logo

Overview

ID MAG04027
Name TLS2_bin.7
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Actinomycetota
Class Thermoleophilia
Order Gaiellales
Family Gaiellaceae
Genus JAICNY01
Species JAICNY01 sp025930955
Assembly information
Completeness (%) 77.87
Contamination (%) 2.06
GC content (%) 73.0
N50 (bp) 8,949
Genome size (bp) 2,471,467

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2422

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1005109_0 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000744 411.0
TLS2_k127_1005109_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 344.0
TLS2_k127_1005109_2 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000095 169.0
TLS2_k127_1005109_3 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000000000000000000000000001338 140.0
TLS2_k127_1005109_4 - - - - 0.000000001218 61.0
TLS2_k127_1021967_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.105e-207 666.0
TLS2_k127_1021967_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 514.0
TLS2_k127_1021967_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000209 179.0
TLS2_k127_1021967_3 Acetyltransferase (GNAT) domain - - - 0.000000000001527 80.0
TLS2_k127_1027808_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008265 455.0
TLS2_k127_1027808_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 370.0
TLS2_k127_1027808_2 Aminotransferase class-V K00283 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 296.0
TLS2_k127_1027808_3 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000000000009649 196.0
TLS2_k127_1027808_4 Beta-eliminating lyase K01668 - 4.1.99.2 0.000000000000000000000000000000000000000000000004834 177.0
TLS2_k127_1037227_0 Cytochrome C and Quinol oxidase polypeptide I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 365.0
TLS2_k127_1037227_1 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000002967 263.0
TLS2_k127_1037227_2 amino acid transport K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000299 255.0
TLS2_k127_1037227_3 - - - - 0.0000000000000000000000003638 113.0
TLS2_k127_1037227_4 Cytochrome c K05301 - 1.8.2.1 0.0000000000004551 72.0
TLS2_k127_1052088_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004159 579.0
TLS2_k127_1052088_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008807 326.0
TLS2_k127_1052088_2 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000001777 140.0
TLS2_k127_1052088_3 Histidine kinase - - - 0.0000000000000000000000000000000002749 143.0
TLS2_k127_1060753_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 1.141e-206 651.0
TLS2_k127_1060753_1 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 404.0
TLS2_k127_1060753_2 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006502 285.0
TLS2_k127_1060753_3 Oligoendopeptidase f K01283,K08602 - 3.4.15.1 0.00000000000000000000000000000000000000000000000000000000000000000000000003234 268.0
TLS2_k127_1060753_4 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000000000000001213 207.0
TLS2_k127_1060753_6 PFAM CMP dCMP deaminase zinc-binding K01489 - 3.5.4.5 0.000000000001958 69.0
TLS2_k127_1065265_0 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits K16881 - 2.7.7.13,5.4.2.8 1.396e-214 699.0
TLS2_k127_1065265_1 Forkhead associated domain - - - 0.000000000000000000000000000000000000000000000003299 177.0
TLS2_k127_1065265_2 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000000000000000000000005617 177.0
TLS2_k127_1065265_3 CDP-alcohol phosphatidyltransferase K00995,K08744 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 0.0000000000000000006697 91.0
TLS2_k127_1065265_4 - - - - 0.00000000000000003095 84.0
TLS2_k127_1065442_0 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008441 406.0
TLS2_k127_1065442_1 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 364.0
TLS2_k127_1065442_2 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003992 347.0
TLS2_k127_1065442_3 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 317.0
TLS2_k127_1065442_4 TonB-dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000001094 222.0
TLS2_k127_1065442_5 Cupin - - - 0.0000000000000000000000000000000000000000000005803 183.0
TLS2_k127_1065442_6 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.000000000000000000000000000001188 129.0
TLS2_k127_1065442_7 PFAM thioesterase superfamily protein K07107 - - 0.0000000000000000000000000005133 121.0
TLS2_k127_1065442_8 glutamine-fructose-6-phosphate transaminase (isomerizing) activity K00820 - 2.6.1.16 0.00000000000000000000000245 117.0
TLS2_k127_1065442_9 - - - - 0.0004976 53.0
TLS2_k127_1095379_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 353.0
TLS2_k127_1095379_1 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 298.0
TLS2_k127_1095379_2 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009669 291.0
TLS2_k127_1095379_3 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.000000000000000000000000000000000000000000000000000000000000001742 232.0
TLS2_k127_1095379_4 Conserved TM helix - - - 0.00000000000000000000000000000000000000000000000000000000005863 214.0
TLS2_k127_1095379_5 PFAM extracellular solute-binding protein, family 5 K15580 - - 0.000000000000000000000000000000000000000000000000003653 209.0
TLS2_k127_1095379_6 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950,K13940 - 2.7.6.3,4.1.2.25 0.00000000000000000000000000000000000007786 156.0
TLS2_k127_1095379_7 Protein of unknown function (DUF2469) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000002294 96.0
TLS2_k127_1095379_8 Dihydroneopterin aldolase K01633,K13940 GO:0008150,GO:0040007 1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8 0.0000000000009335 80.0
TLS2_k127_1098474_0 TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000692 464.0
TLS2_k127_1098474_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 450.0
TLS2_k127_1098474_2 ATP dependent DNA ligase C terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004215 284.0
TLS2_k127_1098474_3 HAD-superfamily hydrolase, subfamily IA - - - 0.000000000000000000000000000000000000000000000000000000000000002265 233.0
TLS2_k127_1098474_4 TrkA-C domain protein K07228 - - 0.000000000000000000000000000000006282 138.0
TLS2_k127_1098474_5 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000001188 88.0
TLS2_k127_1098474_6 Repeats in polycystic kidney disease 1 (PKD1) and other proteins K01126,K01181 - 3.1.4.46,3.2.1.8 0.0000000000000008316 87.0
TLS2_k127_1098474_7 PA26 p53-induced protein (sestrin) - - - 0.00000000000004172 82.0
TLS2_k127_1098474_8 PA14 domain - - - 0.000000001694 67.0
TLS2_k127_1098474_9 COG0475 Kef-type K transport systems, membrane components K03455 - - 0.00000109 53.0
TLS2_k127_1105648_0 xanthine dehydrogenase, a b hammerhead - - - 1.553e-268 857.0
TLS2_k127_1105648_1 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008424 553.0
TLS2_k127_1105648_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 393.0
TLS2_k127_1105648_3 Enoyl-CoA hydratase K07539,K18570 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003886 290.0
TLS2_k127_1105648_4 PFAM molybdopterin dehydrogenase, FAD-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002224 265.0
TLS2_k127_1105648_5 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000007472 160.0
TLS2_k127_1105648_6 Putative inner membrane exporter, YdcZ K09936 - - 0.00000000000002263 81.0
TLS2_k127_1129618_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 8.638e-219 707.0
TLS2_k127_1129618_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 458.0
TLS2_k127_1129618_2 Cleaves the N-terminal amino acid of tripeptides K01258 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 452.0
TLS2_k127_1129618_4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000303 249.0
TLS2_k127_1129618_5 bifunctional deaminase-reductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000288 233.0
TLS2_k127_1129618_6 Peptidase M1, membrane alanine aminopeptidase - - - 0.0000000000000000000000000176 110.0
TLS2_k127_1129618_7 - - - - 0.0000000000000001611 83.0
TLS2_k127_1129618_8 - - - - 0.0000000000001646 85.0
TLS2_k127_1141536_0 Belongs to the aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 450.0
TLS2_k127_1141536_1 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 342.0
TLS2_k127_1141536_2 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004402 275.0
TLS2_k127_1141536_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001495 269.0
TLS2_k127_1141536_4 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000001346 145.0
TLS2_k127_1146043_0 pilus assembly protein ATPase CpaF K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 521.0
TLS2_k127_1146043_1 ABC 3 transport family K11708 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005333 389.0
TLS2_k127_1146043_10 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000841 107.0
TLS2_k127_1146043_11 Domain of unknown function (DUF4328) - - - 0.0000000000000000000009148 108.0
TLS2_k127_1146043_12 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000001445 77.0
TLS2_k127_1146043_13 TadE-like protein - - - 0.00000006712 62.0
TLS2_k127_1146043_14 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000002271 54.0
TLS2_k127_1146043_15 Pilus assembly protein K02279 - - 0.000002738 58.0
TLS2_k127_1146043_2 Belongs to the bacterial solute-binding protein 9 family K09818,K11707 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 392.0
TLS2_k127_1146043_3 ATPases associated with a variety of cellular activities K09820,K11710 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 377.0
TLS2_k127_1146043_4 PFAM ABC-3 protein K11709 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008455 339.0
TLS2_k127_1146043_5 Diacylglycerol kinase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000007736 224.0
TLS2_k127_1146043_6 chromosome partitioning K02282 - - 0.0000000000000000000000000000000000000000000000000000000000007263 227.0
TLS2_k127_1146043_7 Type II secretion system (T2SS), protein F K12510 - - 0.00000000000000000000000000000000000000000000000000005225 212.0
TLS2_k127_1146043_8 PFAM type II secretion system K12511 - - 0.0000000000000000000000000000000000000000000000001918 188.0
TLS2_k127_1146043_9 Transglycosylase SLT domain - - - 0.0000000000000000000000002064 121.0
TLS2_k127_1156950_0 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000000000000000000001953 250.0
TLS2_k127_1156950_1 AsnC-type helix-turn-helix domain K05710 - - 0.000000000000000000000000000000000000000000000000000000000005458 216.0
TLS2_k127_1156950_2 - - - - 0.00009347 49.0
TLS2_k127_1201701_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000387 237.0
TLS2_k127_1201701_1 Family 5 K15580 - - 0.0000000000000000000000000000000000000000000000000000001965 220.0
TLS2_k127_1201701_2 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000008534 201.0
TLS2_k127_1220767_0 5'-nucleotidase, C-terminal domain K01081,K01119 - 3.1.3.5,3.1.3.6,3.1.4.16 2.814e-209 673.0
TLS2_k127_1220767_1 Ribosomal protein S1-like RNA-binding domain K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009514 571.0
TLS2_k127_1220767_2 Soluble lytic murein transglycosylase and related regulatory proteins K08309 - - 0.000000000000000000000000000008269 134.0
TLS2_k127_1220767_3 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000003901 95.0
TLS2_k127_1220767_4 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.000003583 49.0
TLS2_k127_1240473_0 the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 504.0
TLS2_k127_1240473_1 Alanine dehydrogenase/PNT, N-terminal domain K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004232 417.0
TLS2_k127_1240473_2 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.000000000000000000000000004891 126.0
TLS2_k127_1240473_3 WD40-like Beta Propeller Repeat K03641 - - 0.0000000000000000000000008602 121.0
TLS2_k127_1240473_4 Transglycosylase associated protein - - - 0.0000000000000007035 78.0
TLS2_k127_1240473_5 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0000000008423 72.0
TLS2_k127_1242380_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 346.0
TLS2_k127_1242380_1 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000000000000006731 224.0
TLS2_k127_1242380_2 Domain of Unknown Function (DUF326) - - - 0.0000000000000000000000000000000000000000000000009344 178.0
TLS2_k127_1242380_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000001079 187.0
TLS2_k127_1242380_4 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000001213 174.0
TLS2_k127_1242380_5 ATP-grasp - - - 0.00000000000000000000000000000000000000004011 166.0
TLS2_k127_1242380_6 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000006889 154.0
TLS2_k127_125518_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 604.0
TLS2_k127_125518_1 Belongs to the ABC transporter superfamily K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005888 419.0
TLS2_k127_125518_2 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 409.0
TLS2_k127_125518_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 384.0
TLS2_k127_125518_4 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 364.0
TLS2_k127_125518_5 ABC transporter (Permease) K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003991 338.0
TLS2_k127_125518_6 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 330.0
TLS2_k127_125518_7 Peptidase family S58 K01266 - 3.4.11.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007273 314.0
TLS2_k127_125518_8 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002506 285.0
TLS2_k127_125518_9 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000002828 240.0
TLS2_k127_1277082_0 56kDa selenium binding protein (SBP56) K17285 - - 1.47e-228 716.0
TLS2_k127_1277082_1 Daunorubicin resistance ABC transporter ATP-binding subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007351 505.0
TLS2_k127_1277082_2 Transport permease protein K01992,K18233 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 409.0
TLS2_k127_1277082_3 - - - - 0.000000000000000000000000000000000000003857 153.0
TLS2_k127_1303955_0 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004107 451.0
TLS2_k127_1303955_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009176 387.0
TLS2_k127_1303955_2 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 302.0
TLS2_k127_1303955_3 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001419 287.0
TLS2_k127_1303955_4 AP endonuclease family 2 K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000003812 264.0
TLS2_k127_1303955_5 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000001378 192.0
TLS2_k127_1303955_6 - - - - 0.0000000000000000000000000000000001801 144.0
TLS2_k127_1303955_7 - - - - 0.0000000000000856 73.0
TLS2_k127_1303955_8 Transcriptional regulatory protein, C terminal - - - 0.0000000000002715 74.0
TLS2_k127_1303955_9 deoxyhypusine monooxygenase activity - - - 0.000000001973 65.0
TLS2_k127_1326683_0 Zinc carboxypeptidase - - - 1.18e-233 748.0
TLS2_k127_1326683_1 Lon protease (S16) C-terminal proteolytic domain K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 472.0
TLS2_k127_1326683_2 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003355 283.0
TLS2_k127_1326683_4 Fungalysin metallopeptidase (M36) - - - 0.000000000000000000001026 111.0
TLS2_k127_1326683_5 HxlR-like helix-turn-helix - - - 0.000000000000000562 82.0
TLS2_k127_1369072_0 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000009538 241.0
TLS2_k127_1369072_1 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000004401 150.0
TLS2_k127_1385156_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 621.0
TLS2_k127_1385156_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 351.0
TLS2_k127_1385156_2 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005369 344.0
TLS2_k127_1385156_3 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 333.0
TLS2_k127_1385156_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 310.0
TLS2_k127_1385156_5 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005689 299.0
TLS2_k127_149544_0 AAA domain (dynein-related subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 381.0
TLS2_k127_149544_1 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 381.0
TLS2_k127_149544_10 OsmC-like protein - - - 0.0000000000000000000000000294 118.0
TLS2_k127_149544_11 Peptidoglycan-binding domain 1 protein K01185,K17733 - 3.2.1.17 0.0000000000000000004391 98.0
TLS2_k127_149544_12 DNA-binding transcription factor activity - - - 0.0000000000000000006857 95.0
TLS2_k127_149544_13 Belongs to the BolA IbaG family - - - 0.00000000001565 73.0
TLS2_k127_149544_14 Rhodanese Homology Domain - - - 0.00002825 57.0
TLS2_k127_149544_2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K03520 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008532 360.0
TLS2_k127_149544_3 von Willebrand factor, type A K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000817 327.0
TLS2_k127_149544_4 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 297.0
TLS2_k127_149544_5 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000006633 245.0
TLS2_k127_149544_6 AI-2E family transporter - - - 0.0000000000000000000000000000000001978 151.0
TLS2_k127_149544_7 Thioredoxin K05838 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000004239 147.0
TLS2_k127_149544_8 Glutaredoxin K07390 - - 0.0000000000000000000000000000000006627 134.0
TLS2_k127_149544_9 SPTR Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein K07005 - - 0.00000000000000000000000002016 113.0
TLS2_k127_1526276_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 323.0
TLS2_k127_1526276_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000003884 164.0
TLS2_k127_1526276_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000001509 108.0
TLS2_k127_1526276_3 Cold shock protein K03704 - - 0.00000000000000000000003415 101.0
TLS2_k127_1562805_0 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779,K11784 - 1.21.98.1,2.5.1.77 4.31e-240 759.0
TLS2_k127_1562805_1 FAD linked oxidases, C-terminal domain K00102,K11472 - 1.1.2.4 2.373e-220 718.0
TLS2_k127_1562805_2 4Fe-4S dicluster domain - - - 2.133e-204 643.0
TLS2_k127_1562805_4 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 520.0
TLS2_k127_1562805_5 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 362.0
TLS2_k127_1562805_6 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000000000000009191 157.0
TLS2_k127_1562805_7 - - - - 0.0000000000000003071 92.0
TLS2_k127_159120_0 Transmembrane secretion effector K18215 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007876 387.0
TLS2_k127_159120_1 Transmembrane secretion effector K18215 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009219 361.0
TLS2_k127_159120_2 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004818 340.0
TLS2_k127_159120_3 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000003425 185.0
TLS2_k127_159120_5 Type VI secretion system effector, Hcp K11903 - - 0.0000000000000000000000000000000000004429 145.0
TLS2_k127_1642303_0 DNA polymerase X K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 483.0
TLS2_k127_1642303_1 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001579 286.0
TLS2_k127_1642303_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 GO:0008150,GO:0040007 2.7.4.16 0.000000000000000000000000000000000000000000001282 174.0
TLS2_k127_1642303_3 cytochrome - - - 0.0000000000000000000000000000000000000003589 165.0
TLS2_k127_1642303_4 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000002362 140.0
TLS2_k127_1642303_5 mechanosensitive ion channel K16052,K22044 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000002282 65.0
TLS2_k127_166165_0 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 509.0
TLS2_k127_166165_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005825 358.0
TLS2_k127_166165_2 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 344.0
TLS2_k127_166165_3 LAO AO transport system ATPase K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008837 293.0
TLS2_k127_166165_4 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 284.0
TLS2_k127_166165_5 Major Facilitator Superfamily K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 296.0
TLS2_k127_166165_6 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001507 270.0
TLS2_k127_166165_7 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000000000000000000005142 224.0
TLS2_k127_166165_8 Biotin carboxylase C-terminal domain K01968 - 6.4.1.4 0.000000000000004033 79.0
TLS2_k127_1703251_0 PFAM response regulator receiver K02282 - - 0.00000000007076 74.0
TLS2_k127_1703251_1 Pilus assembly protein K02279 - - 0.00000001131 65.0
TLS2_k127_1703251_2 TadE-like protein - - - 0.00000002506 61.0
TLS2_k127_1703251_3 Flp pilus assembly protein, pilin Flp K02651 - - 0.0004045 50.0
TLS2_k127_1703251_4 Putative Tad-like Flp pilus-assembly - - - 0.000603 53.0
TLS2_k127_171096_0 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 370.0
TLS2_k127_171096_1 Alpha Beta K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 327.0
TLS2_k127_171096_2 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 309.0
TLS2_k127_171096_3 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000002982 205.0
TLS2_k127_171096_4 DNA binding - - - 0.000000000000000000000000000000000000000000001522 177.0
TLS2_k127_1761019_0 Tubulin/FtsZ family, GTPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008987 422.0
TLS2_k127_1761019_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005949 414.0
TLS2_k127_1761019_2 Cellulose biosynthesis protein BcsQ K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 365.0
TLS2_k127_1761019_3 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 341.0
TLS2_k127_1761019_4 DEAD/H associated K03724 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002335 251.0
TLS2_k127_1761019_5 Formamidopyrimidine-DNA glycosylase H2TH domain - - - 0.0000000000000000000000000000000000000000000000000006037 194.0
TLS2_k127_1761019_6 CBD_II K01179,K01183 - 3.2.1.14,3.2.1.4 0.00000000000000000000000000000000000000000000001131 195.0
TLS2_k127_1761019_7 peptidase M36 K01417 - - 0.0000000000000000000000000000000000000000000003488 192.0
TLS2_k127_1761019_8 Domain of unknown function (DUF4383) - - - 0.00000000000000000000000000000000000000002191 163.0
TLS2_k127_1761019_9 - - - - 0.000000000007288 78.0
TLS2_k127_1779096_0 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004998 452.0
TLS2_k127_1779096_1 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 464.0
TLS2_k127_1779096_2 Rhomboid family K19225 - 3.4.21.105 0.000000000000000000000000000000000000000000000000000109 201.0
TLS2_k127_1779096_3 impB/mucB/samB family - - - 0.00000000000000000000000000000000000007333 161.0
TLS2_k127_1779096_4 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0000000000000000000000000000000028 144.0
TLS2_k127_1779096_5 Belongs to the ComB family K05979 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 0.00000000000000000000000000000118 130.0
TLS2_k127_1779096_6 pyruvate phosphate dikinase K01006 - 2.7.9.1 0.000000002192 58.0
TLS2_k127_1820767_0 CoA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 377.0
TLS2_k127_1820767_1 6-phospho-beta-galactosidase activity - - - 0.00000000000000000000000000000000774 144.0
TLS2_k127_1820767_2 membrane protein involved in the export of O-antigen and teichoic acid - - - 0.000000000000004329 89.0
TLS2_k127_1872070_0 aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002616 416.0
TLS2_k127_1872070_1 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 401.0
TLS2_k127_1872070_2 Proline racemase K01777 - 5.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003196 365.0
TLS2_k127_1872070_3 metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 355.0
TLS2_k127_1872070_4 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007042 300.0
TLS2_k127_1872070_5 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 308.0
TLS2_k127_1872070_6 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001 245.0
TLS2_k127_1872070_7 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000111 208.0
TLS2_k127_1889643_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 5.019e-245 793.0
TLS2_k127_1889643_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 591.0
TLS2_k127_1889643_10 Cupin 2, conserved barrel domain protein K21700 - - 0.0000000000000000003141 91.0
TLS2_k127_1889643_11 Lytic transglycolase - - - 0.0000000001858 67.0
TLS2_k127_1889643_12 Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B) K04757 GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 2.7.11.1 0.00001418 55.0
TLS2_k127_1889643_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003268 535.0
TLS2_k127_1889643_3 PFAM Phenylalanine and histidine ammonia-lyase K01745,K10775 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009072,GO:0009698,GO:0009699,GO:0009800,GO:0009803,GO:0009987,GO:0016043,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0019438,GO:0019748,GO:0019752,GO:0022607,GO:0032787,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044550,GO:0045548,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 4.3.1.24,4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 533.0
TLS2_k127_1889643_4 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004885 439.0
TLS2_k127_1889643_5 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 381.0
TLS2_k127_1889643_6 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000001089 269.0
TLS2_k127_1889643_7 Sigma-70 region 3 K03090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001677 257.0
TLS2_k127_1889643_8 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000001878 175.0
TLS2_k127_1889643_9 Formiminotransferase domain K00603,K01746,K13990 - 2.1.2.5,4.3.1.4 0.0000000000000000000000000000000000000008314 154.0
TLS2_k127_1906485_0 cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 431.0
TLS2_k127_1906485_1 short-chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006317 335.0
TLS2_k127_1906485_2 Histidine kinase K02484 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 340.0
TLS2_k127_1906485_3 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003439 269.0
TLS2_k127_1906485_4 COG2931 RTX toxins and related Ca2 -binding proteins K01406 - 3.4.24.40 0.00000000000000000000000000000000000000009788 174.0
TLS2_k127_1906485_5 - - - - 0.000000000000000000000000000000000000001165 165.0
TLS2_k127_1906485_6 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000004637 145.0
TLS2_k127_1906485_7 EamA-like transporter family - - - 0.0000000000000000000000000004879 124.0
TLS2_k127_1906485_8 - - - - 0.000000000001345 80.0
TLS2_k127_1906485_9 Lipopolysaccharide assembly protein A domain - - - 0.0005953 46.0
TLS2_k127_1914704_0 Helix-hairpin-helix motif K14162 - 2.7.7.7 0.0 1107.0
TLS2_k127_1914704_1 MMPL family - - - 1.682e-242 769.0
TLS2_k127_1914704_10 DinB family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000366 274.0
TLS2_k127_1914704_11 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000001132 259.0
TLS2_k127_1914704_12 Aminotransferase class-V K11325 - - 0.00000000000000000000000000000000000000000000000000000000000000004588 245.0
TLS2_k127_1914704_13 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000005419 234.0
TLS2_k127_1914704_14 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA K09772 - - 0.000000000000000000000000000000000000000000000000000000003957 207.0
TLS2_k127_1914704_15 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000001507 214.0
TLS2_k127_1914704_16 ABC-2 family transporter protein - - - 0.0000000000000000000000000000000000000000000000004908 199.0
TLS2_k127_1914704_17 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000001153 191.0
TLS2_k127_1914704_18 Alanine racemase, N-terminal domain K06997 - - 0.000000000000000000000000000000000000000000000003723 186.0
TLS2_k127_1914704_19 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000517 193.0
TLS2_k127_1914704_2 tRNA nucleotidyltransferase poly(A) polymerase K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 531.0
TLS2_k127_1914704_20 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000225 160.0
TLS2_k127_1914704_21 - - - - 0.00000000000000000000000000000000000007846 164.0
TLS2_k127_1914704_22 PFAM peptidase M50 - - - 0.0000000000000000000000000000000000004067 163.0
TLS2_k127_1914704_23 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000006339 142.0
TLS2_k127_1914704_24 WD40-like Beta Propeller Repeat K03641,K08676 - - 0.000000000000000000000000000000005197 151.0
TLS2_k127_1914704_25 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000001298 117.0
TLS2_k127_1914704_26 diguanylate cyclase - - - 0.0000000000000000000000002126 118.0
TLS2_k127_1914704_27 Cupin - - - 0.000000000000000000000203 106.0
TLS2_k127_1914704_28 PFAM Prokaryotic dksA traR C4-type zinc finger - - - 0.0000000000000000004999 92.0
TLS2_k127_1914704_29 AraC-like ligand binding domain - - - 0.000000000000001594 86.0
TLS2_k127_1914704_3 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 508.0
TLS2_k127_1914704_30 PFAM DivIVA family protein K04074 - - 0.000000000000001715 83.0
TLS2_k127_1914704_31 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000003091 83.0
TLS2_k127_1914704_32 YGGT family K02221 - - 0.0000000000106 68.0
TLS2_k127_1914704_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 352.0
TLS2_k127_1914704_5 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007242 322.0
TLS2_k127_1914704_6 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 315.0
TLS2_k127_1914704_7 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008986 327.0
TLS2_k127_1914704_8 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 299.0
TLS2_k127_1914704_9 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 289.0
TLS2_k127_1923684_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 302.0
TLS2_k127_1923684_1 6-phospho-beta-galactosidase activity K21000 - - 0.00000000000000000000000000000000000000000000000000000000003631 223.0
TLS2_k127_1923684_2 6-phospho-beta-galactosidase activity K21000 - - 0.0000000000000000000000000000000000000000000000000000000005145 219.0
TLS2_k127_1941771_0 Pyridoxal-phosphate dependent enzyme K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 484.0
TLS2_k127_1941771_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002875 362.0
TLS2_k127_1941771_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K01665,K03342,K13503,K13950 - 2.6.1.85,4.1.3.27,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009867 298.0
TLS2_k127_1941771_3 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000005073 229.0
TLS2_k127_1941771_4 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.0000000000000000000000000000000000000000004 180.0
TLS2_k127_1941771_5 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000001909 172.0
TLS2_k127_1961927_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 492.0
TLS2_k127_1961927_1 glycosyl transferase, family 51 K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004378 409.0
TLS2_k127_1961927_10 Aminoacyl-tRNA editing domain - - - 0.00000000000000000000001684 106.0
TLS2_k127_1961927_11 cellulose binding K01179 - 3.2.1.4 0.00000000001255 76.0
TLS2_k127_1961927_12 - - - - 0.0006268 50.0
TLS2_k127_1961927_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 382.0
TLS2_k127_1961927_3 Aminotransferase, class V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007416 376.0
TLS2_k127_1961927_4 Belongs to the DNA glycosylase MPG family K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000003776 260.0
TLS2_k127_1961927_5 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000001168 211.0
TLS2_k127_1961927_6 Domain of unknown function (DUF4111) - - - 0.0000000000000000000000000000000000000000004499 177.0
TLS2_k127_1961927_7 Peptidoglycan binding domain - - - 0.000000000000000000000000000000000000000000486 173.0
TLS2_k127_1961927_8 OsmC-like protein K04063 - - 0.000000000000000000000000000000000000000001676 162.0
TLS2_k127_1961927_9 - - - - 0.000000000000000000000000000000000009939 139.0
TLS2_k127_1966370_0 MMPL family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 551.0
TLS2_k127_1966370_1 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000006459 124.0
TLS2_k127_197777_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004777 548.0
TLS2_k127_197777_1 PFAM Transketolase central region K00162 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000924 501.0
TLS2_k127_197777_10 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000001127 217.0
TLS2_k127_197777_11 Cytochrome b subunit of the bc K03888 - - 0.00000000000000000000000000000000000000111 156.0
TLS2_k127_197777_12 CHRD domain - - - 0.000000000000000000000000000000000009683 143.0
TLS2_k127_197777_13 Diacylglycerol kinase - - - 0.00000000000000000000000000000001178 141.0
TLS2_k127_197777_14 GtrA-like protein - - - 0.0000000000000000000000000007281 128.0
TLS2_k127_197777_15 Glycosyltransferase family 87 - - - 0.000000000000000000000000002868 129.0
TLS2_k127_197777_16 Rieske 2Fe-2S - - - 0.000000000000000000000001964 114.0
TLS2_k127_197777_18 - - - - 0.00000000000006916 87.0
TLS2_k127_197777_19 Belongs to the thioredoxin family K03671 - - 0.00000000003605 67.0
TLS2_k127_197777_2 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 450.0
TLS2_k127_197777_20 Bacterial regulatory proteins, tetR family - - - 0.000000004788 59.0
TLS2_k127_197777_3 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 411.0
TLS2_k127_197777_4 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007096 385.0
TLS2_k127_197777_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006102 394.0
TLS2_k127_197777_6 Serine dehydrogenase proteinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 326.0
TLS2_k127_197777_7 Cytochrome b K03887 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000996 306.0
TLS2_k127_197777_8 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006616 316.0
TLS2_k127_197777_9 YmdB-like protein K09769 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002985 259.0
TLS2_k127_1984303_0 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 2.29e-293 927.0
TLS2_k127_1984303_1 Belongs to the ABC transporter superfamily K02031,K02032 - - 1.745e-196 633.0
TLS2_k127_1984303_10 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000982 277.0
TLS2_k127_1984303_11 Metallopeptidase family M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000005371 260.0
TLS2_k127_1984303_12 response to copper ion - - - 0.0000000000000000000000000000000000000000000000000000000000000000001037 246.0
TLS2_k127_1984303_13 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000001828 235.0
TLS2_k127_1984303_14 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000002121 232.0
TLS2_k127_1984303_15 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000002276 221.0
TLS2_k127_1984303_16 Short-chain dehydrogenase reductase sdr - - - 0.000000000000000000000000000000000000000000000000004126 207.0
TLS2_k127_1984303_17 NAD dependent epimerase/dehydratase family K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000001238 174.0
TLS2_k127_1984303_18 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000366 156.0
TLS2_k127_1984303_19 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000002848 158.0
TLS2_k127_1984303_2 Extracellular solute-binding protein, family 5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 437.0
TLS2_k127_1984303_20 Domain of Unknown Function (DUF1206) - - - 0.0000000000000000003795 88.0
TLS2_k127_1984303_21 - - - - 0.0000000000000004392 85.0
TLS2_k127_1984303_22 Cytochrome c K05301 - 1.8.2.1 0.00000000000164 74.0
TLS2_k127_1984303_23 Heavy-metal-associated domain K07213 - - 0.0000000004404 73.0
TLS2_k127_1984303_25 domain protein K21687 - - 0.00000001497 65.0
TLS2_k127_1984303_3 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009585 412.0
TLS2_k127_1984303_4 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 364.0
TLS2_k127_1984303_5 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007859 356.0
TLS2_k127_1984303_6 helix_turn _helix lactose operon repressor K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 335.0
TLS2_k127_1984303_7 NAD dependent epimerase dehydratase family protein K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 310.0
TLS2_k127_1984303_8 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 308.0
TLS2_k127_1984303_9 pyridine nucleotide-disulphide oxidoreductase K00529,K05301,K17229 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.18.1.3,1.8.2.1,1.8.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000003995 271.0
TLS2_k127_1987347_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 403.0
TLS2_k127_1987347_1 Phospholipid methyltransferase - - - 0.000000000000000000000000000000000000000000000000000008069 206.0
TLS2_k127_1987347_2 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000000000000000000000000001363 156.0
TLS2_k127_1987347_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000000000000000000000000000728 124.0
TLS2_k127_1987347_4 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.0000000000000000007929 92.0
TLS2_k127_2037765_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 396.0
TLS2_k127_2037765_1 Cytochrome b K03887 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 303.0
TLS2_k127_2037765_2 Cytochrome b subunit of the bc K03888 - - 0.0000000000000000000000000000000000000000949 160.0
TLS2_k127_2037765_3 Rieske 2Fe-2S - - - 0.0000000000000000000000008262 115.0
TLS2_k127_2087242_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03169 - 5.99.1.2 4.529e-301 939.0
TLS2_k127_2087242_1 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009156,GO:0009161,GO:0009163,GO:0009164,GO:0009165,GO:0009167,GO:0009168,GO:0009987,GO:0015949,GO:0015950,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0032261,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 320.0
TLS2_k127_2087242_10 response regulator - - - 0.00000000000001875 78.0
TLS2_k127_2087242_11 Helix-turn-helix XRE-family like proteins - - - 0.0000000000001322 83.0
TLS2_k127_2087242_12 Transcriptional regulator K03556 - - 0.0001156 51.0
TLS2_k127_2087242_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 310.0
TLS2_k127_2087242_3 5'-3' exonuclease K02335 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000001204 252.0
TLS2_k127_2087242_4 Fe-S oxidoreductase K18928 - - 0.000000000000000000000000000000000000000000000000001786 190.0
TLS2_k127_2087242_5 PFAM Metal-dependent phosphohydrolase, HD - - - 0.0000000000000000000000000000000000000000007768 176.0
TLS2_k127_2087242_6 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000003192 133.0
TLS2_k127_2087242_7 ATP-dependent transcriptional regulator, MalT-like, LuxR family K03556 - - 0.00000000000000000000000006829 125.0
TLS2_k127_2087242_8 Glycosyl transferases group 1 K08256 - 2.4.1.345 0.0000000000000000002524 93.0
TLS2_k127_2087242_9 LVIVD repeat - - - 0.0000000000000000806 92.0
TLS2_k127_2106730_0 Domain of unknown function (DUF1998) K06877 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006379 553.0
TLS2_k127_2106730_1 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008541 452.0
TLS2_k127_2106730_2 belongs to the sigma-70 factor family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 445.0
TLS2_k127_2106730_3 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 416.0
TLS2_k127_2106730_4 YCII-related domain - - - 0.0000000000000000000000000001977 120.0
TLS2_k127_2106730_5 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000006963 127.0
TLS2_k127_2106730_6 YCII-related domain - - - 0.00000000000000000000004486 104.0
TLS2_k127_2122601_0 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 509.0
TLS2_k127_2122601_1 Peptidase family M23 K21471 - - 0.00000000000000000000000000000000000000006871 165.0
TLS2_k127_2122601_2 NmrA-like family - - - 0.000000000000000000000000000498 123.0
TLS2_k127_2122601_3 CcmE - - - 0.00000000000000001312 88.0
TLS2_k127_2122601_4 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.0000000005432 72.0
TLS2_k127_2122601_5 - - - - 0.0000000007375 65.0
TLS2_k127_2165571_0 Glycosyl transferase, family 20 K00697 - 2.4.1.15,2.4.1.347 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 444.0
TLS2_k127_2165571_1 Glycosyl transferases group 1 K13057 - 2.4.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001156 279.0
TLS2_k127_2165571_10 Uroporphyrinogen-III synthase HemD K13542 - 2.1.1.107,4.2.1.75 0.000000000001613 80.0
TLS2_k127_2165571_2 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000005727 267.0
TLS2_k127_2165571_3 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000001258 215.0
TLS2_k127_2165571_4 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000009031 184.0
TLS2_k127_2165571_5 Cytochrome C assembly protein K02195 - - 0.000000000000000000000000000000000000000000000001159 183.0
TLS2_k127_2165571_6 TIGRFAM molybdenum cofactor synthesis domain K03635 - 2.8.1.12 0.000000000000000000000000000000000000000006553 168.0
TLS2_k127_2165571_7 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000001754 161.0
TLS2_k127_2165571_8 heme ABC exporter, ATP-binding protein CcmA K02193 - 3.6.3.41 0.000000000000000000000000000000001256 148.0
TLS2_k127_2165571_9 CcmB protein K02194 - - 0.0000000000000000000001988 110.0
TLS2_k127_2217566_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 363.0
TLS2_k127_2217566_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009758 267.0
TLS2_k127_2217566_2 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000358 173.0
TLS2_k127_2217566_3 Acylphosphatase K01512 - 3.6.1.7 0.000000000000000000001058 109.0
TLS2_k127_2217566_4 Sporulation protein YtfJ - - - 0.000000000003081 77.0
TLS2_k127_2229120_0 Homoserine dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001799 292.0
TLS2_k127_2229120_1 Hexapeptide repeat of succinyl-transferase K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000004564 239.0
TLS2_k127_2229120_2 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000005455 224.0
TLS2_k127_2229120_3 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000000000003748 217.0
TLS2_k127_2229120_4 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.0000000000000000000000000000000000000000002487 177.0
TLS2_k127_2229120_5 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.000000000000000000000000000000005006 130.0
TLS2_k127_2229120_6 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0008002 42.0
TLS2_k127_223494_0 cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 463.0
TLS2_k127_223494_1 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004557 417.0
TLS2_k127_223494_10 COG0346 Lactoylglutathione lyase and related lyases K07032 - - 0.000000000000000000000000000000000000000000000000002224 196.0
TLS2_k127_223494_11 Protein of unknown function (DUF1361) - - - 0.00000000000000000000000000000000000000000001715 169.0
TLS2_k127_223494_12 Flavin reductase like domain - - - 0.00000000000000000000000000000000000004201 150.0
TLS2_k127_223494_13 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.0000000000000000000007493 109.0
TLS2_k127_223494_14 carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.00000000000000000003423 99.0
TLS2_k127_223494_15 Thioesterase superfamily - - - 0.000000000000000001655 91.0
TLS2_k127_223494_16 Bacterial-like globin K06886 - - 0.000000000000000006095 98.0
TLS2_k127_223494_2 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003293 354.0
TLS2_k127_223494_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007037 290.0
TLS2_k127_223494_4 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 287.0
TLS2_k127_223494_5 amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000008475 250.0
TLS2_k127_223494_6 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002625 247.0
TLS2_k127_223494_7 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000003255 225.0
TLS2_k127_223494_8 4-hydroxyphenylacetate 3-hydroxylase N terminal K00483 - 1.14.14.9 0.0000000000000000000000000000000000000000000000000000001506 197.0
TLS2_k127_223494_9 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.000000000000000000000000000000000000000000000000000002338 212.0
TLS2_k127_2242691_0 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000002286 192.0
TLS2_k127_2242691_1 ATPase associated with various cellular activities K03924 - - 0.0000000000000000000000001802 108.0
TLS2_k127_2242691_2 Phosphatase - - - 0.000000000000005165 89.0
TLS2_k127_2242691_3 PFAM bifunctional deaminase-reductase domain protein - - - 0.0000000000005426 70.0
TLS2_k127_2242691_4 RibD C-terminal domain - - - 0.00000004045 55.0
TLS2_k127_2261856_0 Alcohol dehydrogenase GroES-like domain - - - 1.823e-196 627.0
TLS2_k127_2261856_1 UvrD-like helicase C-terminal domain K03657 GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 423.0
TLS2_k127_2261856_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 298.0
TLS2_k127_2261856_3 cyclase dehydrase - - - 0.00000000000000000000000000000000000000000000000000000007101 201.0
TLS2_k127_2261856_4 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000009724 121.0
TLS2_k127_2261856_5 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000008303 93.0
TLS2_k127_2281190_0 Glycosyl transferase, family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000004628 232.0
TLS2_k127_232732_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 565.0
TLS2_k127_232732_1 Pyridoxal-phosphate dependent enzyme K01505,K05396 - 3.5.99.7,4.4.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009644 540.0
TLS2_k127_232732_2 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 495.0
TLS2_k127_232732_3 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004223 294.0
TLS2_k127_232732_4 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000002587 255.0
TLS2_k127_232732_5 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000009761 219.0
TLS2_k127_232732_6 Protein of unknown function (DUF4230) - - - 0.00000000000000000000000000000000000000000000002231 179.0
TLS2_k127_232732_7 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000002481 177.0
TLS2_k127_232732_8 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000006724 157.0
TLS2_k127_232732_9 Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon K03709 - - 0.000000000000000000000000000001186 141.0
TLS2_k127_2347873_0 6-phosphogluconolactonase K01057 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 0.000000000000000000000000000000000000000028 164.0
TLS2_k127_2347873_1 PFAM FecR protein - - - 0.00002351 57.0
TLS2_k127_2359603_0 LVIVD repeat - - - 1.697e-221 702.0
TLS2_k127_2359603_1 Low temperature requirement - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 524.0
TLS2_k127_2359603_2 PAP2 superfamily - - - 0.000000000000000000000000000000000000000000000000000005912 202.0
TLS2_k127_2359603_3 Domain of unknown function (DUF4142) - - - 0.0000000000000000000000000000000000000001282 159.0
TLS2_k127_2359603_4 glycerophosphoryl diester phosphodiesterase - - - 0.0000000000000000000000000000001484 132.0
TLS2_k127_2359603_5 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000000000000004776 119.0
TLS2_k127_2359603_6 - - - - 0.000000001763 64.0
TLS2_k127_2401126_0 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000001504 167.0
TLS2_k127_2401126_1 ATP-dependent Clp protease adaptor protein ClpS K06891 - - 0.0000000000000000000000000001251 117.0
TLS2_k127_2412055_0 Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 509.0
TLS2_k127_2412055_1 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 429.0
TLS2_k127_2412055_2 - K06197 - - 0.000000005568 66.0
TLS2_k127_2428262_0 integral membrane sensor signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007785 417.0
TLS2_k127_2428262_1 Two component transcriptional regulator, winged helix family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 317.0
TLS2_k127_2428262_10 Sulphur transport - - - 0.0000000000000000000000000000001613 135.0
TLS2_k127_2428262_2 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 293.0
TLS2_k127_2428262_3 Threonine dehydratase K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 296.0
TLS2_k127_2428262_4 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000181 273.0
TLS2_k127_2428262_5 - - - - 0.00000000000000000000000000000000000000000001354 170.0
TLS2_k127_2428262_6 Domain of unknown function (DUF4032) - - - 0.0000000000000000000000000000000000000129 149.0
TLS2_k127_2428262_7 Sulphur transport K07112 - - 0.0000000000000000000000000000000000005563 147.0
TLS2_k127_2428262_8 Predicted integral membrane protein (DUF2269) - - - 0.0000000000000000000000000000000001664 139.0
TLS2_k127_2428262_9 TfoX N-terminal domain - - - 0.00000000000000000000000000000000131 133.0
TLS2_k127_2439666_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002785 289.0
TLS2_k127_2439666_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007781 277.0
TLS2_k127_2439666_10 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000007097 126.0
TLS2_k127_2439666_11 deacetylase - - - 0.0000000000000464 85.0
TLS2_k127_2439666_12 Cupin domain - - - 0.0000000000003361 81.0
TLS2_k127_2439666_13 Phosphotransferase enzyme family - - - 0.000000004895 70.0
TLS2_k127_2439666_2 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001424 255.0
TLS2_k127_2439666_3 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000004456 237.0
TLS2_k127_2439666_4 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000008046 212.0
TLS2_k127_2439666_5 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000002147 204.0
TLS2_k127_2439666_6 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000000000006082 193.0
TLS2_k127_2439666_7 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000002624 184.0
TLS2_k127_2439666_8 Cupin - - - 0.000000000000000000000000000102 128.0
TLS2_k127_2439666_9 Glycosyltransferase like family 2 - - - 0.000000000000000000000000004893 121.0
TLS2_k127_2520419_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 382.0
TLS2_k127_2520419_1 Formate/nitrite transporter K06212 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 311.0
TLS2_k127_2520419_2 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000001084 237.0
TLS2_k127_2520419_3 - - - - 0.0000000000000000000000001587 115.0
TLS2_k127_2520419_4 Domain of unknown function DUF87 K06915 - - 0.00000000006109 64.0
TLS2_k127_2541072_0 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000806 379.0
TLS2_k127_2541072_1 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000005863 250.0
TLS2_k127_2541072_2 Belongs to the FPP GGPP synthase family - - - 0.00000000000000000000000000000000000000000000000000000000000001104 228.0
TLS2_k127_2541072_3 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000006311 196.0
TLS2_k127_2541072_4 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.00000000000000000000000000000000000002605 154.0
TLS2_k127_2541072_5 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000002052 143.0
TLS2_k127_25713_0 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 584.0
TLS2_k127_25713_1 NUDIX domain K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004051 302.0
TLS2_k127_25713_2 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000000008557 217.0
TLS2_k127_2577882_0 Type III restriction enzyme, res subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 606.0
TLS2_k127_2577882_1 Aldo/keto reductase family K05882 - 1.1.1.91 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 432.0
TLS2_k127_2577882_2 PAC2 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007085 293.0
TLS2_k127_2577882_3 cytochrome oxidase assembly K02259 - - 0.000000000000000000000000000000000000002115 162.0
TLS2_k127_2577882_4 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000004432 156.0
TLS2_k127_2577882_5 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000002551 106.0
TLS2_k127_2642364_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 497.0
TLS2_k127_2642364_1 Peptidase family M41 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000381 474.0
TLS2_k127_2642364_2 Protein of unknown function (DUF1385) - - - 0.0000000000000000000000000000000000000000000000000002158 195.0
TLS2_k127_2642364_3 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000003043 148.0
TLS2_k127_264778_0 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 584.0
TLS2_k127_264778_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000421 301.0
TLS2_k127_264778_2 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000007729 227.0
TLS2_k127_264778_3 MOSC domain - - - 0.0000000000000000000000000000000000000000000000008413 196.0
TLS2_k127_264778_4 Putative neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.0000000000001393 74.0
TLS2_k127_266663_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.43e-306 979.0
TLS2_k127_266663_1 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000000000000000000000000000000007476 195.0
TLS2_k127_266663_2 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000001081 150.0
TLS2_k127_266663_3 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000000000000000001561 153.0
TLS2_k127_2751221_0 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 389.0
TLS2_k127_2751221_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 336.0
TLS2_k127_2751221_2 PspC domain protein K03973 - - 0.000000001871 59.0
TLS2_k127_2805847_0 PFAM Phenylalanine and histidine ammonia-lyase K01745,K10775 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009072,GO:0009698,GO:0009699,GO:0009800,GO:0009803,GO:0009987,GO:0016043,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0019438,GO:0019748,GO:0019752,GO:0022607,GO:0032787,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044550,GO:0045548,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 4.3.1.24,4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 522.0
TLS2_k127_2805847_1 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000008327 85.0
TLS2_k127_2805847_2 PFAM Formiminotransferase domain K00603,K13990 - 2.1.2.5,4.3.1.4 0.000000001233 61.0
TLS2_k127_2810787_0 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003666 436.0
TLS2_k127_2810787_1 Amidohydrolase family K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 318.0
TLS2_k127_2810787_2 DNA-templated transcription, initiation - - - 0.0000000000000000000000000000001503 126.0
TLS2_k127_2814870_0 Protein of unknown function (DUF2652) - - - 0.00000000000000000000000000000000000000000000000000000000000000001971 237.0
TLS2_k127_2814870_1 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000005411 182.0
TLS2_k127_2814870_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000001249 91.0
TLS2_k127_2814870_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000602 57.0
TLS2_k127_2841909_0 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 603.0
TLS2_k127_2841909_1 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001805 288.0
TLS2_k127_2841909_2 Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway K00068,K18124,K18125 GO:0000166,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005515,GO:0005534,GO:0005536,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006012,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019320,GO:0019388,GO:0019595,GO:0022607,GO:0030246,GO:0033498,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046430,GO:0046872,GO:0046914,GO:0046983,GO:0047910,GO:0047936,GO:0048029,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051262,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.1.1.140,1.1.1.359,1.1.1.360 0.00000000000000000000000000000000000000000000000000000000000000000000000000009177 269.0
TLS2_k127_2841909_3 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000007259 226.0
TLS2_k127_2841909_4 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000001829 225.0
TLS2_k127_2841909_5 PFAM SMP-30 Gluconolaconase K14274 - - 0.00000000000000000000000000000000000000000000000004407 183.0
TLS2_k127_2841909_6 Two component transcriptional regulator, winged helix family K02483 - - 0.000000000000000000000000000000006041 131.0
TLS2_k127_2841909_7 Domain of unknown function (DUF202) K00389 - - 0.00000000000000008607 93.0
TLS2_k127_2841909_8 - - - - 0.000000002674 60.0
TLS2_k127_2842035_0 ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007872 250.0
TLS2_k127_2842035_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000001151 171.0
TLS2_k127_2842035_2 GYD domain - - - 0.000000000000001465 78.0
TLS2_k127_2852643_0 Glycosyl Transferase - - - 8.15e-305 956.0
TLS2_k127_2852643_1 phosphorelay signal transduction system K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 472.0
TLS2_k127_2852643_2 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000000000000000002656 208.0
TLS2_k127_2852643_3 - - - - 0.000000005474 66.0
TLS2_k127_2863141_0 HD domain - - - 0.000000000000000000000000000000000000000000000000000001031 218.0
TLS2_k127_2863141_1 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000008078 181.0
TLS2_k127_2863141_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000003751 137.0
TLS2_k127_2863141_3 Two component transcriptional regulator, LuxR family - - - 0.00000000000000000000000000001932 136.0
TLS2_k127_2871552_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 5.152e-220 705.0
TLS2_k127_2871552_1 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K09972,K10041 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 379.0
TLS2_k127_2871552_2 amino acid transport K09969 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008463 352.0
TLS2_k127_2871552_3 PFAM extracellular solute-binding protein family 1 K11069 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 348.0
TLS2_k127_2871552_4 Binding-protein-dependent transport system inner membrane component K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 337.0
TLS2_k127_2871552_5 Binding-protein-dependent transport system inner membrane component K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 321.0
TLS2_k127_2871552_6 Binding-protein-dependent transport system inner membrane component K09970 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000408 287.0
TLS2_k127_2871552_7 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K09971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000899 299.0
TLS2_k127_2871552_8 cyclohydrolase K01746 - 4.3.1.4 0.000009668 53.0
TLS2_k127_2885214_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009141 560.0
TLS2_k127_2885214_1 ABC1 family K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 377.0
TLS2_k127_2885214_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006844 286.0
TLS2_k127_2885214_3 Oxidoreductase NAD-binding domain - - - 0.0000000000000000000000000000000001024 141.0
TLS2_k127_2885214_4 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.00000000000000009318 83.0
TLS2_k127_2885214_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.00000000000006903 86.0
TLS2_k127_2885214_6 ATP synthase, subunit b - - - 0.00000000007786 71.0
TLS2_k127_2885742_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 6.261e-214 682.0
TLS2_k127_2885742_1 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004777 366.0
TLS2_k127_2885742_10 WD40-like Beta Propeller Repeat - - - 0.00000000006584 75.0
TLS2_k127_2885742_2 Beta-lactamase class C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000462 347.0
TLS2_k127_2885742_3 TIR domain - - - 0.00000000000000000000000000000000003243 153.0
TLS2_k127_2885742_4 belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000001785 133.0
TLS2_k127_2885742_5 polyketide cyclase - - - 0.000000000000000000000000000000001813 145.0
TLS2_k127_2885742_6 Subtilisin inhibitor-like - - - 0.00000000000000000000001181 111.0
TLS2_k127_2885742_7 Redoxin K03564 - 1.11.1.15 0.00000000000000000004568 105.0
TLS2_k127_2885742_8 Protein of unknown function (DUF4231) - - - 0.0000000000000001237 80.0
TLS2_k127_2885742_9 cAMP-dependent protein kinase regulator activity K04739 GO:0000086,GO:0000166,GO:0000278,GO:0001664,GO:0001674,GO:0001932,GO:0001933,GO:0001934,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0005952,GO:0006082,GO:0006469,GO:0006629,GO:0006631,GO:0006950,GO:0006996,GO:0007049,GO:0007154,GO:0007165,GO:0007346,GO:0007596,GO:0007599,GO:0007610,GO:0007611,GO:0007612,GO:0008150,GO:0008152,GO:0008603,GO:0009410,GO:0009611,GO:0009719,GO:0009725,GO:0009892,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010389,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010720,GO:0014070,GO:0015630,GO:0016020,GO:0016043,GO:0017076,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019752,GO:0019866,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0022402,GO:0022406,GO:0022607,GO:0023052,GO:0030030,GO:0030031,GO:0030104,GO:0030234,GO:0030291,GO:0030315,GO:0030425,GO:0030551,GO:0030552,GO:0030554,GO:0031090,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031625,GO:0031690,GO:0031698,GO:0031966,GO:0031967,GO:0031975,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032870,GO:0032991,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035556,GO:0036094,GO:0036477,GO:0042060,GO:0042221,GO:0042325,GO:0042326,GO:0042327,GO:0042383,GO:0042493,GO:0042585,GO:0042592,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043025,GO:0043073,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043197,GO:0043198,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043434,GO:0043436,GO:0043549,GO:0043900,GO:0043902,GO:0043933,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044297,GO:0044309,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0044770,GO:0044772,GO:0044782,GO:0044839,GO:0044853,GO:0045121,GO:0045202,GO:0045595,GO:0045597,GO:0045787,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046983,GO:0048471,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048871,GO:0048878,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050817,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051018,GO:0051094,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051248,GO:0051259,GO:0051291,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051446,GO:0051640,GO:0051641,GO:0051716,GO:0051726,GO:0060255,GO:0060271,GO:0060281,GO:0060282,GO:0060284,GO:0061695,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071944,GO:0080090,GO:0090068,GO:0097159,GO:0097332,GO:0097338,GO:0097367,GO:0097447,GO:0097458,GO:0097546,GO:0097711,GO:0098589,GO:0098590,GO:0098772,GO:0098794,GO:0098805,GO:0098857,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:0140056,GO:1900193,GO:1900195,GO:1901265,GO:1901363,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901987,GO:1901990,GO:1902494,GO:1902749,GO:1902911,GO:1903047,GO:1903429,GO:1903431,GO:1903538,GO:1904146,GO:1905879,GO:1905881,GO:1990234,GO:2000241,GO:2000243,GO:2000479,GO:2000480 - 0.0000000000002807 77.0
TLS2_k127_2918933_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006074 484.0
TLS2_k127_2918933_1 Cysteine synthase K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 472.0
TLS2_k127_2918933_2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000004597 145.0
TLS2_k127_2932179_0 Zn_pept - - - 0.0 1147.0
TLS2_k127_2932179_1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K15778 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 497.0
TLS2_k127_2932179_2 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000459 432.0
TLS2_k127_2932179_3 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 368.0
TLS2_k127_2932179_4 PFAM histidine triad (HIT) protein K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000000000004931 205.0
TLS2_k127_2932179_5 Domain present in phytochromes and cGMP-specific phosphodiesterases. K08968 - 1.8.4.14 0.000000000000000000000000000000000000000000001394 172.0
TLS2_k127_2932179_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000009141 89.0
TLS2_k127_2934370_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006762 436.0
TLS2_k127_2934370_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 360.0
TLS2_k127_2934370_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008975 320.0
TLS2_k127_2934370_3 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 299.0
TLS2_k127_2934370_4 oxidoreductase - - - 0.00000000000000000000000000000000000000000005107 179.0
TLS2_k127_2934370_5 cAMP-dependent protein kinase regulator activity K04739 GO:0000003,GO:0000166,GO:0000187,GO:0000226,GO:0000280,GO:0001704,GO:0001707,GO:0001932,GO:0001933,GO:0001934,GO:0002682,GO:0002683,GO:0002694,GO:0002695,GO:0003006,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0005952,GO:0006355,GO:0006357,GO:0006464,GO:0006468,GO:0006469,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0007010,GO:0007015,GO:0007017,GO:0007049,GO:0007143,GO:0007154,GO:0007162,GO:0007163,GO:0007165,GO:0007267,GO:0007268,GO:0007274,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007369,GO:0007389,GO:0007498,GO:0007507,GO:0007591,GO:0007596,GO:0007599,GO:0007610,GO:0007611,GO:0007612,GO:0007613,GO:0007635,GO:0008103,GO:0008150,GO:0008152,GO:0008283,GO:0008285,GO:0008306,GO:0008355,GO:0008603,GO:0009611,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009798,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009994,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010628,GO:0010639,GO:0010646,GO:0010647,GO:0010648,GO:0010721,GO:0010738,GO:0010927,GO:0010948,GO:0014706,GO:0014855,GO:0015630,GO:0016020,GO:0016043,GO:0016310,GO:0016325,GO:0017076,GO:0019207,GO:0019210,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019932,GO:0019933,GO:0019935,GO:0019953,GO:0021700,GO:0022402,GO:0022407,GO:0022408,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030029,GO:0030036,GO:0030104,GO:0030154,GO:0030155,GO:0030234,GO:0030239,GO:0030291,GO:0030435,GO:0030551,GO:0030552,GO:0030554,GO:0030587,GO:0030951,GO:0030952,GO:0031032,GO:0031154,GO:0031156,GO:0031285,GO:0031288,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031594,GO:0031625,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0032870,GO:0032878,GO:0032944,GO:0032945,GO:0032989,GO:0032991,GO:0033002,GO:0033043,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035265,GO:0035556,GO:0036094,GO:0036211,GO:0040007,GO:0040020,GO:0042048,GO:0042060,GO:0042127,GO:0042129,GO:0042130,GO:0042221,GO:0042303,GO:0042325,GO:0042326,GO:0042327,GO:0042493,GO:0042592,GO:0042692,GO:0042802,GO:0042995,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043405,GO:0043406,GO:0043408,GO:0043410,GO:0043412,GO:0043434,GO:0043549,GO:0043900,GO:0043901,GO:0043934,GO:0043949,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044853,GO:0045121,GO:0045202,GO:0045214,GO:0045471,GO:0045595,GO:0045596,GO:0045786,GO:0045835,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046006,GO:0046007,GO:0046677,GO:0048285,GO:0048332,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048520,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048589,GO:0048598,GO:0048599,GO:0048609,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048856,GO:0048869,GO:0048871,GO:0048878,GO:0050670,GO:0050672,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050795,GO:0050817,GO:0050863,GO:0050865,GO:0050866,GO:0050868,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051018,GO:0051093,GO:0051128,GO:0051129,GO:0051146,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051249,GO:0051250,GO:0051252,GO:0051321,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051447,GO:0051703,GO:0051704,GO:0051716,GO:0051726,GO:0051783,GO:0051784,GO:0055001,GO:0055002,GO:0055017,GO:0060038,GO:0060255,GO:0060259,GO:0060281,GO:0060283,GO:0060284,GO:0060419,GO:0060537,GO:0061061,GO:0061695,GO:0061939,GO:0065007,GO:0065008,GO:0065009,GO:0070663,GO:0070664,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071902,GO:0071944,GO:0072359,GO:0072375,GO:0080090,GO:0090036,GO:0090038,GO:0090702,GO:0097159,GO:0097305,GO:0097367,GO:0097435,GO:0097546,GO:0098589,GO:0098590,GO:0098772,GO:0098805,GO:0098857,GO:0098916,GO:0099120,GO:0099536,GO:0099537,GO:0120025,GO:0120038,GO:0140013,GO:1900193,GO:1900194,GO:1901265,GO:1901363,GO:1901564,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902494,GO:1902531,GO:1902532,GO:1902533,GO:1902911,GO:1903037,GO:1903038,GO:1903046,GO:1903429,GO:1903430,GO:1903506,GO:1903538,GO:1905879,GO:1905880,GO:1990234,GO:2000112,GO:2000114,GO:2000241,GO:2000242,GO:2000253,GO:2000479,GO:2000480,GO:2001141 - 0.00000009671 64.0
TLS2_k127_2936774_0 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 394.0
TLS2_k127_2936774_1 PFAM catalytic domain of components of various dehydrogenase complexes K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 312.0
TLS2_k127_2936774_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000001139 242.0
TLS2_k127_2936774_3 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000003865 251.0
TLS2_k127_2936774_4 Transmembrane secretion effector - - - 0.0000000000000000001637 103.0
TLS2_k127_2936774_5 Family of unknown function (DUF5317) - - - 0.000000000004242 79.0
TLS2_k127_2936774_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000004634 57.0
TLS2_k127_2946658_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 604.0
TLS2_k127_2946658_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 458.0
TLS2_k127_2946658_10 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000003712 59.0
TLS2_k127_2946658_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 428.0
TLS2_k127_2946658_3 Low temperature requirement A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 423.0
TLS2_k127_2946658_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 329.0
TLS2_k127_2946658_5 PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009301 325.0
TLS2_k127_2946658_6 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000002343 215.0
TLS2_k127_2946658_7 HD-GYP domain K03540 - 3.1.26.5 0.0000000000000000000000000000000000000000000000000000001435 208.0
TLS2_k127_2946658_8 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000001569 135.0
TLS2_k127_2946658_9 ABC-2 family transporter protein K01992 - - 0.00000000000000000000005363 114.0
TLS2_k127_2948506_0 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 497.0
TLS2_k127_2948506_1 type II secretion system protein E K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000007116 238.0
TLS2_k127_2948506_2 cellulase activity - - - 0.00000000000000000000000000000000000000000000001926 199.0
TLS2_k127_2948506_3 Type ii secretion system K12510 - - 0.000000000000000000000000000000000000000000004312 187.0
TLS2_k127_2948506_4 Type II secretion system (T2SS), protein F K12511 - - 0.0000000000000000000000000000000000006002 151.0
TLS2_k127_2948506_6 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000001062 104.0
TLS2_k127_2959523_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 2.678e-257 807.0
TLS2_k127_2959523_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 310.0
TLS2_k127_2959523_2 metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007425 289.0
TLS2_k127_2959523_3 - - - - 0.0000000000000000000000000000000000000000000000000003664 196.0
TLS2_k127_2959523_4 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000003117 147.0
TLS2_k127_2959523_5 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000008809 134.0
TLS2_k127_2959523_6 ECF sigma factor K03088 - - 0.0000000000000001664 87.0
TLS2_k127_2961803_0 AP endonuclease family 2 C terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 574.0
TLS2_k127_2961803_1 Uncharacterised protein family (UPF0261) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 540.0
TLS2_k127_2961803_10 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004662 250.0
TLS2_k127_2961803_11 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000131 127.0
TLS2_k127_2961803_12 transcriptional regulator DeoR family K02081,K03436 - - 0.00000000000000000000000000001067 128.0
TLS2_k127_2961803_13 Cupin - - - 0.0000000000000000000003071 110.0
TLS2_k127_2961803_2 Phosphoenolpyruvate hydrolase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 464.0
TLS2_k127_2961803_3 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006408 411.0
TLS2_k127_2961803_4 Uncharacterised protein family (UPF0261) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003621 421.0
TLS2_k127_2961803_5 FAD linked oxidases, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008613 404.0
TLS2_k127_2961803_6 Periplasmic binding protein K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006461 381.0
TLS2_k127_2961803_7 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004816 338.0
TLS2_k127_2961803_8 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 324.0
TLS2_k127_2961803_9 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002599 269.0
TLS2_k127_299031_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1639.0
TLS2_k127_299031_1 Animal haem peroxidase - - - 6.048e-232 732.0
TLS2_k127_299031_2 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 316.0
TLS2_k127_299031_3 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000504 227.0
TLS2_k127_299031_4 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000005092 201.0
TLS2_k127_299031_5 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000001081 202.0
TLS2_k127_299031_6 NADP oxidoreductase coenzyme F420-dependent - - - 0.00000000000000000000000000000000003146 142.0
TLS2_k127_299031_7 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000002744 125.0
TLS2_k127_299031_8 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.000000000000000004067 93.0
TLS2_k127_2998688_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 572.0
TLS2_k127_2998688_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000801 385.0
TLS2_k127_2998688_2 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001346 238.0
TLS2_k127_2998688_3 (twin-arginine translocation) pathway signal - - - 0.00000000000000000000000000000000000000001823 169.0
TLS2_k127_2998688_4 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594 - 1.16.3.1 0.0000000000000000000000000003633 130.0
TLS2_k127_2998688_5 Peptidase family M50 K11749 - - 0.000000000000000000000002759 107.0
TLS2_k127_2998688_6 - - - - 0.0000000000000000000004294 104.0
TLS2_k127_2998688_7 - - - - 0.00000003922 61.0
TLS2_k127_2998688_8 IrrE N-terminal-like domain K07110 GO:0001666,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0036293,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070482,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0004646 47.0
TLS2_k127_2999447_0 MMPL family - - - 3.682e-232 742.0
TLS2_k127_2999447_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 426.0
TLS2_k127_2999447_2 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 321.0
TLS2_k127_2999447_3 Multicopper oxidase K08100 - 1.3.3.5 0.000000000000000000000000000000000000000000000000000000000002209 212.0
TLS2_k127_2999447_4 Transcriptional regulator, MarR family - - - 0.000000000000000000000000000000000000000000007496 172.0
TLS2_k127_2999447_5 Cupin - - - 0.000000000000000000000000000000000000000002492 158.0
TLS2_k127_2999447_6 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.00000000000000000000000000000000000000004076 155.0
TLS2_k127_3001354_0 PFAM NADH Ubiquinone plastoquinone (complex I) K05565 - - 6.622e-248 787.0
TLS2_k127_3001354_1 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 566.0
TLS2_k127_3001354_10 Na H antiporter subunit K05571 - - 0.0000000000000000000000000000003652 130.0
TLS2_k127_3001354_11 PFAM NADH-ubiquinone oxidoreductase chain 4L K05567 - - 0.00000000000000000000000000001071 129.0
TLS2_k127_3001354_12 Multiple resistance and pH regulation protein F K05570 - - 0.0000000000000000000000623 107.0
TLS2_k127_3001354_13 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000001621 82.0
TLS2_k127_3001354_2 NADH ubiquinone plastoquinone K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 533.0
TLS2_k127_3001354_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 407.0
TLS2_k127_3001354_4 SAICAR synthetase K01923,K01945 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 349.0
TLS2_k127_3001354_5 Neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 314.0
TLS2_k127_3001354_6 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001601 284.0
TLS2_k127_3001354_7 MOSC domain - - - 0.00000000000000000000000000000000000000000000000005253 199.0
TLS2_k127_3001354_8 Cation antiporter K05569 - - 0.00000000000000000000000000000003376 145.0
TLS2_k127_3001354_9 Na H antiporter MnhB subunit-related protein K05566 - - 0.0000000000000000000000000000001006 130.0
TLS2_k127_3008623_0 peptidase dimerisation domain K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 374.0
TLS2_k127_3008623_1 COGs COG3367 conserved K16149 - 2.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 326.0
TLS2_k127_3008623_2 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000198 215.0
TLS2_k127_3008623_3 ATP-grasp domain - - - 0.000000000000000000000000000000000001412 154.0
TLS2_k127_3008623_4 Belongs to the universal stress protein A family - - - 0.00000000167 69.0
TLS2_k127_3014153_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009783 615.0
TLS2_k127_3014153_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 348.0
TLS2_k127_3014153_2 (E1) component, eukaryotic type, alpha subunit K21416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001083 257.0
TLS2_k127_3027652_0 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004841 501.0
TLS2_k127_3027652_1 Phosphorylase superfamily K00772,K03784 - 2.4.2.1,2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 301.0
TLS2_k127_3027652_10 Domain of unknown function (DUF4349) - - - 0.00000000000000000000001108 112.0
TLS2_k127_3027652_11 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000002824 88.0
TLS2_k127_3027652_12 Thioesterase K07107 - - 0.000000000000002618 85.0
TLS2_k127_3027652_13 Cupin domain - - - 0.0000000000008139 75.0
TLS2_k127_3027652_2 Carbon-nitrogen hydrolase K11206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006277 274.0
TLS2_k127_3027652_3 NIF3 (NGG1p interacting factor 3) - - - 0.00000000000000000000000000000000000000000000000000000000000000002053 231.0
TLS2_k127_3027652_4 vancomycin resistance protein - - - 0.0000000000000000000000000000000000000000000000000000001231 219.0
TLS2_k127_3027652_5 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000000005003 197.0
TLS2_k127_3027652_6 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000371 195.0
TLS2_k127_3027652_7 glycoside hydrolase, family K01207 - 3.2.1.52 0.00000000000000000000000000000002282 138.0
TLS2_k127_3027652_8 CoA binding domain K06929 - - 0.000000000000000000000000000000038 129.0
TLS2_k127_3027652_9 Domain of unknown function (DUF4081) K06976 - - 0.0000000000000000000000000000005981 132.0
TLS2_k127_3035370_0 protein involved in exopolysaccharide biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000397 652.0
TLS2_k127_3035370_1 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004337 466.0
TLS2_k127_3035370_2 myo-inosose-2 dehydratase activity K01805 - 5.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 425.0
TLS2_k127_3035370_3 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007054 368.0
TLS2_k127_3035370_4 ATPases associated with a variety of cellular activities K10545 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004825 347.0
TLS2_k127_3042446_0 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 597.0
TLS2_k127_3042446_1 type II secretion system protein E K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 501.0
TLS2_k127_3042446_10 - - - - 0.0000000000000000000000001134 118.0
TLS2_k127_3042446_11 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000005374 89.0
TLS2_k127_3042446_12 Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.000000000000000006946 86.0
TLS2_k127_3042446_13 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000000000000001521 85.0
TLS2_k127_3042446_14 Helix-turn-helix XRE-family like proteins K15256 - - 0.0000105 52.0
TLS2_k127_3042446_2 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 392.0
TLS2_k127_3042446_3 Arylsulfatase a K01133 - 3.1.6.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 305.0
TLS2_k127_3042446_4 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002828 290.0
TLS2_k127_3042446_5 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000008969 199.0
TLS2_k127_3042446_6 Peptidase A24A, prepilin type IV K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000001269 188.0
TLS2_k127_3042446_7 Protein of unknown function (DUF1360) - - - 0.0000000000000000000000000000000000001126 148.0
TLS2_k127_3042446_8 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000002136 157.0
TLS2_k127_3042446_9 AhpC/TSA family - - - 0.000000000000000000000000000000000002155 157.0
TLS2_k127_3042470_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 351.0
TLS2_k127_3042470_1 serine threonine protein kinase K08884 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000007606 269.0
TLS2_k127_3042470_2 Bacterial extracellular solute-binding protein K02027,K10232 - - 0.0000000000000000000000000000000000000000000000000000000003786 227.0
TLS2_k127_3042470_3 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000007043 162.0
TLS2_k127_304821_0 Cell motility and secretion Intracellular trafficking and secretion - - - 0.0000000000001325 79.0
TLS2_k127_3053627_0 The glycine cleavage system catalyzes the degradation of glycine - - - 3.247e-316 1030.0
TLS2_k127_3053627_1 acyl-CoA dehydrogenase - - - 9.242e-231 722.0
TLS2_k127_3053627_10 - - - - 0.0000000000000000004875 101.0
TLS2_k127_3053627_11 Protein of unknown function (DUF1272) K09984 - - 0.000000000000002689 76.0
TLS2_k127_3053627_12 Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 0.0000000000002032 81.0
TLS2_k127_3053627_13 PAS domain - - - 0.000000000004009 78.0
TLS2_k127_3053627_14 JAB/MPN domain - - - 0.0000001854 64.0
TLS2_k127_3053627_15 Tetratricopeptide repeat - - - 0.000564 51.0
TLS2_k127_3053627_2 domain protein K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 481.0
TLS2_k127_3053627_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006594 439.0
TLS2_k127_3053627_4 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008525 428.0
TLS2_k127_3053627_5 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008283 363.0
TLS2_k127_3053627_6 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006546 287.0
TLS2_k127_3053627_7 Two component transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000001547 175.0
TLS2_k127_3053627_8 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000000001003 170.0
TLS2_k127_3053627_9 FAD dependent oxidoreductase - - - 0.00000000000000000001723 96.0
TLS2_k127_3058656_0 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000002607 233.0
TLS2_k127_3058656_1 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000006442 231.0
TLS2_k127_3058656_2 SMART PAS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000004772 223.0
TLS2_k127_3058656_3 PFAM response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000000000006856 123.0
TLS2_k127_30627_0 dipeptidyl-peptidase K01281 - 3.4.14.11 8.33e-209 678.0
TLS2_k127_30627_1 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs K05825,K18907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 395.0
TLS2_k127_30627_2 - - - - 0.000000000000000000000000000000000000000000000000000004394 199.0
TLS2_k127_3066721_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 354.0
TLS2_k127_3066721_1 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000000000000000000000001018 183.0
TLS2_k127_3066721_2 - - - - 0.000000000002665 80.0
TLS2_k127_3083632_0 ATPases associated with a variety of cellular activities K02056,K06400 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 596.0
TLS2_k127_3083632_1 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 403.0
TLS2_k127_3083632_2 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007224 377.0
TLS2_k127_3083632_3 Belongs to the CinA family K03742,K03743 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 313.0
TLS2_k127_3083632_4 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - 0.00000000000000000000000000000000000000000000000000000000000002993 216.0
TLS2_k127_3083632_5 Basic membrane lipoprotein K07335 - - 0.000000000000000000000000000000000000000000000000000000000001089 215.0
TLS2_k127_3083632_6 Domain of unknown function (DUF4115) - - - 0.00000000000000000000002016 110.0
TLS2_k127_3083632_7 LigT like Phosphoesterase K01975 - 3.1.4.58 0.000000000002706 79.0
TLS2_k127_3139601_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 5.831e-241 768.0
TLS2_k127_3139601_1 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 622.0
TLS2_k127_3139601_2 PFAM regulatory protein LuxR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 433.0
TLS2_k127_3139601_3 Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000002027 172.0
TLS2_k127_3149392_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004626 336.0
TLS2_k127_3149392_1 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000001804 224.0
TLS2_k127_3149392_2 WbqC-like protein family - - - 0.00000000000000000000000000000000000000000004429 181.0
TLS2_k127_3149392_3 Sulfotransferase family - - - 0.0000000000000000000000000000000000000005517 171.0
TLS2_k127_3149392_4 O-Antigen ligase - - - 0.00000009359 65.0
TLS2_k127_3164161_0 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 449.0
TLS2_k127_3164161_1 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001702 244.0
TLS2_k127_3164161_2 helix_turn_helix ASNC type K03718 - - 0.000000000000000000000000000000000000000002842 164.0
TLS2_k127_3164161_3 Polysaccharide biosynthesis C-terminal domain - - - 0.00000000000000000000000000000008406 141.0
TLS2_k127_3170244_0 Carbamoylphosphate synthase large subunit K01955 GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 297.0
TLS2_k127_3170244_1 Catalyzes the conversion of dihydroorotate to orotate K00254,K17828 - 1.3.1.14,1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000003155 235.0
TLS2_k127_3170244_2 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000001054 175.0
TLS2_k127_3170244_3 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain K02823 - - 0.000000000000000000000000000000000000001998 156.0
TLS2_k127_3170244_4 - - - - 0.000000000000000000000000000000000003713 140.0
TLS2_k127_3170244_5 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.6 0.000000001815 68.0
TLS2_k127_3178042_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K16881 - 2.7.7.13,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 626.0
TLS2_k127_3178042_1 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000001891 227.0
TLS2_k127_3178042_2 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000000232 199.0
TLS2_k127_3178042_4 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000341 98.0
TLS2_k127_3178042_5 - - - - 0.00000000000000005834 83.0
TLS2_k127_3207878_0 Belongs to the transketolase family K00615 - 2.2.1.1 4.184e-269 841.0
TLS2_k127_3207878_1 ABC transporter K06158 - - 3.241e-203 653.0
TLS2_k127_3207878_2 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 595.0
TLS2_k127_3207878_3 Transaldolase/Fructose-6-phosphate aldolase K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008459 461.0
TLS2_k127_3207878_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810,K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005161 382.0
TLS2_k127_3207878_5 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 358.0
TLS2_k127_3207878_6 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000000001331 188.0
TLS2_k127_3207878_7 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000004789 196.0
TLS2_k127_3207878_8 Glucose-6-phosphate dehydrogenase subunit - - - 0.00000000000000000000000000001659 135.0
TLS2_k127_3228628_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 566.0
TLS2_k127_3228628_1 Trk-type K transport K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006664 501.0
TLS2_k127_3228628_2 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 319.0
TLS2_k127_3228628_3 TrkA-C domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000012 246.0
TLS2_k127_3228628_4 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000005278 233.0
TLS2_k127_3228628_5 - - - - 0.000000000000000000000000000000000000000000000001027 189.0
TLS2_k127_3228628_6 VanZ like family - - - 0.0000000006062 72.0
TLS2_k127_3230574_0 Pfam Sulfatase K01130 - 3.1.6.1 1.312e-209 666.0
TLS2_k127_3230574_1 Amino acid permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 531.0
TLS2_k127_3230574_2 Anaerobic c4-dicarboxylate membrane transporter K07792 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 388.0
TLS2_k127_3230574_3 Peptidase dimerisation domain K01270 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007473 347.0
TLS2_k127_3230574_4 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000005942 155.0
TLS2_k127_3230574_5 - - - - 0.0000000000000000000000000000000001271 139.0
TLS2_k127_3230574_6 AI-2E family transporter - - - 0.00000005427 66.0
TLS2_k127_3247913_0 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 529.0
TLS2_k127_3247913_1 Thioesterase - - - 0.000000000000000000000000000000000000000000000000002261 190.0
TLS2_k127_3247913_2 Activator of Hsp90 ATPase - - - 0.0000000000000000000000000000000000000000000001638 172.0
TLS2_k127_3247913_3 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000002296 162.0
TLS2_k127_3247913_4 PFAM FAD dependent oxidoreductase - - - 0.00000000000000000000000000000002623 134.0
TLS2_k127_3247913_5 Glycosyltransferase Family 4 K14949 - 2.7.11.1 0.0000000000000000000000000000001104 141.0
TLS2_k127_3259073_0 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009783 576.0
TLS2_k127_3259073_1 Belongs to the sulfur carrier protein TusA family - - - 0.00000000000000000000000000000000000000000000000000000000000000002952 230.0
TLS2_k127_3259073_2 Peptidase M1, membrane alanine aminopeptidase - - - 0.000000000000000000000000000000000000000000008043 177.0
TLS2_k127_3259073_3 PFAM DsrC family protein K11179 - - 0.00000000000000000000000000000000000503 156.0
TLS2_k127_3259073_4 OsmC-like protein K06889,K07397 - - 0.00000007921 57.0
TLS2_k127_3259459_0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 568.0
TLS2_k127_3259459_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 477.0
TLS2_k127_3259459_10 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000002103 204.0
TLS2_k127_3259459_11 Amino acid ABC transporter, permease protein, 3-TM K02029 - - 0.0000000000000000000000000000000000000000000000000892 192.0
TLS2_k127_3259459_12 Belongs to the bacterial solute-binding protein 3 family K02030 - - 0.000000000000000000000000000000000000000000000002774 184.0
TLS2_k127_3259459_13 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000008818 187.0
TLS2_k127_3259459_14 Binds the 23S rRNA K02909 - - 0.0000000000000000000000000003962 117.0
TLS2_k127_3259459_15 Telomere recombination K07566 - 2.7.7.87 0.00000000000000000000000004252 119.0
TLS2_k127_3259459_16 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000008212 110.0
TLS2_k127_3259459_17 ThiS family - - - 0.0001151 53.0
TLS2_k127_3259459_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 366.0
TLS2_k127_3259459_3 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005801 321.0
TLS2_k127_3259459_4 abc transporter atp-binding protein K02028,K10038 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 307.0
TLS2_k127_3259459_5 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000916 289.0
TLS2_k127_3259459_6 Protein of unknown function (DUF1385) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001439 282.0
TLS2_k127_3259459_7 Electron transfer flavoprotein domain K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001557 271.0
TLS2_k127_3259459_8 Electron transfer flavoprotein domain K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000002479 244.0
TLS2_k127_3259459_9 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000002233 224.0
TLS2_k127_3264176_0 xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 4.644e-301 942.0
TLS2_k127_3264176_1 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K03520 - 1.2.5.3 2.253e-294 910.0
TLS2_k127_3264176_10 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000002322 231.0
TLS2_k127_3264176_11 COGs COG2080 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS CutS homologs K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000049 238.0
TLS2_k127_3264176_12 helix_turn_helix ASNC type - - - 0.0000000000000000000000000000000000000000000000000000005875 198.0
TLS2_k127_3264176_13 YHS domain K07402 - - 0.000000000000000000000000000000000000000000000000008569 206.0
TLS2_k127_3264176_14 carbon monoxide dehydrogenase subunit G K09386 - - 0.000000000000000000000000000000000000761 158.0
TLS2_k127_3264176_15 MobA-Related Protein K07141 - 2.7.7.76 0.000000000000000000000000001994 120.0
TLS2_k127_3264176_16 CAAX protease self-immunity - - - 0.00000000000000000000004674 109.0
TLS2_k127_3264176_2 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 584.0
TLS2_k127_3264176_3 Homocysteine S-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 600.0
TLS2_k127_3264176_4 Cobalamin-independent synthase, Catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 470.0
TLS2_k127_3264176_5 XdhC Rossmann domain K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 336.0
TLS2_k127_3264176_6 PFAM molybdopterin dehydrogenase, FAD-binding K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008444 347.0
TLS2_k127_3264176_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006396 309.0
TLS2_k127_3264176_8 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001967 275.0
TLS2_k127_3264176_9 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000002728 273.0
TLS2_k127_3294951_0 Amidohydrolase family K01464 - 3.5.2.2 6.582e-225 722.0
TLS2_k127_3294951_1 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000449 602.0
TLS2_k127_3294951_10 DNA import into cell involved in transformation K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002451 268.0
TLS2_k127_3294951_11 COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D K01424 - 3.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000108 269.0
TLS2_k127_3294951_12 PFAM binding-protein-dependent transport systems inner membrane component K02054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003629 261.0
TLS2_k127_3294951_13 MaoC like domain K18290 - 4.2.1.56 0.00000000000000000000000000000000000000000000000000000000000000000001016 238.0
TLS2_k127_3294951_14 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000000000000001526 213.0
TLS2_k127_3294951_15 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000005515 201.0
TLS2_k127_3294951_17 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00005282 56.0
TLS2_k127_3294951_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 578.0
TLS2_k127_3294951_3 Polysaccharide deacetylase K22278 - 3.5.1.104 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 541.0
TLS2_k127_3294951_4 Cobalamin synthesis protein cobW C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007396 375.0
TLS2_k127_3294951_5 protein involved in propionate catabolism - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 374.0
TLS2_k127_3294951_6 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007043 326.0
TLS2_k127_3294951_7 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052,K11072 - 3.6.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 328.0
TLS2_k127_3294951_8 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K13995 - 3.5.1.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 332.0
TLS2_k127_3294951_9 Required for the activity of the bacterial periplasmic transport system of putrescine K02055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009725 284.0
TLS2_k127_3331809_0 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004891 373.0
TLS2_k127_3331809_1 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006548 316.0
TLS2_k127_3331809_2 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000003568 104.0
TLS2_k127_3331809_3 Transcriptional regulator - - - 0.0000000000000005043 92.0
TLS2_k127_3365449_0 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004841 543.0
TLS2_k127_3365449_1 Glycosyl transferase family 2 K00786 - - 0.000000000000000000000000000000000006616 148.0
TLS2_k127_3368828_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 1.713e-260 829.0
TLS2_k127_3368828_1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 607.0
TLS2_k127_3368828_10 Phosphoenolpyruvate phosphomutase - - - 0.000000000006925 66.0
TLS2_k127_3368828_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006753 559.0
TLS2_k127_3368828_3 Alpha-glucan phosphorylase K00688 - 2.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 533.0
TLS2_k127_3368828_4 AAA domain, putative AbiEii toxin, Type IV TA system K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 460.0
TLS2_k127_3368828_5 ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 382.0
TLS2_k127_3368828_6 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K18357 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000007965 256.0
TLS2_k127_3368828_7 Belongs to the ompA family K20276 - - 0.000000000000000000000000000000000000000000000000000001319 218.0
TLS2_k127_3368828_8 Methyltransferase domain - - - 0.000000000000000000000000000000000000008566 156.0
TLS2_k127_3368828_9 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000161 111.0
TLS2_k127_3391247_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 4.774e-195 619.0
TLS2_k127_3391247_1 Phosphorylase superfamily K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005508 346.0
TLS2_k127_3391247_2 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 349.0
TLS2_k127_3391247_3 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001229 263.0
TLS2_k127_3391247_4 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000003877 222.0
TLS2_k127_3391247_5 WD domain, G-beta repeat K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000007512 211.0
TLS2_k127_3391247_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000001004 136.0
TLS2_k127_3391247_7 Alpha beta hydrolase - - - 0.00000000000000000001933 101.0
TLS2_k127_3391247_8 - - - - 0.000000000001157 74.0
TLS2_k127_3402199_0 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 463.0
TLS2_k127_3402199_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000001448 184.0
TLS2_k127_3530742_0 hydrolase, family 65, central catalytic K10231 - 2.4.1.230 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008855 582.0
TLS2_k127_3530742_1 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000000000000000001307 223.0
TLS2_k127_3530742_2 - - - - 0.000000000000000000000000000000000000000000000005241 179.0
TLS2_k127_3530742_3 - - - - 0.0000000000000000000000000000000000000000584 160.0
TLS2_k127_3530742_4 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000007987 161.0
TLS2_k127_3530742_5 AMP binding - - - 0.00000000000000806 88.0
TLS2_k127_3688357_0 NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007878 312.0
TLS2_k127_3688357_1 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000003373 205.0
TLS2_k127_3688357_2 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.00000000000000000000000000005081 131.0
TLS2_k127_3688357_3 PSP1 C-terminal conserved region - - - 0.0000000000000000000000001031 123.0
TLS2_k127_3746968_0 PFAM Band 7 protein - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003761 432.0
TLS2_k127_3746968_1 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000007908 226.0
TLS2_k127_3746968_2 pfkB family carbohydrate kinase K00852 - 2.7.1.15 0.0000000000000000000000000000000000000000000000000000001405 207.0
TLS2_k127_3746968_3 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000000003209 184.0
TLS2_k127_3746968_4 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000000000005572 141.0
TLS2_k127_3746968_5 NfeD-like C-terminal, partner-binding - - - 0.00000000000000000000000000000005158 141.0
TLS2_k127_3746968_6 Sigma-70 region 2 - - - 0.00000000004706 71.0
TLS2_k127_3768213_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 472.0
TLS2_k127_3768213_1 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01667 - 4.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000737 374.0
TLS2_k127_3768213_10 cell division protein FtsQ K03589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - 0.0000000615 64.0
TLS2_k127_3768213_2 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 358.0
TLS2_k127_3768213_3 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007725 329.0
TLS2_k127_3768213_4 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003923 291.0
TLS2_k127_3768213_5 Mur ligase family, catalytic domain K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000002551 273.0
TLS2_k127_3768213_6 Protein of unknown function, DUF480 - - - 0.000000000000000000000000000000000000000000000000000000000000000000396 237.0
TLS2_k127_3768213_7 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000003879 203.0
TLS2_k127_3768213_8 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000001743 205.0
TLS2_k127_3768213_9 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000003471 82.0
TLS2_k127_3768746_0 Zn_pept - - - 0.0 1170.0
TLS2_k127_3768746_1 DHH family K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000716 506.0
TLS2_k127_3768746_10 Glycosylase K01246 - 3.2.2.20 0.00000000000000000006358 90.0
TLS2_k127_3768746_11 cellulose binding - - - 0.00000000000004521 86.0
TLS2_k127_3768746_12 cellulose binding - - - 0.0000000000003779 80.0
TLS2_k127_3768746_2 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 424.0
TLS2_k127_3768746_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007892 421.0
TLS2_k127_3768746_4 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000494 285.0
TLS2_k127_3768746_5 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000009257 224.0
TLS2_k127_3768746_6 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.0000000000000000000000000000000000000000000000000004191 190.0
TLS2_k127_3768746_7 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000001163 160.0
TLS2_k127_3768746_8 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000013 149.0
TLS2_k127_3768746_9 - - - - 0.000000000000000000000000000000009822 135.0
TLS2_k127_37719_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 3.736e-203 651.0
TLS2_k127_37719_1 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006447 529.0
TLS2_k127_37719_10 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.0000000000000000002698 89.0
TLS2_k127_37719_11 Protein conserved in bacteria K09764 - - 0.0000000000000000142 85.0
TLS2_k127_37719_12 Nucleic-acid-binding protein implicated in transcription termination K02600,K07742 - - 0.000000003145 70.0
TLS2_k127_37719_13 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0000006513 60.0
TLS2_k127_37719_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 526.0
TLS2_k127_37719_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 343.0
TLS2_k127_37719_4 DHH family K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008264 301.0
TLS2_k127_37719_5 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000533 228.0
TLS2_k127_37719_6 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000002067 184.0
TLS2_k127_37719_7 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000004325 130.0
TLS2_k127_37719_8 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000000003144 126.0
TLS2_k127_37719_9 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000002333 116.0
TLS2_k127_3778932_0 peptidase U62, modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004568 403.0
TLS2_k127_3778932_1 LVIVD repeat - - - 0.0000000000000001347 93.0
TLS2_k127_3778932_2 LVIVD repeat - - - 0.0000004177 63.0
TLS2_k127_3784895_0 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005863 320.0
TLS2_k127_3784895_1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001524 273.0
TLS2_k127_3784895_2 Domain of unknown function (DUF2520) - - - 0.000000000000000000000000000000000002144 144.0
TLS2_k127_3784895_3 Peptidase S24-like K13280 - 3.4.21.89 0.0000000000000000000000000000000001461 147.0
TLS2_k127_3784895_4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000002573 136.0
TLS2_k127_3784895_5 - - - - 0.0000000000000000000000982 109.0
TLS2_k127_3784895_6 belongs to the glycosyl hydrolase 13 family - - - 0.00000000009258 70.0
TLS2_k127_3790622_0 Carbamoyl-phosphate synthetase large chain domain protein K11263 - 6.3.4.14,6.4.1.2,6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 582.0
TLS2_k127_3790622_1 Sucrase/ferredoxin-like - - - 0.000000000000000000000000000000000000000000006598 175.0
TLS2_k127_3790622_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.5 0.000000000000000000000004343 111.0
TLS2_k127_3790622_3 A domain family that is part of the cupin metalloenzyme superfamily. - - - 0.0000000000004266 70.0
TLS2_k127_3790622_4 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00005524 55.0
TLS2_k127_3790622_5 NlpC/P60 family - - - 0.0001868 54.0
TLS2_k127_3790622_6 - - - - 0.0004335 47.0
TLS2_k127_3805717_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006588 503.0
TLS2_k127_3805717_1 Type I GTP cyclohydrolase folE2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005062 326.0
TLS2_k127_3805717_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000001191 132.0
TLS2_k127_3805717_12 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02484 - 2.7.13.3 0.000000008393 67.0
TLS2_k127_3805717_13 - - - - 0.0000001494 61.0
TLS2_k127_3805717_14 Anti-sigma-K factor rskA - - - 0.0004374 52.0
TLS2_k127_3805717_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000009494 256.0
TLS2_k127_3805717_3 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000008314 239.0
TLS2_k127_3805717_4 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000001542 222.0
TLS2_k127_3805717_5 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 GO:0000166,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0036094,GO:0040007,GO:0042083,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050797,GO:0070402,GO:0097159,GO:1901265,GO:1901363 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000001554 209.0
TLS2_k127_3805717_6 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000002287 200.0
TLS2_k127_3805717_7 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000001371 179.0
TLS2_k127_3805717_8 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000005644 155.0
TLS2_k127_3805717_9 PFAM short-chain dehydrogenase reductase SDR K03793 - 1.5.1.33 0.0000000000000000000000000000000000003934 150.0
TLS2_k127_3810067_0 Cell shape determining protein MreB Mrl K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008865 573.0
TLS2_k127_3810067_1 Ribonuclease E/G family K08301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003825 566.0
TLS2_k127_3810067_2 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005582 365.0
TLS2_k127_3810067_3 Belongs to the SEDS family K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 301.0
TLS2_k127_3810067_4 PFAM Transposase IS200 like - - - 0.000000000000000000000000000000000000000000000001626 182.0
TLS2_k127_3810067_5 rod shape-determining protein MreC K03570 - - 0.0000000000000000000000000000000000003542 152.0
TLS2_k127_3810067_6 rod shape-determining protein MreD K03571 - - 0.0000000003545 72.0
TLS2_k127_3810067_7 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000002554 60.0
TLS2_k127_3811135_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005725 388.0
TLS2_k127_3811135_1 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 362.0
TLS2_k127_3811135_2 ATPase (P-type) K01537,K12952 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000257 261.0
TLS2_k127_3811135_3 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000005245 208.0
TLS2_k127_3811135_4 Pfam:Pyridox_oxidase - - - 0.000000000000000000000000000000000000000000000000005523 190.0
TLS2_k127_3811135_5 COG2346, Truncated hemoglobins K03406,K06886 GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016491,GO:0016705,GO:0016708,GO:0017144,GO:0019825,GO:0020012,GO:0020037,GO:0030682,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043207,GO:0044237,GO:0044248,GO:0044270,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0048037,GO:0050896,GO:0051213,GO:0051410,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0072593,GO:0075136,GO:0097159,GO:0098754,GO:1901363,GO:1901698,GO:2001057 - 0.00000000000000000000000000000003085 129.0
TLS2_k127_3811190_0 Binding-protein-dependent transport systems inner membrane component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 478.0
TLS2_k127_3811190_1 iron ion homeostasis K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000885 351.0
TLS2_k127_3811190_10 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000001478 111.0
TLS2_k127_3811190_11 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000008317 85.0
TLS2_k127_3811190_12 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000002276 65.0
TLS2_k127_3811190_2 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006465 344.0
TLS2_k127_3811190_3 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 320.0
TLS2_k127_3811190_4 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000000000000000283 241.0
TLS2_k127_3811190_5 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000000000000000000000005363 201.0
TLS2_k127_3811190_6 Putative esterase K07214 - - 0.00000000000000000000000000000000000000000000000000001466 200.0
TLS2_k127_3811190_7 Participates in initiation and elongation during chromosome replication K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.0000000000000000000000000000000000000003882 154.0
TLS2_k127_3811190_8 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000002827 160.0
TLS2_k127_3811190_9 Binds to the 23S rRNA K02939 - - 0.00000000000000000000000000000000002321 146.0
TLS2_k127_3812041_0 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 550.0
TLS2_k127_3812041_1 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009841 484.0
TLS2_k127_3812041_2 MMPL family K06994 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 480.0
TLS2_k127_3812041_3 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006051 332.0
TLS2_k127_3812041_4 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000006261 262.0
TLS2_k127_3812041_5 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001152 251.0
TLS2_k127_3812041_6 FeoA K03709 - - 0.00000000000000000000000000000000000000000000000000000006266 218.0
TLS2_k127_3812041_7 Belongs to the GcvT family K06980 - - 0.00000000000000000000000000002674 131.0
TLS2_k127_3812041_8 Rieske [2Fe-2S] domain K00363 - 1.7.1.15 0.00000000000000001365 90.0
TLS2_k127_3812041_9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000002608 76.0
TLS2_k127_3817979_0 Fumarate hydratase class II K01679 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 547.0
TLS2_k127_3817979_1 aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 438.0
TLS2_k127_3817979_2 Pyridine nucleotide-disulphide oxidoreductase K21567 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003211 287.0
TLS2_k127_3817979_3 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000004079 235.0
TLS2_k127_3817979_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000005219 231.0
TLS2_k127_3817979_5 TIGRFAM iron-sulfur cluster assembly accessory protein - - - 0.000000000000000000000000000004291 126.0
TLS2_k127_3817979_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000007181 127.0
TLS2_k127_3817979_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.0000000000000000000005841 100.0
TLS2_k127_3817979_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000001266 98.0
TLS2_k127_3817979_9 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.0000000002758 63.0
TLS2_k127_3823270_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 497.0
TLS2_k127_3823270_1 magnesium chelatase, ChlI subunit K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006489 445.0
TLS2_k127_3823270_10 PFAM Peptidase S24 S26A S26B, conserved region K03100 - 3.4.21.89 0.00000000000000000000000000000000000000001241 169.0
TLS2_k127_3823270_11 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000002226 135.0
TLS2_k127_3823270_12 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000000000000566 114.0
TLS2_k127_3823270_13 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000603 87.0
TLS2_k127_3823270_14 Belongs to the UPF0102 family K07460 - - 0.000000000001068 80.0
TLS2_k127_3823270_15 Belongs to the UPF0109 family K06960 - - 0.000000000003517 80.0
TLS2_k127_3823270_16 Dodecin K09165 - - 0.0000000008459 68.0
TLS2_k127_3823270_17 drug resistance transporter, EmrB QacA subfamily - - - 0.000146 48.0
TLS2_k127_3823270_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 315.0
TLS2_k127_3823270_3 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 300.0
TLS2_k127_3823270_4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000004237 223.0
TLS2_k127_3823270_5 TIGRFAM DNA protecting protein DprA K04096 - - 0.000000000000000000000000000000000000000000000000000000006323 224.0
TLS2_k127_3823270_6 RecF/RecN/SMC N terminal domain K03529 - - 0.000000000000000000000000000000000000000000000000000001234 196.0
TLS2_k127_3823270_7 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000009598 204.0
TLS2_k127_3823270_8 ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000601 201.0
TLS2_k127_3823270_9 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000000000002178 169.0
TLS2_k127_3823973_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005521 568.0
TLS2_k127_3823973_1 Psort location Cytoplasmic, score 7.50 K01250 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007769 314.0
TLS2_k127_3823973_2 Ftsk_gamma K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001245 300.0
TLS2_k127_3823973_3 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0046835,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000002166 251.0
TLS2_k127_3823973_4 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000005179 173.0
TLS2_k127_3836843_0 homoserine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 589.0
TLS2_k127_3836843_1 TIGRFAM glucose-1-phosphate cytidylyltransferase K00978 - 2.7.7.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 387.0
TLS2_k127_3836843_2 GDP-mannose 4,6 dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 372.0
TLS2_k127_3836843_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009854 340.0
TLS2_k127_3836843_4 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000005065 249.0
TLS2_k127_3836843_5 Glycosyl transferase, family 2 K07011 - - 0.0000000000000000000000000000000000002409 161.0
TLS2_k127_3836843_6 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000007075 151.0
TLS2_k127_3836843_7 PFAM PHP domain protein K01104 - 3.1.3.48 0.00000000000000000000000005912 124.0
TLS2_k127_3836843_8 Chain length determinant protein - - - 0.0000000000000000000000005532 120.0
TLS2_k127_3836843_9 O-Antigen ligase - - - 0.00000000000001426 87.0
TLS2_k127_3838186_0 Manganese containing catalase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003723 476.0
TLS2_k127_3838186_1 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 424.0
TLS2_k127_3838186_2 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 292.0
TLS2_k127_3838186_3 - - - - 0.0000000000000000000000000000000000000000000000000000000004528 208.0
TLS2_k127_3838186_4 - - - - 0.000000000000000000000000000000000000000000002144 176.0
TLS2_k127_3838186_5 PA domain - - - 0.000000000000000000000000000001625 121.0
TLS2_k127_3838186_6 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000009841 106.0
TLS2_k127_3842284_0 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007253 435.0
TLS2_k127_3842284_1 Glycosyl hydrolases family 16 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 302.0
TLS2_k127_3842284_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004902 265.0
TLS2_k127_3842284_3 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000009226 233.0
TLS2_k127_3842284_4 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000007948 203.0
TLS2_k127_3842284_5 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000004454 205.0
TLS2_k127_3842284_6 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000003155 173.0
TLS2_k127_3842284_7 Alpha/beta hydrolase family - - - 0.0000000000000000000000000001513 135.0
TLS2_k127_3842284_8 Peptidase propeptide and YPEB domain - - - 0.000000000000000000000006676 104.0
TLS2_k127_3842284_9 cellulose binding - - - 0.0000000000000000000001354 103.0
TLS2_k127_3869513_0 Malate synthase K01638 - 2.3.3.9 9.427e-213 679.0
TLS2_k127_3869513_1 Isocitrate lyase K01637 - 4.1.3.1 3.326e-208 654.0
TLS2_k127_3869513_10 CarD-like/TRCF domain K07736 - - 0.0000000000000000000000000000000000000000000000000000000000000002573 224.0
TLS2_k127_3869513_11 Protein of unknown function (DUF1295) - - - 0.0000000000000000000000000000000000000000000000000000000000004895 235.0
TLS2_k127_3869513_12 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000006123 209.0
TLS2_k127_3869513_13 Protein of unknown function (DUF1365) K09701 - - 0.0000000000000000000000000000000000000000000000009258 188.0
TLS2_k127_3869513_14 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000125 178.0
TLS2_k127_3869513_15 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576 2.7.7.60 0.00000000000000000000000000000000000001152 159.0
TLS2_k127_3869513_16 PFAM pyridoxamine 5'-phosphate oxidase-related - - - 0.0000000000000000000000000000000000002672 147.0
TLS2_k127_3869513_17 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000005366 116.0
TLS2_k127_3869513_18 Glycosyltransferase like family 2 - - - 0.0000000000000000004196 94.0
TLS2_k127_3869513_19 Alpha/beta hydrolase family - - - 0.00000000000003071 81.0
TLS2_k127_3869513_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009624 482.0
TLS2_k127_3869513_20 growth of symbiont in host cell K07003 - - 0.0001406 54.0
TLS2_k127_3869513_3 DNA integrity scanning protein DisA K07067 - 2.7.7.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 373.0
TLS2_k127_3869513_4 amine oxidase K06954 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 372.0
TLS2_k127_3869513_5 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005827 366.0
TLS2_k127_3869513_6 synthase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006088 325.0
TLS2_k127_3869513_7 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 298.0
TLS2_k127_3869513_8 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001254 291.0
TLS2_k127_3869513_9 endonuclease III K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006772 253.0
TLS2_k127_3882588_0 Phosphohydrolase-associated domain K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 381.0
TLS2_k127_3882588_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 333.0
TLS2_k127_3882588_2 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000001364 228.0
TLS2_k127_3882588_3 Cysteine-rich secretory protein family - - - 0.0000000000000174 84.0
TLS2_k127_3882588_4 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.0000000000858 63.0
TLS2_k127_3885251_0 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 552.0
TLS2_k127_3885251_1 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 453.0
TLS2_k127_3885251_2 PFAM Amidohydrolase 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 366.0
TLS2_k127_3885251_3 DEAD/H associated K03724 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005191 336.0
TLS2_k127_3885251_4 PFAM peptidase M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 334.0
TLS2_k127_3885251_5 MMPL family K06994 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 297.0
TLS2_k127_3885251_6 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000004617 130.0
TLS2_k127_3885251_7 conserved protein, contains double-stranded beta-helix domain - - - 0.0000000000000000000000000000001227 130.0
TLS2_k127_3885251_8 Periplasmic component of the Tol biopolymer transport system - - - 0.000129 53.0
TLS2_k127_3894177_0 Belongs to the dCTP deaminase family K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000034 258.0
TLS2_k127_3894177_1 3-beta hydroxysteroid dehydrogenase K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000006074 171.0
TLS2_k127_3894177_2 O-methyltransferase - - - 0.00000000000000000000000000000002482 138.0
TLS2_k127_3894177_3 Rieske 2Fe-2S iron-sulphur domain K05710 - - 0.0000000000000000000000000000004612 124.0
TLS2_k127_3894177_4 SUF system FeS assembly protein, NifU family K04488 - - 0.000000000000000000002104 96.0
TLS2_k127_3930621_0 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 419.0
TLS2_k127_3930621_1 DNA methylase K00590 - 2.1.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 338.0
TLS2_k127_3930621_10 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.000000000000000000000003229 111.0
TLS2_k127_3930621_11 - - - - 0.000000000155 67.0
TLS2_k127_3930621_13 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000004017 66.0
TLS2_k127_3930621_14 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.00004733 56.0
TLS2_k127_3930621_15 - - - - 0.000134 47.0
TLS2_k127_3930621_2 proline dehydrogenase activity K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000533 302.0
TLS2_k127_3930621_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002356 282.0
TLS2_k127_3930621_4 KR domain K10780 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000000147 256.0
TLS2_k127_3930621_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000001423 230.0
TLS2_k127_3930621_6 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000001586 193.0
TLS2_k127_3930621_7 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.0000000000000000000000000000000000000000001431 173.0
TLS2_k127_3930621_8 EamA-like transporter family - - - 0.0000000000000000000000000000000007035 143.0
TLS2_k127_3930621_9 HAD-superfamily hydrolase, subfamily IB, PSPase-like K08966 - 3.1.3.87 0.00000000000000000000000002241 116.0
TLS2_k127_3941808_0 aconitate hydratase K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 6.422e-291 913.0
TLS2_k127_3941808_1 chromate transporter K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 525.0
TLS2_k127_3941808_2 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009875 323.0
TLS2_k127_3941808_3 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001409 246.0
TLS2_k127_3941808_4 Pfam 2OG-Fe(II) oxygenase - - - 0.000000000000000000000000000000000000000000000001156 198.0
TLS2_k127_3941808_5 glutamate-cysteine ligase activity K06048 GO:0003674,GO:0003824,GO:0016874,GO:0016879 - 0.000000000000103 84.0
TLS2_k127_3997301_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 5.544e-206 662.0
TLS2_k127_3997301_1 I and II form the functional core of the enzyme complex. electrons originating in cytochrome C are transferred via HemE a and cu(a) to the binuclear center formed by HemE A3 and cu(B) K02275 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000003772 267.0
TLS2_k127_3997301_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000181 248.0
TLS2_k127_3997301_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 GO:0008150,GO:0040007 - 0.00000000000000000000000000000000000000000000000000000000000000007358 228.0
TLS2_k127_3997301_4 amino acid transport - - - 0.0000000000000000000000000000000000000000002183 162.0
TLS2_k127_4009001_0 Multicopper oxidase K00368 - 1.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 327.0
TLS2_k127_4009001_1 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001594 261.0
TLS2_k127_4033626_0 Belongs to the aldehyde dehydrogenase family - - - 3.893e-219 691.0
TLS2_k127_4033626_1 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 474.0
TLS2_k127_4033626_2 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000012 137.0
TLS2_k127_4033626_3 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000006341 83.0
TLS2_k127_404980_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 382.0
TLS2_k127_404980_1 helix_turn_helix, Lux Regulon K03556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 388.0
TLS2_k127_404980_2 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006704 269.0
TLS2_k127_404980_3 Pfam Response regulator receiver K07689 - - 0.00000000000000000000000000000000041 141.0
TLS2_k127_404980_4 Phospholipase_D-nuclease N-terminal - - - 0.00000000000000000000000000001305 123.0
TLS2_k127_404980_5 - - - - 0.0000000000000000000001982 105.0
TLS2_k127_4054617_0 saccharopine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 425.0
TLS2_k127_4054617_1 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000005852 228.0
TLS2_k127_4054617_2 - - - - 0.000000000000000000000000000000000000000000000000000000000001279 224.0
TLS2_k127_4054617_3 - - - - 0.00000003474 55.0
TLS2_k127_4054617_4 Dehydrogenase E1 component K11381 - 1.2.4.4 0.0009897 48.0
TLS2_k127_4063605_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008757 556.0
TLS2_k127_4063605_1 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000514 279.0
TLS2_k127_4063605_2 - - - - 0.000000000000001153 92.0
TLS2_k127_4068489_0 TIGRFAM Amidase, hydantoinase carbamoylase K02083,K06016 - 3.5.1.6,3.5.1.87,3.5.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 603.0
TLS2_k127_4068489_1 Ectoine utilization protein EutC K01750,K19244 - 1.4.1.1,4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007136 529.0
TLS2_k127_4068489_10 Isochorismatase family K13995 - 3.5.1.107 0.000000000000000000000000000000000000000000000003516 183.0
TLS2_k127_4068489_11 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000008534 186.0
TLS2_k127_4068489_12 Thioredoxin - - - 0.0000000000000000000001988 104.0
TLS2_k127_4068489_13 Putative regulatory protein - - - 0.00000005735 55.0
TLS2_k127_4068489_14 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0005907 48.0
TLS2_k127_4068489_2 L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005426 535.0
TLS2_k127_4068489_3 FAD linked oxidases, C-terminal domain K11472 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 445.0
TLS2_k127_4068489_4 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000766 371.0
TLS2_k127_4068489_5 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 350.0
TLS2_k127_4068489_6 Acetamidase/Formamidase family K01455 - 3.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 325.0
TLS2_k127_4068489_7 Carbon-nitrogen hydrolase K01501 - 3.5.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000004513 253.0
TLS2_k127_4068489_8 COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000002831 230.0
TLS2_k127_4068489_9 Thioesterase K07107 - - 0.000000000000000000000000000000000000000000000000000000001592 204.0
TLS2_k127_4072237_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 5.393e-219 690.0
TLS2_k127_4072237_1 protein methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 446.0
TLS2_k127_4072237_10 Protein conserved in bacteria K09914 - - 0.0000000003574 72.0
TLS2_k127_4072237_11 - - - - 0.0000001764 57.0
TLS2_k127_4072237_12 - - - - 0.0007687 49.0
TLS2_k127_4072237_2 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 307.0
TLS2_k127_4072237_3 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005337 304.0
TLS2_k127_4072237_4 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006751 252.0
TLS2_k127_4072237_5 Protein of unknown function (DUF354) K09726 - - 0.0000000000000000000000000000000000000000000000000000000000111 228.0
TLS2_k127_4072237_6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109,K02113 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000005913 108.0
TLS2_k127_4072237_7 ATP synthase B/B' CF(0) K02109 - - 0.000000000000000000009419 98.0
TLS2_k127_4072237_8 ATP synthase subunit C K02110 - - 0.0000000000000000008824 99.0
TLS2_k127_4072237_9 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000004254 67.0
TLS2_k127_4078048_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 435.0
TLS2_k127_4078048_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 385.0
TLS2_k127_4078048_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000372 268.0
TLS2_k127_4078048_3 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001647 264.0
TLS2_k127_4078048_4 Phosphoesterase K07098 - - 0.00000000000000000000000000000000003024 147.0
TLS2_k127_4078048_5 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000009793 112.0
TLS2_k127_4078048_6 acetyltransferase - - - 0.00000000005698 71.0
TLS2_k127_4078048_7 - - - - 0.00000000007037 64.0
TLS2_k127_4078048_8 Heterodisulfide reductase, subunit B K00241 - - 0.000000009679 57.0
TLS2_k127_4088750_0 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.0000000000000000000000000000000000000000000000000003371 199.0
TLS2_k127_4088750_1 pyridoxamine 5-phosphate - - - 0.000000000000000000000000000003564 127.0
TLS2_k127_4088750_2 CoA-transferase family III - - - 0.00000000000000000000341 94.0
TLS2_k127_4088750_3 Sodium/hydrogen exchanger family - - - 0.0002229 48.0
TLS2_k127_416129_0 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002733 606.0
TLS2_k127_416129_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 520.0
TLS2_k127_416129_10 response to antibiotic K02066,K04749,K07122 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716 - 0.0000000000000000000002297 99.0
TLS2_k127_416129_11 ThiS family - - - 0.000000000000000000001116 109.0
TLS2_k127_416129_12 - - - - 0.0001651 54.0
TLS2_k127_416129_2 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 486.0
TLS2_k127_416129_3 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 433.0
TLS2_k127_416129_4 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 374.0
TLS2_k127_416129_5 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 320.0
TLS2_k127_416129_6 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006393 252.0
TLS2_k127_416129_7 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000512 259.0
TLS2_k127_416129_8 Uncharacterized conserved protein (DUF2277) - - - 0.0000000000000000000000000000004808 132.0
TLS2_k127_416129_9 Protein of unknown function (DUF3303) - - - 0.000000000000000000000000234 106.0
TLS2_k127_4176332_0 Beta-eliminating lyase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 338.0
TLS2_k127_4176332_1 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 315.0
TLS2_k127_4176332_2 Putative peptidoglycan binding domain - - - 0.0000000000000000000000000000000000002604 153.0
TLS2_k127_4184388_0 Fungalysin metallopeptidase (M36) - - - 0.0 1042.0
TLS2_k127_4184388_1 Fungalysin metallopeptidase (M36) - - - 4.733e-301 953.0
TLS2_k127_4184388_2 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006615 614.0
TLS2_k127_4184388_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000008732 158.0
TLS2_k127_4184388_4 Fungalysin metallopeptidase (M36) - - - 0.00000000003036 71.0
TLS2_k127_4275462_0 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008607 398.0
TLS2_k127_4275462_1 ABC-2 family transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 342.0
TLS2_k127_4275462_2 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 348.0
TLS2_k127_4275462_3 Copper resistance protein D K14166 - - 0.0000000000000000000000000000000000000000000000000000000006786 222.0
TLS2_k127_4275462_4 Domain of unkown function (DUF1775) - - - 0.000000000000000000000000000000009942 136.0
TLS2_k127_4275462_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000001621 84.0
TLS2_k127_4275462_6 LVIVD repeat - - - 0.0000000001589 75.0
TLS2_k127_4275462_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000001334 58.0
TLS2_k127_4303391_0 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008843 428.0
TLS2_k127_4303391_1 MiaB-like tRNA modifying enzyme K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000001985 252.0
TLS2_k127_4303391_2 Prokaryotic diacylglycerol kinase K00887,K00901 - 2.7.1.107,2.7.1.66 0.0000000000000000000000000000000000000000000000000005321 201.0
TLS2_k127_4303391_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000003412 171.0
TLS2_k127_4303391_4 Ribosomal protein L11 methyltransferase (PrmA) K02687 - - 0.0000000000000000000000000000001798 130.0
TLS2_k127_4303391_5 Histidine triad (Hit) protein K02503 - - 0.00000000000000000000000001052 112.0
TLS2_k127_4303391_6 Yqey-like protein K09117 - - 0.00000000000000000000000006209 115.0
TLS2_k127_4303391_7 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.0000000000000000000000001659 121.0
TLS2_k127_4303391_8 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000005988 87.0
TLS2_k127_4328220_0 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002903 608.0
TLS2_k127_4328220_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004851 599.0
TLS2_k127_4328220_2 Zinc-binding dehydrogenase K00121 - 1.1.1.1,1.1.1.284 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 404.0
TLS2_k127_4328220_3 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009328 328.0
TLS2_k127_4328220_4 glutamine synthetase K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000004134 261.0
TLS2_k127_4328220_5 molybdopterin oxidoreductase Fe4S4 region K05299 - 1.17.1.10 0.0000000000000000000000000000000000000000000000000000000000000007135 224.0
TLS2_k127_4685051_0 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 397.0
TLS2_k127_4685051_1 Elongation factor SelB, winged helix K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005732 344.0
TLS2_k127_4685051_2 PFAM bifunctional deaminase-reductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000136 267.0
TLS2_k127_4685051_3 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007617 266.0
TLS2_k127_4685051_4 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000007152 248.0
TLS2_k127_4685051_5 MoaE protein K21142 - 2.8.1.12 0.000000000000000000000000000000000000000000000002059 179.0
TLS2_k127_4685051_6 - - - - 0.000000002103 70.0
TLS2_k127_4706483_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.036e-247 777.0
TLS2_k127_4706483_1 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 464.0
TLS2_k127_4706483_2 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000001515 118.0
TLS2_k127_4708242_0 Cation transport protein K03498 - - 2.289e-200 637.0
TLS2_k127_4708242_1 Seryl-tRNA synthetase N-terminal domain K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 490.0
TLS2_k127_4708242_10 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.000000000000000000000000000000000000000000000000000000004026 211.0
TLS2_k127_4708242_11 HAD-superfamily hydrolase, subfamily IIB - - - 0.000000000000000000000000000000000000000000000000000001034 207.0
TLS2_k127_4708242_12 Phospholipase/Carboxylesterase K06999 - - 0.000000000000000000000000000000000000000000000000006623 201.0
TLS2_k127_4708242_13 Belongs to the peptidase S8 family K17734 - - 0.000000000000000000000000000000000000000000000000008832 203.0
TLS2_k127_4708242_14 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000000000000000002426 180.0
TLS2_k127_4708242_15 - - - - 0.0000000000000000000000000000000000000000000002762 173.0
TLS2_k127_4708242_16 Belongs to the ompA family K20276 - - 0.000000000000000000000000000000000000000000009196 183.0
TLS2_k127_4708242_17 Protein of unknown function (DUF429) - - - 0.000000000000000000000000000000002069 138.0
TLS2_k127_4708242_18 Domain of unknown function (DUF4260) - - - 0.00000000000000000000000000000193 132.0
TLS2_k127_4708242_19 - - - - 0.000000000004264 76.0
TLS2_k127_4708242_2 amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 454.0
TLS2_k127_4708242_20 Cytochrome C oxidase, cbb3-type, subunit III K05301 - 1.8.2.1 0.00000000001208 78.0
TLS2_k127_4708242_21 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.00003858 57.0
TLS2_k127_4708242_22 COG0475 Kef-type K transport systems, membrane components K03455 - - 0.00004913 47.0
TLS2_k127_4708242_3 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 419.0
TLS2_k127_4708242_4 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005843 339.0
TLS2_k127_4708242_5 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007119 316.0
TLS2_k127_4708242_6 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 304.0
TLS2_k127_4708242_7 alcohol dehydrogenase K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000161 280.0
TLS2_k127_4708242_8 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001317 258.0
TLS2_k127_4708242_9 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000008121 235.0
TLS2_k127_4728915_0 Methionine synthase K00548 - 2.1.1.13 0.0 1319.0
TLS2_k127_4728915_1 transcriptional regulator - - - 0.00000000000000000000000000000000000006923 144.0
TLS2_k127_4728915_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000008439 85.0
TLS2_k127_4728915_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000001953 73.0
TLS2_k127_4728915_4 - - - - 0.0000003475 60.0
TLS2_k127_4729825_0 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 379.0
TLS2_k127_4729825_1 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008757 325.0
TLS2_k127_4729825_10 Methyltransferase domain - - - 0.0000001618 63.0
TLS2_k127_4729825_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001844 295.0
TLS2_k127_4729825_3 bifunctional deaminase-reductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001303 259.0
TLS2_k127_4729825_4 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000004407 220.0
TLS2_k127_4729825_5 lysR family - - - 0.00000000000000000000000000000000000000000000000000006552 208.0
TLS2_k127_4729825_6 InterPro IPR014922 - - - 0.00000000000000000000000000000000000000000000000007375 190.0
TLS2_k127_4729825_7 membrane K07149 - - 0.0000000000000000000000000000000000246 143.0
TLS2_k127_4729825_8 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000007447 122.0
TLS2_k127_4729825_9 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000001538 115.0
TLS2_k127_4731825_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 565.0
TLS2_k127_4731825_1 Uncharacterised protein family (UPF0261) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 547.0
TLS2_k127_4731825_10 PFAM SMP-30 Gluconolaconase K14274 - - 0.00000000000000000000000000000000000000000000000006817 182.0
TLS2_k127_4731825_11 Cupin - - - 0.00000000000000000003216 104.0
TLS2_k127_4731825_2 Phosphoenolpyruvate hydrolase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 464.0
TLS2_k127_4731825_3 FAD linked oxidase domain protein K00803,K11472 - 2.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 395.0
TLS2_k127_4731825_4 Periplasmic binding protein K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005294 383.0
TLS2_k127_4731825_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004539 334.0
TLS2_k127_4731825_6 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 327.0
TLS2_k127_4731825_7 Belongs to the binding-protein-dependent transport system permease family K01997,K11960 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008353 325.0
TLS2_k127_4731825_8 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 309.0
TLS2_k127_4731825_9 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000281 275.0
TLS2_k127_4746951_0 IMP dehydrogenase GMP reductase K00088 - 1.1.1.205 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009546 340.0
TLS2_k127_4746951_1 pfkB family carbohydrate kinase K00882 - 2.7.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 316.0
TLS2_k127_4746951_10 nucleoside triphosphate catabolic process K01776,K02428 - 3.6.1.66,5.1.1.3 0.000000000000000000000000000000000005996 152.0
TLS2_k127_4746951_11 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000177 139.0
TLS2_k127_4746951_12 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000001125 108.0
TLS2_k127_4746951_13 bacterial (prokaryotic) histone like domain - - - 0.0000000000000000000003173 111.0
TLS2_k127_4746951_14 Belongs to the UPF0761 family K07058 - - 0.000000000001128 78.0
TLS2_k127_4746951_15 PFAM LysM domain - - - 0.000006728 58.0
TLS2_k127_4746951_2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000006742 269.0
TLS2_k127_4746951_3 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000008137 248.0
TLS2_k127_4746951_4 DNA polymerase III, epsilon subunit K02342 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000001628 234.0
TLS2_k127_4746951_5 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000001724 209.0
TLS2_k127_4746951_6 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000001566 212.0
TLS2_k127_4746951_7 PFAM MgtC SapB transporter K07507 - - 0.000000000000000000000000000000000000000000003116 174.0
TLS2_k127_4746951_8 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000002553 164.0
TLS2_k127_4746951_9 YCII-related domain K09780 - - 0.0000000000000000000000000000000000000009521 150.0
TLS2_k127_4748920_0 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000003105 237.0
TLS2_k127_4748920_1 - - - - 0.000000000000000000000000000000000000000000004806 172.0
TLS2_k127_4748920_2 Beta-lactamase K01286 - 3.4.16.4 0.000000000000000000000000000001156 140.0
TLS2_k127_4748920_3 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000002773 127.0
TLS2_k127_4775655_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 4.172e-308 972.0
TLS2_k127_4775655_1 GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 454.0
TLS2_k127_4775655_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 349.0
TLS2_k127_4775655_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000008313 227.0
TLS2_k127_4775655_4 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001634 202.0
TLS2_k127_4775655_5 Forkhead associated domain - - - 0.0000000000000000000000000000001657 139.0
TLS2_k127_4797524_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 428.0
TLS2_k127_4797524_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 345.0
TLS2_k127_4797524_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 331.0
TLS2_k127_4797524_3 Belongs to the dCTP deaminase family K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000104 275.0
TLS2_k127_4797524_4 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000002688 166.0
TLS2_k127_4797524_5 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.000000000000000000000000003726 123.0
TLS2_k127_4799406_0 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000345 490.0
TLS2_k127_4799406_1 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002831 293.0
TLS2_k127_4799406_2 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000002046 250.0
TLS2_k127_4799406_3 6-phosphogluconolactonase K00851,K01057 - 2.7.1.12,3.1.1.31 0.000000002085 61.0
TLS2_k127_4799406_4 PFAM FecR protein - - - 0.0000005232 63.0
TLS2_k127_4804180_0 Intein splicing domain K02469 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 0.0 1025.0
TLS2_k127_4804180_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008150,GO:0008152,GO:0009295,GO:0009330,GO:0009987,GO:0016043,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.99.1.3 5.855e-240 765.0
TLS2_k127_4804180_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 318.0
TLS2_k127_4804180_3 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.0000000000000000000000000000000000000000000000000000000000000000000108 246.0
TLS2_k127_4804180_4 Belongs to the UPF0232 family - - - 0.0000002014 61.0
TLS2_k127_4820686_0 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 407.0
TLS2_k127_4820686_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007673 322.0
TLS2_k127_4820686_2 Dehydrogenase E1 component K00161,K00166,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 326.0
TLS2_k127_4820686_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 295.0
TLS2_k127_4820686_4 TIGRFAM 2-oxoglutarate dehydrogenase, E2 component K00658 - 2.3.1.61 0.00000000000000000000000000000000000000009464 161.0
TLS2_k127_4820686_5 ASCH domain - - - 0.0000000000000000000000000000000000004286 147.0
TLS2_k127_4820686_6 NUDIX domain - - - 0.00000000000000000000000000000000001071 142.0
TLS2_k127_4820686_7 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000003316 123.0
TLS2_k127_4829157_0 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 435.0
TLS2_k127_4829157_1 COG COG1459 Type II secretory pathway component PulF Cell motility and secretion Intracellular trafficking and secretion K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 356.0
TLS2_k127_4829157_2 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000004099 193.0
TLS2_k127_4829157_3 Type II secretion system (T2SS), protein M K02664 - - 0.000000000005569 79.0
TLS2_k127_4829157_4 PFAM Fimbrial assembly family protein K02663 - - 0.0007483 52.0
TLS2_k127_4829157_5 Prepilin-type N-terminal cleavage methylation domain K02650 - - 0.0009458 48.0
TLS2_k127_483441_0 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000000000000004071 221.0
TLS2_k127_483441_1 GatB domain K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000225 160.0
TLS2_k127_483441_2 domain, Protein - - - 0.000000000000000000003493 107.0
TLS2_k127_483441_3 - - - - 0.0000000000000001148 88.0
TLS2_k127_4842222_0 Carbamoyltransferase C-terminus K00612 - - 2.557e-265 827.0
TLS2_k127_4842222_1 Starch synthase catalytic domain - - - 3.141e-223 725.0
TLS2_k127_4842222_2 HAD-hyrolase-like K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009388 598.0
TLS2_k127_4842222_3 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 409.0
TLS2_k127_4842222_4 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 361.0
TLS2_k127_4842222_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 333.0
TLS2_k127_4842222_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 317.0
TLS2_k127_4842222_7 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007561 287.0
TLS2_k127_4842222_8 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000004957 190.0
TLS2_k127_4842222_9 glycosyl transferase group 1 - - - 0.0000000000000005688 91.0
TLS2_k127_4885925_0 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005022 341.0
TLS2_k127_4885925_1 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000458 238.0
TLS2_k127_4885925_2 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000000000000000000000000004223 180.0
TLS2_k127_4885925_3 Domain of unknown function (DUF4234) - - - 0.000000001376 64.0
TLS2_k127_4885925_4 - - - - 0.00000009456 67.0
TLS2_k127_4963739_0 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000001935 259.0
TLS2_k127_4963739_1 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.00000000000000000000000000000000000000003216 159.0
TLS2_k127_4963739_2 Acetyltransferase (GNAT) domain K03825 - - 0.00000000000000003031 85.0
TLS2_k127_4963739_3 Putative diguanylate phosphodiesterase - - - 0.0000000006626 70.0
TLS2_k127_5052869_0 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 400.0
TLS2_k127_5052869_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 374.0
TLS2_k127_5052869_2 Putative inner membrane exporter, YdcZ K09936 - - 0.000000000000000000000000000000000001506 145.0
TLS2_k127_5052869_3 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000000000000000000000000000001423 142.0
TLS2_k127_5052869_4 Redoxin - - - 0.0000000000000001807 85.0
TLS2_k127_5052869_5 2TM domain - - - 0.000000049 60.0
TLS2_k127_50840_0 EamA-like transporter family K03298 - - 0.000000000000000000000000000000000000000000000000000000537 210.0
TLS2_k127_50840_1 FCD - - - 0.0000000000000000000000000000000000000000002112 177.0
TLS2_k127_50840_2 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000001062 136.0
TLS2_k127_5096191_0 Aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 478.0
TLS2_k127_5096191_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.7.7 0.0000000000000000000000000000000000000000001599 167.0
TLS2_k127_5096191_2 - - - - 0.0000000000000000000000000000597 121.0
TLS2_k127_5096191_3 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.000000004826 59.0
TLS2_k127_5098932_0 Alpha-amylase domain K01187 - 3.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 425.0
TLS2_k127_5098932_1 Methyltransferase small domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 380.0
TLS2_k127_5098932_2 Acetyltransferase (GNAT) domain K03827 - - 0.000000000000000000000000000000000000000000000000000000001188 207.0
TLS2_k127_5098932_3 TIGRFAM filamentous hemagglutinin family N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000805 222.0
TLS2_k127_5098932_4 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain K02479 - - 0.000000000000000000000000000000000000124 159.0
TLS2_k127_5098932_5 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000001271 148.0
TLS2_k127_5098932_6 Ribonuclease B OB domain K03704 - - 0.0000000000000000000000006362 105.0
TLS2_k127_5098932_7 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.00000000000000000000009101 102.0
TLS2_k127_5098932_8 - - - - 0.0000000000000000007876 101.0
TLS2_k127_5098932_9 Parallel beta-helix repeats - - - 0.0000000000005189 83.0
TLS2_k127_5133173_0 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003814 263.0
TLS2_k127_5133173_1 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000001104 250.0
TLS2_k127_5133173_10 Methyltransferase domain K14374,K18896 - 2.1.1.156 0.000000000001577 79.0
TLS2_k127_5133173_11 PFAM O-Antigen ligase - - - 0.0001113 55.0
TLS2_k127_5133173_12 Glycosyltransferase family 87 - - - 0.0006922 52.0
TLS2_k127_5133173_13 protein involved in exopolysaccharide biosynthesis - - - 0.0007674 51.0
TLS2_k127_5133173_2 PQQ enzyme repeat - - - 0.000000000000000000000000000000000000000000000000000000000003444 227.0
TLS2_k127_5133173_3 GDP-mannose 4,6 dehydratase K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000006527 180.0
TLS2_k127_5133173_4 sugar transferase - - - 0.000000000000000000000000000000000000000000000006829 175.0
TLS2_k127_5133173_5 ATP-grasp - - - 0.00000000000000000000000000000000000000000000001343 186.0
TLS2_k127_5133173_6 ATP-grasp - - - 0.00000000000000000000000000000000001114 154.0
TLS2_k127_5133173_7 Belongs to the eIF-2B alpha beta delta subunits family K03680 - - 0.000000000000000000000000155 118.0
TLS2_k127_5133173_8 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000001538 109.0
TLS2_k127_5133173_9 Peptidase family M23 - - - 0.000000000000004112 89.0
TLS2_k127_5145786_0 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003988 275.0
TLS2_k127_5145786_1 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001938 242.0
TLS2_k127_5145786_2 epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001992 239.0
TLS2_k127_5159239_0 Drug exporters of the RND superfamily K06994,K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 551.0
TLS2_k127_5159239_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003354 291.0
TLS2_k127_5159239_2 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000001807 192.0
TLS2_k127_5159239_3 Nuclease-related domain - - - 0.0000000005226 71.0
TLS2_k127_5183416_0 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 491.0
TLS2_k127_5183416_1 (2R)-phospho-3-sulfolactate synthase (ComA) K08097 - 4.4.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 312.0
TLS2_k127_5183416_2 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 314.0
TLS2_k127_5183416_3 Belongs to the PAPS reductase family. CysH subfamily K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000009281 247.0
TLS2_k127_5183416_4 L( )-tartrate dehydratase subunit beta K01678,K03780 - 4.2.1.2,4.2.1.32 0.0000000000000000000000000000000000000000000000000000000000003825 230.0
TLS2_k127_5183416_5 Catalyzes the synthesis of activated sulfate K00390,K00860,K00958,K13811 GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010134,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0070566,GO:0071704,GO:1901564 1.8.4.10,1.8.4.8,2.7.1.25,2.7.7.4 0.000000000000000000000000000000000000000000000000000000001882 216.0
TLS2_k127_5183416_6 FAD binding domain K00239,K00278 - 1.3.5.1,1.3.5.4,1.4.3.16 0.00000000000000000000000000000000000000009551 154.0
TLS2_k127_525923_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850,K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 424.0
TLS2_k127_525923_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 377.0
TLS2_k127_525923_2 Aldehyde dehydrogenase K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 319.0
TLS2_k127_525923_3 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000002572 209.0
TLS2_k127_525923_4 Belongs to the TrpC family K01609 - 4.1.1.48 0.00000008894 61.0
TLS2_k127_52616_0 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 387.0
TLS2_k127_52616_1 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.0000000000000000005188 92.0
TLS2_k127_52616_2 AAA ATPase K06915 - - 0.00000000000006544 74.0
TLS2_k127_52616_3 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000000004853 74.0
TLS2_k127_52616_4 Haemolysin-type calcium-binding repeat (2 copies) K11005 - - 0.000001322 60.0
TLS2_k127_5402114_0 COG COG0371 Glycerol dehydrogenase and related enzymes Energy production and conversion K00096 - 1.1.1.261 0.00000000000000000000000000000000000000000000000000000000000000000000000000001836 282.0
TLS2_k127_5402114_1 Glycosyltransferase like family 2 K16555 - - 0.000000000000000000000000000000000000461 159.0
TLS2_k127_5402114_2 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000002853 144.0
TLS2_k127_5402114_3 Glycosyltransferase like family 2 K07011 - - 0.0000000000000000000000000000001388 143.0
TLS2_k127_5402114_4 PFAM Polysaccharide deacetylase - - - 0.0000000000000000000001674 108.0
TLS2_k127_5402114_5 CDP-alcohol phosphatidyltransferase - - - 0.000000000000000004134 99.0
TLS2_k127_5402114_6 transferase - - - 0.0000000000000252 86.0
TLS2_k127_5447948_0 E1-E2 ATPase K01533 - 3.6.3.4 7.016e-294 920.0
TLS2_k127_5447948_1 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 312.0
TLS2_k127_5447948_2 Metal-sensitive transcriptional repressor K21600 - - 0.0000000000000000000000000004866 115.0
TLS2_k127_5490532_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 2.343e-275 873.0
TLS2_k127_5490532_1 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009489 521.0
TLS2_k127_5490532_10 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000001279 195.0
TLS2_k127_5490532_11 YceI-like domain - - - 0.00000000000000000000000000000000004394 141.0
TLS2_k127_5490532_12 COGs COG3593 ATP-dependent endonuclease of the OLD family K07459 - - 0.000000000000000000000000000003205 135.0
TLS2_k127_5490532_13 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000000005902 127.0
TLS2_k127_5490532_14 cheY-homologous receiver domain - - - 0.0000000000000000000000000002157 119.0
TLS2_k127_5490532_15 MarR family - - - 0.00000000000000000000999 98.0
TLS2_k127_5490532_16 Putative tRNA binding domain K06878 - - 0.0000000000000002497 79.0
TLS2_k127_5490532_17 Involved in the tonB-independent uptake of proteins - - - 0.0000000000002163 83.0
TLS2_k127_5490532_18 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000004077 66.0
TLS2_k127_5490532_19 Ethanolamine utilisation protein EutQ - - - 0.0000002118 59.0
TLS2_k127_5490532_2 Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine K18911 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008213,GO:0008276,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0019439,GO:0019538,GO:0019752,GO:0032259,GO:0034641,GO:0036211,GO:0042398,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052707,GO:0052708,GO:0052709,GO:0052803,GO:0052805,GO:0071704,GO:0071944,GO:0097164,GO:0140096,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 381.0
TLS2_k127_5490532_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 385.0
TLS2_k127_5490532_4 Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 391.0
TLS2_k127_5490532_5 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 368.0
TLS2_k127_5490532_6 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 355.0
TLS2_k127_5490532_7 Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine K18912 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0019439,GO:0019752,GO:0034641,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0055114,GO:0071704,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 1.14.99.50 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 356.0
TLS2_k127_5490532_8 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000001267 242.0
TLS2_k127_5490532_9 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000001483 198.0
TLS2_k127_550957_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 596.0
TLS2_k127_550957_1 Dak1_2 K07030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 354.0
TLS2_k127_550957_10 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000000001085 91.0
TLS2_k127_550957_2 Riboflavin biosynthesis protein RibD K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 302.0
TLS2_k127_550957_3 Uncharacterised protein, DegV family COG1307 - - - 0.00000000000000000000000000000000000000000000000000000000296 210.0
TLS2_k127_550957_4 riboflavin synthase, alpha K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000003214 194.0
TLS2_k127_550957_5 16S rRNA methyltransferase RsmB/F K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000003857 192.0
TLS2_k127_550957_6 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.0000000000000000000000000000000000000000008421 175.0
TLS2_k127_550957_7 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000001246 158.0
TLS2_k127_550957_8 COG2335 Secreted and surface protein containing fasciclin-like repeats - - - 0.00000000000000000000000000000000008732 136.0
TLS2_k127_550957_9 cheY-homologous receiver domain - - - 0.000000000000000001054 99.0
TLS2_k127_5616135_0 PFAM ABC transporter related K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 331.0
TLS2_k127_5616135_1 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960,K20810 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31,3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000067 278.0
TLS2_k127_5616135_2 TIGRFAM FeS assembly protein SufB K07033,K09014 - - 0.0000000000000000000000000000000000000000000000000000001726 197.0
TLS2_k127_5616135_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.000000000000000000000000000001013 131.0
TLS2_k127_5616135_4 Belongs to the anti-sigma-factor antagonist family K04749 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000002231 124.0
TLS2_k127_5616135_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000002391 71.0
TLS2_k127_5616135_6 PFAM blue (type 1) copper domain protein K07243 - - 0.0000000000364 71.0
TLS2_k127_5617311_0 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 336.0
TLS2_k127_5617311_1 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.0000000000000000000000000000000000000000000000000000000003923 215.0
TLS2_k127_5617311_2 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.000000000000000000000000000000000000000000000000000006138 203.0
TLS2_k127_5617311_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000003529 127.0
TLS2_k127_5617311_4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000001009 109.0
TLS2_k127_5617311_5 PFAM Bacterial membrane flanked domain - - - 0.0000004169 60.0
TLS2_k127_5626180_0 Sodium:sulfate symporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 518.0
TLS2_k127_5626180_1 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 496.0
TLS2_k127_5626180_10 Uncharacterized conserved protein (COG2071) K09166 - - 0.00000000004823 71.0
TLS2_k127_5626180_2 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007949 436.0
TLS2_k127_5626180_3 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 433.0
TLS2_k127_5626180_4 Belongs to the LDH MDH superfamily. LDH family K00016,K00024 - 1.1.1.27,1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 394.0
TLS2_k127_5626180_5 Phage integrase, N-terminal SAM-like domain K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002575 255.0
TLS2_k127_5626180_6 Phage integrase, N-terminal SAM-like domain K03733 - - 0.000000000000000000000000000000000000000000000000000000003001 214.0
TLS2_k127_5626180_7 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000001291 158.0
TLS2_k127_5626180_8 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000007292 158.0
TLS2_k127_5626180_9 Lon protease (S16) C-terminal proteolytic domain K07177 - - 0.000000000000000000000000000000001707 140.0
TLS2_k127_5630934_0 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 313.0
TLS2_k127_5630934_1 Enoyl-CoA hydratase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000001702 244.0
TLS2_k127_5630934_2 Predicted membrane protein (DUF2339) - - - 0.000000000000000000000000000000000000000000000000000000000000004346 241.0
TLS2_k127_5630934_3 Enoyl-CoA hydratase K07539,K18570 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.000000000000000000000000000000000000000000000000000000000000777 214.0
TLS2_k127_5630934_4 Pfam:DUF59 K02612 - - 0.00000000000000005442 80.0
TLS2_k127_5630934_5 sequence-specific DNA binding - - - 0.00000000000004535 83.0
TLS2_k127_5636166_0 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 7.311e-314 990.0
TLS2_k127_5636166_1 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 9.214e-282 882.0
TLS2_k127_5636166_10 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000001666 216.0
TLS2_k127_5636166_11 Amino acid synthesis - - - 0.0000000000000000000000000000000000000000000000000000002397 200.0
TLS2_k127_5636166_12 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K19647 - 1.1.1.291,1.1.1.31 0.0000000000000000000000000000000000000000000000000000008844 202.0
TLS2_k127_5636166_13 FCD - - - 0.00000000000000000000000000000000000000000000009812 179.0
TLS2_k127_5636166_14 Major facilitator Superfamily K02445 - - 0.0000000000000000000000000000324 132.0
TLS2_k127_5636166_15 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.00000000000000000000000000003663 128.0
TLS2_k127_5636166_16 Required for the activity of the bacterial periplasmic transport system of putrescine K02055 - - 0.000000000000000000000000001312 122.0
TLS2_k127_5636166_17 COG3209 Rhs family protein - - - 0.0000000000000000000001015 100.0
TLS2_k127_5636166_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 4.2.1.33,4.2.1.35 3.201e-214 675.0
TLS2_k127_5636166_3 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749,K18313 - 2.8.3.16,2.8.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008395 591.0
TLS2_k127_5636166_4 Pyruvate carboxyltransferase K01640,K18314 - 4.1.3.4,4.1.3.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007483 380.0
TLS2_k127_5636166_5 PFAM Multicopper oxidase K06324 - 1.16.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 389.0
TLS2_k127_5636166_6 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006801 341.0
TLS2_k127_5636166_7 Protein of unknown function (DUF3891) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000361 299.0
TLS2_k127_5636166_8 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002215 270.0
TLS2_k127_5636166_9 Galactose oxidase, central domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002934 261.0
TLS2_k127_5642123_0 COG COG0210 Superfamily I DNA and RNA helicases DNA replication recombination and repair K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 628.0
TLS2_k127_5642123_1 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004764 253.0
TLS2_k127_5642123_2 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.00000000000000000000000000000000000000000002266 178.0
TLS2_k127_5642123_3 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.0000000000000000000000000000000000009468 149.0
TLS2_k127_5642123_4 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.0000000000000000000000001056 109.0
TLS2_k127_5642123_5 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000001401 115.0
TLS2_k127_5649818_0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 6.753e-256 798.0
TLS2_k127_5649818_1 Molybdate transporter of MFS superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 379.0
TLS2_k127_5649818_2 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000008711 239.0
TLS2_k127_5649818_3 Ferritin-like domain K22336 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000924 196.0
TLS2_k127_5649818_5 Rhodanese Homology Domain - - - 0.000000000006176 77.0
TLS2_k127_5653169_0 Aldehyde dehydrogenase family K00294,K13821 - 1.2.1.88,1.5.5.2 6.421e-224 722.0
TLS2_k127_5653169_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 2.745e-202 647.0
TLS2_k127_5653169_10 Sir2 family K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000003069 245.0
TLS2_k127_5653169_11 Protein kinase domain K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000001855 230.0
TLS2_k127_5653169_12 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000002029 216.0
TLS2_k127_5653169_13 - - - - 0.000000000000000000000000000000000000000000000000000000001017 211.0
TLS2_k127_5653169_14 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000001028 224.0
TLS2_k127_5653169_15 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000007274 189.0
TLS2_k127_5653169_16 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000002715 160.0
TLS2_k127_5653169_17 May be required for sporulation K09762 - - 0.00000000000000000000000000000000000118 158.0
TLS2_k127_5653169_18 ECF sigma factor K03088 - - 0.00000000000000000000000000002562 124.0
TLS2_k127_5653169_19 serine threonine protein kinase - - - 0.0000000000000000000009598 102.0
TLS2_k127_5653169_2 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009603 511.0
TLS2_k127_5653169_20 COG0350 Methylated DNA-protein cysteine methyltransferase K00567 - 2.1.1.63 0.00000000000000000002793 107.0
TLS2_k127_5653169_21 permeases of the drug metabolite transporter (Dmt) superfamily K03298 - - 0.000000000000001628 87.0
TLS2_k127_5653169_22 - - - - 0.0000000000000194 80.0
TLS2_k127_5653169_23 - - - - 0.00000000401 62.0
TLS2_k127_5653169_24 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - - 0.0000004448 58.0
TLS2_k127_5653169_3 Glyceraldehyde-3-phosphate dehydrogenase, type I K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003811 445.0
TLS2_k127_5653169_4 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 397.0
TLS2_k127_5653169_5 Arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 409.0
TLS2_k127_5653169_6 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 395.0
TLS2_k127_5653169_7 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 328.0
TLS2_k127_5653169_8 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003122 287.0
TLS2_k127_5653169_9 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000001094 248.0
TLS2_k127_5656224_0 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000002121 124.0
TLS2_k127_5656224_1 PFAM Cupin 2 conserved barrel domain protein - - - 0.00000000000001676 76.0
TLS2_k127_5656224_2 - - - - 0.0000764 51.0
TLS2_k127_5659012_0 LVIVD repeat - - - 3.311e-241 756.0
TLS2_k127_5659012_1 Transcriptional regulator padr family - - - 0.000000000000000000000000004414 114.0
TLS2_k127_5659012_2 membrane K08972 - - 0.0000000000000001005 86.0
TLS2_k127_5659012_3 Phospholipase_D-nuclease N-terminal - - - 0.00000000001114 69.0
TLS2_k127_5659012_4 - - - - 0.0007324 51.0
TLS2_k127_5667672_0 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004846 364.0
TLS2_k127_5667672_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000008736 270.0
TLS2_k127_5667672_2 LysE type translocator - - - 0.000000000000000000000000000000000000000000000000000000000008537 214.0
TLS2_k127_5667672_3 Phosphoribosyl transferase domain K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000005501 210.0
TLS2_k127_5690709_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008827 484.0
TLS2_k127_5690709_1 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000000000000000000000008177 151.0
TLS2_k127_5690709_2 Methyltransferase domain - - - 0.00000000000000000000000000000000001222 141.0
TLS2_k127_5690709_3 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.000000000000000000001093 104.0
TLS2_k127_5700707_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004909 306.0
TLS2_k127_5700707_1 PAC2 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 289.0
TLS2_k127_5700707_2 Amidinotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001645 275.0
TLS2_k127_5700707_3 Type III restriction enzyme, res subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008526 276.0
TLS2_k127_5700707_4 cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000003503 166.0
TLS2_k127_5700707_5 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000001229 130.0
TLS2_k127_5704910_0 Belongs to the arginase family K01476 GO:0003674,GO:0003824,GO:0004053,GO:0006082,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 3.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001344 253.0
TLS2_k127_5704910_1 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000004141 226.0
TLS2_k127_5704910_2 MgsA AAA+ ATPase C terminal K07478 - - 0.00000000000000000000000000000000001424 139.0
TLS2_k127_5704910_3 Serine aminopeptidase, S33 K19311 GO:0003674,GO:0003824,GO:0005488,GO:0005504,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016298,GO:0016787,GO:0016788,GO:0019752,GO:0031406,GO:0032787,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0072329,GO:0104004,GO:1901575 - 0.00000000000000000000000000000000002231 145.0
TLS2_k127_5705541_0 PFAM Endonuclease Exonuclease phosphatase K07004 - - 2.446e-205 700.0
TLS2_k127_5705541_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03696 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 624.0
TLS2_k127_5705541_10 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 291.0
TLS2_k127_5705541_11 IPP transferase K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000003094 233.0
TLS2_k127_5705541_12 phosphatase K01083,K07004 - 3.1.3.8 0.00000000000000000000000000000000000000000000000000000000000000006201 256.0
TLS2_k127_5705541_13 CobB/CobQ-like glutamine amidotransferase domain K07009 - - 0.0000000000000000000000000000000000000000000000000000000000000001866 249.0
TLS2_k127_5705541_14 Metal-dependent phosphohydrolase, HD region - - - 0.00000000000000000000000000000000000000000000000000008931 213.0
TLS2_k127_5705541_15 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000000000000000002053 184.0
TLS2_k127_5705541_16 Cupin domain - - - 0.0000000000000000000000000000000000000000004543 168.0
TLS2_k127_5705541_17 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000152 151.0
TLS2_k127_5705541_18 protein tyrosine phosphatase activity K01104 - 3.1.3.48 0.00000000000000000000000005751 117.0
TLS2_k127_5705541_19 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.00000000000000000000003775 115.0
TLS2_k127_5705541_2 Endoribonuclease that initiates mRNA decay K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 531.0
TLS2_k127_5705541_20 Hydrolase, NUDIX family - - - 0.0000000000000001344 89.0
TLS2_k127_5705541_21 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0050896,GO:0051704,GO:0051716,GO:0071496 - 0.000000000002467 70.0
TLS2_k127_5705541_22 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.00002284 55.0
TLS2_k127_5705541_23 Modulates RecA activity K03565 - - 0.0001053 53.0
TLS2_k127_5705541_3 Domain of unknown function (DUF1727) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006514 447.0
TLS2_k127_5705541_4 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 432.0
TLS2_k127_5705541_5 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 430.0
TLS2_k127_5705541_6 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005953 388.0
TLS2_k127_5705541_7 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 337.0
TLS2_k127_5705541_8 Tetrahydrodipicolinate N-succinyltransferase N-terminal K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006784 347.0
TLS2_k127_5705541_9 Peptidase dimerisation domain K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004035 308.0
TLS2_k127_5712716_0 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000005039 187.0
TLS2_k127_5712716_1 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000005029 172.0
TLS2_k127_5712716_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000001038 156.0
TLS2_k127_5712716_3 lipopolysaccharide transmembrane transporter activity K03466,K07058 - - 0.000000000000000000000000000001262 134.0
TLS2_k127_5712716_4 - - - - 0.0000000000000000000004638 106.0
TLS2_k127_5713642_0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1379.0
TLS2_k127_5713642_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 1.307e-215 699.0
TLS2_k127_5713642_10 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000003911 170.0
TLS2_k127_5713642_11 isochorismatase - - - 0.00000000000000000000000000002618 129.0
TLS2_k127_5713642_12 LVIVD repeat - - - 0.0000000000000000502 88.0
TLS2_k127_5713642_13 Histidine kinase-like ATPase domain - - - 0.000000000747 64.0
TLS2_k127_5713642_14 cellular response to starvation - GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496 - 0.00000001078 63.0
TLS2_k127_5713642_15 Antibiotic biosynthesis monooxygenase - - - 0.00001308 52.0
TLS2_k127_5713642_2 CobW/HypB/UreG, nucleotide-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005294 537.0
TLS2_k127_5713642_3 Glycosyl transferases group 1 K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004013 531.0
TLS2_k127_5713642_4 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009509 525.0
TLS2_k127_5713642_5 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 496.0
TLS2_k127_5713642_6 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000484 404.0
TLS2_k127_5713642_7 Type III restriction enzyme, res subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 372.0
TLS2_k127_5713642_8 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 328.0
TLS2_k127_5713642_9 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 314.0
TLS2_k127_5720127_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.781e-200 676.0
TLS2_k127_5720127_1 glycosyl transferase, family 51 K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008249 444.0
TLS2_k127_5720127_2 MoaE protein K21142 - 2.8.1.12 0.000000000000000000000000000000000000000000000006914 185.0
TLS2_k127_5728654_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 316.0
TLS2_k127_5728654_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 323.0
TLS2_k127_5728654_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000001062 252.0
TLS2_k127_5728654_3 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000002797 200.0
TLS2_k127_5728654_4 His Kinase A (phosphoacceptor) domain K07654 - 2.7.13.3 0.0000000000000000000000000000002717 143.0
TLS2_k127_5735046_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 349.0
TLS2_k127_5735046_1 Belongs to the UPF0173 family - - - 0.00000000000000000000000000000000000000000000000000000000000000004379 236.0
TLS2_k127_5735046_2 Sigma-70 region 2 - - - 0.000000000000000000000000000000000000000000000000000000000000002214 224.0
TLS2_k127_5735046_3 Lactonase, 7-bladed beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000004736 219.0
TLS2_k127_5735046_5 Transmembrane anti-sigma factor - - - 0.00000000000000000008584 91.0
TLS2_k127_5735046_6 Putative zinc-finger - - - 0.00000000000002471 77.0
TLS2_k127_5735046_7 Family of unknown function (DUF1028) - - - 0.00000000002275 64.0
TLS2_k127_5737247_0 Phosphate transporter family K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 387.0
TLS2_k127_5737247_1 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000007354 190.0
TLS2_k127_5737328_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 575.0
TLS2_k127_5737328_1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000005618 222.0
TLS2_k127_5737328_2 protein conserved in bacteria K01056 - 3.1.1.29 0.000000000000000000000000000000000000000000000001286 192.0
TLS2_k127_5737328_3 Ribosomal protein L20 K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000000001082 148.0
TLS2_k127_5737328_4 tRNA rRNA methyltransferase, SpoU K03437 - - 0.0000000000000000000000000000000007306 149.0
TLS2_k127_5737328_5 SnoaL-like domain - - - 0.00000000000000000000000001381 126.0
TLS2_k127_5737328_6 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000002035 70.0
TLS2_k127_5744223_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 342.0
TLS2_k127_5744223_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008555 332.0
TLS2_k127_5744223_2 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000002547 246.0
TLS2_k127_5744223_3 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000000000000006586 243.0
TLS2_k127_5744223_4 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000001042 187.0
TLS2_k127_5744223_5 Peptidase family M50 K11749 - - 0.000000000000000000000000000000000000000000003237 187.0
TLS2_k127_5744223_6 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000001672 139.0
TLS2_k127_5744223_7 Gram-negative-bacterium-type cell wall biogenesis - - - 0.00000000000000000000001486 117.0
TLS2_k127_5745333_0 Carboxypeptidase - - - 5.715e-304 953.0
TLS2_k127_5745333_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 340.0
TLS2_k127_5745333_10 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000003568 98.0
TLS2_k127_5745333_11 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000009743 60.0
TLS2_k127_5745333_12 Acyltransferase K00655 - 2.3.1.51 0.0004483 53.0
TLS2_k127_5745333_2 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000002412 259.0
TLS2_k127_5745333_3 Belongs to the HAD-like hydrolase superfamily K02566 - - 0.00000000000000000000000000000000000000000000000000000000000000000001167 241.0
TLS2_k127_5745333_4 Response regulator receiver K02479 - - 0.000000000000000000000000000000000000000000000000000000001078 216.0
TLS2_k127_5745333_5 peroxiredoxin activity - - - 0.000000000000000000000000000000000000000002581 160.0
TLS2_k127_5745333_6 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.0000000000000000000000000000000000000001061 165.0
TLS2_k127_5745333_7 Histidine kinase - - - 0.0000000000000000000000000000000000000003257 156.0
TLS2_k127_5745333_8 RF-1 domain K15034 - - 0.000000000000000000000002889 116.0
TLS2_k127_5745333_9 Belongs to the universal stress protein A family - - - 0.0000000000000000000000306 104.0
TLS2_k127_5755022_0 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 529.0
TLS2_k127_5755022_1 Class II aldolase adducin family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005345 437.0
TLS2_k127_5755022_10 Phosphoglycerate mutase family K02226,K22316 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 0.00000000000779 78.0
TLS2_k127_5755022_11 PASTA K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.0000007681 58.0
TLS2_k127_5755022_2 PFAM FAD dependent oxidoreductase K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 419.0
TLS2_k127_5755022_3 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007683 282.0
TLS2_k127_5755022_4 Permease for cytosine/purines, uracil, thiamine, allantoin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000421 290.0
TLS2_k127_5755022_5 epimerase dehydratase K00091 - 1.1.1.219 0.00000000000000000000000000000000000000001174 171.0
TLS2_k127_5755022_7 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000015 126.0
TLS2_k127_5755022_8 - - - - 0.00000000000000000000000003946 123.0
TLS2_k127_5755022_9 Cupin domain - - - 0.0000000000003698 73.0
TLS2_k127_5763380_0 Phenazine biosynthesis PhzC PhzF protein K06998 - 5.3.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 340.0
TLS2_k127_5763380_1 PFAM ABC transporter related K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008525 329.0
TLS2_k127_5763380_10 Pyridoxal-dependent decarboxylase conserved domain - - - 0.0000000000000000002264 88.0
TLS2_k127_5763380_2 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 301.0
TLS2_k127_5763380_3 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003571 281.0
TLS2_k127_5763380_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001266 293.0
TLS2_k127_5763380_5 B12 binding domain K22491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003858 273.0
TLS2_k127_5763380_6 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003689 279.0
TLS2_k127_5763380_7 ABC-type branched-chain amino acid transport systems ATPase component K01996,K11958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002071 271.0
TLS2_k127_5763380_8 Domain of unknown function (DUF378) - - - 0.000000000000000000002895 96.0
TLS2_k127_5763380_9 ABC transporter K01990 - - 0.0000000000000000001559 94.0
TLS2_k127_5769836_0 COG0004 Ammonia permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006015 616.0
TLS2_k127_5769836_1 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008146 511.0
TLS2_k127_5769836_2 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 491.0
TLS2_k127_5769836_3 Glutamine amidotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 441.0
TLS2_k127_5769836_4 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 376.0
TLS2_k127_5769836_5 Glutamate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 379.0
TLS2_k127_5769836_6 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000005179 227.0
TLS2_k127_5769836_7 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000001434 209.0
TLS2_k127_5769836_8 Belongs to the glutamate synthase family - - - 0.00000000000000000000000000000000000000002488 168.0
TLS2_k127_5769836_9 dehydratase K01724 - 4.2.1.96 0.00003726 47.0
TLS2_k127_5774556_0 dehydrogenase K18369 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 507.0
TLS2_k127_5774556_1 Mycolic acid cyclopropane synthetase K00574,K20238 - 2.1.1.317,2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007019 444.0
TLS2_k127_5774556_2 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 327.0
TLS2_k127_5774556_3 Glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007843 263.0
TLS2_k127_5774556_4 Appr-1'-p processing enzyme - - - 0.00000000000000000000000000000001035 129.0
TLS2_k127_5777580_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 413.0
TLS2_k127_5777580_1 Peptidase, M16 K07263 - - 0.000000000000000000000000000000000000000000001603 186.0
TLS2_k127_5777580_2 - - - - 0.0000000000000000000000000000000000006338 139.0
TLS2_k127_5777580_3 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000008178 119.0
TLS2_k127_5777580_4 translation release factor activity - - - 0.00000000000000000000000904 113.0
TLS2_k127_5777580_5 AraC-like ligand binding domain - - - 0.0000000000007826 70.0
TLS2_k127_5777580_6 COGs COG3367 conserved - - - 0.000000418 53.0
TLS2_k127_5785294_0 FAD linked oxidases, C-terminal domain K00102,K00104 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.2.4,1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 579.0
TLS2_k127_5785294_1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 310.0
TLS2_k127_5785294_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000003018 227.0
TLS2_k127_5785294_3 overlaps another CDS with the same product name K11472 - - 0.000000000000000000000000000000000000000009206 165.0
TLS2_k127_5785294_4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000001056 169.0
TLS2_k127_5789280_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 596.0
TLS2_k127_5789280_1 Methionine synthase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 505.0
TLS2_k127_5789280_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005082 507.0
TLS2_k127_5789280_3 Cell envelope-related transcriptional attenuator domain - - - 0.0000000000000000000000000000000000000000003419 180.0
TLS2_k127_5789280_4 Nucleotidyl transferase - - - 0.000000000000000000000000000000000000001503 171.0
TLS2_k127_5789280_5 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000001441 154.0
TLS2_k127_5789280_6 Mannose-6-phosphate isomerase - - - 0.000000000000000000000000000000009195 142.0
TLS2_k127_5792742_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003724 473.0
TLS2_k127_5792742_1 PFAM Transposase IS200 like - - - 0.00000000000000000000000000000000000000000000000000000001083 205.0
TLS2_k127_5792742_2 Pfam:DUF385 - - - 0.0000000000000000000000000000000005595 135.0
TLS2_k127_5794630_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1114.0
TLS2_k127_5794630_1 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 411.0
TLS2_k127_5794630_2 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 386.0
TLS2_k127_5794630_3 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate K00756 GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003793 290.0
TLS2_k127_5794630_4 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000000000000002791 244.0
TLS2_k127_5794630_5 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000001498 242.0
TLS2_k127_5794630_6 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000000000000000000000000000001224 184.0
TLS2_k127_5794630_7 Glutaredoxin K03676 - - 0.00000000000000000000005169 101.0
TLS2_k127_5831964_0 cyclopropane-fatty-acyl-phospholipid synthase K00574,K18827 - 2.1.1.294,2.1.1.79,2.7.1.181 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 413.0
TLS2_k127_5831964_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006173 407.0
TLS2_k127_5831964_2 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004898 334.0
TLS2_k127_5831964_3 3-demethylubiquinone-9 3-O-methyltransferase activity K00568,K20444 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 332.0
TLS2_k127_5831964_4 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000007621 82.0
TLS2_k127_5873727_0 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 362.0
TLS2_k127_5873727_1 PFAM Glycosyl transferase family 2 K10012,K20534 - 2.4.2.53 0.0000000000000000000000000000000000000000000000000000000000002478 227.0
TLS2_k127_5873727_2 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000002491 74.0
TLS2_k127_5873727_3 - - - - 0.0000000182 67.0
TLS2_k127_5881948_0 Epoxide hydrolase N terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005594 420.0
TLS2_k127_5881948_1 AhpC/TSA family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003178 301.0
TLS2_k127_5881948_2 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000002195 225.0
TLS2_k127_5881948_3 AhpC/TSA family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000002663 218.0
TLS2_k127_5889872_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 326.0
TLS2_k127_5889872_1 PFAM ATP-binding region, ATPase domain protein K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000001142 212.0
TLS2_k127_5889872_2 DNA-templated transcription, initiation K03088 - - 0.000002452 51.0
TLS2_k127_5889872_3 Phosphoenolpyruvate phosphomutase - - - 0.0004207 45.0
TLS2_k127_5902396_0 Flavin containing amine oxidoreductase K00274,K03343 - 1.4.3.10,1.4.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 434.0
TLS2_k127_5902396_1 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 381.0
TLS2_k127_5902396_2 COG1960 Acyl-CoA dehydrogenases K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 350.0
TLS2_k127_5902396_3 Rieske 2Fe-2S K00499 - 1.14.15.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 368.0
TLS2_k127_5902396_4 Putrescine transport system permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 337.0
TLS2_k127_5902396_5 CoA binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001249 291.0
TLS2_k127_5902396_6 Thioesterase superfamily K07107 - - 0.00000000000000004313 92.0
TLS2_k127_5902396_7 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000003669 81.0
TLS2_k127_5902543_0 Squalene--hopene cyclase K06045 - 4.2.1.129,5.4.99.17 2.637e-206 660.0
TLS2_k127_5902543_1 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008445 334.0
TLS2_k127_5902543_2 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003653 280.0
TLS2_k127_5902543_3 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000004332 241.0
TLS2_k127_5902543_4 phytoene synthase K02291 GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000004556 226.0
TLS2_k127_5902543_5 NmrA-like family K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000005921 226.0
TLS2_k127_5902543_6 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00007437 47.0
TLS2_k127_5902543_7 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0004706 52.0
TLS2_k127_59521_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 436.0
TLS2_k127_59521_1 Competence protein K02238 - - 0.000000000000000000000000000000000000000000000000000000000000006641 243.0
TLS2_k127_59521_2 Colicin V production protein - - - 0.0000000000000000000000000000000000000000000000000000000000003758 226.0
TLS2_k127_59521_3 Helix-hairpin-helix motif K02237 - - 0.00000000000000000000000000000000000005126 150.0
TLS2_k127_5986763_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 3.708e-252 788.0
TLS2_k127_5986763_1 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006389 448.0
TLS2_k127_5986763_10 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000001268 134.0
TLS2_k127_5986763_11 Belongs to the ClpA ClpB family K03696 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944 - 0.0000000000000000000000000002516 124.0
TLS2_k127_5986763_12 translation initiation factor activity - - - 0.00000000000000002409 86.0
TLS2_k127_5986763_13 ClpX C4-type zinc finger - - - 0.000000000009765 74.0
TLS2_k127_5986763_2 HMGL-like K18314 - 4.1.3.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006774 366.0
TLS2_k127_5986763_3 PFAM Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 325.0
TLS2_k127_5986763_4 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000729 333.0
TLS2_k127_5986763_5 PFAM Homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 320.0
TLS2_k127_5986763_6 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 304.0
TLS2_k127_5986763_7 Ornithine cyclodeaminase/mu-crystallin family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006151 268.0
TLS2_k127_5986763_8 sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000325 268.0
TLS2_k127_5986763_9 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.00000000000000000000000000000000000000012 171.0
TLS2_k127_6030077_0 DNA methylase K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006674 381.0
TLS2_k127_6030077_1 Glycosyl transferases group 1 K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 327.0
TLS2_k127_6030077_2 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000000000000000000000000000005839 142.0
TLS2_k127_6030077_3 Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B) K04757 GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 2.7.11.1 0.0000000000000000001232 93.0
TLS2_k127_6045209_0 PFAM UDP-glucose GDP-mannose dehydrogenase K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 454.0
TLS2_k127_6045209_1 Glycosyl transferase, family 4 K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004103 301.0
TLS2_k127_6045209_2 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000005001 262.0
TLS2_k127_6045209_3 CoA-binding domain K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000002083 180.0
TLS2_k127_6045209_4 Epimerase dehydratase K01784,K17947 - 5.1.3.2,5.1.3.25 0.00000000000000000009555 104.0
TLS2_k127_6045209_5 NAD-dependent epimerase dehydratase K01784,K17947 - 5.1.3.2,5.1.3.25 0.000000000001579 78.0
TLS2_k127_6052058_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006103 370.0
TLS2_k127_6052058_1 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779,K11784 - 1.21.98.1,2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 351.0
TLS2_k127_6052058_10 Ferric uptake regulator family K03711 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000006469 125.0
TLS2_k127_6052058_12 ompA family - - - 0.00000000459 70.0
TLS2_k127_6052058_13 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.0002837 53.0
TLS2_k127_6052058_2 AzlC protein - - - 0.0000000000000000000000000000000000000000000000000000000000000009235 233.0
TLS2_k127_6052058_3 PFAM N-acetylglucosaminyl phosphatidylinositol deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000004718 225.0
TLS2_k127_6052058_4 ABC 3 transport family K09816 - - 0.000000000000000000000000000000000000000000000000000000000247 214.0
TLS2_k127_6052058_5 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.00000000000000000000000000000000000000000000000000000007102 208.0
TLS2_k127_6052058_6 Pfam SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000002432 189.0
TLS2_k127_6052058_7 ATPases associated with a variety of cellular activities K09817 - - 0.00000000000000000000000000000000000000000000000115 196.0
TLS2_k127_6052058_8 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000001189 181.0
TLS2_k127_6052058_9 D-glucuronyl C5-epimerase C-terminus - - - 0.0000000000000000000000000000001032 142.0
TLS2_k127_6054215_0 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate K00756 GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 447.0
TLS2_k127_6054215_1 Belongs to the AlaDH PNT family K00259 GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030312,GO:0036293,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 449.0
TLS2_k127_6054215_2 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008525 428.0
TLS2_k127_6054215_3 Peptidase dimerisation domain K01258 - 3.4.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 331.0
TLS2_k127_6054215_4 PFAM NUDIX hydrolase K01515 - 3.6.1.13 0.000000000000000000000000000006323 126.0
TLS2_k127_6054215_5 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.00000000000009099 71.0
TLS2_k127_6054215_6 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000005794 68.0
TLS2_k127_6055191_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 380.0
TLS2_k127_6055191_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007057 371.0
TLS2_k127_6055191_2 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000006652 192.0
TLS2_k127_6055191_3 Protein of unknown function (DUF1211) - - - 0.000000000000000004603 93.0
TLS2_k127_6083236_0 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 1.61e-255 795.0
TLS2_k127_6083236_1 PFAM FAD dependent oxidoreductase K00303 - 1.5.3.1 0.000000000000000000000000000000000000000001317 165.0
TLS2_k127_6083236_2 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000002971 159.0
TLS2_k127_6083236_3 Hemolysin-type calcium-binding region - - - 0.00000000000000000000000000000000008729 147.0
TLS2_k127_6083236_4 - - - - 0.000000000000000000000000000000006662 130.0
TLS2_k127_6083236_6 COG0662 Mannose-6-phosphate isomerase - - - 0.000000000002349 80.0
TLS2_k127_6090666_1 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002472 284.0
TLS2_k127_6095661_0 Iron-sulfur cluster-binding protein K18929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 458.0
TLS2_k127_6095661_1 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008724 310.0
TLS2_k127_6095661_10 Imidazoleglycerol-phosphate dehydratase K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 0.00000000000000000000000000000000000000001162 176.0
TLS2_k127_6095661_11 Inositol monophosphatase K01092,K05602 GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,3.1.3.25 0.0000000000000000000000000000000000000001017 166.0
TLS2_k127_6095661_12 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000002022 150.0
TLS2_k127_6095661_13 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.00000000000000000000000000000001035 138.0
TLS2_k127_6095661_14 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000001131 147.0
TLS2_k127_6095661_15 Pfam:DUF162 K00782 - - 0.000000000000001372 89.0
TLS2_k127_6095661_16 protein, YerC YecD - - - 0.00000000000003429 84.0
TLS2_k127_6095661_17 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000001173 76.0
TLS2_k127_6095661_18 Protein of unknown function (DUF2752) - - - 0.000000001603 70.0
TLS2_k127_6095661_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000005762 273.0
TLS2_k127_6095661_3 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000001441 256.0
TLS2_k127_6095661_4 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000004251 229.0
TLS2_k127_6095661_5 aminodeoxychorismate synthase K01665,K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000007823 223.0
TLS2_k127_6095661_6 RDD family - - - 0.000000000000000000000000000000000000000000000000000001215 200.0
TLS2_k127_6095661_7 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000298 175.0
TLS2_k127_6095661_8 Histidine biosynthesis bifunctional protein HisIE K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000004138 174.0
TLS2_k127_6095661_9 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K02619 - 4.1.3.38 0.0000000000000000000000000000000000000000000005397 183.0
TLS2_k127_6099550_0 Aminotransferase class-V K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006526 594.0
TLS2_k127_6099550_1 PFAM oxidoreductase, molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 341.0
TLS2_k127_6099550_2 Oxidoreductase FAD-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001505 281.0
TLS2_k127_6099550_3 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000003193 191.0
TLS2_k127_6099550_4 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000002279 158.0
TLS2_k127_6099550_5 PspC domain K03973 - - 0.0000000000000008983 78.0
TLS2_k127_6099550_6 - - - - 0.00000000000002434 85.0
TLS2_k127_6099550_7 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.0000000004252 62.0
TLS2_k127_6099550_8 Rho termination factor - - - 0.0000001351 62.0
TLS2_k127_6215050_0 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009944 414.0
TLS2_k127_6215050_1 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 404.0
TLS2_k127_6215050_2 Formate dehydrogenase, beta subunit K00122 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 370.0
TLS2_k127_6215050_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000811 282.0
TLS2_k127_6215050_4 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000006735 164.0
TLS2_k127_6215050_5 molybdopterin oxidoreductase Fe4S4 region K05299 - 1.17.1.10 0.0000000000000000000000000006805 124.0
TLS2_k127_6215050_6 MobA-like NTP transferase domain K07141,K19190 - 1.1.1.328,2.7.7.76 0.00000002895 66.0
TLS2_k127_630831_0 Thermophilic metalloprotease (M29) K19689 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009008 396.0
TLS2_k127_630831_1 PFAM peptidase M29, aminopeptidase II K19689 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008906 383.0
TLS2_k127_630831_2 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 334.0
TLS2_k127_630831_3 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000001489 226.0
TLS2_k127_630831_4 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000005886 237.0
TLS2_k127_630831_5 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000136 160.0
TLS2_k127_630831_6 LysM domain - - - 0.000000002217 63.0
TLS2_k127_630831_7 LVIVD repeat - - - 0.00000001634 57.0
TLS2_k127_6337505_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005647 465.0
TLS2_k127_6337505_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 329.0
TLS2_k127_6337505_2 Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004513 253.0
TLS2_k127_6337505_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.5 0.000000000000005852 81.0
TLS2_k127_6398551_0 Belongs to the aldehyde dehydrogenase family K22187 - - 8.885e-217 683.0
TLS2_k127_6398551_1 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000002852 209.0
TLS2_k127_6398551_2 - - - - 0.000000000000000000000000000001076 140.0
TLS2_k127_6398551_3 tRNA (adenine(22)-N(1))-methyltransferase K06967 - 2.1.1.217 0.000000000000000000000000000001507 129.0
TLS2_k127_6398551_4 Belongs to the GTP cyclohydrolase I type 2 NIF3 family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000002927 120.0
TLS2_k127_6412208_0 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 473.0
TLS2_k127_6412208_1 geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000000000000176 210.0
TLS2_k127_6412208_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.00000000000000000000000000000000000000000000000001951 185.0
TLS2_k127_6412208_3 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000001513 117.0
TLS2_k127_651685_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003447 363.0
TLS2_k127_651685_1 Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004434 286.0
TLS2_k127_651685_2 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000385 199.0
TLS2_k127_651685_3 nuclear export factor GLE1 K07040 - - 0.0000000000000000000000000727 116.0
TLS2_k127_651685_4 positive regulation of macromolecule biosynthetic process - - - 0.00000000000000009552 84.0
TLS2_k127_6551544_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 421.0
TLS2_k127_6551544_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 419.0
TLS2_k127_6551544_10 Belongs to the universal ribosomal protein uS5 family K02988 - - 0.00000000000000000000000000000000000000000000000000000000000001615 229.0
TLS2_k127_6551544_11 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000000000001871 216.0
TLS2_k127_6551544_12 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000001601 203.0
TLS2_k127_6551544_13 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000002178 169.0
TLS2_k127_6551544_14 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000005179 169.0
TLS2_k127_6551544_15 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000002912 156.0
TLS2_k127_6551544_16 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000001569 156.0
TLS2_k127_6551544_17 50S ribosomal protein L4 K02926 - - 0.000000000000000000000000000000000000006424 161.0
TLS2_k127_6551544_18 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.0000000000000000000000000000000000005629 161.0
TLS2_k127_6551544_19 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000005326 154.0
TLS2_k127_6551544_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 404.0
TLS2_k127_6551544_20 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000002747 137.0
TLS2_k127_6551544_21 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.0000000000000000000000000000001849 125.0
TLS2_k127_6551544_22 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000001629 124.0
TLS2_k127_6551544_23 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000002239 120.0
TLS2_k127_6551544_24 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000002964 105.0
TLS2_k127_6551544_25 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000001377 101.0
TLS2_k127_6551544_26 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000000003525 77.0
TLS2_k127_6551544_27 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000000004616 76.0
TLS2_k127_6551544_28 PFAM Activator of Hsp90 ATPase 1 family protein - - - 0.000000000000008306 76.0
TLS2_k127_6551544_29 ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000009105 70.0
TLS2_k127_6551544_3 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006567 341.0
TLS2_k127_6551544_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 304.0
TLS2_k127_6551544_5 Metallopeptidase family M24 K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 308.0
TLS2_k127_6551544_6 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001909 261.0
TLS2_k127_6551544_7 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007839 249.0
TLS2_k127_6551544_8 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000004023 251.0
TLS2_k127_6551544_9 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000000000000000000000005416 224.0
TLS2_k127_6560671_0 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009856 520.0
TLS2_k127_6560671_1 methyltransferase K13311,K13326,K21335 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0046983 2.1.1.234 0.000000000000000000000000000000000000000000000000000000001032 208.0
TLS2_k127_6560671_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000001312 205.0
TLS2_k127_6569034_0 Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP K05716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 380.0
TLS2_k127_6569034_1 acid phosphatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009085 330.0
TLS2_k127_6569034_2 2-phosphoglycerate kinase K05715 - - 0.00000000000000000000000000000000000000000000000000002181 213.0
TLS2_k127_6569034_3 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000001024 129.0
TLS2_k127_6569034_4 Psort location Cytoplasmic, score K00760 - 2.4.2.8 0.0000000000000000000000000000001024 129.0
TLS2_k127_6569034_5 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.0000000000000000182 87.0
TLS2_k127_6584126_0 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009721 504.0
TLS2_k127_6584126_1 Acetyl-CoA carboxylase, biotin carboxyl carrier protein K01571 - 4.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004391 366.0
TLS2_k127_6584126_10 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000008672 193.0
TLS2_k127_6584126_11 Shikimate dehydrogenase substrate binding domain K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000001992 194.0
TLS2_k127_6584126_12 Protein of unknown function (DUF3891) - - - 0.0000000000000000000000000000000000000000000000001896 195.0
TLS2_k127_6584126_13 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000001022 171.0
TLS2_k127_6584126_14 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000188 176.0
TLS2_k127_6584126_15 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000001256 171.0
TLS2_k127_6584126_16 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.3.4.2 0.0000000000000000000000000000000000185 137.0
TLS2_k127_6584126_17 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000007207 102.0
TLS2_k127_6584126_18 membrane K08972 - - 0.000000000000002413 80.0
TLS2_k127_6584126_19 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000005271 85.0
TLS2_k127_6584126_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 352.0
TLS2_k127_6584126_3 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 336.0
TLS2_k127_6584126_4 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 309.0
TLS2_k127_6584126_5 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001236 293.0
TLS2_k127_6584126_6 Creatinase Prolidase N-terminal domain K01262,K01271 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000003795 265.0
TLS2_k127_6584126_7 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000004108 251.0
TLS2_k127_6584126_8 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000001047 251.0
TLS2_k127_6584126_9 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000004491 218.0
TLS2_k127_6591951_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004785 467.0
TLS2_k127_6591951_1 Arylsulfatase a K01133 - 3.1.6.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 343.0
TLS2_k127_6591951_2 Arylsulfatase a K01133 - 3.1.6.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008201 334.0
TLS2_k127_6610533_0 Histidine kinase K07675 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 335.0
TLS2_k127_6610533_1 helix_turn_helix, Lux Regulon K07696 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007724 341.0
TLS2_k127_6610533_2 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 318.0
TLS2_k127_6610533_3 Belongs to the glycerate kinase type-1 family K00865 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000001342 249.0
TLS2_k127_6610533_4 Glycosyl transferases group 1 K08256 - 2.4.1.345 0.00000000000000000000000000000000000000000000000000000000002463 217.0
TLS2_k127_6610533_5 DNA methylase K00590 - 2.1.1.113 0.0000000000000000000000000000000002065 142.0
TLS2_k127_6610533_6 cyclic nucleotide binding K10914 - - 0.0000000000000000001106 98.0
TLS2_k127_6610533_7 lysyltransferase activity K07027 - - 0.00000000000011 85.0
TLS2_k127_6610533_8 - - - - 0.0000000001219 64.0
TLS2_k127_6610533_9 transglycosylase associated protein - - - 0.0009289 51.0
TLS2_k127_6610943_0 PFAM MMPL domain protein K06994 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 516.0
TLS2_k127_6610943_1 Multicopper oxidase K00368 - 1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000005329 267.0
TLS2_k127_6610943_2 Transcriptional regulator - - - 0.000000000000000000000000000000003241 142.0
TLS2_k127_6610943_3 Glycosyl transferases group 1 - - - 0.00000000000000000000002291 102.0
TLS2_k127_6610943_4 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000003747 110.0
TLS2_k127_6610943_5 - - - - 0.000000000000000002045 99.0
TLS2_k127_6610943_6 Aminoglycoside phosphotransferase - - - 0.0000000000000001363 92.0
TLS2_k127_6610943_7 Psort location Cytoplasmic, score - - - 0.00004522 49.0
TLS2_k127_6615703_0 ABC transporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 494.0
TLS2_k127_6615703_1 Protein-disulfide isomerase - - - 0.0000000000000000000000000000000000000000001703 171.0
TLS2_k127_6615703_2 VKc - - - 0.000000000000964 81.0
TLS2_k127_6619819_0 Metal-dependent phosphohydrolase, HD region - - - 0.000000000000000000000000000000000000000000000000000002074 207.0
TLS2_k127_6619819_1 - - - - 0.0000000000000000000000000000000000000000000002762 173.0
TLS2_k127_6619819_2 - - - - 0.00000000000000000000000001899 124.0
TLS2_k127_6619819_3 TIGRFAM Tyrosine recombinase XerD K04763 - - 0.00000000000000005834 92.0
TLS2_k127_6621287_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 385.0
TLS2_k127_6621287_1 phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 384.0
TLS2_k127_6621287_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 349.0
TLS2_k127_6621287_3 binding-protein-dependent transport systems inner membrane component K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 328.0
TLS2_k127_6621287_4 Pfam Cation efflux - - - 0.00000000000000000000000000000000000000000000000000000000000000000004267 240.0
TLS2_k127_6621287_5 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000008284 185.0
TLS2_k127_6621287_6 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000006961 175.0
TLS2_k127_6621287_7 Histidine kinase K07636 - 2.7.13.3 0.00000000000000000008614 91.0
TLS2_k127_6622060_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 463.0
TLS2_k127_6622060_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008562 402.0
TLS2_k127_6622060_2 A domain family that is part of the cupin metalloenzyme superfamily. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000308 276.0
TLS2_k127_6622060_3 Sucrase/ferredoxin-like - - - 0.000000000000000007392 88.0
TLS2_k127_6637084_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 338.0
TLS2_k127_6637084_1 PFAM 60 kDa inner membrane insertion protein K03217 - - 0.00000000000000000000000000000000000000000000026 183.0
TLS2_k127_6637084_2 PFAM Single-stranded nucleic acid binding R3H K06346 - - 0.0000000000000000000000000000006119 138.0
TLS2_k127_6637084_3 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000283 104.0
TLS2_k127_6637084_4 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000011 106.0
TLS2_k127_6637084_5 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000000000261 87.0
TLS2_k127_6637084_6 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000008808 61.0
TLS2_k127_6637835_0 Belongs to the ABC transporter superfamily K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 559.0
TLS2_k127_6637835_1 SdrD B-like domain K10233 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 575.0
TLS2_k127_6637835_10 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000000000000000000000000000000000000001177 162.0
TLS2_k127_6637835_11 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000001557 141.0
TLS2_k127_6637835_12 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.00000000000000000000000000006047 135.0
TLS2_k127_6637835_13 Protein of unknown function (DUF501) K09009 - - 0.00000000000000000000000000006326 122.0
TLS2_k127_6637835_14 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.000000000000000000000000000449 123.0
TLS2_k127_6637835_15 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000002851 102.0
TLS2_k127_6637835_16 PFAM phosphoesterase, PA-phosphatase related K19302 - 3.6.1.27 0.000000000000002258 90.0
TLS2_k127_6637835_17 subunit of a heme lyase K02200 - - 0.000000000000134 82.0
TLS2_k127_6637835_18 ferredoxin - - - 0.0000000000004607 81.0
TLS2_k127_6637835_19 Acetyltransferase (GNAT) domain - - - 0.0000000000009006 81.0
TLS2_k127_6637835_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 557.0
TLS2_k127_6637835_21 Domain of unknown function (DUF309) K09763 - - 0.00000000493 66.0
TLS2_k127_6637835_22 Septum formation initiator - - - 0.0000001196 57.0
TLS2_k127_6637835_23 - - - - 0.000001435 54.0
TLS2_k127_6637835_3 Bacterial extracellular solute-binding protein K10232 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006381 533.0
TLS2_k127_6637835_4 Isocitrate/isopropylmalate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 503.0
TLS2_k127_6637835_5 Spermine/spermidine synthase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 430.0
TLS2_k127_6637835_6 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 416.0
TLS2_k127_6637835_7 Binding-protein-dependent transport system inner membrane component K10234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 314.0
TLS2_k127_6637835_8 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000005301 227.0
TLS2_k127_6637835_9 SMART protein phosphatase 2C domain protein - - - 0.0000000000000000000000000000000000000000000000009053 201.0
TLS2_k127_6647036_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000009101 256.0
TLS2_k127_6647036_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K15856 - 1.1.1.281 0.0000000000000000000000000000000000000000000000000000000000001618 236.0
TLS2_k127_6647036_2 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000006328 221.0
TLS2_k127_6647036_3 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000002434 224.0
TLS2_k127_6647036_4 O-antigen ligase like membrane protein - - - 0.00000000000000000000000000000000000000000000000003344 198.0
TLS2_k127_6657203_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000877 484.0
TLS2_k127_6657203_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 321.0
TLS2_k127_6657203_2 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000002264 237.0
TLS2_k127_6657203_3 FR47-like protein K03789 - 2.3.1.128 0.00000000000000000000000000000000000001767 158.0
TLS2_k127_6657203_4 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000000000000000009692 147.0
TLS2_k127_6657203_5 Belongs to the peptidase S8 family - - - 0.0000000000000000000000001295 124.0
TLS2_k127_6657203_6 Glycoprotease family K14742 GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - 0.00000000000000000000001817 108.0
TLS2_k127_6657203_7 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - 0.000000000000000002182 89.0
TLS2_k127_6657203_8 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.0000000000000003401 80.0
TLS2_k127_6657203_9 TIGRFAM regulatory protein, FmdB - - - 0.000000003032 63.0
TLS2_k127_6660390_0 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000002042 256.0
TLS2_k127_6660390_1 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000003856 240.0
TLS2_k127_6660390_2 Protein of unknown function (DUF2817) - - - 0.000000000000000000000000000000000000000000000005745 181.0
TLS2_k127_6660390_3 Belongs to the carbohydrate kinase PfkB family - - - 0.0000000000000000000000000000000000000002778 163.0
TLS2_k127_6660390_4 cell envelope-related transcriptional attenuator - - - 0.000000000000000000000000000000000000000341 166.0
TLS2_k127_6660390_5 GYD domain - - - 0.00000000000000000000000558 114.0
TLS2_k127_6660390_6 Regulatory protein, FmdB - - - 0.000000000000000004077 89.0
TLS2_k127_6660390_7 Penicillin-insensitive murein endopeptidase K07261 - - 0.0000000002869 72.0
TLS2_k127_6660390_8 PFAM blue (type 1) copper domain protein - - - 0.0000429 56.0
TLS2_k127_6665808_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K01281 - 3.4.14.11 1.295e-222 710.0
TLS2_k127_6665808_1 transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 432.0
TLS2_k127_6665808_2 Endonuclease NucS K07503 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 319.0
TLS2_k127_6665808_3 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000001404 215.0
TLS2_k127_6665808_4 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000003701 194.0
TLS2_k127_6665808_5 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.000000000000000000000000000000000000000001491 170.0
TLS2_k127_6666327_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002221 269.0
TLS2_k127_6666327_1 Bacterial sugar transferase K16566 - - 0.00000000000000000000000000000000000000000000000000001818 196.0
TLS2_k127_6678154_0 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000003244 219.0
TLS2_k127_6678154_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000005497 152.0
TLS2_k127_6678154_2 TonB-dependent receptor - - - 0.000000000001161 73.0
TLS2_k127_6678154_3 Putative zinc-finger - - - 0.000009252 51.0
TLS2_k127_6678154_4 LytR cell envelope-related transcriptional attenuator - - - 0.00004657 55.0
TLS2_k127_6694627_0 3-oxoacyl-[acyl-carrier-protein] synthase activity K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 450.0
TLS2_k127_6694627_1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 366.0
TLS2_k127_6694627_10 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000001019 140.0
TLS2_k127_6694627_11 acetyltransferase - - - 0.00001959 55.0
TLS2_k127_6694627_2 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 326.0
TLS2_k127_6694627_3 Psort location Cytoplasmic, score K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000009245 262.0
TLS2_k127_6694627_4 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000001869 250.0
TLS2_k127_6694627_5 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000006431 191.0
TLS2_k127_6694627_6 protein potentially involved in peptidoglycan biosynthesis - - - 0.000000000000000000000000000000000000000000000000001407 211.0
TLS2_k127_6694627_7 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000296 175.0
TLS2_k127_6694627_8 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000000000185 151.0
TLS2_k127_6694627_9 Band 7 protein - - - 0.00000000000000000000000000000001234 128.0
TLS2_k127_6697015_0 Zn_pept - - - 0.00000000000000000000000000000000000000000000000000000000000000002486 240.0
TLS2_k127_6697015_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000005817 193.0
TLS2_k127_6697015_2 Major Facilitator Superfamily K08191 - - 0.0000003493 61.0
TLS2_k127_6697015_3 Fungalysin metallopeptidase (M36) - - - 0.0000009623 61.0
TLS2_k127_6697015_4 endopeptidase activity - - - 0.000003072 59.0
TLS2_k127_6698044_0 Mandelate Racemase Muconate Lactonizing - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 438.0
TLS2_k127_6698044_1 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 304.0
TLS2_k127_6698044_2 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000005836 130.0
TLS2_k127_6698044_3 cyclase dehydrase - - - 0.000000000197 61.0
TLS2_k127_6698044_4 - - - - 0.0007114 47.0
TLS2_k127_6703539_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 472.0
TLS2_k127_6703539_1 Integral membrane protein TerC family K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 361.0
TLS2_k127_6703539_2 PFAM Glucose Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000522 330.0
TLS2_k127_6703539_3 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001483 284.0
TLS2_k127_6703539_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001715 253.0
TLS2_k127_6703539_5 Cbs domain - - - 0.00000000000000000000000000000000000000000000000957 179.0
TLS2_k127_6703539_6 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000003817 179.0
TLS2_k127_6703539_7 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000001685 96.0
TLS2_k127_6704873_0 Flavin containing amine oxidoreductase - - - 1.635e-225 707.0
TLS2_k127_6704873_1 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 388.0
TLS2_k127_6704873_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008005 392.0
TLS2_k127_6704873_3 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006097 384.0
TLS2_k127_6704873_4 lysyltransferase activity K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000233 264.0
TLS2_k127_6704873_5 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000004788 201.0
TLS2_k127_6704873_6 cytochrome c oxidase - - - 0.00000000000000000000000000005349 126.0
TLS2_k127_6704873_7 Peptidase, M28 K19702 - 3.4.11.24 0.00000000000000001376 93.0
TLS2_k127_6704873_8 - - - - 0.0001569 48.0
TLS2_k127_6711587_0 PFAM glycoside hydrolase 15-related - - - 3.539e-264 827.0
TLS2_k127_6711587_1 Sigma-70 factor, region 1.2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 365.0
TLS2_k127_6711587_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 328.0
TLS2_k127_6711587_3 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 316.0
TLS2_k127_6711587_4 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000005739 242.0
TLS2_k127_6711587_5 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000001458 187.0
TLS2_k127_6711587_6 cellulase activity - - - 0.00000000000000000000000000000000000000000000002193 197.0
TLS2_k127_6711587_7 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000003149 160.0
TLS2_k127_6726025_0 Belongs to the aldehyde dehydrogenase family K00130 - 1.2.1.8 9.369e-203 652.0
TLS2_k127_6726025_1 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 522.0
TLS2_k127_6726025_2 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 385.0
TLS2_k127_6726025_3 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 391.0
TLS2_k127_6726025_4 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 367.0
TLS2_k127_6726025_5 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008221 337.0
TLS2_k127_6726025_6 peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000156 238.0
TLS2_k127_6726025_7 amino acid K16238 - - 0.0000000000000000000000000000000000000000000000000002173 190.0
TLS2_k127_6726025_8 - - - - 0.000000000000000000002486 101.0
TLS2_k127_6726578_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 587.0
TLS2_k127_6726578_1 tRNA (Uracil-5-)-methyltransferase K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 420.0
TLS2_k127_6726578_10 PFAM Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000001285 122.0
TLS2_k127_6726578_11 RDD family - - - 0.00000000000000000000000000001467 124.0
TLS2_k127_6726578_2 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 370.0
TLS2_k127_6726578_3 Oligoendopeptidase f K01283 - 3.4.15.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004295 381.0
TLS2_k127_6726578_4 Amino acid kinase family K00926 - 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000002227 256.0
TLS2_k127_6726578_5 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000005934 222.0
TLS2_k127_6726578_6 EamA-like transporter family - - - 0.000000000000000000000000000000000000127 152.0
TLS2_k127_6726578_7 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000005474 152.0
TLS2_k127_6726578_8 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000005678 128.0
TLS2_k127_6726578_9 Zincin-like metallopeptidase - - - 0.000000000000000000000000000004459 136.0
TLS2_k127_6728930_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 4.842e-319 1015.0
TLS2_k127_6728930_1 Trehalose synthase K05343 GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576 3.2.1.1,5.4.99.16 3.769e-272 848.0
TLS2_k127_6728930_2 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214,K02438 - 3.2.1.196,3.2.1.68 3.294e-233 730.0
TLS2_k127_6728930_3 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 3.245e-227 718.0
TLS2_k127_6728930_4 protein, probably involved in trehalose biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 501.0
TLS2_k127_6728930_5 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 460.0
TLS2_k127_6728930_6 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000004678 198.0
TLS2_k127_6728930_7 Endonuclease Exonuclease Phosphatase - - - 0.000000000000000000000000000000000000000000002082 168.0
TLS2_k127_6734191_0 PFAM regulatory protein LuxR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 528.0
TLS2_k127_6734191_1 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 462.0
TLS2_k127_6734191_2 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000001386 231.0
TLS2_k127_6747608_0 glycosyl transferase, family 51 K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007307 454.0
TLS2_k127_6747608_1 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 306.0
TLS2_k127_6747608_10 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000006167 124.0
TLS2_k127_6747608_11 HAD-superfamily hydrolase, subfamily IA, variant K07025 - - 0.000000000000000000000000006318 119.0
TLS2_k127_6747608_12 mechanosensitive ion channel - - - 0.0000000000000000000000003875 119.0
TLS2_k127_6747608_13 - - - - 0.0000000000000000000002012 101.0
TLS2_k127_6747608_14 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.000000000000000001271 98.0
TLS2_k127_6747608_15 Chorismate mutase K03856,K04092,K04093,K04516,K13853 - 2.5.1.54,5.4.99.5 0.00000000000000001709 85.0
TLS2_k127_6747608_16 CAAX protease self-immunity K07052 - - 0.000000000003404 76.0
TLS2_k127_6747608_17 PA domain K19701 - 3.4.11.10,3.4.11.6 0.00002918 57.0
TLS2_k127_6747608_2 Cys/Met metabolism PLP-dependent enzyme K01760,K01761 - 4.4.1.11,4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009619 317.0
TLS2_k127_6747608_3 Cellulose biosynthesis protein BcsQ K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005539 274.0
TLS2_k127_6747608_4 molybdopterin binding domain K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000003237 287.0
TLS2_k127_6747608_5 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001076 242.0
TLS2_k127_6747608_6 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000001157 211.0
TLS2_k127_6747608_7 PFAM Single-stranded nucleic acid binding R3H K06346 - - 0.000000000000000000000000000000005923 138.0
TLS2_k127_6747608_8 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000000004803 136.0
TLS2_k127_6747608_9 60Kd inner membrane protein K03217 - - 0.0000000000000000000000000003385 121.0
TLS2_k127_6747644_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 4.591e-271 845.0
TLS2_k127_6747644_1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 298.0
TLS2_k127_6747644_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000001612 154.0
TLS2_k127_6747644_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000209 133.0
TLS2_k127_6758799_0 Response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000000000000000000000000000001472 187.0
TLS2_k127_6758799_1 Histidine kinase K07636 - 2.7.13.3 0.00000000000001063 84.0
TLS2_k127_6758799_2 Methyltransferase type 11 K07755 - 2.1.1.137 0.000000005303 58.0
TLS2_k127_6776782_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 334.0
TLS2_k127_6776782_1 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000009301 261.0
TLS2_k127_6776782_2 PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000004178 263.0
TLS2_k127_6776782_3 response regulator receiver K07668,K07775 - - 0.000000000000000000000000000000000000000000000000000000000000000000000128 246.0
TLS2_k127_6776782_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000006659 189.0
TLS2_k127_6776782_5 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000001182 147.0
TLS2_k127_6776782_6 Aldehyde dehydrogenase family - - - 0.0000001417 61.0
TLS2_k127_6784110_0 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009204 454.0
TLS2_k127_6784110_1 UV-endonuclease UvdE K13281 - - 0.000000000000000000000000000000000000000000000000000000000000000000002725 249.0
TLS2_k127_6784110_2 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000008262 115.0
TLS2_k127_6784110_3 - - - - 0.00000000000001229 75.0
TLS2_k127_6784110_4 Peptidoglycan-binding domain 1 protein K03791 - - 0.0001629 52.0
TLS2_k127_68288_1 cellulase activity - - - 0.00000000000000000000002585 115.0
TLS2_k127_68288_3 Beta-galactosidase - - - 0.000000000369 72.0
TLS2_k127_68288_4 Periplasmic component of the Tol biopolymer transport system - - - 0.00002612 57.0
TLS2_k127_6839424_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 8.373e-242 765.0
TLS2_k127_6839424_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007974 617.0
TLS2_k127_6839424_10 Transcriptional regulator - - - 0.0000000000000000007253 102.0
TLS2_k127_6839424_11 DNA glycosylase K03649 - 3.2.2.28 0.000001183 53.0
TLS2_k127_6839424_12 PFAM OsmC family protein - - - 0.0007536 51.0
TLS2_k127_6839424_2 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 411.0
TLS2_k127_6839424_3 AAA ATPase central domain protein - GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019725,GO:0030003,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033212,GO:0033214,GO:0033554,GO:0040007,GO:0042592,GO:0042594,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051704,GO:0051716,GO:0055065,GO:0055069,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071944,GO:0072507,GO:0098771 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 392.0
TLS2_k127_6839424_4 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009052 361.0
TLS2_k127_6839424_5 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004299 298.0
TLS2_k127_6839424_6 Amidinotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001031 276.0
TLS2_k127_6839424_7 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000002258 202.0
TLS2_k127_6839424_8 oxidoreductase activity, acting on CH-OH group of donors - - - 0.00000000000000000000000000000000000000000000000000009111 202.0
TLS2_k127_6839424_9 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000157 102.0
TLS2_k127_6854894_0 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003402 408.0
TLS2_k127_6854894_1 Reductase C-terminal K00529 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 332.0
TLS2_k127_6854894_2 T4-like virus tail tube protein gp19 - - - 0.00000000000000000000000000000000000000000000000000000001412 203.0
TLS2_k127_6854894_3 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000008742 141.0
TLS2_k127_6854894_4 PFAM Ferric reductase domain protein transmembrane component domain K17247 - - 0.00000000000000000000000004682 117.0
TLS2_k127_6854894_6 4Fe-4S single cluster domain - - - 0.00004235 54.0
TLS2_k127_6882017_0 PFAM ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006929 358.0
TLS2_k127_6882017_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 342.0
TLS2_k127_6882017_2 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000008397 196.0
TLS2_k127_6882017_3 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000007016 105.0
TLS2_k127_6882017_4 Protein of unknown function DUF58 - - - 0.000000000000000000000001521 121.0
TLS2_k127_6882017_5 Carbon-nitrogen hydrolase K03820 - - 0.0000003665 60.0
TLS2_k127_6885545_0 DNA primase, small subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 486.0
TLS2_k127_6885545_1 PFAM ABC transporter K02028,K02029,K10008 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004781 339.0
TLS2_k127_6885545_10 - - - - 0.00000000000000000000000000284 114.0
TLS2_k127_6885545_11 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.00000004452 56.0
TLS2_k127_6885545_12 Histidine kinase - - - 0.000001937 60.0
TLS2_k127_6885545_2 Binding-protein-dependent transport system inner membrane component K02029,K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009998 327.0
TLS2_k127_6885545_3 WYL domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 302.0
TLS2_k127_6885545_4 Bacterial periplasmic substrate-binding proteins K02030,K02424,K17073 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 289.0
TLS2_k127_6885545_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000002015 239.0
TLS2_k127_6885545_6 Haemolysin-III related K11068 - - 0.000000000000000000000000000000000000000000000000000000000000000007229 231.0
TLS2_k127_6885545_7 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000002082 203.0
TLS2_k127_6885545_8 - - - - 0.00000000000000000000000000000000000000000001124 177.0
TLS2_k127_6885545_9 SnoaL-like domain - - - 0.000000000000000000000000000000000000006895 147.0
TLS2_k127_68967_0 Fungalysin metallopeptidase (M36) - - - 2.246e-292 929.0
TLS2_k127_68967_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 616.0
TLS2_k127_68967_10 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000006678 123.0
TLS2_k127_68967_11 Heat shock 70 kDa protein K04043 - - 0.0000000000000000007672 87.0
TLS2_k127_68967_2 Myo-inositol-1-phosphate synthase K01858 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 561.0
TLS2_k127_68967_3 Orn Lys Arg decarboxylase K01585 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005523 450.0
TLS2_k127_68967_4 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 449.0
TLS2_k127_68967_5 PHP-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005716 352.0
TLS2_k127_68967_6 PFAM cyclase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008749 257.0
TLS2_k127_68967_7 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000002017 216.0
TLS2_k127_68967_8 Uracil DNA glycosylase superfamily - - - 0.00000000000000000000000000000000000000000000000009767 201.0
TLS2_k127_68967_9 PAP2 superfamily - - - 0.00000000000000000000000000000000000381 146.0
TLS2_k127_691406_0 RNB K12573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003471 484.0
TLS2_k127_691406_1 glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 387.0
TLS2_k127_691406_2 ATPases associated with a variety of cellular activities K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009516 319.0
TLS2_k127_691406_3 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000009084 240.0
TLS2_k127_691406_4 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000007554 190.0
TLS2_k127_691406_5 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.000000000000000000000000000000000000000000000003922 183.0
TLS2_k127_6946112_0 DNA polymerase III alpha subunit K02337,K14162 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 387.0
TLS2_k127_6946112_1 Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000000000001668 165.0
TLS2_k127_6946112_2 translation initiation factor activity K06996 - - 0.0000000000000000000000000000305 121.0
TLS2_k127_6946112_3 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000001859 117.0
TLS2_k127_6946112_4 Transglycosylase SLT domain - - - 0.000000000000000000006908 104.0
TLS2_k127_6946112_5 - - - - 0.0000005286 60.0
TLS2_k127_6946112_6 6-phosphogluconolactonase activity - - - 0.0005817 44.0
TLS2_k127_6999299_0 TIGRFAM Translation elongation factor K02355 - - 4.05e-199 641.0
TLS2_k127_6999299_1 RNA polymerase sigma factor K02405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 342.0
TLS2_k127_6999299_2 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004222 307.0
TLS2_k127_6999299_3 D-amino acid K00285 - 1.4.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 303.0
TLS2_k127_6999299_4 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002341 258.0
TLS2_k127_6999299_5 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000001618 233.0
TLS2_k127_6999299_6 - - - - 0.0000000000000000003881 96.0
TLS2_k127_6999299_8 - - - - 0.0000000000000131 78.0
TLS2_k127_7000276_0 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001468 284.0
TLS2_k127_7000276_1 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.0000000000000000000000000000000000000000000000000000000001397 207.0
TLS2_k127_7000276_2 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000001202 196.0
TLS2_k127_7000276_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000000000000000000000000004424 186.0
TLS2_k127_7000276_4 Conserved hypothetical protein 95 - - - 0.0000000000000000000000000000000000000000000008491 171.0
TLS2_k127_7000276_5 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000000000007312 138.0
TLS2_k127_7000276_6 Bacterial transcriptional activator domain - - - 0.000000000000000000000000001653 114.0
TLS2_k127_7000276_7 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.000000000000000000001925 96.0
TLS2_k127_7000276_8 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000002311 94.0
TLS2_k127_7001060_0 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000004552 236.0
TLS2_k127_7001060_1 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000006507 227.0
TLS2_k127_7001060_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000004426 215.0
TLS2_k127_7001060_3 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000001276 188.0
TLS2_k127_7001060_4 NLP P60 protein K21471 - - 0.000000000000000000000000000000000000002844 160.0
TLS2_k127_7001060_5 G5 - - - 0.000000000000000000705 102.0
TLS2_k127_7001060_6 Peptidase, S9A B C family, catalytic domain protein - - - 0.000000000001761 79.0
TLS2_k127_7001060_7 - - - - 0.000000001611 61.0
TLS2_k127_7052299_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 461.0
TLS2_k127_7052299_1 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000532 311.0
TLS2_k127_7052299_3 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000012 121.0
TLS2_k127_7052299_4 SUF system FeS assembly protein K04488 - - 0.00000000000000000000007559 103.0
TLS2_k127_7052299_5 Cold-shock K03704 - - 0.0000000000000000005062 101.0
TLS2_k127_7089285_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 434.0
TLS2_k127_7089285_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 393.0
TLS2_k127_7089285_10 NfeD-like C-terminal, partner-binding K07403 - - 0.000000001425 63.0
TLS2_k127_7089285_11 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.00000001348 57.0
TLS2_k127_7089285_2 EamA-like transporter family K11939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007474 360.0
TLS2_k127_7089285_3 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008779 357.0
TLS2_k127_7089285_4 Carbon-nitrogen hydrolase K01501 - 3.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000475 286.0
TLS2_k127_7089285_5 helix_turn_helix ASNC type K03719 - - 0.00000000000000000000000000000000000000000000000000001228 197.0
TLS2_k127_7089285_6 transcription factor binding - - - 0.00000000000000000000000000000000000000001623 157.0
TLS2_k127_7089285_7 translation release factor activity K03265 - - 0.000000000000000000000001549 117.0
TLS2_k127_7089285_8 EamA-like transporter family - - - 0.000000000000000000000003627 114.0
TLS2_k127_7089285_9 Protein of unknown function (DUF3105) - - - 0.00000000000000006819 90.0
TLS2_k127_7133671_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 530.0
TLS2_k127_7133671_1 ABC transporter, ATP-binding protein K02028 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 305.0
TLS2_k127_7133671_2 Amino acid ABC transporter, permease protein, 3-TM K02029 - - 0.0000000000000000000000000000000000000000006885 169.0
TLS2_k127_7133671_3 Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.000000000000000000000000001063 126.0
TLS2_k127_7147099_0 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 455.0
TLS2_k127_7147099_1 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000003735 100.0
TLS2_k127_7147099_2 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000004452 57.0
TLS2_k127_7155039_0 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 398.0
TLS2_k127_7155039_1 Glyoxalase-like domain K07104 - 1.13.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000114 256.0
TLS2_k127_7155039_2 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000004175 170.0
TLS2_k127_7155039_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 0.000000000000000000000000000001192 127.0
TLS2_k127_7155039_4 glyoxalase III activity - - - 0.00000000000000000000000000001456 127.0
TLS2_k127_7155039_5 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000002472 121.0
TLS2_k127_7155039_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000146 111.0
TLS2_k127_7155039_7 Domain of unknown function (DUF4190) - - - 0.0000000000009196 78.0
TLS2_k127_7155039_8 polysaccharide deacetylase - - - 0.00000006238 55.0
TLS2_k127_7155039_9 - - - - 0.0000009131 57.0
TLS2_k127_7195677_0 Flavin containing amine oxidoreductase K00274,K03343 - 1.4.3.10,1.4.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 439.0
TLS2_k127_7195677_1 Lysine methyltransferase - - - 0.0000000000000000000000000000000000000000000004913 176.0
TLS2_k127_7195677_2 protein histidine kinase activity - - - 0.000000000000000001014 97.0
TLS2_k127_7195677_3 Rieske 2Fe-2S K00499 - 1.14.15.7 0.00000000000005867 73.0
TLS2_k127_7195677_4 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000002024 59.0
TLS2_k127_7242680_0 Rhodanese Homology Domain - - - 8.113e-208 654.0
TLS2_k127_7242680_1 Participates in transcription elongation, termination and antitermination K02601 - - 0.000000000000000000000000000000000000000000000000000000000000001066 228.0
TLS2_k127_7242680_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000000003198 217.0
TLS2_k127_7242680_3 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000005261 98.0
TLS2_k127_7242680_4 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.000000000000000001184 86.0
TLS2_k127_7242680_5 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000179 53.0
TLS2_k127_7340193_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 7.644e-290 918.0
TLS2_k127_7340193_1 Cysteine-rich domain K11473 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 293.0
TLS2_k127_7340193_2 alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000002352 204.0
TLS2_k127_7340193_3 Serine aminopeptidase, S33 - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000001289 108.0
TLS2_k127_7340193_4 Predicted membrane protein (DUF2231) - - - 0.000000000000007002 81.0
TLS2_k127_7371024_0 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 559.0
TLS2_k127_7371024_1 50S ribosome-binding GTPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 461.0
TLS2_k127_7371024_2 ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 350.0
TLS2_k127_7371024_3 Periplasmic binding protein domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000174 289.0
TLS2_k127_7371024_4 repeat protein - - - 0.0000000000000000000000000000000000000001276 163.0
TLS2_k127_7371024_5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000001332 117.0
TLS2_k127_7389108_0 DAHP synthetase I family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 407.0
TLS2_k127_7389108_1 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 368.0
TLS2_k127_7389108_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 292.0
TLS2_k127_7389108_3 RNA pseudouridylate synthase K06178 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000007857 242.0
TLS2_k127_7389108_4 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.0000000000000000000000000000000000000000000000000004368 186.0
TLS2_k127_7389108_5 Segregation and condensation complex subunit ScpB K06024 - - 0.000000000000000000000000000000000000293 154.0
TLS2_k127_7389108_6 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000008301 154.0
TLS2_k127_7389108_7 GYD domain - - - 0.0000000000000000237 89.0
TLS2_k127_7389108_8 - - - - 0.0005888 47.0
TLS2_k127_780224_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 460.0
TLS2_k127_780224_1 Belongs to the SEDS family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 408.0
TLS2_k127_780224_2 Penicillin binding protein transpeptidase domain K05364 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 345.0
TLS2_k127_780224_3 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000005613 282.0
TLS2_k127_780224_4 Protein of unknown function (DUF2662) - - - 0.0000000000000000000000000000000000000000000000000000000000003946 229.0
TLS2_k127_780224_5 Forkhead associated domain - - - 0.000000000000000000006899 98.0
TLS2_k127_786200_0 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000001094 199.0
TLS2_k127_786200_1 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000275 190.0
TLS2_k127_786200_2 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000001092 183.0
TLS2_k127_786200_3 Iron-containing alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000004286 186.0
TLS2_k127_786200_4 - - - - 0.0003642 52.0
TLS2_k127_851_0 Glycosyl transferase 4-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 334.0
TLS2_k127_851_1 cation diffusion facilitator family transporter K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006447 302.0
TLS2_k127_851_2 Sigma-70 region 2 K03091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003564 259.0
TLS2_k127_851_3 Putative modulator of DNA gyrase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002195 256.0
TLS2_k127_851_4 Putative modulator of DNA gyrase - - - 0.00000000000000000000000000000000000001494 145.0
TLS2_k127_851_5 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000007982 109.0
TLS2_k127_851_6 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.00000001974 58.0
TLS2_k127_89268_0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003212 455.0
TLS2_k127_89268_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008261 353.0
TLS2_k127_89268_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000001935 222.0
TLS2_k127_89268_3 PFAM NADH Ubiquinone plastoquinone (complex I) K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000424 168.0
TLS2_k127_89268_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000006836 109.0
TLS2_k127_89268_5 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000006841 75.0
TLS2_k127_89268_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000005097 53.0
TLS2_k127_944839_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 446.0
TLS2_k127_944839_1 Fibronectin type III domain - - - 0.000000000000000000000000000000001651 145.0
TLS2_k127_947877_0 MacB-like periplasmic core domain K02004 - - 4.925e-220 717.0
TLS2_k127_947877_1 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007642 343.0
TLS2_k127_947877_2 pyrroloquinoline quinone binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003175 266.0
TLS2_k127_947877_3 Hydrolase K07025 - - 0.000000000000000000001962 103.0
TLS2_k127_947877_4 peptidoglycan catabolic process - - - 0.00000000001247 74.0
TLS2_k127_947877_5 Peptidoglycan-binding domain 1 protein - - - 0.00001854 55.0
TLS2_k127_968392_0 4-hydroxyphenylacetate 3-hydroxylase N terminal K00483 - 1.14.14.9 2.82e-201 661.0
TLS2_k127_968392_1 Belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 595.0
TLS2_k127_968392_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003035 313.0
TLS2_k127_968392_3 PFAM Peptidase family M23 K21472 - - 0.0000000000000000000000194 117.0
TLS2_k127_968392_4 PFAM flavin reductase domain protein FMN-binding K14631,K21185 - - 0.000000000000000236 93.0
TLS2_k127_968392_5 response to heat K07090 - - 0.0000000000002036 81.0
TLS2_k127_968392_6 Sulfite exporter TauE/SafE K07090 - - 0.0000000005658 64.0
TLS2_k127_968392_7 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000005857 58.0
TLS2_k127_974005_0 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 386.0
TLS2_k127_974005_1 Binding-protein-dependent transport system inner membrane component K10234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006773 303.0
TLS2_k127_974005_2 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000000000000000000001074 165.0
TLS2_k127_974005_3 flavoprotein involved in K transport - - - 0.00000006433 64.0
TLS2_k127_974005_4 Nitrous oxidase accessory protein K07218 - - 0.0000621 56.0
TLS2_k127_984074_0 ATPase (P-type) K01537,K12952 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 500.0
TLS2_k127_984074_1 Domain of unknown function (DUF4389) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002771 424.0
TLS2_k127_984074_2 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 370.0
TLS2_k127_984074_3 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000001266 204.0
TLS2_k127_984074_4 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000001109 173.0