLS2_k127_5623293_5 Domain of unknown function DUF21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 347.0
TLS2_k127_5623293_6 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000000000000000000002785 198.0
TLS2_k127_5623293_7 Erythromycin esterase - - - 0.00000000000000000000000000000000000001854 167.0
TLS2_k127_5623293_8 acetyltransferase K09181 - - 0.000000000000000000000001603 110.0
TLS2_k127_5634092_0 fatty acid desaturase K00508 - 1.14.19.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 597.0
TLS2_k127_5634092_1 hydrolase, family 65, central catalytic K10231 - 2.4.1.230 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 559.0
TLS2_k127_5634092_2 Oxidoreductase FAD-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 451.0
TLS2_k127_5634092_3 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 392.0
TLS2_k127_5634092_4 Protein of unknown function (DUF421) - - - 0.0000000000000000000000000000000000000000000000000000000000000549 217.0
TLS2_k127_5634092_5 - K10716 - - 0.000000000000000000000000000000000000000000000000000007948 192.0
TLS2_k127_5634092_6 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000000001415 150.0
TLS2_k127_5634092_7 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000000000000001424 119.0
TLS2_k127_5634092_8 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000000000005223 105.0
TLS2_k127_5661078_0 Elongation factor G C-terminus K06207 - - 3.764e-317 982.0
TLS2_k127_5661078_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K15580 - - 1.827e-228 721.0
TLS2_k127_5661078_11 trisaccharide binding - - - 0.00000000004224 75.0
TLS2_k127_5661078_2 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00239,K00278 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4,1.4.3.16 3.843e-211 666.0
TLS2_k127_5661078_3 Oligopeptide/dipeptide transporter, C-terminal region K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 499.0
TLS2_k127_5661078_4 Binding-protein-dependent transport system inner membrane component K02033,K15581 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 477.0
TLS2_k127_5661078_5 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 391.0
TLS2_k127_5661078_6 N-terminal TM domain of oligopeptide transport permease C K02034,K15582 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 372.0
TLS2_k127_5661078_7 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000004536 177.0
TLS2_k127_5661078_8 Belongs to the NUDIX hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000008339 176.0
TLS2_k127_5661078_9 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000001526 141.0
TLS2_k127_5707989_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 5.477e-312 987.0
TLS2_k127_5707989_1 acetyl-CoA carboxylase K01962,K01963 - 2.1.3.15,6.4.1.2 1.198e-238 745.0
TLS2_k127_5707989_10 SseB protein N-terminal domain - - - 0.00000000000000000000000000002593 125.0
TLS2_k127_5707989_11 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000001996 106.0
TLS2_k127_5707989_12 PFAM Methylamine utilisation protein MauE - - - 0.00000001314 63.0
TLS2_k127_5707989_2 Responsible for the hydrolysis of barbituric acid (2,4,6-trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid K03383,K19794 - 3.5.2.1,3.5.2.15 1.174e-194 618.0
TLS2_k127_5707989_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007501 578.0
TLS2_k127_5707989_4 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 415.0
TLS2_k127_5707989_5 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 303.0
TLS2_k127_5707989_6 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006635 279.0
TLS2_k127_5707989_7 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001123 274.0
TLS2_k127_5707989_8 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000001268 211.0
TLS2_k127_5707989_9 - - - - 0.00000000000000000000000000000000000000000003851 162.0
TLS2_k127_5709330_0 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005198 362.0
TLS2_k127_5709330_1 NAD(P) transhydrogenase, alpha subunit K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000003939 226.0
TLS2_k127_5723739_0 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001786 267.0
TLS2_k127_5723739_1 Thioredoxin - - - 0.00000000000000000000000000000000000000000001429 166.0
TLS2_k127_5723739_2 Domain of unknown function (DUF4395) - - - 0.000000000000000000000000000000000001005 147.0
TLS2_k127_5723739_3 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000003024 139.0
TLS2_k127_5723739_4 ThiS family - - - 0.00000000000000000000002706 109.0
TLS2_k127_5723739_5 sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000004549 101.0
TLS2_k127_5723739_6 - - - - 0.0001627 53.0
TLS2_k127_572961_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1433.0
TLS2_k127_572961_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 2.083e-230 718.0
TLS2_k127_572961_2 Mur ligase, middle domain protein K11754 GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 555.0
TLS2_k127_572961_3 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 515.0
TLS2_k127_572961_4 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008665 437.0
TLS2_k127_572961_5 Mandelate Racemase Muconate Lactonizing - - - 0.000000000000000000000000000000000000000000000000000000000000002226 237.0
TLS2_k127_572961_6 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000001225 212.0
TLS2_k127_572961_7 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000000000000003408 161.0
TLS2_k127_572961_8 Protein of unknown function (DUF4233) - - - 0.00000000000000000000004347 110.0
TLS2_k127_5743674_0 Luciferase-like monooxygenase - - - 3.294e-218 680.0
TLS2_k127_5743674_1 DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 297.0
TLS2_k127_5743674_2 Macrocin-O-methyltransferase (TylF) K19856,K21325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002583 275.0
TLS2_k127_5743674_3 NADPH-dependent FMN reductase K00299 - 1.5.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000009871 245.0
TLS2_k127_5769528_0 Isochorismate synthase K02552 - 5.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 548.0
TLS2_k127_5769528_1 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000003333 248.0
TLS2_k127_5769528_2 Protein conserved in bacteria - - - 0.00000000000000000000000000004235 132.0
TLS2_k127_5790740_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 500.0
TLS2_k127_5790740_1 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006114 331.0
TLS2_k127_5790740_2 Cation transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 307.0
TLS2_k127_5790740_3 Efflux transporter, RND family, MFP subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 304.0
TLS2_k127_5814270_0 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 6.368e-267 829.0
TLS2_k127_5814270_1 PspC domain - - - 0.000000000000000001179 89.0
TLS2_k127_5838755_0 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 306.0
TLS2_k127_5838755_1 - - - - 0.000000000000001628 87.0
TLS2_k127_5847254_0 PFAM Carboxylesterase K03929 - - 1.074e-229 720.0
TLS2_k127_5847254_1 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01007,K08483 - 2.7.3.9,2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 378.0
TLS2_k127_5847254_2 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007735 338.0
TLS2_k127_5847254_3 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.000009839 48.0
TLS2_k127_584800_0 ABC transporter - - - 0.0 1410.0
TLS2_k127_584800_1 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 582.0
TLS2_k127_584800_10 Histidine kinase - - - 0.00000000000000000000000000000000000000002543 162.0
TLS2_k127_584800_11 - - - - 0.0000000000000000000000000000002019 136.0
TLS2_k127_584800_2 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 310.0
TLS2_k127_584800_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006177 299.0
TLS2_k127_584800_4 Amidinotransferase K01482 - 3.5.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008879 301.0
TLS2_k127_584800_5 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003144 272.0
TLS2_k127_584800_6 PFAM Bacterial regulatory helix-turn-helix proteins, AraC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001504 270.0
TLS2_k127_584800_7 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001395 271.0
TLS2_k127_584800_8 sequence-specific DNA binding - - - 0.0000000000000000000000000000000000000000000000000000000912 201.0
TLS2_k127_584800_9 Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters - GO:0001000,GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0043167,GO:0043169,GO:0043175,GO:0045893,GO:0045935,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000006698 161.0
TLS2_k127_5848724_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 0.0 1093.0
TLS2_k127_5848724_1 carbon monoxide dehydrogenase subunit G K09386 - - 0.000000000000000000000000000000000000000000000000001593 205.0
TLS2_k127_5858859_0 Sodium/hydrogen exchanger family K11105 - - 6.981e-211 669.0
TLS2_k127_5858859_1 Fic/DOC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 601.0
TLS2_k127_5858859_10 - - - - 0.00000000000000000000000000000000003031 142.0
TLS2_k127_5858859_11 LytR cell envelope-related transcriptional attenuator - - - 0.00000000000000003092 89.0
TLS2_k127_5858859_2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 552.0
TLS2_k127_5858859_3 Bacterial protein of unknown function (DUF853) K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 416.0
TLS2_k127_5858859_4 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000386 355.0
TLS2_k127_5858859_5 NAD(P) transhydrogenase, alpha subunit K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001506 275.0
TLS2_k127_5858859_6 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K11991 - 3.5.4.1,3.5.4.33 0.000000000000000000000000000000000000000000000000000000000000000001195 229.0
TLS2_k127_5858859_7 tRNA adenosine - - - 0.00000000000000000000000000000000000000000000000000005177 194.0
TLS2_k127_5858859_8 Transcription regulator of the Arc MetJ class - - - 0.0000000000000000000000000000000000000000002498 162.0
TLS2_k127_5858859_9 NADP transhydrogenase K00324 - 1.6.1.2 0.00000000000000000000000000000000001573 138.0
TLS2_k127_5874230_0 PFAM extracellular solute-binding protein family 5 K02035 - - 1.669e-226 709.0
TLS2_k127_5874230_1 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005821 506.0
TLS2_k127_5874230_2 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 464.0
TLS2_k127_5874230_3 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 441.0
TLS2_k127_5874230_4 ABC-type dipeptide oligopeptide nickel transport system, permease component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008478 401.0
TLS2_k127_5945501_0 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 561.0
TLS2_k127_5945501_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 379.0
TLS2_k127_5945501_2 Cupin domain - - - 0.00005724 46.0
TLS2_k127_5945501_3 SpoIIAA-like - - - 0.0001273 45.0
TLS2_k127_5974589_0 Flavin containing amine oxidoreductase - - - 4.548e-239 748.0
TLS2_k127_5974589_1 Arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 2.599e-222 702.0
TLS2_k127_5974589_10 - - - - 0.000001052 60.0
TLS2_k127_5974589_11 Histone deacetylase domain - - - 0.000003296 50.0
TLS2_k127_5974589_12 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.00014 47.0
TLS2_k127_5974589_2 Peptidase family S58 K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004528 410.0
TLS2_k127_5974589_3 HAD-hyrolase-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003619 255.0
TLS2_k127_5974589_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001974 251.0
TLS2_k127_5974589_5 Tellurite resistance protein TehB - - - 0.0000000000000000000000000000000000000000000000000000000000000000001575 235.0
TLS2_k127_5974589_6 BetI-type transcriptional repressor, C-terminal - - - 0.000000000000000000000000000000000000000000000001766 184.0
TLS2_k127_5974589_7 - - - - 0.0000000000000000005508 89.0
TLS2_k127_5974589_8 PFAM CBS domain - - - 0.00000000000000000192 90.0
TLS2_k127_5983726_0 Penicillin binding protein transpeptidase domain K05364 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 561.0
TLS2_k127_5983726_1 Belongs to the SEDS family K03588 GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005144 535.0
TLS2_k127_5983726_2 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 511.0
TLS2_k127_5983726_3 Serine/threonine phosphatases, family 2C, catalytic domain K20074 GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005487 351.0
TLS2_k127_5983726_4 Protein of unknown function (DUF2662) - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000007351 258.0
TLS2_k127_5983726_5 Inner membrane component of T3SS, cytoplasmic domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.00000000000000000000000000000000000000000417 168.0
TLS2_k127_5983726_6 PFAM peptidase C60, sortase A and B - - - 0.00000000000001989 83.0
TLS2_k127_5994022_0 Phytoene dehydrogenase-like oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 614.0
TLS2_k127_5994022_1 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 385.0
TLS2_k127_5994022_2 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001135 280.0
TLS2_k127_5994022_3 RNA polymerase K03090 GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000001264 256.0
TLS2_k127_5994022_4 ANTAR - - - 0.00000000000000000000000000000000000000000000000001158 190.0
TLS2_k127_5994022_5 CAAX protease self-immunity K07052 - - 0.0000000000000000001074 96.0
TLS2_k127_5994022_6 - - - - 0.000000004905 67.0
TLS2_k127_5994022_7 Hemerythrin HHE cation binding domain - - - 0.0002094 51.0
TLS2_k127_6033722_0 Fatty acid desaturase K03921 - 1.14.19.11,1.14.19.2,1.14.19.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 472.0
TLS2_k127_6033722_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002169 254.0
TLS2_k127_6033722_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000003193 226.0
TLS2_k127_6033722_3 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000001498 211.0
TLS2_k127_6033722_4 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000001817 181.0
TLS2_k127_6033722_5 Belongs to the dCTP deaminase family K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.00000000000000000000000000000000000000000001492 164.0
TLS2_k127_6033722_6 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000003659 165.0
TLS2_k127_6033722_7 Butyryl-CoA dehydrogenase - - - 0.0000000000000000000002562 97.0
TLS2_k127_6046560_0 Putative exonuclease SbcCD, C subunit - - - 0.0 1189.0
TLS2_k127_6046560_1 Protein of unknown function (DUF3375) - - - 5.982e-194 616.0
TLS2_k127_6046560_10 Domain of unknown function (DUF4194) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001455 286.0
TLS2_k127_6046560_11 DeoR C terminal sensor domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000005795 245.0
TLS2_k127_6046560_12 nuclease K01174,K07038 - 3.1.31.1 0.0000000000000000000000000000000007443 141.0
TLS2_k127_6046560_13 Staphylococcal nuclease homologues - - - 0.0000000000000000001332 93.0
TLS2_k127_6046560_14 Bacterial transcriptional repressor C-terminal - - - 0.0000000000006403 72.0
TLS2_k127_6046560_15 PIN domain K07064 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.000001799 55.0
TLS2_k127_6046560_2 family 4 K01222 - 3.2.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 537.0
TLS2_k127_6046560_3 Bacterial extracellular solute-binding protein K10117 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 526.0
TLS2_k127_6046560_4 pfkB family carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 419.0
TLS2_k127_6046560_5 Binding-protein-dependent transport system inner membrane component K10118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007913 413.0
TLS2_k127_6046560_6 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006009 388.0
TLS2_k127_6046560_7 ABC transporter permease K10119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 372.0
TLS2_k127_6046560_8 Major pilin protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 335.0
TLS2_k127_6046560_9 transcriptional regulator K02444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 293.0
TLS2_k127_6057066_0 Evidence 2b Function of strongly homologous gene K05343 - 3.2.1.1,5.4.99.16 2.827e-258 807.0
TLS2_k127_6057066_1 Peptidase family S41 - - - 4.755e-233 738.0
TLS2_k127_6057066_10 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 346.0
TLS2_k127_6057066_11 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K20469 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 330.0
TLS2_k127_6057066_12 Lycopene cyclase protein K06443 - 5.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003454 295.0
TLS2_k127_6057066_13 lipopolysaccharide transmembrane transporter activity K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003021 268.0
TLS2_k127_6057066_14 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006685 264.0
TLS2_k127_6057066_15 sh3 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000002317 240.0
TLS2_k127_6057066_16 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004593 235.0
TLS2_k127_6057066_17 TIGRFAM redox-sensitive transcriptional activator SoxR K13639 - - 0.0000000000000000000000000000000000000000000000000000000000000001423 224.0
TLS2_k127_6057066_18 protein conserved in bacteria K09957 - - 0.00000000000000000000000000000000000000000000003414 179.0
TLS2_k127_6057066_19 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000002417 168.0
TLS2_k127_6057066_2 Belongs to the arginase family K01480 - 3.5.3.11 1.266e-210 660.0
TLS2_k127_6057066_20 NUDIX domain - - - 0.00000000000000000000000000000000000000003184 156.0
TLS2_k127_6057066_21 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000641 151.0
TLS2_k127_6057066_22 Transcriptional regulator, MarR family - - - 0.000000000000000000000000000000000000002813 150.0
TLS2_k127_6057066_23 Pfam:DUF385 - - - 0.0000000000000000000000002578 115.0
TLS2_k127_6057066_24 Acyltransferase family - - - 0.00000000000000001801 83.0
TLS2_k127_6057066_25 COG3209 Rhs family protein - - - 0.000000003605 69.0
TLS2_k127_6057066_3 Glutathione S-transferase, C-terminal domain K07393 - 1.8.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 597.0
TLS2_k127_6057066_4 Cation efflux family K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 429.0
TLS2_k127_6057066_5 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 392.0
TLS2_k127_6057066_6 Peptidase s1 and s6 chymotrypsin hap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 383.0
TLS2_k127_6057066_7 Domain of unknown function (DUF427) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 373.0
TLS2_k127_6057066_8 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 357.0
TLS2_k127_6057066_9 NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 356.0
TLS2_k127_6074174_0 DEAD DEAH box helicase - - - 0.0 1299.0
TLS2_k127_6074174_1 MMPL family - - - 2.854e-226 737.0
TLS2_k127_6074174_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001375 278.0
TLS2_k127_6074174_11 CAAX protease self-immunity - - - 0.000000000000000000000000000000000000000000000000000000000000000000001987 248.0
TLS2_k127_6074174_12 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000002838 240.0
TLS2_k127_6074174_13 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000001392 213.0
TLS2_k127_6074174_14 DNA-binding transcriptional activator of the SARP family - - - 0.00000000000000000000000000000000000000000000000000007164 196.0
TLS2_k127_6074174_15 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000000000000000000000000001212 170.0
TLS2_k127_6074174_16 Beta-lactamase K01286 - 3.4.16.4 0.0000000000000000000000000000000000002836 155.0
TLS2_k127_6074174_17 Tetratricopeptide repeat - - - 0.000000000000000000000000003098 123.0
TLS2_k127_6074174_18 Ppx GppA phosphatase K01524 GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237 3.6.1.11,3.6.1.40 0.0000000002504 69.0
TLS2_k127_6074174_2 AAA domain - - - 1.375e-195 637.0
TLS2_k127_6074174_20 - - - - 0.0000003509 62.0
TLS2_k127_6074174_3 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 593.0
TLS2_k127_6074174_4 Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process K07067 - 2.7.7.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 565.0
TLS2_k127_6074174_5 Belongs to the glutaminase family K01425 GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 3.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003983 386.0
TLS2_k127_6074174_6 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 383.0
TLS2_k127_6074174_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 368.0
TLS2_k127_6074174_8 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004932 336.0
TLS2_k127_6074174_9 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003921 274.0
TLS2_k127_6076588_0 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008591 490.0
TLS2_k127_6076588_1 response regulator K22010 GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 290.0
TLS2_k127_6076588_2 ABC-type branched-chain amino acid transport K01999 - - 0.00000000000000000000000001205 126.0
TLS2_k127_6136212_0 phosphoserine phosphatase K01079 GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 522.0
TLS2_k127_6136212_1 acetyl-CoA hydrolase K18288 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 491.0
TLS2_k127_6136212_10 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000105 285.0
TLS2_k127_6136212_11 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.00000000000000000000000000000000000000000000000000000000000000009028 231.0
TLS2_k127_6136212_12 - - - - 0.000000000000000000000000000000000000000000000001093 186.0
TLS2_k127_6136212_13 - - - - 0.00000000000000000000000000000000000000000000326 172.0
TLS2_k127_6136212_14 NfeD-like C-terminal, partner-binding - - - 0.000000000000000000000000000000000000000000008903 168.0
TLS2_k127_6136212_15 phosphohistidine phosphatase, SixA K08296 - - 0.0000000000000000002129 90.0
TLS2_k127_6136212_16 Cold shock K03704 - - 0.0000000006754 64.0
TLS2_k127_6136212_17 - - - - 0.00000008381 63.0
TLS2_k127_6136212_18 - - - - 0.0000001528 55.0
TLS2_k127_6136212_19 deoxyribodipyrimidine photolyase-related protein K06876 - - 0.00005598 54.0
TLS2_k127_6136212_2 alcohol dehydrogenase K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 462.0
TLS2_k127_6136212_3 PFAM sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 456.0
TLS2_k127_6136212_4 prohibitin homologues - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 442.0
TLS2_k127_6136212_5 Deoxyribodipyrimidine photo-lyase-related protein K06876 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 385.0
TLS2_k127_6136212_6 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008749 383.0
TLS2_k127_6136212_7 SpoU rRNA Methylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003646 331.0
TLS2_k127_6136212_8 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005838 334.0
TLS2_k127_6136212_9 ADP-ribose pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004811 279.0
TLS2_k127_6169559_0 Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 487.0
TLS2_k127_6169559_1 Transposase - - - 0.000000001379 60.0
TLS2_k127_6169559_2 Short C-terminal domain K08982 - - 0.00003726 47.0
TLS2_k127_6174724_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0 1042.0
TLS2_k127_6174724_1 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 2.549e-263 823.0
TLS2_k127_6174724_2 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 326.0
TLS2_k127_6174724_3 polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000003086 137.0
TLS2_k127_6188150_0 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008725 554.0
TLS2_k127_6188150_1 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 543.0
TLS2_k127_6188150_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 426.0
TLS2_k127_6188150_3 Activator of hsp90 atpase 1 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004162 241.0
TLS2_k127_6188150_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000001576 227.0
TLS2_k127_6188150_5 PFAM Bacterial regulatory protein, arsR family - - - 0.000000000000000000000000000000000000000000000000001034 186.0
TLS2_k127_6188150_6 Protein of unknown function (DUF2089) - - - 0.000000000000000000000000000000000003313 152.0
TLS2_k127_6188150_7 Transcriptional regulator, MarR family - - - 0.0000000001593 71.0
TLS2_k127_6191329_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1111.0
TLS2_k127_6191329_1 Domain of unknown function (DUF1998) K06877 - - 0.0 1038.0
TLS2_k127_6191329_2 Amidohydrolase family - - - 6.568e-211 669.0
TLS2_k127_6191329_3 alanine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006031 533.0
TLS2_k127_6191329_4 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 316.0
TLS2_k127_6191329_5 Belongs to the anti-sigma-factor antagonist family K04749 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000002211 196.0
TLS2_k127_6191329_6 anti-sigma regulatory factor - - - 0.0000000000000002081 85.0
TLS2_k127_6198684_0 Magnesium chelatase, subunit ChlI C-terminal K07391 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 571.0
TLS2_k127_6198684_1 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 417.0
TLS2_k127_6198684_2 Protein of unknown function (DUF3048) C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 374.0
TLS2_k127_6198684_3 DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008243 316.0
TLS2_k127_6198684_4 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000003268 176.0
TLS2_k127_6198684_5 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000000000000000000002758 157.0
TLS2_k127_6198684_6 PFAM extracellular solute-binding protein family 5 K02035 - - 0.000000000000000004665 89.0
TLS2_k127_6212_0 Beta-eliminating lyase K01667,K01668 - 4.1.99.1,4.1.99.2 1.665e-246 770.0
TLS2_k127_6212_1 Pyridoxal-phosphate dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005035 340.0
TLS2_k127_6212_2 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002818 284.0
TLS2_k127_6212_3 protein conserved in cyanobacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000003562 230.0
TLS2_k127_6212_4 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000004604 222.0
TLS2_k127_6212_5 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000416 194.0
TLS2_k127_6212_6 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000002864 165.0
TLS2_k127_6212_7 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000003542 169.0
TLS2_k127_6212_8 efflux transmembrane transporter activity - - - 0.000000000000000000004362 107.0
TLS2_k127_6238953_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000704 518.0
TLS2_k127_6238953_1 Exporter of polyketide K01992 - - 0.00000000000000000000000000000000000000000000000000000000001292 214.0
TLS2_k127_6246796_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.0 1153.0
TLS2_k127_6246796_1 COG3209 Rhs family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 331.0
TLS2_k127_6246796_2 Uncharacterized protein conserved in bacteria (DUF2344) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007431 294.0
TLS2_k127_624848_0 AMP-binding enzyme C-terminal domain K00666 - - 1.578e-241 769.0
TLS2_k127_624848_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 432.0
TLS2_k127_624848_2 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009498 353.0
TLS2_k127_624848_3 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 333.0
TLS2_k127_624848_4 Carbon-nitrogen hydrolase K11206 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003317 333.0
TLS2_k127_624848_5 ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000797 276.0
TLS2_k127_624848_6 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor - - - 0.0000000000000000007662 94.0
TLS2_k127_6250405_0 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007823 564.0
TLS2_k127_6250405_1 Dihydroxyacetone kinase K05878 - 2.7.1.121 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 557.0
TLS2_k127_6250405_2 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006978 316.0
TLS2_k127_6250405_3 Dak2 K05879 - 2.7.1.121 0.0000000000000000000000000000002882 124.0
TLS2_k127_6271432_0 fructose-bisphosphate aldolase K01624 GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003524 566.0
TLS2_k127_6271432_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001976 250.0
TLS2_k127_6271432_2 Protein of unknown function (DUF3151) - - - 0.0000000000000000000000000000000000000000000000000000000001102 214.0
TLS2_k127_6271432_3 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000002915 182.0
TLS2_k127_6271432_4 TIGRFAM Phosphotransferase System HPr (HPr) Family K11189 - - 0.0000000000000000000000007042 107.0
TLS2_k127_6271432_5 FGGY family of carbohydrate kinases, N-terminal domain K00851 - 2.7.1.12 0.000000000003088 69.0
TLS2_k127_6271432_6 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.0000004035 52.0
TLS2_k127_6271730_0 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 325.0
TLS2_k127_6271730_1 Belongs to the ABC transporter superfamily K06857,K10112 - 3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003374 314.0
TLS2_k127_6271730_2 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004054 260.0
TLS2_k127_6271730_3 PBP superfamily domain - - - 0.000000000000000000000000000000000000000000000000000001596 203.0
TLS2_k127_6271730_4 Binding-protein-dependent transport system inner membrane component K05773 - - 0.000000000000000000000000000000000000000000000000365 194.0
TLS2_k127_6271730_5 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.0000000000000000000000000000000000003895 141.0
TLS2_k127_6283344_0 Cell wall-active antibiotics response 4TMS YvqF - - - 0.0000000000000000000000000000000002644 143.0
TLS2_k127_6283344_1 Protein of unknown function (DUF4245) - - - 0.000000000000000000007458 102.0
TLS2_k127_6283344_2 Domain of unknown function (DUF1707) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000117 75.0
TLS2_k127_6285386_0 Coenzyme A transferase K01028 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006645 389.0
TLS2_k127_6285386_1 Coenzyme A transferase K01029 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 344.0
TLS2_k127_6285386_2 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - - 0.00000000000000000000000000164 118.0
TLS2_k127_6295120_0 Multicopper oxidase - - - 3.912e-249 779.0
TLS2_k127_6295120_1 pyrimidine-nucleoside phosphorylase K00756,K00758 GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 8.903e-217 679.0
TLS2_k127_6295120_2 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000124 282.0
TLS2_k127_629942_0 HAD-superfamily subfamily IB hydrolase, TIGR01490 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 392.0
TLS2_k127_6317613_0 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 2.005e-226 711.0
TLS2_k127_6317613_1 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001302 280.0
TLS2_k127_6317613_2 Domain of Unknown Function (DUF1206) - - - 0.00000000000000000000000000000000000000000000000000000000000000003374 234.0
TLS2_k127_6322300_0 SNF2 Helicase protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 412.0
TLS2_k127_6322300_1 SWIM zinc finger - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001791 284.0
TLS2_k127_6322443_0 Helicase associated domain (HA2) Add an annotation K03578 - 3.6.4.13 0.0 1354.0
TLS2_k127_6322443_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 582.0
TLS2_k127_6322443_2 Aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000492 212.0
TLS2_k127_6322443_3 domain, Protein K07228 - - 0.000442 53.0
TLS2_k127_6326296_0 tRNA synthetases class I (E and Q), catalytic domain K01885 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.17 3.22e-228 717.0
TLS2_k127_6326296_1 Domain of unknown function (DUF2437) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 405.0
TLS2_k127_6326296_2 CAAX amino terminal protease K07052 - - 0.00000000000000000000000000000000000000000000001116 185.0
TLS2_k127_6328864_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.4.4.2 0.0 1399.0
TLS2_k127_6328864_1 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits K16881 - 2.7.7.13,5.4.2.8 0.0 1151.0
TLS2_k127_6328864_10 Bacterial protein of unknown function (DUF881) - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000005717 221.0
TLS2_k127_6328864_11 Bacterial protein of unknown function (DUF881) - GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000001137 210.0
TLS2_k127_6328864_12 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000000000000001045 199.0
TLS2_k127_6328864_13 polysaccharide deacetylase K14659,K22278 - 3.5.1.104 0.0000000000000000000000000000000000000000000000001288 182.0
TLS2_k127_6328864_14 phosphatidylinositol transporter activity - - - 0.0000000000000000000000000000000000000000000000004106 180.0
TLS2_k127_6328864_15 membrane - - - 0.0000000000000000000000000000000000000001725 165.0
TLS2_k127_6328864_16 - - - - 0.00000000000000000000000000000000002332 150.0
TLS2_k127_6328864_17 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000005881 137.0
TLS2_k127_6328864_18 helix_turn_helix, Lux Regulon K03556 - - 0.000000000000000000001912 97.0
TLS2_k127_6328864_19 helix_turn_helix, Lux Regulon K03556 - - 0.000006591 53.0
TLS2_k127_6328864_2 Putative modulator of DNA gyrase K03568 - - 1.677e-241 754.0
TLS2_k127_6328864_3 luxR family - - - 5.802e-195 639.0
TLS2_k127_6328864_4 modulator of DNA gyrase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 563.0
TLS2_k127_6328864_5 SMART regulatory protein, MerR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004642 288.0
TLS2_k127_6328864_6 helix_turn_helix, mercury resistance - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001049 276.0
TLS2_k127_6328864_7 Bifunctional nuclease K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008292 262.0
TLS2_k127_6328864_8 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000003954 269.0
TLS2_k127_6328864_9 zinc-ribbon domain - - - 0.00000000000000000000000000000000000000000000000000000000000000007048 228.0
TLS2_k127_6357747_0 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 8.501e-195 623.0
TLS2_k127_6357747_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005116 574.0
TLS2_k127_6357747_10 helix_turn _helix lactose operon repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007938 282.0
TLS2_k127_6357747_11 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001077 274.0
TLS2_k127_6357747_12 Sucrose-6F-phosphate phosphohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008946 259.0
TLS2_k127_6357747_13 hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003573 254.0
TLS2_k127_6357747_14 Protein of unknown function (DUF2587) - GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 - 0.0000000000000000000000000000000000000000000000000000000000000000002993 236.0
TLS2_k127_6357747_15 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000002993 219.0
TLS2_k127_6357747_16 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000004453 211.0
TLS2_k127_6357747_17 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000000000000000000000002255 179.0
TLS2_k127_6357747_18 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000000000009332 145.0
TLS2_k127_6357747_19 glyoxalase - - - 0.0000000000000000002709 92.0
TLS2_k127_6357747_2 PFAM tRNA synthetases class I (C) catalytic domain K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 478.0
TLS2_k127_6357747_3 Cys/Met metabolism PLP-dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 408.0
TLS2_k127_6357747_4 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009972 407.0
TLS2_k127_6357747_5 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 377.0
TLS2_k127_6357747_6 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000438 393.0
TLS2_k127_6357747_7 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 301.0
TLS2_k127_6357747_8 SEC-C motif - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 293.0
TLS2_k127_6357747_9 Oxidoreductase K03810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 299.0
TLS2_k127_6361583_0 ATP-grasp domain - - - 0.0 1104.0
TLS2_k127_6361583_1 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008327 481.0
TLS2_k127_6361583_10 RNA polymerase, sigma-24 subunit, ECF subfamily - - - 0.000000000000000000000000000000000000000000000000007318 188.0
TLS2_k127_6361583_11 DNA-binding protein - GO:0008150,GO:0040007 - 0.00000000000000000000000000000000000000000000000002545 204.0
TLS2_k127_6361583_12 Domain of unknown function (DUF4193) - - - 0.00000000000000000000000000000000000000000005548 167.0
TLS2_k127_6361583_13 pfkB family carbohydrate kinase - - - 0.00000000000000000000000008462 121.0
TLS2_k127_6361583_14 Protein of unknown function (DUF3093) - - - 0.0000000000000000000000009624 109.0
TLS2_k127_6361583_15 - - - - 0.0000000000000000000006068 104.0
TLS2_k127_6361583_2 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 429.0
TLS2_k127_6361583_3 FAD linked oxidase domain protein K00103 - 1.1.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000092 431.0
TLS2_k127_6361583_4 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 343.0
TLS2_k127_6361583_5 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 330.0
TLS2_k127_6361583_6 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 333.0
TLS2_k127_6361583_7 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003398 306.0
TLS2_k127_6361583_8 Inositol monophosphatase K01092 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006207 304.0
TLS2_k127_6361583_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001323 254.0
TLS2_k127_6408330_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 443.0
TLS2_k127_6408330_1 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 314.0
TLS2_k127_6408330_2 Binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000755 233.0
TLS2_k127_6408330_3 Ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000001858 104.0
TLS2_k127_6411892_0 Aldo/keto reductase family K19265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000748 565.0
TLS2_k127_6411892_1 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007509 394.0
TLS2_k127_6411892_2 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 350.0
TLS2_k127_6411892_3 PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 317.0
TLS2_k127_6411892_4 epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003263 280.0
TLS2_k127_6411892_5 - - - - 0.000000000000000000000000000000000000000002808 160.0
TLS2_k127_6411892_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000008006 156.0
TLS2_k127_6411892_7 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00382 - 1.8.1.4 0.000000000000000000000000000004639 135.0
TLS2_k127_6411892_8 DNA-binding transcriptional activator of the SARP family - - - 0.000000000000000000000201 111.0
TLS2_k127_6411892_9 Histidine kinase-like ATPase domain - - - 0.0000000000000003358 88.0
TLS2_k127_6419565_0 Belongs to the helicase family. UvrD subfamily K03657 - 3.6.4.12 0.0 1163.0
TLS2_k127_6419565_1 Belongs to the helicase family. UvrD subfamily - - - 0.0 1154.0
TLS2_k127_6419565_10 Glutaredoxin K18917 - 1.20.4.3 0.000000000000000000000000000393 115.0
TLS2_k127_6419565_11 cysteine - - - 0.00000000000000000000000000164 129.0
TLS2_k127_6419565_12 ATP-binding protein - - - 0.000000000000000000000003579 104.0
TLS2_k127_6419565_13 transglycosylase associated protein - - - 0.000000000000000000001352 98.0
TLS2_k127_6419565_15 - - - - 0.000008774 55.0
TLS2_k127_6419565_2 DNA helicase K03657 GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097 3.6.4.12 9.398e-271 851.0
TLS2_k127_6419565_3 ThiF family K21029,K21147 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.80,2.8.1.11 3.222e-201 634.0
TLS2_k127_6419565_4 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 446.0
TLS2_k127_6419565_5 NADH pyrophosphatase K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 354.0
TLS2_k127_6419565_6 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001728 279.0
TLS2_k127_6419565_7 Endonuclease Exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001055 244.0
TLS2_k127_6419565_8 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000009347 213.0
TLS2_k127_6419565_9 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18958 - - 0.000000000000000000000000000000000002326 139.0
TLS2_k127_6423036_0 PFAM AMP-dependent synthetase and ligase K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004224 464.0
TLS2_k127_6423036_1 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000004207 188.0
TLS2_k127_6423036_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000275 159.0
TLS2_k127_6423036_3 PFAM Phosphoglycerate mutase K08296 - - 0.0000000000000000002911 102.0
TLS2_k127_6423036_4 - - - - 0.000001329 60.0
TLS2_k127_6423036_5 3-methyladenine DNA glycosylase - - - 0.000007208 58.0
TLS2_k127_646100_0 Dienelactone hydrolase family - - - 7.889e-287 891.0
TLS2_k127_646100_1 HELICc2 K03722 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.4.12 8.976e-241 760.0
TLS2_k127_646100_2 mannose-6-phosphate isomerase K01809 - 5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 328.0
TLS2_k127_646100_3 Sulfite exporter TauE/SafE - - - 0.00000000000000000000000000000000000000000004347 171.0
TLS2_k127_646100_4 Rho termination factor, N-terminal domain - - - 0.0000000000000000000000000002122 116.0
TLS2_k127_646100_5 - - - - 0.0000000000000000000004903 108.0
TLS2_k127_647564_0 ribonuclease Rne Rng family K08300,K08301 - 3.1.26.12 9.731e-257 818.0
TLS2_k127_647564_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 - 2.736e-208 656.0
TLS2_k127_647564_10 peptidase K21471 - - 0.000000000000000000000000000000000000000000000000003871 199.0
TLS2_k127_647564_11 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.000000000000000000000000000000000000001189 154.0
TLS2_k127_647564_12 - - - - 0.0000000000000000000000000000000000001441 144.0
TLS2_k127_647564_13 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000004209 141.0
TLS2_k127_647564_14 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000001816 53.0
TLS2_k127_647564_2 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 573.0
TLS2_k127_647564_3 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 518.0
TLS2_k127_647564_4 Cytidylyltransferase family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 395.0
TLS2_k127_647564_5 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004539 329.0
TLS2_k127_647564_6 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000007409 251.0
TLS2_k127_647564_7 Phosphoglycerate mutase family K01834,K22306 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237 3.1.3.85,5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000007543 231.0
TLS2_k127_647564_8 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000000001771 198.0
TLS2_k127_647564_9 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000000000000000000000001561 193.0
TLS2_k127_6480142_0 MMPL family K06994,K20470 - - 1.182e-274 864.0
TLS2_k127_6480142_1 GlnD PII-uridylyltransferase K00990 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096 2.7.7.59 1.091e-246 783.0
TLS2_k127_6480142_10 Ribosomal protein S16 K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000009467 201.0
TLS2_k127_6480142_11 KH domain K06960 GO:0008150,GO:0040007 - 0.000000000000000000000000001112 123.0
TLS2_k127_6480142_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 3.6.5.4 6.125e-239 760.0
TLS2_k127_6480142_3 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 481.0
TLS2_k127_6480142_4 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 365.0
TLS2_k127_6480142_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 307.0
TLS2_k127_6480142_6 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000001534 236.0
TLS2_k127_6480142_7 RimM N-terminal domain K02860 GO:0008150,GO:0040007 - 0.00000000000000000000000000000000000000000000000000000000007683 218.0
TLS2_k127_6480142_8 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000005377 202.0
TLS2_k127_6480142_9 Protein of unknown function (DUF2469) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000005652 188.0
TLS2_k127_6534180_0 Carbamoyl-phosphate synthetase ammonia chain K01955 - 6.3.5.5 0.0 1758.0
TLS2_k127_6534180_1 ABC transporter K06158 - - 3.093e-255 802.0
TLS2_k127_6534180_10 Neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 328.0
TLS2_k127_6534180_11 ABC-type cobalt transport system, ATPase component K16784 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 300.0
TLS2_k127_6534180_12 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008623 282.0
TLS2_k127_6534180_13 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000001234 258.0
TLS2_k127_6534180_14 BioY family K03523 - - 0.000000000000000000000000000000000000000000000000000000000001097 218.0
TLS2_k127_6534180_15 Cobalt transport protein K16783 - - 0.000000000000000000000000000000000000000000000001953 192.0
TLS2_k127_6534180_16 integration host factor - - - 0.000000000000000000000000000000000000000000000476 168.0
TLS2_k127_6534180_17 translation release factor activity - - - 0.000000000000000000000000000000000000000000001789 177.0
TLS2_k127_6534180_18 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000002107 154.0
TLS2_k127_6534180_19 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.6 0.000000000000000000000000000000000003081 148.0
TLS2_k127_6534180_2 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 3.429e-232 739.0
TLS2_k127_6534180_20 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000001468 138.0
TLS2_k127_6534180_21 Belongs to the CarA family - - - 0.00000000000000000000000000000006939 141.0
TLS2_k127_6534180_22 transcriptional regulator - - - 0.00000000000000000000000765 108.0
TLS2_k127_6534180_23 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000006338 65.0
TLS2_k127_6534180_3 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.3 2.328e-223 700.0
TLS2_k127_6534180_4 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.5.1.6 2.219e-204 661.0
TLS2_k127_6534180_5 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003328 564.0
TLS2_k127_6534180_6 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 569.0
TLS2_k127_6534180_7 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00226,K00254 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.3.5.2,1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007318 442.0
TLS2_k127_6534180_8 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003587 410.0
TLS2_k127_6534180_9 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006467 361.0
TLS2_k127_6543000_0 PFAM Cys Met metabolism K01739 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 475.0
TLS2_k127_6543000_1 helix_turn_helix gluconate operon transcriptional repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002714 302.0
TLS2_k127_6543000_2 membrane K07149 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001552 265.0
TLS2_k127_656080_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.0 1096.0
TLS2_k127_656080_1 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 1.134e-212 675.0
TLS2_k127_656080_2 Type II/IV secretion system protein K02283 - - 7.719e-207 653.0
TLS2_k127_656080_3 Type II secretion system (T2SS), protein F K12510 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 366.0
TLS2_k127_656080_4 Type II secretion system K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002831 353.0
TLS2_k127_656080_5 PE family - - - 0.00000000000000000003374 96.0
TLS2_k127_6569455_0 Cation transporter/ATPase, N-terminus K01537,K12953 GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.8 8.085e-261 838.0
TLS2_k127_6569455_1 phosphate starvation-inducible protein PhoH K07175 - - 3.874e-234 732.0
TLS2_k127_6569455_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 1.378e-224 702.0
TLS2_k127_6569455_3 PFAM NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 401.0
TLS2_k127_6569455_4 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004278 397.0
TLS2_k127_6569455_5 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000001854 236.0
TLS2_k127_6569455_6 lytic transglycosylase activity - - - 0.0000000000000000000000000000000000000000000001111 180.0
TLS2_k127_6569455_7 ATPase, P-type transporting, HAD superfamily, subfamily IC - - - 0.000000000000000000000000000000000003124 149.0
TLS2_k127_6572582_0 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 400.0
TLS2_k127_6572582_1 assembly protein sufB K09014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 393.0
TLS2_k127_6572582_2 Domain of unknown function (DUF4397) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 349.0
TLS2_k127_6572582_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 295.0
TLS2_k127_6572582_4 transport, permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001038 296.0
TLS2_k127_6572582_5 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000003451 238.0
TLS2_k127_6572582_6 Anti-sigma-K factor rskA - - - 0.000000000000000000000000000000000000000000000000000000000001185 219.0
TLS2_k127_6572582_7 PFAM peptidase C60 sortase A and B - - - 0.000000000000000000000000000000000000000004053 164.0
TLS2_k127_6572582_8 cytochrome oxidase assembly K02259 - - 0.000000000007302 70.0
TLS2_k127_6576249_0 Glycosyl transferases group 1 K16148 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 2.4.1.342 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 545.0
TLS2_k127_6576249_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 444.0
TLS2_k127_6576249_2 Nucleotidyl transferase K00975 GO:0000271,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901576 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007734 354.0
TLS2_k127_6576249_3 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006396 347.0
TLS2_k127_6576249_4 PaaX-like protein K02616 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 316.0
TLS2_k127_6576249_5 Protein of unknown function (DUF3117) - - - 0.000000000000000000001393 108.0
TLS2_k127_6581053_0 Acyl-CoA dehydrogenase, middle domain - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 1.291e-299 931.0
TLS2_k127_6581053_1 malic enzyme K00027 - 1.1.1.38 1.3e-216 683.0
TLS2_k127_6581053_10 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000001611 192.0
TLS2_k127_6581053_11 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000001861 196.0
TLS2_k127_6581053_12 Sigma-70, region 4 - - - 0.00000000000000000000000000001395 124.0
TLS2_k127_6581053_13 lytic transglycosylase activity K21471 - - 0.00000000000000000000000003419 123.0
TLS2_k127_6581053_14 Peptidase family M23 K21471 - - 0.00000000000000000001827 91.0
TLS2_k127_6581053_15 Virulence factor BrkB - - - 0.0000000000000005716 91.0
TLS2_k127_6581053_16 Belongs to the 'phage' integrase family - - - 0.000001716 55.0
TLS2_k127_6581053_2 Bacterial transcriptional activator domain - - - 5.77e-214 704.0
TLS2_k127_6581053_3 mannose-ethanolamine phosphotransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008145 498.0
TLS2_k127_6581053_4 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000329 499.0
TLS2_k127_6581053_5 pfkB family carbohydrate kinase K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 310.0
TLS2_k127_6581053_6 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002866 276.0
TLS2_k127_6581053_7 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000001295 245.0
TLS2_k127_6581053_8 Protein of unknown function (DUF3048) C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000005359 247.0
TLS2_k127_6581053_9 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001183 230.0
TLS2_k127_6582963_0 May be involved in recombinational repair of damaged DNA K03631 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 4.16e-214 682.0
TLS2_k127_6582963_1 Thiamine pyrophosphokinase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 556.0
TLS2_k127_6582963_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 406.0
TLS2_k127_6582963_3 Protein of unknown function (DUF1015) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 368.0
TLS2_k127_6582963_4 Ribosomal RNA methyltransferase RrmJ FtsJ K06442 GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 352.0
TLS2_k127_6582963_5 PFAM Haloacid dehalogenase domain protein hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005559 371.0
TLS2_k127_6582963_6 Belongs to the DEAD box helicase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001466 264.0
TLS2_k127_6582963_7 Copper transport outer membrane protein, MctB - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796 - 0.000000000000000000000000000000000000000000000000000007845 203.0
TLS2_k127_6582963_8 Single-strand binding protein family K03111 - - 0.000000000000000000000000229 115.0
TLS2_k127_6582963_9 granule-associated protein - - - 0.0000000000000000007956 93.0
TLS2_k127_6585402_0 Peptidase family M28 - - - 8.421e-207 651.0
TLS2_k127_6585402_1 PFAM Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 507.0
TLS2_k127_6585402_2 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 487.0
TLS2_k127_6585402_3 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 412.0
TLS2_k127_6585402_4 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD K01144,K03581 - 3.1.11.5 0.0000000000000000000000000000000000000000000000000000000000002586 237.0
TLS2_k127_6585402_5 Peptidase family M23 K21471 - - 0.000000000000000000000000000000000000002257 160.0
TLS2_k127_6585402_6 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K21471 - - 0.00000000000000000000000000000000000002645 164.0
TLS2_k127_6585402_7 - - - - 0.000000000000000003485 94.0
TLS2_k127_6585402_8 - - - - 0.0000000000000001077 86.0
TLS2_k127_6604450_0 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004512 462.0
TLS2_k127_6604450_1 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 434.0
TLS2_k127_6604450_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005218 330.0
TLS2_k127_6604450_3 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001895 284.0
TLS2_k127_6604450_4 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000000000000000006824 158.0
TLS2_k127_6604450_6 Universal stress protein family - - - 0.000001522 55.0
TLS2_k127_6605790_0 FGGY family of carbohydrate kinases, N-terminal domain K00854 - 2.7.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 613.0
TLS2_k127_6605790_1 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000076 243.0
TLS2_k127_6606533_0 Exodeoxyribonuclease V, gamma subunit K03583 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.5 0.0 1252.0
TLS2_k127_6606533_1 Phenylalanyl-tRNA synthetase K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 471.0
TLS2_k127_6606533_10 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000006375 86.0
TLS2_k127_6606533_11 Enoyl-(Acyl carrier protein) reductase - - - 0.000000005303 58.0
TLS2_k127_6606533_2 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 423.0
TLS2_k127_6606533_3 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006662 420.0
TLS2_k127_6606533_4 Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 420.0
TLS2_k127_6606533_5 unusual protein kinase K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 410.0
TLS2_k127_6606533_6 Acetyltransferase (isoleucine patch K00661 - 2.3.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000001424 260.0
TLS2_k127_6606533_7 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004556 263.0
TLS2_k127_6606533_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001088 229.0
TLS2_k127_6606533_9 PFAM Rieske 2Fe-2S K16937 - 1.8.5.2 0.0000000000000000000000000002308 119.0
TLS2_k127_6624213_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 0.0 1161.0
TLS2_k127_6624213_1 Peptidase family S49 K04773,K04774 - - 0.0002177 44.0
TLS2_k127_6624966_0 Alkyl sulfatase dimerisation - - - 0.0 1015.0
TLS2_k127_6624966_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 612.0
TLS2_k127_6624966_10 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000003852 168.0
TLS2_k127_6624966_11 AAA ATPase domain - - - 0.000000000000000000003518 93.0
TLS2_k127_6624966_12 Serine aminopeptidase, S33 K22250 - 3.1.1.76 0.000000000000000001812 86.0
TLS2_k127_6624966_13 Plasmid pRiA4b ORF-3-like protein - - - 0.000000000002947 69.0
TLS2_k127_6624966_14 - - - - 0.00000000001342 74.0
TLS2_k127_6624966_2 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 513.0
TLS2_k127_6624966_3 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 502.0
TLS2_k127_6624966_4 Plasmid pRiA4b ORF-3-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 420.0
TLS2_k127_6624966_5 zinc transporter K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 346.0
TLS2_k127_6624966_6 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005897 309.0
TLS2_k127_6624966_7 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 297.0
TLS2_k127_6624966_8 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K00657,K07023 - 2.3.1.57 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008385 283.0
TLS2_k127_6624966_9 Uncharacterized protein conserved in bacteria (DUF2255) - - - 0.000000000000000000000000000000000000000000000000000000000000216 213.0
TLS2_k127_6637128_0 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 2.788e-225 717.0
TLS2_k127_6637128_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 1.346e-214 677.0
TLS2_k127_6637128_2 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004248 583.0
TLS2_k127_6637128_3 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 395.0
TLS2_k127_6637128_4 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 322.0
TLS2_k127_6637128_5 ferrous iron binding - - - 0.0000000000000000000000000000000000000000000000000000000000000003767 228.0
TLS2_k127_6657162_0 Phosphate starvation-inducible protein PhoH K06217 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 610.0
TLS2_k127_6657162_1 Transporter associated domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 556.0
TLS2_k127_6657162_2 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004288 492.0
TLS2_k127_6657162_3 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000000000000000000000000000004841 216.0
TLS2_k127_6657162_4 EamA-like transporter family K03298 - - 0.00000000000000000000000000000000000002952 156.0
TLS2_k127_6657162_5 cytidine deaminase - - - 0.0000000000000000000000000000000001042 136.0
TLS2_k127_6661971_0 Phosphopantetheine attachment site - - - 0.0 1422.0
TLS2_k127_666834_0 bacterial-type flagellum organization - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 470.0
TLS2_k127_666834_1 SAF - - - 0.00000000000000000000000001828 121.0
TLS2_k127_666834_2 Helix-turn-helix domain - - - 0.00000001011 56.0
TLS2_k127_6669881_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0 1035.0
TLS2_k127_6669881_1 Belongs to the 5'-nucleotidase family K01081 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005305 623.0
TLS2_k127_6669881_2 Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol K15520 GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701 2.3.1.189 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 378.0
TLS2_k127_6669881_3 CHAD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 342.0
TLS2_k127_6698931_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 7.971e-211 676.0
TLS2_k127_6698931_1 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 9.492e-200 638.0
TLS2_k127_6698931_10 SpoU rRNA Methylase family K00556 - 2.1.1.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 337.0
TLS2_k127_6698931_11 Dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 326.0
TLS2_k127_6698931_12 Domain of unknown function (DUF368) K08974 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 310.0
TLS2_k127_6698931_13 GntR family K03710 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 295.0
TLS2_k127_6698931_14 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003806 281.0
TLS2_k127_6698931_15 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007757 262.0
TLS2_k127_6698931_16 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000001571 256.0
TLS2_k127_6698931_17 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000002781 214.0
TLS2_k127_6698931_18 ATPases associated with a variety of cellular activities K15555 - - 0.00000000000000000000000000000000000000000000000000006367 194.0
TLS2_k127_6698931_19 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 K02777,K02802 - 2.7.1.193 0.000000000000000000000000000000000000000000000000002815 191.0
TLS2_k127_6698931_2 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000507 618.0
TLS2_k127_6698931_20 phosphonoacetaldehyde hydrolase activity K01489,K19270 - 3.1.3.23,3.5.4.5 0.0000000000000000000000000000000000000000001026 170.0
TLS2_k127_6698931_21 phosphotransferase system K02803 - 2.7.1.193 0.0000000000000000000000000002749 123.0
TLS2_k127_6698931_22 - - - - 0.0000000000000000005975 100.0
TLS2_k127_6698931_23 CHAT domain - - - 0.0000000000000000008793 91.0
TLS2_k127_6698931_24 - - - - 0.0000000000000007474 89.0
TLS2_k127_6698931_25 LemA family K03744 - - 0.000000002774 66.0
TLS2_k127_6698931_3 Phosphotransferase system, EIIC K02804 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 625.0
TLS2_k127_6698931_4 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006668 591.0
TLS2_k127_6698931_5 Cys/Met metabolism PLP-dependent enzyme K00812,K10907,K14267 - 2.6.1.1,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004285 536.0
TLS2_k127_6698931_6 SIS domain K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005945 448.0
TLS2_k127_6698931_7 Belongs to the HAD-like hydrolase superfamily K02566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003655 394.0
TLS2_k127_6698931_8 Amidohydrolase family K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 389.0
TLS2_k127_6698931_9 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 376.0
TLS2_k127_6716628_0 FAD linked oxidases, C-terminal domain K00102,K11472 - 1.1.2.4 3.371e-274 854.0
TLS2_k127_6716628_1 Cysteine-rich domain - - - 8.85e-231 719.0
TLS2_k127_6716628_2 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 501.0
TLS2_k127_6716628_3 Tryptophanyl-tRNA synthetase K01867 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 483.0
TLS2_k127_6716628_4 Transporter associated domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 470.0
TLS2_k127_6716628_5 LigT like Phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009989 254.0
TLS2_k127_6716628_6 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000004144 231.0
TLS2_k127_6716628_7 Ribonuclease K07058 - - 0.000000000000000000000000000000000000000000001414 186.0
TLS2_k127_6716628_8 - - - - 0.000000000000000000000000000009291 130.0
TLS2_k127_6752130_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360 3.6.4.12 3.729e-249 789.0
TLS2_k127_6752130_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000001611 244.0
TLS2_k127_6752130_2 metal-binding, possibly nucleic acid-binding protein K07040 GO:0008150,GO:0040007 - 0.000000000000000000000000000000000000000000000000000000000000000002701 237.0
TLS2_k127_6752130_3 Dihydroxyacetone kinase K07030 - - 0.000000000000000000000000000000000000000000000000000000000000004899 232.0
TLS2_k127_6752130_4 methyltransferase K08316 - 2.1.1.171 0.00000000000000000000000000000000000000000000000000000000000004179 224.0
TLS2_k127_6752130_5 structural constituent of ribosome K02911 - - 0.0000000001263 66.0
TLS2_k127_6753794_0 Sodium:alanine symporter family K03310 - - 6.357e-206 653.0
TLS2_k127_6753794_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.8.1.7,4.4.1.16 1.984e-203 642.0
TLS2_k127_6753794_10 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.00000000000000000000000000000000000000000000000000000000000001618 228.0
TLS2_k127_6753794_11 SUF system FeS assembly protein, NifU family K04488 - - 0.0000000000000000000000000000000000000000000000000002694 206.0
TLS2_k127_6753794_12 Pfam:DUF59 - - - 0.0000000000000000000000000000000000000000000000003243 190.0
TLS2_k127_6753794_13 AMP binding - - - 0.0000000000000000000000000000000000000004979 158.0
TLS2_k127_6753794_14 Belongs to the PRA-PH family K01523 GO:0000287,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0044403,GO:0044419,GO:0044464,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0071944,GO:0075136,GO:0075139 3.6.1.31 0.0000000000000000000000000000000006004 132.0
TLS2_k127_6753794_15 PFAM ATPase associated with various cellular activities AAA_5 - - - 0.000000000004231 69.0
TLS2_k127_6753794_16 ATPases associated with a variety of cellular activities K09013 - - 0.00000002225 55.0
TLS2_k127_6753794_2 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005159 612.0
TLS2_k127_6753794_3 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 561.0
TLS2_k127_6753794_4 Formyl transferase, C-terminal domain K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 473.0
TLS2_k127_6753794_5 ATP phosphoribosyltransferase K00765,K02502 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 412.0
TLS2_k127_6753794_6 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016020,GO:0016070,GO:0034641,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 405.0
TLS2_k127_6753794_7 Ribulose-phosphate 3 epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 336.0
TLS2_k127_6753794_8 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 308.0
TLS2_k127_6753794_9 riboflavin synthase, alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006578 267.0
TLS2_k127_6761348_0 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 0.0 1017.0
TLS2_k127_6761348_1 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 2.036e-238 776.0
TLS2_k127_6761348_10 Histidine kinase - - - 0.000000000000000000176 90.0
TLS2_k127_6761348_11 FR47-like protein - - - 0.000000000000000002529 88.0
TLS2_k127_6761348_2 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 443.0
TLS2_k127_6761348_3 ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 376.0
TLS2_k127_6761348_4 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 338.0
TLS2_k127_6761348_5 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 333.0
TLS2_k127_6761348_6 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 298.0
TLS2_k127_6761348_7 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002237 289.0
TLS2_k127_6761348_8 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005996 273.0
TLS2_k127_6761348_9 TrkA-C domain K07228 - - 0.00000000000000000000000000000000000000001985 173.0
TLS2_k127_6784261_0 transcriptional activator domain - - - 3.742e-254 820.0
TLS2_k127_6784261_1 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 335.0
TLS2_k127_6784261_2 Protein of unknown function DUF86 - - - 0.0000000000000000000000000000000004634 136.0
TLS2_k127_6784261_3 Heavy-metal-associated domain K01533,K01534,K12954,K17686 - 3.6.3.3,3.6.3.4,3.6.3.5,3.6.3.54 0.00000000000000006158 86.0
TLS2_k127_6784261_4 Host cell surface-exposed lipoprotein - - - 0.000000000002765 75.0
TLS2_k127_6784261_5 PFAM DNA polymerase, beta domain protein region K07075 - - 0.0005852 48.0
TLS2_k127_6803685_0 phenylacetic acid degradation protein paaN - - - 6.113e-231 730.0
TLS2_k127_6803685_1 Bacterial extracellular solute-binding protein K10232 - - 8.743e-211 662.0
TLS2_k127_6803685_2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008836 572.0
TLS2_k127_6803685_3 Belongs to the thiolase family K00626,K00632,K07823 - 2.3.1.16,2.3.1.174,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004936 538.0
TLS2_k127_6803685_4 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 498.0
TLS2_k127_6803685_5 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 337.0
TLS2_k127_6803685_6 MDMPI C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004013 249.0
TLS2_k127_6803685_7 Phenylacetic acid degradation protein PaaD K02614 - - 0.00000000000000000000000000000000000000000001763 179.0
TLS2_k127_6803685_8 - - - - 0.000000000000002177 79.0
TLS2_k127_6803685_9 ANTAR - - - 0.0001086 45.0
TLS2_k127_6805084_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 376.0
TLS2_k127_6805084_1 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006015 346.0
TLS2_k127_6805084_2 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.000000000000000000000000000000000000001227 171.0
TLS2_k127_6815073_0 AAA ATPase domain - - - 9.103e-200 629.0
TLS2_k127_6815073_1 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 475.0
TLS2_k127_6815073_2 Formamidopyrimidine-DNA glycosylase N-terminal domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 403.0
TLS2_k127_6815073_3 Subtilisin inhibitor-like - - - 0.0000000000000000000000007637 110.0
TLS2_k127_6815073_4 FAD linked oxidase - - - 0.000000000000000002303 86.0
TLS2_k127_6819100_0 PhoH-like protein K06217 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 342.0
TLS2_k127_6819100_1 Sigma-70, region 4 - - - 0.00000000000000000000000000000000000000000000000000000000001223 212.0
TLS2_k127_6819100_2 HIT domain K02503 - - 0.000000000000000000000000000000000000000000008798 165.0
TLS2_k127_6848016_0 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 525.0
TLS2_k127_6848016_1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000004148 209.0
TLS2_k127_688568_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0008094,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0042623,GO:0061505,GO:0140097 5.99.1.3 0.0 1205.0
TLS2_k127_688568_1 Participates in initiation and elongation during chromosome replication K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.0 1077.0
TLS2_k127_688568_10 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008659 511.0
TLS2_k127_688568_11 Ami_3 K01448 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 484.0
TLS2_k127_688568_12 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005451 472.0
TLS2_k127_688568_13 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 471.0
TLS2_k127_688568_14 MATE efflux family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 473.0
TLS2_k127_688568_15 chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 430.0
TLS2_k127_688568_16 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005931 426.0
TLS2_k127_688568_17 MviN-like protein K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005857 436.0
TLS2_k127_688568_18 PFAM ParB domain protein nuclease K03497 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 416.0
TLS2_k127_688568_19 Glycosyltransferase family 87 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007924 420.0
TLS2_k127_688568_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 2.5e-323 1002.0
TLS2_k127_688568_20 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 412.0
TLS2_k127_688568_21 integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 396.0
TLS2_k127_688568_22 Xylose isomerase-like TIM barrel K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 382.0
TLS2_k127_688568_23 Alanine racemase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 355.0
TLS2_k127_688568_24 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007577 340.0
TLS2_k127_688568_25 serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004557 351.0
TLS2_k127_688568_26 60Kd inner membrane protein K03217 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 331.0
TLS2_k127_688568_27 Nitrate and nitrite sensing - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 329.0
TLS2_k127_688568_28 ATP- GTP-binding protein K06945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001583 278.0
TLS2_k127_688568_29 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002827 271.0
TLS2_k127_688568_3 tRNA nucleotidyltransferase poly(A) polymerase K00970,K00974 - 2.7.7.19,2.7.7.72 2.398e-219 689.0
TLS2_k127_688568_30 Single-stranded DNA-binding protein K03111 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001471 249.0
TLS2_k127_688568_31 R3H domain protein K06346 - - 0.00000000000000000000000000000000000000000000000000000000000000003159 228.0
TLS2_k127_688568_32 YceI-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002408 226.0
TLS2_k127_688568_33 belongs to the sigma-70 factor family, ECF subfamily K03088 GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000278 228.0
TLS2_k127_688568_34 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.000000000000000000000000000000000000000000000000000000000000002625 227.0
TLS2_k127_688568_35 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001984 200.0
TLS2_k127_688568_36 Belongs to the Nudix hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000002176 204.0
TLS2_k127_688568_37 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000002529 203.0
TLS2_k127_688568_38 Tfp pilus assembly protein FimV - - - 0.000000000000000000000000000000000000000000000000000139 213.0
TLS2_k127_688568_39 Protein of unknown function (DUF721) - - - 0.00000000000000000000000000000000000000000000000000231 195.0
TLS2_k127_688568_4 Alanine-glyoxylate amino-transferase K05825 - - 1.141e-211 668.0
TLS2_k127_688568_40 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000000000000005457 180.0
TLS2_k127_688568_41 Belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.0000000000000000000000000000000000000000000006949 168.0
TLS2_k127_688568_42 Roadblock lc7 family protein K07131 - - 0.0000000000000000000000000000000000000000004492 160.0
TLS2_k127_688568_43 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000003764 150.0
TLS2_k127_688568_44 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000002163 156.0
TLS2_k127_688568_45 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000000006006 123.0
TLS2_k127_688568_46 - - - - 0.00000000000000000000000000001431 131.0
TLS2_k127_688568_47 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 GO:0008150,GO:0040007 3.1.26.5 0.00000000000000000000000006173 111.0
TLS2_k127_688568_48 - - - - 0.00000000000000002528 89.0
TLS2_k127_688568_5 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 - 3.005e-203 644.0
TLS2_k127_688568_50 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000000006727 75.0
TLS2_k127_688568_51 Bacterial regulatory proteins, tetR family - - - 0.00000000004487 65.0
TLS2_k127_688568_52 Protein of unknown function (DUF742) - - - 0.000000000157 69.0
TLS2_k127_688568_53 AntiSigma factor - - - 0.00000000137 70.0
TLS2_k127_688568_54 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress - - - 0.000000001873 66.0
TLS2_k127_688568_6 Myo-inositol-1-phosphate synthase K01858 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 2.347e-201 640.0
TLS2_k127_688568_7 Transglycosylase - - - 3.801e-198 644.0
TLS2_k127_688568_8 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 531.0
TLS2_k127_688568_9 FemAB family K05363 - 2.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 528.0
TLS2_k127_6891811_0 DEAD DEAH box helicase domain protein K03724 - - 0.0 2141.0
TLS2_k127_6891811_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 524.0
TLS2_k127_6891811_10 ROK family - - - 0.00000000000000000000000000000000181 142.0
TLS2_k127_6891811_11 Helix-turn-helix - GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000000000000000000001577 126.0
TLS2_k127_6891811_12 Flavin reductase like domain - - - 0.000000000000000000000013 113.0
TLS2_k127_6891811_13 Protein of unknown function (DUF3046) - - - 0.000000000000000000004457 93.0
TLS2_k127_6891811_14 Protein of unknown function (DUF1211) - - - 0.00000000000000000001239 101.0
TLS2_k127_6891811_15 ROK family - - - 0.0000000000000000001815 98.0
TLS2_k127_6891811_2 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 514.0
TLS2_k127_6891811_3 LAGLIDADG DNA endonuclease family K03553 GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 466.0
TLS2_k127_6891811_4 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009096 362.0
TLS2_k127_6891811_5 Glycosylase K05522 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008194 344.0
TLS2_k127_6891811_6 Competence-damaged protein K03742,K03743 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 333.0
TLS2_k127_6891811_7 CDP-alcohol phosphatidyltransferase K00995,K08744 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000265 246.0
TLS2_k127_6891811_8 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000455 179.0
TLS2_k127_6891811_9 Antibiotic biosynthesis monooxygenase K09932 - - 0.000000000000000000000000000000000000000000005446 178.0
TLS2_k127_6898227_0 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 599.0
TLS2_k127_6898227_1 geranylgeranyl reductase K21401 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 1.3.99.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000374 597.0
TLS2_k127_6898227_10 META domain K03668 - - 0.0009356 49.0
TLS2_k127_6898227_2 Flavin-binding monooxygenase-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 540.0
TLS2_k127_6898227_3 20S proteasome - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 336.0
TLS2_k127_6898227_4 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000003085 231.0
TLS2_k127_6898227_5 lipopolysaccharide transmembrane transporter activity K07058 - - 0.0000000000000000000000000000000000000000000000000000000008171 219.0
TLS2_k127_6898227_6 Rhodanese Homology Domain - - - 0.00000000000000000000000000006222 121.0
TLS2_k127_6898227_7 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000001813 111.0
TLS2_k127_6898227_8 Site-specific recombinases, DNA invertase Pin homologs - - - 0.00000000000000000006541 92.0
TLS2_k127_6899972_0 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003256 377.0
TLS2_k127_6899972_1 Hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009101 360.0
TLS2_k127_6899972_10 - - - - 0.000000000000000000000713 107.0
TLS2_k127_6899972_11 - - - - 0.00001885 53.0
TLS2_k127_6899972_2 helix_turn_helix, cAMP Regulatory protein K10914 GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 349.0
TLS2_k127_6899972_3 NUDIX domain K18568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 295.0
TLS2_k127_6899972_4 Colicin V production protein - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004954 287.0
TLS2_k127_6899972_5 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000161 267.0
TLS2_k127_6899972_6 NUDIX hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000235 272.0
TLS2_k127_6899972_7 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003624 261.0
TLS2_k127_6899972_8 helix_turn_helix ASNC type - - - 0.0000000000000000000000000000000000000000000000000000000000000001248 226.0
TLS2_k127_6899972_9 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000002301 226.0
TLS2_k127_6902188_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 2.338e-232 735.0
TLS2_k127_6902188_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278,K00767 - 1.4.3.16,2.4.2.19 2.661e-217 699.0
TLS2_k127_6902188_2 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 375.0
TLS2_k127_6902188_3 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 364.0
TLS2_k127_6902188_4 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003219 345.0
TLS2_k127_6902188_5 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000998 317.0
TLS2_k127_6902188_6 Acetyltransferase (GNAT) domain K00619 GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000005236 246.0
TLS2_k127_6902188_7 Lsr2 - - - 0.000000000000000000000000000271 123.0
TLS2_k127_6909998_0 Oxidoreductase FAD-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 364.0
TLS2_k127_6909998_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 323.0
TLS2_k127_6909998_2 - - - - 0.00000000000000000000000000000001144 129.0
TLS2_k127_6909998_3 Oxidoreductase molybdopterin binding domain - - - 0.000000000000000000001879 93.0
TLS2_k127_6909998_4 Evidence 2b Function of strongly homologous gene - - - 0.0000000000000000005292 93.0
TLS2_k127_6909998_5 Pyridine nucleotide-disulphide oxidoreductase K21567 - 1.18.1.2,1.19.1.1 0.0000000000002522 73.0
TLS2_k127_6909998_6 Evidence 2b Function of strongly homologous gene - - - 0.000009522 52.0
TLS2_k127_6948166_0 Nitrate reductase K02824 - - 7.68e-221 696.0
TLS2_k127_6948166_1 Protein of unknown function (DUF1116) - - - 2.261e-204 647.0
TLS2_k127_6948166_2 transcriptional regulator K09684 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 610.0
TLS2_k127_6948166_3 Protein of unknown function (DUF1116) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000038 488.0
TLS2_k127_6948166_4 Molybdopterin dehydrogenase K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 340.0
TLS2_k127_6948166_5 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS K03518,K19186 - 1.2.5.3,1.5.99.14 0.00000000000000000000000000000000000000000000000000000000000000000000000004577 258.0
TLS2_k127_6948166_6 Xanthine dehydrogenase K03520 - 1.2.5.3 0.0000000000000000000000000000000000000007986 154.0
TLS2_k127_6948166_7 Protein of unknown function (DUF2877) - - - 0.000000000000000000000000001367 124.0
TLS2_k127_6950295_0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1313.0
TLS2_k127_6950295_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005261 377.0
TLS2_k127_6950295_2 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 354.0
TLS2_k127_6950295_3 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004268 315.0
TLS2_k127_6950295_4 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001921 283.0
TLS2_k127_6950295_5 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.0000000000000000000000000000003826 124.0
TLS2_k127_6969740_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 3.6.3.14 1.68e-271 847.0
TLS2_k127_6969740_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.6.3.14 1.085e-244 765.0
TLS2_k127_6969740_10 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000962 414.0
TLS2_k127_6969740_11 Glycosyl transferase family 4 K02851 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009017 405.0
TLS2_k127_6969740_12 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003613 322.0
TLS2_k127_6969740_13 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 314.0
TLS2_k127_6969740_14 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 314.0
TLS2_k127_6969740_15 PAP2 superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001764 295.0
TLS2_k127_6969740_16 Belongs to the SUA5 family K07566 GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000001694 278.0
TLS2_k127_6969740_17 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009833 268.0
TLS2_k127_6969740_18 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000001308 280.0
TLS2_k127_6969740_19 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109,K02113 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000006185 221.0
TLS2_k127_6969740_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 4.29e-232 734.0
TLS2_k127_6969740_20 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000001769 184.0
TLS2_k127_6969740_21 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000000000000000000000000002093 143.0
TLS2_k127_6969740_22 Binds the 23S rRNA K02909 GO:0008150,GO:0040007 - 0.000000000000000000000000000000002117 141.0
TLS2_k127_6969740_23 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000005844 142.0
TLS2_k127_6969740_24 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.0000000000000000000000000005853 113.0
TLS2_k127_6969740_25 Protein of unknown function (DUF2550) - - - 0.0000000000000000000000000113 114.0
TLS2_k127_6969740_26 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation - - - 0.000000000000000000000001756 116.0
TLS2_k127_6969740_27 Belongs to the anti-sigma-factor antagonist family - - - 0.000000000000000000002013 96.0
TLS2_k127_6969740_28 - - - - 0.0000000000004354 81.0
TLS2_k127_6969740_29 - - - - 0.000000000007587 74.0
TLS2_k127_6969740_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 2.558e-218 683.0
TLS2_k127_6969740_30 - - - - 0.00000000005293 64.0
TLS2_k127_6969740_31 - - - - 0.0000000004605 66.0
TLS2_k127_6969740_4 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 1.092e-204 649.0
TLS2_k127_6969740_5 homoserine dehydrogenase K00003,K12524 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.3,2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008341 608.0
TLS2_k127_6969740_6 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) K00790 GO:0008150,GO:0040007 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006103 566.0
TLS2_k127_6969740_7 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009607 520.0
TLS2_k127_6969740_8 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 GO:0008150,GO:0040007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 520.0
TLS2_k127_6969740_9 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006185 499.0
TLS2_k127_6977976_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657 3.3.1.1 2.606e-263 818.0
TLS2_k127_6977976_1 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.8 5.145e-196 620.0
TLS2_k127_6977976_10 Domain of unknown function (DUF4129) - - - 0.0000001014 55.0
TLS2_k127_6977976_2 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 552.0
TLS2_k127_6977976_3 associated with various cellular activities K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 499.0
TLS2_k127_6977976_4 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 451.0
TLS2_k127_6977976_5 cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000536 417.0
TLS2_k127_6977976_6 Sugar isomerase (SIS) K15916 - 5.3.1.8,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 337.0
TLS2_k127_6977976_7 - - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000121 268.0
TLS2_k127_6977976_8 RDD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002668 243.0
TLS2_k127_6977976_9 Trm112p-like protein K09791 - - 0.00000000000000000000001051 101.0
TLS2_k127_700141_0 PFAM Nickel-dependent hydrogenase, large subunit K00436 - 1.12.1.2 2.871e-198 639.0
TLS2_k127_700141_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 511.0
TLS2_k127_700141_2 NADH ubiquinone oxidoreductase, 20 K18007 - 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 446.0
TLS2_k127_700141_3 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 417.0
TLS2_k127_700141_4 cyclic nucleotide binding K10914 - - 0.0000000000000000000000000000000000000000000004301 170.0
TLS2_k127_700141_5 spore germination K03605 - - 0.000000000000000000000000000000000000000002671 161.0
TLS2_k127_700141_6 PFAM peptidase C60, sortase A and B - - - 0.0000000000000000000000000000001076 131.0
TLS2_k127_700141_7 transporter K03762 - - 0.000000000000002393 78.0
TLS2_k127_700141_9 - - - - 0.000003077 57.0
TLS2_k127_7014317_0 Thioredoxin reductase K00384 - 1.8.1.9 1.822e-198 633.0
TLS2_k127_7014317_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 548.0
TLS2_k127_7014317_10 Alpha/beta hydrolase family - - - 0.000000000000000000000001988 103.0
TLS2_k127_7014317_11 Histidine kinase - - - 0.00000000000000000136 90.0
TLS2_k127_7014317_12 cheY-homologous receiver domain - - - 0.0000000000005766 71.0
TLS2_k127_7014317_13 - - - - 0.00000000003083 74.0
TLS2_k127_7014317_14 - - - - 0.000001522 55.0
TLS2_k127_7014317_2 PFAM FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 524.0
TLS2_k127_7014317_3 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 521.0
TLS2_k127_7014317_4 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007356 431.0
TLS2_k127_7014317_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 388.0
TLS2_k127_7014317_6 Aminoglycoside 2'-N-acetyltransferase K17840 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016020,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0034069,GO:0044237,GO:0044248,GO:0044464,GO:0047921,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658 2.3.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000001168 260.0
TLS2_k127_7014317_7 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006478 249.0
TLS2_k127_7014317_8 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000001146 194.0
TLS2_k127_7014317_9 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000008359 146.0
TLS2_k127_7022703_0 adenosine deaminase K01488 GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 498.0
TLS2_k127_7022703_1 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 437.0
TLS2_k127_7022703_10 oxidoreductase - - - 0.000007517 48.0
TLS2_k127_7022703_2 PFAM NmrA family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008163 306.0
TLS2_k127_7022703_3 Belongs to the UPF0234 family K09767 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000004827 233.0
TLS2_k127_7022703_4 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000004043 226.0
TLS2_k127_7022703_5 Belongs to the UPF0336 family - - - 0.0000000000000000000000000000000000000000000000000000000001227 214.0
TLS2_k127_7022703_6 dehydratase - - - 0.000000000000000000000000000000000000000000000000000000002789 208.0
TLS2_k127_7022703_7 Domain of unknown function (DUF1772) - - - 0.0000000000000000000000000000000000000000000008055 173.0
TLS2_k127_7022703_8 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.00000000000000000000000001442 111.0
TLS2_k127_7064998_0 3-hydroxyacyl-CoA dehydrogenase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 3.705e-288 902.0
TLS2_k127_7064998_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.793e-278 870.0
TLS2_k127_7064998_10 Protein of unknown function (DUF3000) - - - 0.0000000000000000000000000000000000000000000000000000000000000000133 248.0
TLS2_k127_7064998_11 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000002803 190.0
TLS2_k127_7064998_12 - - - - 0.00000000000000000000000000004452 127.0
TLS2_k127_7064998_13 Domain of unknown function (DUF4349) - - - 0.00000000000000000001689 95.0
TLS2_k127_7064998_2 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 6.337e-214 670.0
TLS2_k127_7064998_3 3-5 exonuclease K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 542.0
TLS2_k127_7064998_4 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007704 499.0
TLS2_k127_7064998_5 PFAM amine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 505.0
TLS2_k127_7064998_6 ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006009 388.0
TLS2_k127_7064998_7 Belongs to the binding-protein-dependent transport system permease family K10544 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 338.0
TLS2_k127_7064998_8 DNA alkylation repair - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004456 275.0
TLS2_k127_7064998_9 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000008805 253.0
TLS2_k127_7066385_0 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 431.0
TLS2_k127_7066385_1 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000008242 184.0
TLS2_k127_7066385_2 Sterol carrier protein - - - 0.0000000000000000000000000000000000000000000004927 183.0
TLS2_k127_7066385_3 Glycosyl transferase 4-like K03525 - 2.7.1.33 0.0000000000001418 83.0
TLS2_k127_7066385_4 - - - - 0.000000007235 59.0
TLS2_k127_7066385_5 - - - - 0.00001376 51.0
TLS2_k127_7066385_6 Endonuclease/Exonuclease/phosphatase family K07004 - - 0.0002817 44.0
TLS2_k127_7086731_0 PFAM Glycosyl transferase family 2 - - - 2.755e-240 784.0
TLS2_k127_7086731_1 F420-0:Gamma-glutamyl ligase K12234 GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002648 530.0
TLS2_k127_7086731_2 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0043743,GO:0044237,GO:0044249,GO:0051186,GO:0051188 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 440.0
TLS2_k127_7086731_3 3-methyladenine DNA glycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 359.0
TLS2_k127_7086731_4 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 342.0
TLS2_k127_7086731_5 Non-essential cell division protein that could be required for efficient cell constriction - - - 0.00000000000000000000000000000000000000000000000000000000004738 228.0
TLS2_k127_7086731_6 Protein of unknown function (DUF3105) - - - 0.000000000000000000000000000000000000000000000000005265 190.0
TLS2_k127_7086731_7 Zincin-like metallopeptidase - - - 0.0000000000000000000000000000000000000003256 160.0
TLS2_k127_7086731_8 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.0000000000000000000000000000000000000005572 153.0
TLS2_k127_7086731_9 Protein of unknown function (DUF3499) - - - 0.000000000000000000000000000000000000001927 155.0
TLS2_k127_7106_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 370.0
TLS2_k127_7106_1 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000003767 234.0
TLS2_k127_7108951_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 5.014e-294 925.0
TLS2_k127_7108951_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 593.0
TLS2_k127_7108951_10 Protein of unknown function DUF86 - - - 0.00000000000000000000000000000000009778 138.0
TLS2_k127_7108951_11 Sterol carrier protein domain - - - 0.00000000000000000000000000000006002 139.0
TLS2_k127_7108951_12 Uncharacterized conserved protein (DUF2278) - - - 0.000000000000000000000008142 110.0
TLS2_k127_7108951_13 YqeY-like protein K09117 - - 0.00000000000000000000005449 108.0
TLS2_k127_7108951_14 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000001103 111.0
TLS2_k127_7108951_15 Uncharacterized conserved protein (DUF2278) - - - 0.000000000000000000007325 99.0
TLS2_k127_7108951_16 response regulator - - - 0.000000000003871 69.0
TLS2_k127_7108951_17 response regulator - - - 0.00000001402 61.0
TLS2_k127_7108951_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004761 558.0
TLS2_k127_7108951_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004847 391.0
TLS2_k127_7108951_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 399.0
TLS2_k127_7108951_5 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 316.0
TLS2_k127_7108951_6 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000000000000000000000000000000000000000000000000002858 232.0
TLS2_k127_7108951_7 3-demethylubiquinone-9 3-methyltransferase K04750 - - 0.0000000000000000000000000000000000000000000000000000000000000005267 222.0
TLS2_k127_7108951_8 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000009201 190.0
TLS2_k127_7108951_9 Nucleotidyltransferase domain K07075 - - 0.00000000000000000000000000000000000000000001005 171.0
TLS2_k127_7113530_0 Histidine kinase K07636,K07654 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009679 584.0
TLS2_k127_7113530_1 Winged helix DNA-binding domain K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 541.0
TLS2_k127_7113530_10 helix_turn_helix, Lux Regulon - - - 0.000000000000000009693 87.0
TLS2_k127_7113530_2 Response regulator receiver K07670 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016310,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 398.0
TLS2_k127_7113530_3 Sporulation and spore germination - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001469 291.0
TLS2_k127_7113530_4 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000000000000000000000000000000000000000000003571 261.0
TLS2_k127_7113530_5 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000007808 246.0
TLS2_k127_7113530_6 phosphoribosyltransferase - - - 0.0000000000000000000000000000000000000000000001878 177.0
TLS2_k127_7113530_7 helix_turn_helix, Lux Regulon K02479 - - 0.0000000000000000000000000000000000000000000003237 172.0
TLS2_k127_7113530_8 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000005885 107.0
TLS2_k127_7113530_9 Domain of unknown function (DUF4129) - - - 0.0000000000000000002564 101.0
TLS2_k127_7143493_0 ACT domain K00928 - 2.7.2.4 3.565e-215 674.0
TLS2_k127_7143493_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006134 607.0
TLS2_k127_7143493_10 Bacterial protein of unknown function (DUF853) K06915 - - 0.00009277 45.0
TLS2_k127_7143493_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 571.0
TLS2_k127_7143493_3 PA domain K01301 - 3.4.17.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 484.0
TLS2_k127_7143493_4 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 383.0
TLS2_k127_7143493_5 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 382.0
TLS2_k127_7143493_6 Domain of unknown function (DUF5063) - - - 0.0000000000000000000000000000000000000000000000000000000000000002246 226.0
TLS2_k127_7143493_7 GatB YqeY K09117 - - 0.0000000000000000000000000000000000000000000007175 173.0
TLS2_k127_7143493_8 YbaB/EbfC DNA-binding family K09747 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000001497 127.0
TLS2_k127_7143493_9 Phage integrase, N-terminal SAM-like domain - - - 0.00000000263 61.0
TLS2_k127_7155492_0 PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A K01908 - 6.2.1.17 3.276e-309 959.0
TLS2_k127_7155492_1 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 613.0
TLS2_k127_7155492_2 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006612 581.0
TLS2_k127_7155492_3 Protein of unknown function (DUF1298) K00635 - 2.3.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 500.0
TLS2_k127_7155492_4 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.00000000000000000000000000000000000000000000000000000000003225 207.0
TLS2_k127_7155492_5 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000002142 195.0
TLS2_k127_7155492_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000856 168.0
TLS2_k127_7155492_7 - - - - 0.000000006104 68.0
TLS2_k127_7159012_0 Activator of Hsp90 ATPase 1 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005823 276.0
TLS2_k127_7159012_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000005135 229.0
TLS2_k127_7159012_2 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000001512 188.0
TLS2_k127_7159012_3 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000007859 183.0
TLS2_k127_71680_0 - - - - 3.322e-217 705.0
TLS2_k127_71680_1 Belongs to the citrate synthase family K01647 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.3.3.1 1.933e-198 622.0
TLS2_k127_71680_10 Protein of unknown function (DUF2530) - - - 0.00000000000000000000004937 101.0
TLS2_k127_71680_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 571.0
TLS2_k127_71680_3 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 477.0
TLS2_k127_71680_4 Aldo/keto reductase family K13315 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004954 471.0
TLS2_k127_71680_5 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007228 460.0
TLS2_k127_71680_6 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010181,GO:0016491,GO:0016614,GO:0016899,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032553,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.4.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000004737 267.0
TLS2_k127_71680_7 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000000000426 177.0
TLS2_k127_71680_8 MDMPI C-terminal domain - - - 0.0000000000000000000000000000000000000000001911 172.0
TLS2_k127_71680_9 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000004704 162.0
TLS2_k127_7174606_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0 1031.0
TLS2_k127_7174606_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 3.87e-221 694.0
TLS2_k127_7174606_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 471.0
TLS2_k127_7174606_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005712 360.0
TLS2_k127_7174606_4 cytochrome oxidase assembly K02259 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006164 305.0
TLS2_k127_7174606_5 - - - - 0.0000000002923 72.0
TLS2_k127_7208608_0 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 328.0
TLS2_k127_7208608_1 ABC-2 family transporter protein K01990,K01992 - - 0.0000000000000000000000000000000000000000000000000007094 189.0
TLS2_k127_7208608_2 - - - - 0.000000005052 59.0
TLS2_k127_7212763_0 Transcriptional regulator - - - 1.485e-224 730.0
TLS2_k127_7212763_1 Oxidoreductase K17218 - 1.8.5.4 6.642e-197 632.0
TLS2_k127_7212763_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 386.0
TLS2_k127_7212763_3 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001299 248.0
TLS2_k127_7212763_4 CAAX protease self-immunity - - - 0.000000000000000000000000000000000000000000000000000000000000000000003259 245.0
TLS2_k127_7212763_5 WYL domain K13573 - - 0.000000000000000000000000000000000000000000000004968 176.0
TLS2_k127_7212763_6 PFAM DsrC family protein K11179 - - 0.0000000000000000000000000000000000000000000117 168.0
TLS2_k127_7212763_7 Protein of unknown function (DUF1641) - - - 0.000000000000000000000000000000000291 141.0
TLS2_k127_7212763_8 Sensory domain found in PocR K07315 - 3.1.3.3 0.000000000000000000000000000044 129.0
TLS2_k127_7212763_9 Bacterial transcriptional activator domain - - - 0.00000000000000000005006 91.0
TLS2_k127_7213194_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 452.0
TLS2_k127_7213194_1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000002001 235.0
TLS2_k127_7213194_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000001548 199.0
TLS2_k127_7293477_0 Amidohydrolase family - - - 1.124e-223 705.0
TLS2_k127_7293477_1 Peptidase family S41 - - - 1.593e-197 635.0
TLS2_k127_7293477_10 transposition, DNA-mediated - - - 0.000000000000006655 76.0
TLS2_k127_7293477_2 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00956 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005593 592.0
TLS2_k127_7293477_3 TIGRFAM sulfate adenylyltransferase, small subunit K00957 - 2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 507.0
TLS2_k127_7293477_4 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 499.0
TLS2_k127_7293477_5 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 457.0
TLS2_k127_7293477_6 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 415.0
TLS2_k127_7293477_7 Belongs to the PAPS reductase family. CysH subfamily K00390 GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000632 334.0
TLS2_k127_7293477_8 ABC transporter K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003627 265.0
TLS2_k127_7293477_9 Adenylylsulphate kinase K00860 - 2.7.1.25 0.00000000000000000000000000000000000000000000000003735 196.0
TLS2_k127_7439231_0 Na H antiporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 574.0
TLS2_k127_7439231_1 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000998 409.0
TLS2_k127_7439231_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001713 282.0
TLS2_k127_7439231_3 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000000000000004558 183.0
TLS2_k127_7439231_4 membrane protein of uknown function UCP014873 - - - 0.0000000000000000000000000000001029 135.0
TLS2_k127_7442010_0 Alpha-amylase domain - - - 0.0 1193.0
TLS2_k127_7442010_1 ABC transporter - - - 6.499e-283 877.0
TLS2_k127_7442010_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008815 586.0
TLS2_k127_7442010_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002323 375.0
TLS2_k127_7442010_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 327.0
TLS2_k127_7442010_5 ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000003289 217.0
TLS2_k127_7442010_6 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000001538 156.0
TLS2_k127_7452708_0 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 536.0
TLS2_k127_7452708_1 Helicase conserved C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 443.0
TLS2_k127_7452708_2 iron dependent repressor - - - 0.00000000000000000000000000000000000000000000003105 185.0
TLS2_k127_7452708_3 PFAM transcriptional regulator PadR family protein K10947 - - 0.00000000000000000000000000000000000001807 147.0
TLS2_k127_7452708_4 membrane - - - 0.000000000000000000000000000001071 134.0
TLS2_k127_7452708_5 PIN domain K07064 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045926,GO:0048519,GO:0050789,GO:0065007,GO:0071944 - 0.000000000000000000000000000002703 125.0
TLS2_k127_7452708_6 CHAT domain - - - 0.00000000000000000000000003246 110.0
TLS2_k127_7452708_7 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000001695 73.0
TLS2_k127_784497_0 amidohydrolase - - - 2.726e-232 731.0
TLS2_k127_784497_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002708 544.0
TLS2_k127_784497_2 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 389.0
TLS2_k127_784497_3 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 356.0
TLS2_k127_784497_4 PFAM HhH-GPD family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000002889 248.0
TLS2_k127_784497_5 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000003516 181.0
TLS2_k127_784497_6 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.0000000000000000006598 89.0
TLS2_k127_797903_0 Alpha-galactosidase K07407 - 3.2.1.22 1.359e-297 930.0
TLS2_k127_797903_1 beta-galactosidase K12308 - 3.2.1.23 6.251e-289 900.0
TLS2_k127_797903_10 Transporter associated domain K03699 - - 0.000000000000000000000000000000005825 130.0
TLS2_k127_797903_11 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000009761 65.0
TLS2_k127_797903_2 Bacterial extracellular solute-binding protein K02027 - - 7.605e-214 674.0
TLS2_k127_797903_3 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 505.0
TLS2_k127_797903_4 GDP-mannose 4,6 dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 446.0
TLS2_k127_797903_5 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 426.0
TLS2_k127_797903_6 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 429.0
TLS2_k127_797903_7 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 412.0
TLS2_k127_797903_8 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008457 404.0
TLS2_k127_797903_9 transcriptional regulator, DeoR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 329.0
TLS2_k127_80309_0 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 538.0
TLS2_k127_80309_1 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 494.0
TLS2_k127_80309_2 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 325.0
TLS2_k127_80309_3 ANTAR - - - 0.00000000000000003362 84.0
TLS2_k127_80309_4 antisigma factor binding K06378 - - 0.00000003577 66.0
TLS2_k127_80309_5 STAS domain - - - 0.000000108 61.0
TLS2_k127_822722_0 Methionine synthase K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0 1756.0
TLS2_k127_822722_1 ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis K13527 GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 - 1.995e-309 955.0
TLS2_k127_822722_10 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K13571 GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 446.0
TLS2_k127_822722_11 Proteasome subunit K03433 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 414.0
TLS2_k127_822722_12 PAC2 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 398.0
TLS2_k127_822722_13 PFAM ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 388.0
TLS2_k127_822722_14 RecB family exonuclease K07465 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 379.0
TLS2_k127_822722_15 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006609 352.0
TLS2_k127_822722_16 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 342.0
TLS2_k127_822722_17 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 341.0
TLS2_k127_822722_18 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004446 350.0
TLS2_k127_822722_19 Phosphatidylinositol - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009639 317.0
TLS2_k127_822722_2 MacB-like periplasmic core domain K02004 - - 2.717e-275 870.0
TLS2_k127_822722_20 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 311.0
TLS2_k127_822722_21 PFAM Phosphoglycerate mutase K01834 - 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 289.0
TLS2_k127_822722_22 Protein of unknown function (DUF3090) - - - 0.0000000000000000000000000000000000000000000000000000000000000000457 228.0
TLS2_k127_822722_23 Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation K13570 GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000007797 92.0
TLS2_k127_822722_3 proteasome accessory factor PafA2 K20814 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 2.144e-259 814.0
TLS2_k127_822722_4 extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 594.0
TLS2_k127_822722_5 Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins K01883,K15526 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.1.1.16,6.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 589.0
TLS2_k127_822722_6 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 462.0
TLS2_k127_822722_7 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 463.0
TLS2_k127_822722_8 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 456.0
TLS2_k127_822722_9 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003842 467.0
TLS2_k127_82870_0 DNA primase, small subunit K01971 - 6.5.1.1 1.23e-206 653.0
TLS2_k127_82870_1 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005378 502.0
TLS2_k127_82870_2 Alcohol dehydrogenase GroES-like domain K00148 - 1.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005813 460.0
TLS2_k127_82870_3 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000000006844 216.0
TLS2_k127_872087_0 Saccharopine dehydrogenase NADP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 305.0
TLS2_k127_872087_1 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009141 303.0
TLS2_k127_875115_0 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K21159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 557.0
TLS2_k127_875115_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009988 548.0
TLS2_k127_875115_2 Flavin-binding monooxygenase-like K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 486.0
TLS2_k127_875115_3 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 410.0
TLS2_k127_875115_4 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000137 301.0
TLS2_k127_875115_5 PAP2 superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004165 270.0
TLS2_k127_875115_6 Alpha beta hydrolase K00433 - 1.11.1.10 0.0000000000000000000000000000000000000000000000000000000000000000002264 250.0
TLS2_k127_875115_7 - - - - 0.000000000000000000000000008123 128.0
TLS2_k127_875115_8 Methyltransferase small domain - - - 0.00000005365 56.0
TLS2_k127_943520_0 Acyl transferase domain - - - 1.389e-263 838.0
TLS2_k127_943520_1 Acetyl-CoA carboxylase, central region - - - 0.0000000000000000000000000000000000000000000000000000000008315 207.0
TLS2_k127_947165_0 FMN-dependent dehydrogenase K00101 - 1.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000953 628.0
TLS2_k127_947165_1 Acetamidase/Formamidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 612.0
TLS2_k127_947165_2 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 567.0
TLS2_k127_947165_3 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 516.0
TLS2_k127_947165_4 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 509.0
TLS2_k127_947165_5 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 431.0
TLS2_k127_947165_6 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.00000000000000000000000000000000000001148 147.0
TLS2_k127_947165_7 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000000000000003905 106.0
TLS2_k127_947165_8 HNH endonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000007967 106.0
TLS2_k127_947165_9 - - - - 0.0004255 52.0
TLS2_k127_952556_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 5.536e-243 758.0
TLS2_k127_952556_1 Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence K03333 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114 1.1.3.6 1.533e-235 741.0
TLS2_k127_952556_2 IMP dehydrogenase / GMP reductase domain K00088 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003776 604.0
TLS2_k127_952556_3 Belongs to the aldehyde dehydrogenase family K00135 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009013,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 572.0
TLS2_k127_952556_4 helix_turn_helix, mercury resistance K22491 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002249 256.0
TLS2_k127_952556_5 ECF sigma factor K03088 GO:0000988,GO:0000990,GO:0002791,GO:0003674,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0032880,GO:0043254,GO:0044087,GO:0044419,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051223,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070201,GO:0080090,GO:0090087,GO:0140110,GO:1903506,GO:1903530,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000003244 230.0
TLS2_k127_952556_6 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.000000000000000000000000000000000000000000004121 166.0
TLS2_k127_964158_0 Cystathionine beta-synthase K01697 GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 4.2.1.22 1.921e-231 726.0
TLS2_k127_964158_1 Belongs to the thiolase family K00626 - 2.3.1.9 7.044e-201 631.0
TLS2_k127_964158_2 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 500.0
TLS2_k127_964158_3 G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005776 377.0
TLS2_k127_964158_4 PFAM dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 302.0
TLS2_k127_964158_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000005706 64.0
TLS2_k127_964158_6 - - - - 0.000003126 53.0