Overview

ID MAG04042
Name TLS3_bin.19
Sample SMP0105
Taxonomy
Kingdom Bacteria
Phylum Spirochaetota
Class Leptospiria
Order Turneriellales
Family Turneriellaceae
Genus Turneriella
Species
Assembly information
Completeness (%) 70.94
Contamination (%) 2.14
GC content (%) 53.0
N50 (bp) 2,756
Genome size (bp) 3,601,467

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3244

Gene name Description KEGG GOs EC E-value Score Sequence
TLS3_k127_1003657_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000001837 258.0
TLS3_k127_1009058_0 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007147 365.0
TLS3_k127_1009058_1 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000001098 229.0
TLS3_k127_1009058_2 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000003576 171.0
TLS3_k127_1016723_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 368.0
TLS3_k127_1016723_1 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008859 304.0
TLS3_k127_1027121_0 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000000000000000000000000000000000003664 272.0
TLS3_k127_1027121_1 PFAM Pseudouridine synthase, RsuA and RluB C D E F K06177,K06180 - 5.4.99.23,5.4.99.28,5.4.99.29 0.0000000000000000000000000000000000002439 151.0
TLS3_k127_1027121_2 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000002346 72.0
TLS3_k127_1030847_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000005575 175.0
TLS3_k127_1030847_1 ArsC family K00537 - 1.20.4.1 0.000000000000000000000000000001715 125.0
TLS3_k127_1036777_0 Belongs to the peptidase S8 family - - - 0.000000000000000000002543 111.0
TLS3_k127_1041310_0 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.000000000000000000000000000000000005701 143.0
TLS3_k127_1041310_1 Phosphoribosyl transferase domain - - - 0.00002102 54.0
TLS3_k127_104695_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004097 302.0
TLS3_k127_1047224_0 PFAM helicase K03580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 321.0
TLS3_k127_1047224_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000006898 175.0
TLS3_k127_1047224_2 unusual protein kinase - - - 0.000000000000001318 79.0
TLS3_k127_1047224_3 COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing proteins - - - 0.0001515 55.0
TLS3_k127_1049324_0 NAD(P)-binding Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 309.0
TLS3_k127_1050384_0 Outer membrane efflux protein - - - 0.00000000000000000000000000000001239 143.0
TLS3_k127_1050384_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000001524 110.0
TLS3_k127_1050384_2 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.0001774 52.0
TLS3_k127_1059164_0 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000004754 196.0
TLS3_k127_1059164_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000636 182.0
TLS3_k127_1059164_2 including yeast histone deacetylase and acetoin utilization protein - - - 0.0000000000001082 80.0
TLS3_k127_1060252_0 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 349.0
TLS3_k127_1074780_0 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 295.0
TLS3_k127_1085864_0 Glycerophosphoryl diester phosphodiesterase family - - - 0.00000000000000000000000001117 121.0
TLS3_k127_1100168_0 PFAM acyl-CoA dehydrogenase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008216 332.0
TLS3_k127_1100168_1 TonB-dependent Receptor Plug - - - 0.000000000003039 75.0
TLS3_k127_1100777_0 Peptidase C39 family K12541 - - 0.000000000000000000000000000000000000000005554 168.0
TLS3_k127_1106722_0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 302.0
TLS3_k127_1106722_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000003582 260.0
TLS3_k127_1108713_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 481.0
TLS3_k127_1108713_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000798 99.0
TLS3_k127_1109810_0 radical SAM domain protein - - - 0.00000000000000009124 82.0
TLS3_k127_1109810_1 Chitobiase/beta-hexosaminidase C-terminal domain - - - 0.0000002237 62.0
TLS3_k127_1121215_0 dihydroorotase K01466 - 3.5.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007673 273.0
TLS3_k127_1121215_1 Belongs to the glycosyl hydrolase 1 family K05350 - 3.2.1.21 0.00001578 53.0
TLS3_k127_1123738_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000002564 207.0
TLS3_k127_1123738_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000005323 51.0
TLS3_k127_1125195_0 Major Facilitator Superfamily K08159,K19577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000312 270.0
TLS3_k127_1125195_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000003111 102.0
TLS3_k127_1157161_0 CO dehydrogenase flavoprotein C-terminal domain K13481 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 349.0
TLS3_k127_1157161_1 cell wall binding repeat 2 - - - 0.000005069 60.0
TLS3_k127_1178994_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 330.0
TLS3_k127_1178994_1 - - - - 0.00001726 51.0
TLS3_k127_1183504_0 GAF domain - - - 0.000000000316 70.0
TLS3_k127_1185751_0 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007699 403.0
TLS3_k127_1185751_1 Domain of unknown function (DUF1993) K09983 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004052 250.0
TLS3_k127_1185751_2 Psort location Cytoplasmic, score 8.96 K09949 - - 0.00000000000000000000000000000000000001051 158.0
TLS3_k127_1185751_3 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000003061 80.0
TLS3_k127_1185751_4 Flagellar rod assembly protein muramidase FlgJ K02395,K08309 - - 0.00000000004025 69.0
TLS3_k127_1185751_5 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.000000004435 63.0
TLS3_k127_1185751_6 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000001842 62.0
TLS3_k127_1185751_7 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0001462 53.0
TLS3_k127_1189516_0 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.000000000000000000000000000000000000000000000001189 183.0
TLS3_k127_1189516_1 Histidine kinase - - - 0.000000000000000000000000000001797 136.0
TLS3_k127_1191932_0 Hpt domain - - - 0.000000000000000000000000000000000000000000000004756 190.0
TLS3_k127_1193703_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000000000000000000000000000000000002592 179.0
TLS3_k127_1193703_1 Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000002739 66.0
TLS3_k127_1195173_0 AAA domain (Cdc48 subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 321.0
TLS3_k127_1195173_1 VWA containing CoxE family protein K09989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009154 310.0
TLS3_k127_1195173_2 membrane - - - 0.00009791 50.0
TLS3_k127_1195953_0 protein transport K03210 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000004824 86.0
TLS3_k127_1195953_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.0000000000000001281 92.0
TLS3_k127_1201577_0 TonB dependent receptor K02014 - - 0.0000000000003022 80.0
TLS3_k127_1201577_1 Zinc metalloprotease (Elastase) - - - 0.00007694 53.0
TLS3_k127_1218537_0 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000134 224.0
TLS3_k127_1218537_1 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000000005587 151.0
TLS3_k127_1218537_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904 - 0.000000000000000000001864 94.0
TLS3_k127_1225238_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 335.0
TLS3_k127_1225238_1 glyoxalase III activity - - - 0.00000000000000000000002925 105.0
TLS3_k127_1234380_0 Histidine kinase K02482 - 2.7.13.3 0.00000000000000000004755 98.0
TLS3_k127_1234380_1 Response regulator receiver - - - 0.0000000006687 70.0
TLS3_k127_1236783_0 Transglutaminase-like superfamily - - - 0.0000000000001629 81.0
TLS3_k127_1248821_0 - - - - 0.00000000000001666 86.0
TLS3_k127_1262961_0 protein conserved in bacteria K09788 GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046459,GO:0071704,GO:0072329,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 509.0
TLS3_k127_1262961_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000005303 103.0
TLS3_k127_1262961_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000002254 95.0
TLS3_k127_1266403_0 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.000000000000000000000000000000005068 138.0
TLS3_k127_1266403_1 CAAX protease self-immunity K07052 - - 0.0000008978 54.0
TLS3_k127_1274901_0 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000002578 104.0
TLS3_k127_1274901_1 Membrane-bound metallopeptidase - - - 0.0000000000641 72.0
TLS3_k127_1275670_0 PFAM NADH flavin oxidoreductase NADH oxidase K10680 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 512.0
TLS3_k127_1275670_1 - - - - 0.00000000000000000000000000000000000000000000001732 180.0
TLS3_k127_1275670_2 WHG domain - - - 0.000000000000000000000000000006051 123.0
TLS3_k127_1275670_3 Domain of unknown function (DUF4281) - - - 0.0000000000000000000000000003425 119.0
TLS3_k127_1276189_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 286.0
TLS3_k127_1277692_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000597 364.0
TLS3_k127_1286054_0 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000001071 84.0
TLS3_k127_1286054_1 Protein conserved in bacteria - - - 0.00006221 53.0
TLS3_k127_1291931_0 Protein of unknown function (DUF962) - - - 0.000000000000000000000000000000000000000000000000000002011 196.0
TLS3_k127_1298897_0 domain-containing protein K16726 GO:0000785,GO:0001568,GO:0001654,GO:0001745,GO:0001751,GO:0001754,GO:0001817,GO:0001819,GO:0001944,GO:0001955,GO:0002376,GO:0002682,GO:0002684,GO:0002697,GO:0002699,GO:0002831,GO:0002833,GO:0003674,GO:0003682,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005694,GO:0005737,GO:0006275,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007005,GO:0007010,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007275,GO:0007346,GO:0007399,GO:0007423,GO:0007492,GO:0008150,GO:0009605,GO:0009607,GO:0009617,GO:0009653,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009894,GO:0009895,GO:0009966,GO:0009967,GO:0009987,GO:0010506,GO:0010507,GO:0010556,GO:0010564,GO:0010639,GO:0010646,GO:0010647,GO:0010821,GO:0010823,GO:0010927,GO:0010941,GO:0012505,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019730,GO:0019899,GO:0019900,GO:0019901,GO:0021700,GO:0022008,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030182,GO:0030239,GO:0031032,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031329,GO:0031330,GO:0031347,GO:0031349,GO:0031430,GO:0031672,GO:0031674,GO:0031965,GO:0031967,GO:0031975,GO:0032101,GO:0032103,GO:0032501,GO:0032502,GO:0032989,GO:0033043,GO:0039531,GO:0039533,GO:0039535,GO:0040011,GO:0042692,GO:0042742,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043122,GO:0043123,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043292,GO:0043900,GO:0043902,GO:0044085,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0045087,GO:0045088,GO:0045089,GO:0045214,GO:0045595,GO:0045596,GO:0045787,GO:0045931,GO:0046530,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048592,GO:0048646,GO:0048699,GO:0048731,GO:0048749,GO:0048856,GO:0048869,GO:0050688,GO:0050776,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051052,GO:0051093,GO:0051128,GO:0051129,GO:0051146,GO:0051147,GO:0051148,GO:0051150,GO:0051151,GO:0051171,GO:0051239,GO:0051240,GO:0051704,GO:0051707,GO:0051716,GO:0051726,GO:0055001,GO:0055002,GO:0060255,GO:0060361,GO:0060548,GO:0061061,GO:0065007,GO:0070925,GO:0071695,GO:0071840,GO:0072358,GO:0072359,GO:0080090,GO:0080134,GO:0090068,GO:0090596,GO:0097435,GO:0098542,GO:0099080,GO:0099081,GO:0099512,GO:1900087,GO:1900245,GO:1900246,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902531,GO:1902533,GO:1902806,GO:1902808,GO:1903146,GO:1903147,GO:2000045,GO:2000112 - 0.00000000000000000000000000000000000000000009936 181.0
TLS3_k127_1299028_0 Class II Aldolase and Adducin N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000001876 209.0
TLS3_k127_1299028_1 to Saccharomyces cerevisiae FAS1 (YKL182W) K00667,K00668 GO:0001676,GO:0003674,GO:0003824,GO:0004312,GO:0004313,GO:0004314,GO:0004317,GO:0004318,GO:0004319,GO:0004321,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005811,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016409,GO:0016417,GO:0016418,GO:0016419,GO:0016420,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0072330,GO:1901576 2.3.1.86 0.0000000000000000000000000000000004173 145.0
TLS3_k127_1300475_0 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000000000000000000002712 180.0
TLS3_k127_1300475_1 Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K04757 - 2.7.11.1 0.000000000000006966 80.0
TLS3_k127_1303519_0 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000003066 162.0
TLS3_k127_1303519_1 Phenylacetate-CoA oxygenase - - - 0.000000000000000001668 94.0
TLS3_k127_1303519_2 Acetyl xylan esterase (AXE1) K01060 - 3.1.1.41 0.000000000000001346 88.0
TLS3_k127_1303519_3 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.00001269 52.0
TLS3_k127_1310297_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005333 426.0
TLS3_k127_1310297_1 domain protein - - - 0.00000000000000000000000004059 117.0
TLS3_k127_1311480_0 PFAM Cytochrome c assembly protein K02198 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 391.0
TLS3_k127_1311480_1 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 0.00000000000000000000000000000000000000000000000000000000001427 218.0
TLS3_k127_1311480_2 Lipocalin-like domain - - - 0.00000000000009496 72.0
TLS3_k127_1311627_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 372.0
TLS3_k127_1311627_1 Domain of unknown function (DUF4143) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009618 304.0
TLS3_k127_1311627_2 Rhodanese Homology Domain K06917 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 296.0
TLS3_k127_1311627_3 s1 p1 nuclease K05986 - 3.1.30.1 0.00000000000000000000000000000000000000001075 162.0
TLS3_k127_1313431_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008023 324.0
TLS3_k127_1321830_0 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 439.0
TLS3_k127_1321830_1 epimerase K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 430.0
TLS3_k127_1321830_2 Ceramidase - - - 0.00000000000000000000000000000002057 135.0
TLS3_k127_1321830_3 PhnA domain K06193 - - 0.00000000000000000000000002146 109.0
TLS3_k127_1321830_4 regulation of ryanodine-sensitive calcium-release channel activity - - - 0.0000000000000000001802 94.0
TLS3_k127_1321830_5 outer membrane autotransporter barrel domain - - - 0.00000000000000002108 92.0
TLS3_k127_1326663_0 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000004882 190.0
TLS3_k127_1326663_1 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.000000000000000000000000000000000000000002228 161.0
TLS3_k127_1326663_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000009851 102.0
TLS3_k127_1326663_3 - - - - 0.0000000000001089 76.0
TLS3_k127_1333857_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 306.0
TLS3_k127_1333857_1 serine acetyltransferase K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006599 278.0
TLS3_k127_1333857_2 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000001926 176.0
TLS3_k127_1333857_3 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.00000000000000000000000000000000000008313 152.0
TLS3_k127_1333857_4 PAS domain containing protein - - - 0.00000000000000000000000000000006083 143.0
TLS3_k127_1338335_0 Zinc-dependent metalloprotease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001539 260.0
TLS3_k127_1343772_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000003872 233.0
TLS3_k127_1346953_0 Dehydrogenase K00248,K09478 - 1.3.8.1,1.3.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 528.0
TLS3_k127_1347979_0 - - - - 0.000000000002104 79.0
TLS3_k127_1349439_0 Metallopeptidase family M24 K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009223 279.0
TLS3_k127_1349439_1 Belongs to the peptidase S16 family - - - 0.0000000000000000000000000000000000000000000000000366 184.0
TLS3_k127_1349439_2 - - - - 0.00000000000000000000000000000000000000008722 164.0
TLS3_k127_135405_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain K19694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001501 273.0
TLS3_k127_135405_1 - - - - 0.0000323 51.0
TLS3_k127_1356037_0 Component of the core of the flagella K02406 GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 345.0
TLS3_k127_1356037_1 Integral membrane protein - - - 0.000000000000002961 77.0
TLS3_k127_1376577_0 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000004364 274.0
TLS3_k127_1376577_1 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000009402 216.0
TLS3_k127_1376577_10 Putative zinc-finger - - - 0.00004522 49.0
TLS3_k127_1376577_2 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000004732 181.0
TLS3_k127_1376577_3 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000002459 164.0
TLS3_k127_1376577_4 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000003788 157.0
TLS3_k127_1376577_5 DoxX-like family - - - 0.000000000000000000000000000002076 126.0
TLS3_k127_1376577_7 Glutaredoxin K03676,K06191 - - 0.000000000000000002937 87.0
TLS3_k127_1376577_8 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000003498 79.0
TLS3_k127_1376577_9 Sigma-70 region 2 K03088 - - 0.0000000000003514 77.0
TLS3_k127_1381061_0 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000009146 221.0
TLS3_k127_1381061_1 Glyoxalase K04750 - - 0.00000000000000000000000000000000000000714 155.0
TLS3_k127_1381061_2 DoxX-like family - - - 0.00000000000000000000000000000000001638 139.0
TLS3_k127_1387061_0 PFAM Transketolase, C-terminal domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000075 329.0
TLS3_k127_1387061_1 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000003194 209.0
TLS3_k127_1387061_2 Stage II sporulation K07315 - 3.1.3.3 0.0000000007128 71.0
TLS3_k127_1387061_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000001228 62.0
TLS3_k127_1387061_4 Putative diguanylate phosphodiesterase - - - 0.00005222 55.0
TLS3_k127_1389102_0 response regulator, receiver - - - 0.0000000000006619 80.0
TLS3_k127_1389102_1 Methyltransferase K08316 - 2.1.1.171 0.00000000002074 72.0
TLS3_k127_1389102_2 Enoyl-CoA hydratase/isomerase - - - 0.00003974 51.0
TLS3_k127_1391803_0 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000000000000000000000000001144 139.0
TLS3_k127_1391958_0 - - - - 0.0000000000000003995 83.0
TLS3_k127_1391958_1 amidohydrolase - - - 0.000000000001785 70.0
TLS3_k127_1397348_0 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000008889 72.0
TLS3_k127_1397348_1 - - - - 0.00004968 51.0
TLS3_k127_1400834_0 Belongs to the peptidase S16 family - - - 9.325e-211 668.0
TLS3_k127_1400834_1 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000563 160.0
TLS3_k127_1406189_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 3.679e-196 619.0
TLS3_k127_1413385_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000006683 224.0
TLS3_k127_1413385_1 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000003386 61.0
TLS3_k127_1432068_0 SMART alpha amylase catalytic sub domain K01187,K05343 - 3.2.1.1,3.2.1.20,5.4.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 509.0
TLS3_k127_1432068_1 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 411.0
TLS3_k127_1432068_2 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000127 77.0
TLS3_k127_1433059_0 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000637 533.0
TLS3_k127_1433059_1 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000000004749 142.0
TLS3_k127_1436736_0 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000001807 153.0
TLS3_k127_1436736_2 methyl-accepting chemotaxis protein K03406,K05874 - - 0.00003267 55.0
TLS3_k127_145788_0 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009991 402.0
TLS3_k127_145914_0 Cytochrome C biogenesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 385.0
TLS3_k127_145914_1 Sugar (and other) transporter K08151 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009331 350.0
TLS3_k127_145914_2 Glycosyl hydrolases family 18 - - - 0.0000000000000000000000000000000008136 145.0
TLS3_k127_145914_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000009839 48.0
TLS3_k127_1459309_0 Releases the N-terminal proline from various substrates K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 533.0
TLS3_k127_1459309_1 DNA alkylation repair - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 314.0
TLS3_k127_1459309_2 anion transmembrane transporter activity K02049 - - 0.00000000000000000000000000000004792 141.0
TLS3_k127_1459309_3 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000003686 119.0
TLS3_k127_1459309_4 COG2010 Cytochrome c, mono- and diheme variants K07243 - - 0.00001025 51.0
TLS3_k127_145984_0 Transporter, MotA TolQ ExbB proton channel family protein K03561 - - 0.000000000000003941 78.0
TLS3_k127_145984_1 Transport energizing protein, ExbD TolR family K03559 - - 0.0000000000005588 74.0
TLS3_k127_1461663_0 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000529 235.0
TLS3_k127_1461830_0 Transport of potassium into the cell K03549 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 540.0
TLS3_k127_1461830_1 Carboxyl transferase domain K01969 - 6.4.1.4 0.00000000000000000003385 94.0
TLS3_k127_1482243_0 Belongs to the glycosyl hydrolase 43 family K01218 - 3.2.1.78 3.35e-268 837.0
TLS3_k127_1482243_1 polysaccharide catabolic process K07407 - 3.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 329.0
TLS3_k127_1482243_2 major facilitator superfamily MFS_1 - - - 0.00000000000000001482 95.0
TLS3_k127_1482243_3 COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog - - - 0.00000000000005543 85.0
TLS3_k127_1487209_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 377.0
TLS3_k127_1487209_1 Integrin alpha (beta-propellor repeats). - - - 0.00000000000000000000000000000004691 143.0
TLS3_k127_1487209_2 - K03561,K12287 - - 0.0000000000000000000000000004487 131.0
TLS3_k127_1487209_3 TRAP transporter solute receptor TAXI family - - - 0.0000000000000007881 91.0
TLS3_k127_1487291_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 374.0
TLS3_k127_1487291_1 alpha beta - - - 0.0000000000000000000000000000000000000000000000000000000000034 222.0
TLS3_k127_1487291_2 Serine aminopeptidase, S33 - - - 0.000000000000000000000000007658 112.0
TLS3_k127_1489419_0 Exporters of the RND superfamily K07003 - - 0.000000000000000000000000000000000000000000000000000000000000009986 228.0
TLS3_k127_1489419_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000001605 190.0
TLS3_k127_1489419_2 Outer membrane lipoprotein-sorting protein - - - 0.000000000000000000000000000000000000000000000000000756 194.0
TLS3_k127_1489419_3 COG0534 Na -driven multidrug efflux pump K03327 - - 0.00000000000000000000000000000000000003695 149.0
TLS3_k127_1489419_4 Sh3 type 3 domain protein - - - 0.00000001109 67.0
TLS3_k127_1492262_0 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 398.0
TLS3_k127_1492262_1 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.000000000000000000002405 101.0
TLS3_k127_1510089_0 Cobalamin synthesis protein cobW C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 509.0
TLS3_k127_1510089_1 TonB dependent receptor K02014,K16087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 393.0
TLS3_k127_1510089_2 ATP-NAD kinase K00850 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005649 318.0
TLS3_k127_1510089_3 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000001679 98.0
TLS3_k127_1519707_0 Chitobiase/beta-hexosaminidase C-terminal domain - - - 0.000000000003964 81.0
TLS3_k127_1519707_1 cell wall anchor domain - - - 0.0001356 56.0
TLS3_k127_1522237_0 Large family of predicted nucleotide-binding domains - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001549 258.0
TLS3_k127_1522237_1 CarD-like/TRCF domain K07736 - - 0.0000000000000000000000000000000002042 137.0
TLS3_k127_1522237_2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000003478 103.0
TLS3_k127_1522237_3 Belongs to the ompA family - - - 0.0000000000000003548 86.0
TLS3_k127_154714_0 Bile acid sodium symporter K03453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 289.0
TLS3_k127_154714_1 PFAM Glycoside hydrolase 15-related - - - 0.00000000000000000000000000000000000000000000000000000000000006647 233.0
TLS3_k127_1560874_0 NnrS protein K07234 - - 0.00000000000000000000000000000000000000000000009501 182.0
TLS3_k127_1560874_1 Copper resistance protein D - - - 0.000000000000000000000000000000000000414 144.0
TLS3_k127_1560874_2 HHE cation binding domain K07216 - - 0.000000000000000006879 91.0
TLS3_k127_1561215_0 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000005068 69.0
TLS3_k127_1561215_1 PFAM Na Pi-cotransporter K03324 - - 0.0000884 52.0
TLS3_k127_1567795_0 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000001607 209.0
TLS3_k127_1567795_1 Ion channel K10716 - - 0.0000000000000000000000000000000000000000000002069 177.0
TLS3_k127_1568831_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000007644 213.0
TLS3_k127_1568831_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000003567 126.0
TLS3_k127_1572476_0 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000006697 148.0
TLS3_k127_1572476_1 PGAP1-like protein - - - 0.00000003906 64.0
TLS3_k127_1578432_0 pfam abc1 K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001772 284.0
TLS3_k127_1578432_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000003156 101.0
TLS3_k127_1580207_0 Caspase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002811 254.0
TLS3_k127_1580207_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000004534 124.0
TLS3_k127_1580207_2 Belongs to the methyltransferase superfamily K06969 - 2.1.1.191 0.000000000000000000000000002914 115.0
TLS3_k127_1580207_3 AntiSigma factor - - - 0.00000000000005316 81.0
TLS3_k127_1581135_0 UvrD-like helicase C-terminal domain K03656,K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 296.0
TLS3_k127_1586078_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002271 524.0
TLS3_k127_1590097_0 PNKP adenylyltransferase domain, ligase domain K01090 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004938 599.0
TLS3_k127_159545_0 Belongs to the enoyl-CoA hydratase isomerase family K01692 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000298 224.0
TLS3_k127_159545_1 helix_turn_helix, Lux Regulon K11624 - - 0.00000000000000000005956 97.0
TLS3_k127_159952_0 N-terminal domain of unknown function (DUF4140) - - - 0.0000000000000000000000000000000000000005839 168.0
TLS3_k127_1604196_0 Methyl-viologen-reducing hydrogenase, delta subunit K02572,K02573,K03522 - - 0.000000000000000000000000000000000000000000000000000000000000006793 242.0
TLS3_k127_1612781_0 - - - - 0.00000000000000000000000000008112 129.0
TLS3_k127_1614062_0 Histidine kinase - - - 0.0000021 59.0
TLS3_k127_1614062_1 TIGRFAM phosphonate ABC transporter, periplasmic phosphonate-binding protein K02044 - - 0.0001975 48.0
TLS3_k127_1616340_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003829 254.0
TLS3_k127_1616340_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000005717 152.0
TLS3_k127_1616451_0 Activated RNA polymerase II transcriptional coactivator - GO:0000981,GO:0001205,GO:0001228,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003700,GO:0003705,GO:0003712,GO:0003713,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005667,GO:0005730,GO:0006139,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045893,GO:0045935,GO:0045944,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0060260,GO:0060261,GO:0060395,GO:0065007,GO:0070013,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.00002085 49.0
TLS3_k127_1617311_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000875 168.0
TLS3_k127_1617311_1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000007075 114.0
TLS3_k127_1617311_2 Non-essential cell division protein that could be required for efficient cell constriction K20276 - - 0.00000000000000003753 88.0
TLS3_k127_1632286_0 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 547.0
TLS3_k127_1632286_1 ATP-binding region, ATPase domain protein domain protein - - - 0.0002299 47.0
TLS3_k127_1645781_0 Uncharacterized protein family UPF0004 - - - 0.0000000000000000000000000000000000000000000000000000103 201.0
TLS3_k127_164580_0 cyclic nucleotide-binding - - - 0.00000000000000000000000003736 110.0
TLS3_k127_1645824_0 Concanavalin A-like lectin/glucanases superfamily - - - 0.00000000000000000000009765 113.0
TLS3_k127_1648429_0 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 2.087e-231 724.0
TLS3_k127_1648429_1 serine acetyltransferase K00640 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000001252 235.0
TLS3_k127_1649702_0 protein involved in formation of curli polymers - - - 0.00001088 55.0
TLS3_k127_16508_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000006535 211.0
TLS3_k127_16508_1 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K00980 - 2.7.7.39 0.000000000000000000000000000009496 120.0
TLS3_k127_1666135_0 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007983 414.0
TLS3_k127_1666135_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.0000000000000000000000000000000005403 131.0
TLS3_k127_1668228_0 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008384 306.0
TLS3_k127_1668228_1 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.000000000000000000000007139 106.0
TLS3_k127_1671364_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 299.0
TLS3_k127_1671364_1 pfam abc K02065 - - 0.000000000000000000000000000000000000000000000006802 177.0
TLS3_k127_1671364_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000004619 61.0
TLS3_k127_1672576_0 Binds the 23S rRNA K02909 - - 0.00000000000000000000001408 101.0
TLS3_k127_1672576_1 Fatty acid hydroxylase superfamily - - - 0.000001312 55.0
TLS3_k127_1673629_0 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000007102 260.0
TLS3_k127_1673629_1 Appr-1'-p processing enzyme - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000002741 71.0
TLS3_k127_1677191_0 Flagellar protein (FlbD) K02385 - - 0.0000000000001162 72.0
TLS3_k127_1677191_1 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.00000001116 63.0
TLS3_k127_1681568_0 Transglutaminase-like superfamily - - - 0.0000000000000001757 87.0
TLS3_k127_1681568_1 Calcineurin-like phosphoesterase superfamily domain K01113 - 3.1.3.1 0.00000000001976 74.0
TLS3_k127_1686212_0 Periplasmic protein TonB links inner and outer membranes - - - 0.00000000000000000000002912 114.0
TLS3_k127_1691444_0 ribonuclease - GO:0005575,GO:0005576 - 0.00000000000000000000000000000001826 131.0
TLS3_k127_1691444_1 PFAM Integral membrane protein TerC - - - 0.0000000008608 67.0
TLS3_k127_1691444_2 ribonuclease inhibitor K03623 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000001981 60.0
TLS3_k127_1694436_0 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004664 334.0
TLS3_k127_1698709_0 COG2755 Lysophospholipase L1 and related esterases - - - 0.0000001773 63.0
TLS3_k127_1713613_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009326 316.0
TLS3_k127_1714693_0 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000106 138.0
TLS3_k127_1714693_1 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000002729 95.0
TLS3_k127_1722064_0 COG1734 DnaK suppressor protein - - - 0.00000000000000000000009116 101.0
TLS3_k127_1722064_1 PFAM MgtE intracellular K02383 - - 0.0000000000007915 76.0
TLS3_k127_1722064_2 heme binding - - - 0.0000000001567 65.0
TLS3_k127_1722064_3 FAD-binding domain - - - 0.00003737 50.0
TLS3_k127_1723312_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 4.511e-217 681.0
TLS3_k127_1724383_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000003636 196.0
TLS3_k127_1726608_0 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000002397 238.0
TLS3_k127_1728973_0 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000341 300.0
TLS3_k127_1728973_1 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000008337 120.0
TLS3_k127_1728973_2 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000009801 128.0
TLS3_k127_1728973_3 NUDIX hydrolase - - - 0.000000000002846 72.0
TLS3_k127_1729607_0 COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster K06877 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 479.0
TLS3_k127_1729747_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005125 450.0
TLS3_k127_1733249_0 PFAM type II secretion system protein G K02456 - - 0.000000000000000181 81.0
TLS3_k127_1733249_1 Response regulator receiver domain - - - 0.0000000000000007035 81.0
TLS3_k127_1734984_0 Belongs to the ClpA ClpB family K03694 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - 0.0000000000000000000000000000000000000000000004737 175.0
TLS3_k127_1734984_1 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000001378 114.0
TLS3_k127_1734984_2 STAS domain K06378 - - 0.00000000001934 68.0
TLS3_k127_1735452_0 Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum K13626 - - 0.0000000000000000005384 92.0
TLS3_k127_1735452_1 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding K03563 - - 0.0000000000000000008201 88.0
TLS3_k127_1735452_2 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000974 83.0
TLS3_k127_1750670_0 Belongs to the RimK family K05844 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000000000000000004387 174.0
TLS3_k127_1750670_1 ATP-dependent DNA helicase - - - 0.0000000000000000000000000003905 128.0
TLS3_k127_1750670_2 it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction K03656 - 3.6.4.12 0.0000002783 63.0
TLS3_k127_1755262_0 SPFH domain / Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 419.0
TLS3_k127_1755262_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 318.0
TLS3_k127_1755262_2 COG1055 Na H antiporter NhaD and related arsenite permeases - - - 0.0000000000000000000355 91.0
TLS3_k127_1755262_3 His Kinase A (phosphoacceptor) domain K02484,K07653,K07654,K11617 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023051,GO:0023052,GO:0023057,GO:0035556,GO:0036211,GO:0042802,GO:0042803,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046983,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070297,GO:0070298,GO:0071704,GO:0140096,GO:1901564,GO:1902531,GO:1902532 2.7.13.3 0.0004837 51.0
TLS3_k127_1759909_0 1-aminocyclopropane-1-carboxylate deaminase K01505 - 3.5.99.7 0.00000000000000000001998 102.0
TLS3_k127_1759909_1 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.0000000000000000001971 93.0
TLS3_k127_1765766_0 domain protein K01179,K12567,K20276 - 2.7.11.1,3.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000002826 255.0
TLS3_k127_1767069_0 Mur ligase middle domain protein K02558 - 6.3.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005597 329.0
TLS3_k127_1767069_1 Pheromone shutdown protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006221 264.0
TLS3_k127_1767069_2 PFAM Forkhead-associated - - - 0.0000000000008095 76.0
TLS3_k127_176956_0 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.0000000000000000000000000000000000000000000000000006729 194.0
TLS3_k127_176956_1 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000004848 174.0
TLS3_k127_176956_2 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000003921 165.0
TLS3_k127_176956_3 Sigma-70, region 4 K03088 - - 0.0002551 49.0
TLS3_k127_1771296_0 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 504.0
TLS3_k127_1771296_1 cyclic-guanylate-specific phosphodiesterase activity K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004082 381.0
TLS3_k127_1771296_2 response regulator, receiver - - - 0.000000000000000000000000000000000000004457 149.0
TLS3_k127_1778093_0 Flagellar M-ring protein K02409 - - 0.0000000000000000000000000000000000000000000000000000000000000000000312 250.0
TLS3_k127_1778093_1 Flagellar hook-basal body complex protein K02408 - - 0.0001109 46.0
TLS3_k127_1780160_0 helicase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009672 470.0
TLS3_k127_1803092_0 carbon-nitrogen ligase activity, with glutamine as amido-N-donor K09117 - - 0.00000000000000001547 87.0
TLS3_k127_18031_0 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 359.0
TLS3_k127_18031_1 belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000001569 269.0
TLS3_k127_18031_2 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000306 151.0
TLS3_k127_18031_3 7TM diverse intracellular signalling K00694,K07315,K20977 - 2.4.1.12,3.1.3.3 0.00000000000000000000000000000111 138.0
TLS3_k127_18031_4 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000001158 77.0
TLS3_k127_18031_5 SPTR Genome sequencing data, contig C323 - - - 0.000003861 51.0
TLS3_k127_18031_6 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0008189 52.0
TLS3_k127_1803144_0 B domain of TMEM189, localisation domain K20656 - - 0.000000000000000000000000000000000000000000000000000003062 198.0
TLS3_k127_1804700_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001727 266.0
TLS3_k127_1804700_1 CHASE - - - 0.0000000000000000000000000000000000005506 160.0
TLS3_k127_1804700_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000006716 54.0
TLS3_k127_1806422_0 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000841 280.0
TLS3_k127_1806422_1 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.0000000003156 66.0
TLS3_k127_181847_0 transferase activity, transferring glycosyl groups K00694,K00786 - 2.4.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006544 362.0
TLS3_k127_1824982_0 EamA-like transporter family K15268 - - 0.00000000000000000000000000000000000657 144.0
TLS3_k127_1828657_0 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.000000009394 63.0
TLS3_k127_1828657_1 - - - - 0.00002286 55.0
TLS3_k127_1839099_0 Inositol monophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001576 267.0
TLS3_k127_1839099_1 metal-sulfur cluster biosynthetic enzyme K02612,K03593 - - 0.000000000000000000000000000000006554 129.0
TLS3_k127_1839099_2 Water Stress and Hypersensitive response - - - 0.000000000000000000000000002056 122.0
TLS3_k127_184171_0 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 309.0
TLS3_k127_184171_1 Catalyzes the transamination of the aromatic amino acid forming a ketoacid K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 295.0
TLS3_k127_1842129_0 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006137 280.0
TLS3_k127_1842129_1 Peptidase, M23 K21471 - - 0.00000000000000000000000000004672 131.0
TLS3_k127_1842129_2 PpiC-type peptidyl-prolyl cis-trans isomerase K03771 - 5.2.1.8 0.0000000526 64.0
TLS3_k127_1842129_3 Iron-sulfur cluster-binding domain - - - 0.0002404 51.0
TLS3_k127_1844246_0 HlyD family secretion protein K02005 - - 0.0000000000000000000000000000000001689 137.0
TLS3_k127_1845838_0 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002836 493.0
TLS3_k127_1845838_1 Flagellar assembly protein FliH K02411 - - 0.0000000000000000000000000000000000000000000000002458 187.0
TLS3_k127_1845838_2 Flagellar protein export ATPase FliI K02412 - 3.6.3.14 0.000000000000000000000000000000000000003711 153.0
TLS3_k127_1845838_3 Flagellar M-ring protein K02409 - - 0.000000000000000000000003229 104.0
TLS3_k127_1848839_0 transferase activity, transferring glycosyl groups K16555,K16564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000003783 238.0
TLS3_k127_1848839_1 PFAM Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000005661 99.0
TLS3_k127_1848839_2 - - - - 0.00000000000000007718 87.0
TLS3_k127_1860276_0 Glycosyl transferases group 1 K08256 GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 0.000000000000000000000000000000000004857 146.0
TLS3_k127_1860276_1 GtrA-like protein K00995 - 2.7.8.5 0.000000000000000000000000000002717 128.0
TLS3_k127_1861014_0 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000001874 232.0
TLS3_k127_1861014_1 methylenetetrahydrofolate reductase (NAD(P)H) activity K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000576 191.0
TLS3_k127_1865432_0 EcsC protein family - - - 0.0000000000000000000000000000000000000000000000004674 183.0
TLS3_k127_1865432_1 - - - - 0.0000000000000000000000000000006084 124.0
TLS3_k127_186597_0 PFAM pyruvate phosphate dikinase PEP pyruvate-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 417.0
TLS3_k127_186597_1 COG2885 Outer membrane protein and related peptidoglycan-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008615 377.0
TLS3_k127_186597_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K13598 - 2.7.13.3 0.0000001523 63.0
TLS3_k127_186597_3 STAS domain K04749 - - 0.00001102 51.0
TLS3_k127_1867703_0 GTP cyclohydrolase I - - - 0.000000000000000000000000000000000000000000000000000000000000000000109 235.0
TLS3_k127_1867703_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065 6.1.1.16,6.3.1.13 0.0000000000000000000000000000000000000000000000000000001816 199.0
TLS3_k127_187039_0 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000001687 226.0
TLS3_k127_187039_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000009789 126.0
TLS3_k127_187039_2 PFAM Phosphoesterase, HXTX - - - 0.0000000000000000002878 96.0
TLS3_k127_1879692_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008665 396.0
TLS3_k127_1879692_1 S4 RNA-binding domain K06180 - 5.4.99.23 0.00000000000000000000000000000000000000005693 164.0
TLS3_k127_1897433_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000002723 86.0
TLS3_k127_1897433_1 domain protein - - - 0.0000000001766 65.0
TLS3_k127_1915023_0 Hydrophobe amphiphile Efflux-1 (HAE1) family K18138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008112 450.0
TLS3_k127_1915023_1 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000005788 143.0
TLS3_k127_1915023_2 - - - - 0.0000004286 57.0
TLS3_k127_1925861_0 Dual specificity phosphatase, catalytic domain - - - 5.705e-198 644.0
TLS3_k127_1925861_1 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.000000000007807 69.0
TLS3_k127_1927054_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 566.0
TLS3_k127_1932019_0 DNA or RNA helicase of superfamily II K10843 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 531.0
TLS3_k127_1939017_1 - - - - 0.0001317 53.0
TLS3_k127_1940938_0 FAD binding domain K05712 - 1.14.13.127 0.0000000000000000000000000000000000000000001345 168.0
TLS3_k127_1940938_1 AraC family - - - 0.0000000000000000000147 104.0
TLS3_k127_1942071_0 TIGRFAM sulfate ABC transporter, inner membrane subunit CysW K02047 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 367.0
TLS3_k127_1942071_1 Binding-protein-dependent transport system inner membrane component K02046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008761 332.0
TLS3_k127_1944411_0 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 461.0
TLS3_k127_1944411_1 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000008352 154.0
TLS3_k127_194566_0 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.0000000000000000000000000000000000000000000000000000000000001278 227.0
TLS3_k127_1951831_0 Hpt domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004449 309.0
TLS3_k127_1951831_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00005115 53.0
TLS3_k127_195655_0 alcohol dehydrogenase K13954,K19954 - 1.1.1.1 0.00000000000000000000000000000000000000002089 167.0
TLS3_k127_1957392_0 Aldo keto reductase - GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016491,GO:0016614,GO:0016616,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:1990928 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 405.0
TLS3_k127_1957392_1 DoxX K15977 - - 0.0000000000000000000000000000000000000000000004625 172.0
TLS3_k127_1957392_2 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000006143 70.0
TLS3_k127_1957392_3 transcriptional regulator - - - 0.0000000009392 61.0
TLS3_k127_1957392_4 Domain of unknown function (DUF4215) - - - 0.000004297 57.0
TLS3_k127_1958483_0 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.000000000000000000000000000000001596 143.0
TLS3_k127_1964721_0 COGs COG0659 Sulfate permease and related transporter (MFS superfamily) - - - 0.000000000000000000000000000007146 123.0
TLS3_k127_1964721_1 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0009356 49.0
TLS3_k127_1966968_0 PFAM Helicase conserved C-terminal domain K06877 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001059 246.0
TLS3_k127_1966968_1 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.00000000000000000000000000000000000000000000000000000009066 207.0
TLS3_k127_1966968_2 Belongs to the SUA5 family - - - 0.0000000000000000000000000000000000006063 147.0
TLS3_k127_1966968_3 RibD C-terminal domain K00287 - 1.5.1.3 0.00003744 48.0
TLS3_k127_1966968_4 COG0604 NADPH quinone reductase and related Zn-dependent K00344 - 1.6.5.5 0.0004827 43.0
TLS3_k127_1967097_0 stage II sporulation protein E K07315 - 3.1.3.3 0.000000000000000000001052 108.0
TLS3_k127_197424_0 response K18444 - - 0.00000000000000000006644 102.0
TLS3_k127_1980328_0 Belongs to the alpha-IPM synthase homocitrate synthase family K09011 - 2.3.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000896 556.0
TLS3_k127_1980328_1 AhpC TSA family - - - 0.00000000000000000000002807 103.0
TLS3_k127_1983571_0 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 350.0
TLS3_k127_1983571_1 TonB-dependent Receptor Plug Domain - - - 0.00000000000000000000000000001521 126.0
TLS3_k127_1989821_0 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001037 265.0
TLS3_k127_1989821_1 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535,K13599 - 3.5.1.108 0.0000000000000000000000000000000008868 134.0
TLS3_k127_1989821_2 4Fe-4S dicluster domain - - - 0.000000000000000000000004376 110.0
TLS3_k127_1991108_0 O-Antigen ligase K02847 - - 0.0000001536 63.0
TLS3_k127_1993816_0 iron-sulfur binding K00184 - - 1.631e-210 690.0
TLS3_k127_1993816_1 PFAM Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000001658 156.0
TLS3_k127_1993816_2 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000004635 156.0
TLS3_k127_1993816_3 COG2010 Cytochrome c, mono- and diheme variants K07243 - - 0.000000000000007227 81.0
TLS3_k127_1993867_0 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004479 402.0
TLS3_k127_2006071_0 Predicted metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000797 167.0
TLS3_k127_2007170_0 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000791 319.0
TLS3_k127_2007170_1 Protein of unknown function (DUF1761) - - - 0.00000000000000000000000000000008635 126.0
TLS3_k127_2007170_2 membrane K08983 - - 0.0000000000000000000000000005717 119.0
TLS3_k127_2007170_3 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000001259 78.0
TLS3_k127_2007170_4 - - - - 0.0000000000005268 71.0
TLS3_k127_2007170_5 Bacterial regulatory proteins, tetR family - - - 0.0000000002417 68.0
TLS3_k127_2007170_6 Galactose oxidase, central domain - - - 0.0001139 55.0
TLS3_k127_2007299_0 homoserine transmembrane transporter activity K03329,K16327 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039 - 0.00000000000000000000001359 108.0
TLS3_k127_2007299_1 type I secretion outer membrane protein, TolC K12340 - - 0.0002538 53.0
TLS3_k127_2010861_0 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000008408 182.0
TLS3_k127_2010861_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000008538 62.0
TLS3_k127_2013129_0 Putative DNA-binding domain - - - 0.0000000000002302 78.0
TLS3_k127_2015142_0 Serine hydrolase K07002 - - 0.0000000000000000000000000000000000000000001054 163.0
TLS3_k127_2015142_1 pyrroloquinoline quinone binding - - - 0.0000000000000000000000002117 119.0
TLS3_k127_2018868_0 A domain family that is part of the cupin metalloenzyme superfamily. K18850 - 1.14.11.47 0.00000000000000000000000000000000000000000000003239 183.0
TLS3_k127_2018868_1 Thioesterase superfamily protein - - - 0.0000000000002312 73.0
TLS3_k127_2031279_1 Beta-lactamase - - - 0.0005948 42.0
TLS3_k127_2032036_0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000001492 242.0
TLS3_k127_2037891_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000003446 225.0
TLS3_k127_2037891_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000001456 198.0
TLS3_k127_2048393_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.08e-225 705.0
TLS3_k127_2048393_1 - - - - 0.000005854 55.0
TLS3_k127_2056814_0 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003,K05685 - - 6.792e-222 706.0
TLS3_k127_2056814_1 Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II K01835 - 5.4.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009291 333.0
TLS3_k127_2056814_2 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000001812 246.0
TLS3_k127_2057892_0 COG0695 Glutaredoxin and related proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 315.0
TLS3_k127_2057892_1 Ankyrin repeat domain 52 K15502,K15504 - - 0.0000000000002203 80.0
TLS3_k127_2057892_2 6-phosphogluconolactonase K07404 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0017057,GO:0044424,GO:0044444,GO:0044464,GO:0052689 3.1.1.31 0.0000000003404 70.0
TLS3_k127_2062639_0 ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000001104 165.0
TLS3_k127_2065874_0 fatty acid desaturase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 420.0
TLS3_k127_2065925_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 477.0
TLS3_k127_2067217_0 Flagellar motor protein K02557 - - 0.00000000000000000000000000005196 124.0
TLS3_k127_2077895_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000001272 109.0
TLS3_k127_2087509_0 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000002501 193.0
TLS3_k127_2087509_1 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000006488 109.0
TLS3_k127_2091380_0 PFAM GGDEF domain containing protein - - - 0.000000000000003496 86.0
TLS3_k127_2091974_0 - K01278,K03561,K12287 - 3.4.14.5 0.00000000000000000001483 106.0
TLS3_k127_2105293_0 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000002164 261.0
TLS3_k127_2107088_0 subunit (C K02119 - - 0.000000000000000000000000000000165 134.0
TLS3_k127_2107088_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000001037 65.0
TLS3_k127_2108458_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005134 458.0
TLS3_k127_2113943_0 - - - - 0.00000000000000000000000000000000000000000003951 166.0
TLS3_k127_2113943_1 CBS domain K04767,K07168,K07182 - - 0.0000000000000004296 83.0
TLS3_k127_2114350_0 Zinc dependent phospholipase C - - - 0.0000000000000000002883 100.0
TLS3_k127_2114350_1 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000003948 75.0
TLS3_k127_2114448_0 Protein of unknown function (DUF2817) - - - 0.00000000000000000000000000000000000000002386 168.0
TLS3_k127_2114448_1 Hemolysin - - - 0.00000000000000000000000000000848 129.0
TLS3_k127_2114448_2 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000008422 103.0
TLS3_k127_2120254_0 methylcrotonoyl-CoA carboxylase beta chain K01969,K17425 GO:0003674,GO:0003824,GO:0004485,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0007563,GO:0008150,GO:0008152,GO:0009081,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050789,GO:0050793,GO:0051239,GO:0065007,GO:0070013,GO:0071704,GO:1901564,GO:1901605,GO:2000026 6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007422 349.0
TLS3_k127_2120254_1 Enoyl-CoA hydratase K13766 - 4.2.1.18 0.0000000000000000000000000000000000000000000000001173 186.0
TLS3_k127_2128167_0 response regulator K02282,K20971 - - 0.000000000689 70.0
TLS3_k127_2128167_1 response regulator K07712 - - 0.00004955 49.0
TLS3_k127_2138388_0 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004236 281.0
TLS3_k127_2144239_0 malate quinone oxidoreductase K00116 - 1.1.5.4 5.475e-195 618.0
TLS3_k127_2145221_0 Hydrophobe amphiphile Efflux-1 (HAE1) family K18138 - - 1.088e-213 678.0
TLS3_k127_2156276_0 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000008103 119.0
TLS3_k127_2156276_1 - - - - 0.0001022 49.0
TLS3_k127_2160071_0 MFS/sugar transport protein - - - 0.000000000000000000002908 107.0
TLS3_k127_2160071_1 Methyltransferase domain protein - - - 0.000000188 61.0
TLS3_k127_2160071_3 cell wall organization - - - 0.0001169 54.0
TLS3_k127_2161142_0 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009489 348.0
TLS3_k127_216532_0 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.000000000000000000000000001056 119.0
TLS3_k127_216532_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.00002687 54.0
TLS3_k127_216996_0 PFAM Endonuclease Exonuclease phosphatase K07004 - - 0.0000008717 57.0
TLS3_k127_217265_0 phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003804 403.0
TLS3_k127_217265_1 conserved protein (DUF2183) - - - 0.0000000000000000000000000000000000000001015 160.0
TLS3_k127_2172812_0 cyclic nucleotide-binding - - - 0.00000000000000000000000000001412 131.0
TLS3_k127_2172812_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 - 0.00000000000001811 75.0
TLS3_k127_2172827_0 Role in flagellar biosynthesis K02421 - - 0.00000000000000000000000000000000000007329 152.0
TLS3_k127_2172827_1 Flagellar biosynthetic protein FliQ K02420 - - 0.00000000000000000006276 92.0
TLS3_k127_2173893_0 signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000004325 124.0
TLS3_k127_2173929_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000003916 140.0
TLS3_k127_2173929_1 Transcriptional regulatory protein, C terminal K07667 - - 0.00000000000000000000000000009909 117.0
TLS3_k127_2173929_2 - - - - 0.0000001135 56.0
TLS3_k127_218109_0 Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 537.0
TLS3_k127_218109_1 Saccharopine dehydrogenase NADP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002081 276.0
TLS3_k127_218109_2 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000002509 200.0
TLS3_k127_218109_3 PAS fold - - - 0.00000000000000000000000000000000000000000002306 175.0
TLS3_k127_218109_4 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000009439 101.0
TLS3_k127_218109_5 Tetratricopeptide repeat - - - 0.0000000000000471 78.0
TLS3_k127_218109_6 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000005103 68.0
TLS3_k127_218109_7 FecR protein - - - 0.00001684 56.0
TLS3_k127_2182999_0 Amp-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000113 246.0
TLS3_k127_2182999_1 alpha/beta hydrolase fold - - - 0.00000000000000000000344 101.0
TLS3_k127_2186775_0 Metallo-beta-lactamase superfamily - GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006195,GO:0006198,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008081,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009187,GO:0009214,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019932,GO:0019933,GO:0019934,GO:0019935,GO:0023052,GO:0032101,GO:0033036,GO:0034404,GO:0034613,GO:0034641,GO:0034654,GO:0034655,GO:0035556,GO:0040012,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046058,GO:0046434,GO:0046483,GO:0046700,GO:0047555,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0050926,GO:0051179,GO:0051641,GO:0051716,GO:0055086,GO:0061118,GO:0065007,GO:0070727,GO:0071704,GO:0072521,GO:0072523,GO:0072697,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1990778 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 400.0
TLS3_k127_2189458_0 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02461 - - 0.0000169 57.0
TLS3_k127_2190079_0 Sulfate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003966 283.0
TLS3_k127_2190243_0 PFAM Carbamoyl-phosphate synthase L chain ATP-binding K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000001556 195.0
TLS3_k127_219245_0 PFAM glycosyl transferase family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 1.394e-204 661.0
TLS3_k127_219245_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 426.0
TLS3_k127_219245_2 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000000000000000003178 183.0
TLS3_k127_219245_3 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000009285 113.0
TLS3_k127_219245_4 OmpA family - - - 0.0008582 48.0
TLS3_k127_220056_0 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K04068,K10026 - 1.97.1.4,4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000001195 226.0
TLS3_k127_220056_1 TIGRFAM Penicillin-binding protein 2 K05515 - 3.4.16.4 0.0000005213 61.0
TLS3_k127_2200708_0 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000005833 248.0
TLS3_k127_2200708_1 PFAM Integrase catalytic region K07497 - - 0.0000000000000000000000000000000000000000000000000000003464 202.0
TLS3_k127_2204863_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 345.0
TLS3_k127_2204863_1 COGs COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000003017 187.0
TLS3_k127_2207274_0 acyl-CoA dehydrogenase K14448 - 1.3.8.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 472.0
TLS3_k127_2207274_1 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000004505 180.0
TLS3_k127_221094_0 Protein of unknown function (DUF3641) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000814 362.0
TLS3_k127_221094_1 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000004406 142.0
TLS3_k127_221094_2 denitrification pathway - - - 0.00000819 53.0
TLS3_k127_2211857_0 amino acid activation for nonribosomal peptide biosynthetic process K03651,K05889,K12132 - 1.1.2.6,2.7.11.1,3.1.4.53 0.00000004552 64.0
TLS3_k127_2213125_0 Fis Family K02584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007709 356.0
TLS3_k127_2213125_1 SMART Integrin alpha beta-propellor repeat protein - - - 0.0000000000000000000000000000000000000229 162.0
TLS3_k127_2213626_0 PFAM AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 521.0
TLS3_k127_221533_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000005103 154.0
TLS3_k127_221533_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000002067 60.0
TLS3_k127_2219946_0 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.00000000000000000000005211 107.0
TLS3_k127_222181_0 Ferredoxin--NADP reductase K02641 GO:0005575,GO:0005622,GO:0005623,GO:0009579,GO:0016020,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464 1.18.1.2 0.00000000000000000000000000000001244 132.0
TLS3_k127_222181_1 Family 5 K02035,K15580 - - 0.000000000001169 80.0
TLS3_k127_2224650_0 Domain of unknown function (DUF4872) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007399 439.0
TLS3_k127_2224650_1 dicarboxylic acid transport K03309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 386.0
TLS3_k127_2224650_2 Alpha/beta hydrolase family K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001349 251.0
TLS3_k127_2224650_3 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000001464 182.0
TLS3_k127_2224755_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005306 507.0
TLS3_k127_2224755_1 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005298 460.0
TLS3_k127_2231026_0 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007483 280.0
TLS3_k127_2231026_1 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001871 258.0
TLS3_k127_2231026_2 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.0000000000000000000008022 106.0
TLS3_k127_2231026_3 CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.00000000000002245 80.0
TLS3_k127_2231026_4 Tryptophan-rich protein (DUF2389) - - - 0.0000001286 56.0
TLS3_k127_2231026_5 helix_turn_helix, arabinose operon control protein K07720 - - 0.0000003993 59.0
TLS3_k127_2231026_6 Sigma factor PP2C-like phosphatases - - - 0.00001496 58.0
TLS3_k127_2236136_0 RNA repair, ligase-Pnkp-associating, region of Hen1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 531.0
TLS3_k127_2236136_1 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007816 518.0
TLS3_k127_2236136_2 PNKP adenylyltransferase domain, ligase domain - - - 0.00000000000000000000000000004711 117.0
TLS3_k127_2239263_0 Male sterility protein K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 487.0
TLS3_k127_2239263_1 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000005781 223.0
TLS3_k127_2239263_2 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000706 180.0
TLS3_k127_2239263_3 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000004267 76.0
TLS3_k127_2250802_0 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000002362 239.0
TLS3_k127_2250802_1 helix_turn_helix, Lux Regulon K02282 - - 0.00000000000000000000000000001122 124.0
TLS3_k127_2263442_0 Flagellar hook-associated protein, FlgK K02396 - - 0.000000000000000000000000000000000000000000000000000000001454 207.0
TLS3_k127_226371_0 Protein of unknown function (DUF1343) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 304.0
TLS3_k127_228926_0 Putative glycosyl hydrolase domain - - - 0.0000000009027 68.0
TLS3_k127_228926_1 Mycolic acid cyclopropane synthetase K03183 - 2.1.1.163,2.1.1.201 0.00000002354 57.0
TLS3_k127_2299213_0 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07663 - - 0.0000000000000000000000000000000000000000000000000000000000000003716 227.0
TLS3_k127_2299213_1 Histidine kinase K07641,K07711 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031667,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 0.00000000000000000000000000000000000001042 155.0
TLS3_k127_2300633_0 Tetrahydrodipicolinate N-succinyltransferase N-terminal K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009902 354.0
TLS3_k127_2300633_1 PFAM Cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 355.0
TLS3_k127_2300633_2 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 312.0
TLS3_k127_2300633_3 COG2211 Na melibiose symporter and related K03292 - - 0.0000000000000000000000000000000000000000000000000000000008825 217.0
TLS3_k127_2300633_4 tyrosine recombinase XerC K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000001265 208.0
TLS3_k127_2300633_5 - - - - 0.0000000003368 71.0
TLS3_k127_2304595_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000005678 204.0
TLS3_k127_230631_0 Belongs to the ClpA ClpB family K03696 GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - 0.00000000000000000000000000000000000000000000616 171.0
TLS3_k127_230631_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.000000000000000004235 89.0
TLS3_k127_2316164_0 Sugar ABC transporter permease K02026 - - 0.00000000000000000000000000000000000000000000000000000001575 207.0
TLS3_k127_2316164_1 Extracellular solute-binding protein K15770 - - 0.000000000001193 77.0
TLS3_k127_2324790_0 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005824 272.0
TLS3_k127_2324790_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000158 239.0
TLS3_k127_2324790_2 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000002676 57.0
TLS3_k127_2346388_0 Dual-action HEIGH metallo-peptidase - - - 0.0000000009155 70.0
TLS3_k127_2346941_0 fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000001064 188.0
TLS3_k127_2346941_1 tetR family - - - 0.0000000001175 72.0
TLS3_k127_2353603_0 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 420.0
TLS3_k127_2353603_1 ABC transporter K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 306.0
TLS3_k127_2353603_2 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.000003041 56.0
TLS3_k127_2361448_0 COG0208 Ribonucleotide reductase, beta subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008882 320.0
TLS3_k127_2362158_0 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000828 243.0
TLS3_k127_2362158_1 chitinase K01183 - 3.2.1.14 0.0000000000005043 81.0
TLS3_k127_2367009_0 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001736 287.0
TLS3_k127_2367009_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000006221 244.0
TLS3_k127_2367009_2 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.0000000000000000000000000000003014 128.0
TLS3_k127_2367009_3 TIGRFAM Gliding motility-associated protein, GldC - - - 0.00000000000000000000121 98.0
TLS3_k127_2367009_5 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000086 61.0
TLS3_k127_2376239_0 PFAM Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000002056 145.0
TLS3_k127_2376239_1 phosphoesterase, PA-phosphatase related - - - 0.00000000000002588 80.0
TLS3_k127_2381514_0 COGs COG4270 membrane protein - - - 0.000000000000000000000000000000005533 131.0
TLS3_k127_2381514_1 isomerase B K01808 - 5.3.1.6 0.0000000000000000000000000000005328 123.0
TLS3_k127_2386330_0 Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA K00556 - 2.1.1.34 0.0000000000000000000000000000000000000000000003981 174.0
TLS3_k127_2386330_1 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000000000000000000000006897 113.0
TLS3_k127_2399832_0 major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 330.0
TLS3_k127_2399832_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006781 298.0
TLS3_k127_2399832_2 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000001186 186.0
TLS3_k127_2401103_0 cell wall organization - - - 0.0000000004446 73.0
TLS3_k127_2401103_1 Desulfoferrodoxin - - - 0.0000000008905 65.0
TLS3_k127_2407052_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 512.0
TLS3_k127_2407052_1 Type II secretion system (T2SS), protein F K02455,K02653 - - 0.0007 43.0
TLS3_k127_240857_0 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000001052 109.0
TLS3_k127_240857_1 EAL domain - - - 0.000000000000000009795 89.0
TLS3_k127_2410442_0 polysaccharide catabolic process K07407 - 3.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 494.0
TLS3_k127_2410442_1 PFAM glycoside hydrolase, family 16 - - - 0.0000000000000000000004793 113.0
TLS3_k127_2410848_0 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000008081 223.0
TLS3_k127_2410848_1 Cytochrome c - - - 0.00000000000000000000000000000000000000000008396 170.0
TLS3_k127_241285_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 1.648e-214 689.0
TLS3_k127_241285_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000005559 68.0
TLS3_k127_2416149_0 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000004183 179.0
TLS3_k127_2416149_1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - 0.0000000000000000000000000000005066 125.0
TLS3_k127_2416149_2 SnoaL-like domain K06893 - - 0.00000000000000000000001013 105.0
TLS3_k127_2416149_3 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - 0.00000000000000000001033 96.0
TLS3_k127_2420407_0 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 307.0
TLS3_k127_2420407_1 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000135 220.0
TLS3_k127_2420407_2 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000001468 210.0
TLS3_k127_2420407_3 DGC domain - - - 0.00000000000000000000000000000000001536 143.0
TLS3_k127_2420407_4 PFAM Cyclic nucleotide-binding K01420,K21563 - - 0.00000000000000000000002187 108.0
TLS3_k127_2420407_5 SCO1/SenC K07152 - - 0.0000001765 61.0
TLS3_k127_2420480_0 ABC-type sugar transport system periplasmic component K02027 - - 0.000000000594 66.0
TLS3_k127_2420480_1 Belongs to the glycosyl hydrolase 13 family K01200 - 3.2.1.41 0.000000003759 68.0
TLS3_k127_2427305_0 Ammonium Transporter K03320 - - 0.000000000000000001425 88.0
TLS3_k127_242909_0 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000092 460.0
TLS3_k127_242909_1 tRNA-splicing ligase RtcB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000061 314.0
TLS3_k127_242909_2 Ribosome-binding factor A - - - 0.000394 49.0
TLS3_k127_2436414_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008364 618.0
TLS3_k127_2436414_1 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain K19694 - - 0.00000000000000000000000000000000000000000000000000000000000000005653 237.0
TLS3_k127_2437802_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 608.0
TLS3_k127_2437802_1 - K07112 - - 0.00000000000000000000001378 106.0
TLS3_k127_2437802_2 Transporter K07112 - - 0.0000000000000000000006462 99.0
TLS3_k127_2439724_0 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008978 504.0
TLS3_k127_2442697_0 COG2230 Cyclopropane fatty acid synthase and related K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 371.0
TLS3_k127_2442697_1 Beta-lactamase - - - 0.000000000000000002506 91.0
TLS3_k127_2442697_2 B12 binding domain K22491 - - 0.000004605 53.0
TLS3_k127_2443795_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006904 312.0
TLS3_k127_2443795_1 - - - - 0.0000000000000000000000002253 116.0
TLS3_k127_2456451_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005863 320.0
TLS3_k127_2456451_1 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001126 267.0
TLS3_k127_2456451_2 Tellurite resistance protein tehB K03647,K16868 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464 2.1.1.265 0.0000000000000000000000000000000000000000000000000000004216 199.0
TLS3_k127_2456451_3 SpoU rRNA Methylase family - - - 0.000000000000000000000000000000000005473 147.0
TLS3_k127_2456451_5 response regulator, receiver - - - 0.0000000000000000000007315 99.0
TLS3_k127_2457791_0 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007804 251.0
TLS3_k127_2463435_0 Putative metallopeptidase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006076 567.0
TLS3_k127_2464589_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000004352 253.0
TLS3_k127_2467617_0 Endonuclease Exonuclease Phosphatase K01179,K07004 - 3.2.1.4 0.0006886 53.0
TLS3_k127_2472564_0 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 480.0
TLS3_k127_247837_0 Domain of unknown function (DUF4143) - - - 0.00000000000000000000000000000000000000000000000000000000000001762 225.0
TLS3_k127_2484280_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000002659 62.0
TLS3_k127_2488873_0 endonuclease - - - 0.00000000000002745 76.0
TLS3_k127_2488873_1 - - - - 0.000000002482 67.0
TLS3_k127_2494054_0 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000005388 96.0
TLS3_k127_2502840_0 3-beta hydroxysteroid dehydrogenase isomerase K21271,K22320 - 1.1.1.394,1.1.1.412 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 392.0
TLS3_k127_2502840_1 DSBA-like thioredoxin domain K07396 - - 0.0000000000000000000000000000000000000000000000005241 182.0
TLS3_k127_2502840_2 - - - - 0.000000000000000000000000001044 117.0
TLS3_k127_2502840_3 - - - - 0.0000008603 53.0
TLS3_k127_2508825_0 Calcineurin-like phosphoesterase - - - 0.000000000002618 78.0
TLS3_k127_2516796_0 SMART phospholipase D Transphosphatidylase - - - 0.0000000000001605 83.0
TLS3_k127_2516796_1 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.00002062 57.0
TLS3_k127_2518347_0 Zinc finger domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 301.0
TLS3_k127_2518347_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001145 275.0
TLS3_k127_2518347_2 S1 P1 Nuclease - - - 0.000000000005501 69.0
TLS3_k127_2519959_0 Serine phosphatase RsbU regulator of sigma subunit K07315 - 3.1.3.3 0.0000000000000002045 91.0
TLS3_k127_2521960_0 transcriptional regulator K16137 - - 0.0000000000000000000000000000002653 130.0
TLS3_k127_2521960_1 epimerase - - - 0.000000000004079 76.0
TLS3_k127_2521960_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0003758 51.0
TLS3_k127_2527416_0 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.00000000000000000000000004197 118.0
TLS3_k127_2527416_1 single-stranded DNA binding K03111 - - 0.00000000002544 70.0
TLS3_k127_2534022_0 - - - - 0.0000000000003945 82.0
TLS3_k127_2537553_0 NHL repeat containing protein - - - 0.00000000000000004432 94.0
TLS3_k127_2537553_1 peptidyl-tyrosine sulfation - - - 0.0008962 48.0
TLS3_k127_2541283_0 neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000001953 163.0
TLS3_k127_2541283_1 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000003101 110.0
TLS3_k127_2541283_2 Belongs to the ompA family - - - 0.0000000208 64.0
TLS3_k127_254723_0 PFAM Iron-containing alcohol dehydrogenase K00001,K19954 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 306.0
TLS3_k127_254723_1 Hydrophobe amphiphile Efflux-1 (HAE1) family K18138 - - 0.00000007921 57.0
TLS3_k127_2547682_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 9.714e-197 626.0
TLS3_k127_2550391_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681,K20455 GO:0003674,GO:0003824,GO:0003994,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0045333,GO:0046395,GO:0046459,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:1901575 4.2.1.117,4.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 417.0
TLS3_k127_2550391_1 COG1802 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 317.0
TLS3_k127_2550391_2 6-phosphogluconolactonase activity - - - 0.000000000006104 74.0
TLS3_k127_2557139_0 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.00000000000000000000000000000002349 126.0
TLS3_k127_2557139_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000003683 104.0
TLS3_k127_2557139_2 Domain of unknown function (DUF4189) - - - 0.00000000005174 73.0
TLS3_k127_256437_0 - - - - 0.0000000000000000000000000006762 123.0
TLS3_k127_256437_1 PFAM OmpA MotB domain protein K02557 - - 0.00000000000000000000001008 109.0
TLS3_k127_256437_2 glycoside hydrolase - - - 0.00004892 54.0
TLS3_k127_2565798_0 Amidohydrolase family K01464 - 3.5.2.2 3.056e-237 739.0
TLS3_k127_2565798_1 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431,K12251 - 3.5.1.53,3.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 538.0
TLS3_k127_2565798_2 PFAM Permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 350.0
TLS3_k127_2570969_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005531 267.0
TLS3_k127_2570969_1 Peptidase, M23 - - - 0.0000000000000000000000000000000000000000000000000000003515 208.0
TLS3_k127_2570969_2 FAD dependent oxidoreductase - - - 0.000000000002839 78.0
TLS3_k127_2570969_3 Flagellar Assembly Protein A K09749 - - 0.00000001263 64.0
TLS3_k127_2582037_0 COG2223 Nitrate nitrite transporter K02575 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009247 448.0
TLS3_k127_2582037_1 Nitrite and sulphite reductase 4Fe-4S K00362 - 1.7.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 445.0
TLS3_k127_2582037_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000001517 201.0
TLS3_k127_2590508_0 DNA primase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006355 445.0
TLS3_k127_2590508_1 Phage integrase, N-terminal SAM-like domain K04763 - - 0.000000000000000000000000000000000000000000000000000001366 215.0
TLS3_k127_2590508_2 Tyrosine recombinase XerD K04763 - - 0.00000000000000000000000000000000000000000000284 186.0
TLS3_k127_2590508_3 Helix-turn-helix XRE-family like proteins - - - 0.00004061 51.0
TLS3_k127_2595275_0 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000001885 219.0
TLS3_k127_2595275_1 Diguanylate phosphodiesterase - - - 0.0000001807 55.0
TLS3_k127_2597829_0 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000001783 183.0
TLS3_k127_2603392_0 COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000001441 231.0
TLS3_k127_2603392_1 Efflux transporter, RND family, MFP subunit K02005 - - 0.0000000000000000000000000000000000000000000189 172.0
TLS3_k127_2617547_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000001101 160.0
TLS3_k127_2617547_1 Tyrosine recombinase XerC K04763 - - 0.0001006 46.0
TLS3_k127_2625845_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 349.0
TLS3_k127_2642938_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 8.382e-226 707.0
TLS3_k127_2642938_1 flavoprotein involved in K transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 464.0
TLS3_k127_2642938_2 Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000002045 199.0
TLS3_k127_2642938_3 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000004378 103.0
TLS3_k127_2642938_4 - - - - 0.000006351 53.0
TLS3_k127_2647971_0 beta-1,4-mannooligosaccharide phosphorylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 562.0
TLS3_k127_2647971_1 Glycosyltransferase Family 4 - - - 0.00000000000000001788 82.0
TLS3_k127_2647971_2 methylenetetrahydrofolate reductase (NAD(P)H) activity K00297 - 1.5.1.20 0.000000000005718 66.0
TLS3_k127_2653334_0 aspartate kinase, monofunctional class K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 452.0
TLS3_k127_2653334_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 304.0
TLS3_k127_2653334_2 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000001249 240.0
TLS3_k127_2653334_3 Aspartyl protease - - - 0.00000000000000000000000000000000000000403 150.0
TLS3_k127_2653334_4 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.0000000000000003652 93.0
TLS3_k127_265552_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000006493 264.0
TLS3_k127_265552_1 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000008987 62.0
TLS3_k127_265552_2 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - - 0.00009106 46.0
TLS3_k127_2657045_0 PFAM MCP methyltransferase CheR-type K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 356.0
TLS3_k127_2657045_1 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000007399 189.0
TLS3_k127_2657045_2 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000002808 158.0
TLS3_k127_2657045_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000006005 144.0
TLS3_k127_2657045_4 His Kinase A (phosphoacceptor) domain - - - 0.0000000002044 66.0
TLS3_k127_2659865_0 glutamine synthetase K01915 - 6.3.1.2 6.082e-229 715.0
TLS3_k127_2659865_1 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000000000000000008192 223.0
TLS3_k127_2659865_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000001473 102.0
TLS3_k127_2662039_0 CarboxypepD_reg-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007333 469.0
TLS3_k127_2662039_1 Extracellular solute-binding protein - - - 0.000000000000000000000000000006475 128.0
TLS3_k127_2662039_2 MotA/TolQ/ExbB proton channel family K03561 - - 0.000000000000000000000001351 109.0
TLS3_k127_2662039_3 Biopolymer transport protein ExbD/TolR K03560 - - 0.000000000000007677 79.0
TLS3_k127_2662039_4 Ferric siderophore transporter, periplasmic energy transduction protein TonB K03832 - - 0.0000001566 62.0
TLS3_k127_2663564_0 Psort location CytoplasmicMembrane, score K19225 - 3.4.21.105 0.000000000000000000000000000000000000123 152.0
TLS3_k127_2663564_1 acetyltransferase K03789,K03823 - 2.3.1.128,2.3.1.183 0.000000000000000000000000000000001319 135.0
TLS3_k127_2671997_0 Outer membrane lipoprotein-sorting protein - - - 0.00000000000000000000000000000000000000000004412 168.0
TLS3_k127_2671997_1 3D domain K02424 - - 0.00002382 51.0
TLS3_k127_2676447_0 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007133 286.0
TLS3_k127_2681087_0 Chloride channel - - - 2.989e-198 626.0
TLS3_k127_2681087_1 EamA-like transporter family K08978 - - 0.000000000000000000000000000000000000000000001751 168.0
TLS3_k127_2681087_2 acr, cog1993 K09137 - - 0.000000000000000000000000000000114 127.0
TLS3_k127_2681087_3 helix_turn_helix, Lux Regulon - - - 0.0000000000007928 76.0
TLS3_k127_2683607_0 unsaturated fatty acid biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000003395 244.0
TLS3_k127_2685723_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 623.0
TLS3_k127_2685723_1 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000001025 166.0
TLS3_k127_2685723_2 antisigma factor binding K04749,K06378 - - 0.000002346 54.0
TLS3_k127_2686126_0 Peptidyl-prolyl cis-trans isomerase K03775 - 5.2.1.8 0.0000000000000000000000000000000001862 138.0
TLS3_k127_2692588_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 464.0
TLS3_k127_2692588_1 polysaccharide catabolic process K07407 - 3.2.1.22 0.0000000000000000000000000000004221 132.0
TLS3_k127_2692588_2 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.000000000000000000000000003002 118.0
TLS3_k127_2692588_3 Psort location CytoplasmicMembrane, score 10.00 - - - 0.00000000000000006422 93.0
TLS3_k127_269524_0 Amp-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 317.0
TLS3_k127_269524_1 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001898 254.0
TLS3_k127_2695990_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 476.0
TLS3_k127_2695990_1 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000002207 161.0
TLS3_k127_2695990_2 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase - - - 0.0000000006465 69.0
TLS3_k127_2696579_0 PFAM aminoglycoside phosphotransferase K07102 - 2.7.1.221 0.000000000000000000000000000000000000008113 156.0
TLS3_k127_2696579_1 Fic/DOC family K07341 - - 0.00000000000000000000000000000000000000878 148.0
TLS3_k127_2696579_2 SpoVT / AbrB like domain - - - 0.00000000000000005249 82.0
TLS3_k127_2696579_3 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 0.0000000005708 62.0
TLS3_k127_270785_0 histidine kinase HAMP region domain protein K03406 - - 0.000000000000000000000000001607 119.0
TLS3_k127_270785_1 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01840 - 5.4.2.8 0.0000000000000000000000001109 114.0
TLS3_k127_2716271_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000001765 212.0
TLS3_k127_2716271_1 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000201 188.0
TLS3_k127_2716271_2 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000008882 124.0
TLS3_k127_2716271_3 PFAM EAL domain - - - 0.0000000000000000000000000004455 116.0
TLS3_k127_2716271_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000006063 81.0
TLS3_k127_2716271_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0016020,GO:0016469,GO:0032991,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 - 0.0000003048 60.0
TLS3_k127_2719180_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.503e-220 696.0
TLS3_k127_2719180_1 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000501 124.0
TLS3_k127_2719180_2 Chitobiase/beta-hexosaminidase C-terminal domain - - - 0.00000000000000000001255 108.0
TLS3_k127_2728642_0 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 486.0
TLS3_k127_2728642_1 TIGRFAM methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000002339 187.0
TLS3_k127_2728642_2 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.00000000002973 67.0
TLS3_k127_2735444_0 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01740,K10764 - 2.5.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 550.0
TLS3_k127_2735444_1 redox protein, regulator of disulfide bond formation K07397 - - 0.0000000000000000000000000000000000006272 145.0
TLS3_k127_2735444_2 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.00000000000000000000000000002416 121.0
TLS3_k127_2735444_3 Preprotein translocase SecG subunit K03075 - - 0.00005906 52.0
TLS3_k127_2742838_0 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 347.0
TLS3_k127_2742838_1 type II and III secretion system protein K02453 - - 0.000000000000000003958 96.0
TLS3_k127_2748345_0 protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems - - - 0.00000000000000000009708 100.0
TLS3_k127_2748345_1 SUF system FeS assembly protein, NifU family K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.000000000000002927 80.0
TLS3_k127_2748345_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.00000000001836 68.0
TLS3_k127_2748345_3 Copper chaperone PCu(A)C K09796 - - 0.000003014 53.0
TLS3_k127_2756135_0 DEAD-like helicases superfamily K07012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 614.0
TLS3_k127_2757391_0 NHL repeat - - - 0.0000000000000000000000000000000000000000001012 185.0
TLS3_k127_275890_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000001315 186.0
TLS3_k127_2776967_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1067.0
TLS3_k127_2776967_1 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 473.0
TLS3_k127_2776967_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000002773 102.0
TLS3_k127_2781914_0 HDOD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001319 287.0
TLS3_k127_2781914_1 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000005347 129.0
TLS3_k127_2781914_2 TfoX N-terminal domain - - - 0.000000000000000000000000002637 117.0
TLS3_k127_2781914_3 COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07776 - - 0.00000004086 60.0
TLS3_k127_2781914_4 Helix-turn-helix domain - - - 0.000008338 49.0
TLS3_k127_2792459_0 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 433.0
TLS3_k127_2792459_1 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008188 351.0
TLS3_k127_2814348_0 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000009825 181.0
TLS3_k127_2814348_1 START domain - - - 0.000000000000000000000000000000001009 139.0
TLS3_k127_2820101_0 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family K00219 - 1.3.1.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 544.0
TLS3_k127_2820101_1 Retinal pigment epithelial membrane protein K11159 - - 0.000000000000000000000000000000000000000000000000000000000000000004787 239.0
TLS3_k127_2823777_0 40-residue YVTN family beta-propeller - - - 0.000000000000000000000000000000000000000000000000000000000000000000001079 245.0
TLS3_k127_2824063_0 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005167 606.0
TLS3_k127_2824063_1 OmpA family - - - 0.0000000003219 67.0
TLS3_k127_2824063_2 thioesterase - - - 0.0000000003247 66.0
TLS3_k127_2854327_0 acetylornithine and succinylornithine aminotransferase K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008283 363.0
TLS3_k127_2857668_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 5.477e-200 643.0
TLS3_k127_2857668_1 PFAM Retinal pigment epithelial membrane protein K11159 - - 0.0000000000000008669 83.0
TLS3_k127_2879262_0 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000004741 108.0
TLS3_k127_2879262_1 Camp-dependent protein kinase K04739 GO:0000003,GO:0000166,GO:0000226,GO:0000280,GO:0001704,GO:0001707,GO:0001932,GO:0001933,GO:0001934,GO:0002682,GO:0002683,GO:0002694,GO:0002695,GO:0003006,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005929,GO:0005952,GO:0006355,GO:0006357,GO:0006464,GO:0006468,GO:0006469,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0007010,GO:0007015,GO:0007017,GO:0007049,GO:0007143,GO:0007154,GO:0007162,GO:0007163,GO:0007165,GO:0007267,GO:0007268,GO:0007274,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007369,GO:0007389,GO:0007498,GO:0007507,GO:0007591,GO:0007596,GO:0007599,GO:0007610,GO:0007611,GO:0007612,GO:0007613,GO:0007635,GO:0008103,GO:0008150,GO:0008152,GO:0008283,GO:0008285,GO:0008306,GO:0008355,GO:0008603,GO:0009611,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009798,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010639,GO:0010646,GO:0010648,GO:0010721,GO:0010927,GO:0010948,GO:0014706,GO:0014855,GO:0016020,GO:0016043,GO:0016310,GO:0016325,GO:0017076,GO:0019207,GO:0019210,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019932,GO:0019933,GO:0019935,GO:0019953,GO:0021700,GO:0022402,GO:0022407,GO:0022408,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023057,GO:0030029,GO:0030036,GO:0030104,GO:0030154,GO:0030155,GO:0030234,GO:0030239,GO:0030291,GO:0030551,GO:0030552,GO:0030554,GO:0030951,GO:0030952,GO:0031032,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031594,GO:0031625,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0032870,GO:0032878,GO:0032944,GO:0032945,GO:0032989,GO:0032991,GO:0033002,GO:0033043,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035265,GO:0035556,GO:0036094,GO:0036211,GO:0040007,GO:0040020,GO:0042048,GO:0042060,GO:0042127,GO:0042129,GO:0042130,GO:0042221,GO:0042303,GO:0042325,GO:0042326,GO:0042327,GO:0042493,GO:0042592,GO:0042692,GO:0042802,GO:0042995,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043412,GO:0043434,GO:0043549,GO:0043900,GO:0043901,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044441,GO:0044444,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044853,GO:0045121,GO:0045202,GO:0045214,GO:0045471,GO:0045595,GO:0045596,GO:0045786,GO:0045835,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046006,GO:0046007,GO:0046677,GO:0048285,GO:0048332,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048520,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048589,GO:0048598,GO:0048599,GO:0048609,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048856,GO:0048869,GO:0048871,GO:0048878,GO:0050670,GO:0050672,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050795,GO:0050817,GO:0050863,GO:0050865,GO:0050866,GO:0050868,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051018,GO:0051093,GO:0051128,GO:0051129,GO:0051146,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051249,GO:0051250,GO:0051252,GO:0051321,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051447,GO:0051704,GO:0051716,GO:0051726,GO:0051783,GO:0051784,GO:0055001,GO:0055002,GO:0055017,GO:0060038,GO:0060255,GO:0060259,GO:0060281,GO:0060283,GO:0060284,GO:0060419,GO:0060537,GO:0061061,GO:0061695,GO:0065007,GO:0065008,GO:0065009,GO:0070663,GO:0070664,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071944,GO:0072359,GO:0072375,GO:0080090,GO:0090036,GO:0090038,GO:0097159,GO:0097305,GO:0097367,GO:0097435,GO:0097546,GO:0098589,GO:0098590,GO:0098772,GO:0098805,GO:0098857,GO:0098916,GO:0099536,GO:0099537,GO:0120025,GO:0120038,GO:0140013,GO:1900193,GO:1900194,GO:1901265,GO:1901363,GO:1901564,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902494,GO:1902531,GO:1902532,GO:1902911,GO:1903037,GO:1903038,GO:1903046,GO:1903429,GO:1903430,GO:1903506,GO:1903538,GO:1905879,GO:1905880,GO:1990234,GO:2000112,GO:2000114,GO:2000241,GO:2000242,GO:2000253,GO:2000479,GO:2000480,GO:2001141 - 0.000000008357 67.0
TLS3_k127_2883590_0 Circularly permuted ATP-grasp type 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 611.0
TLS3_k127_2883590_1 A predicted alpha-helical domain with a conserved ER motif. - - - 0.000000000000000000000000000000000000000000005017 169.0
TLS3_k127_2898143_0 Belongs to the methyltransferase superfamily K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000541 157.0
TLS3_k127_2910458_0 cheY-homologous receiver domain - - - 0.00000000000000000000000001432 116.0
TLS3_k127_2910458_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000002748 109.0
TLS3_k127_2910458_2 PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain - - - 0.000000001796 62.0
TLS3_k127_2912817_0 Sigma factor PP2C-like phosphatases - - - 0.0000000000000000000000000000000001204 141.0
TLS3_k127_2912817_1 - - - - 0.0000000708 60.0
TLS3_k127_2926933_0 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000003399 188.0
TLS3_k127_2926933_1 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.0000000000000000000000000000002911 128.0
TLS3_k127_2926933_2 MAPEG family - - - 0.000000000000000000007215 96.0
TLS3_k127_2926933_3 Thioesterase superfamily - - - 0.000000000000003105 77.0
TLS3_k127_2926933_4 Jacalin-like lectin domain - - - 0.000000003335 57.0
TLS3_k127_2926945_0 Calcineurin-like phosphoesterase K07098 - - 0.0000000000000000000000000000000000000000000000000000003507 209.0
TLS3_k127_2931197_0 2 iron, 2 sulfur cluster binding K00334 - 1.6.5.3 0.000000000000000000000000000000000000002564 152.0
TLS3_k127_2931197_1 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335,K05587,K17992,K18331 - 1.12.1.3,1.6.5.3 0.00000000002637 73.0
TLS3_k127_2931940_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000004858 233.0
TLS3_k127_2931940_1 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000000000009188 204.0
TLS3_k127_2931940_2 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000002754 63.0
TLS3_k127_2932157_0 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000001104 179.0
TLS3_k127_2932157_1 Tetratricopeptide repeat K05838 - - 0.000000000000000000000000000689 121.0
TLS3_k127_293223_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000003004 132.0
TLS3_k127_293223_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000001975 67.0
TLS3_k127_293223_2 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K03825,K06718 - 2.3.1.178 0.00000000002104 75.0
TLS3_k127_293223_3 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000003583 51.0
TLS3_k127_2938131_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004354 374.0
TLS3_k127_2938131_1 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000008902 131.0
TLS3_k127_2939891_0 penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000004689 280.0
TLS3_k127_2950642_0 ABC transporter K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 378.0
TLS3_k127_2950642_1 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K01919,K01920,K05844 GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0042601,GO:0042763,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.2,6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006027 302.0
TLS3_k127_2950642_2 Transport permease protein K01992 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006456 280.0
TLS3_k127_2950642_3 glutamate--cysteine ligase K01919 - 6.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000001609 243.0
TLS3_k127_2950642_4 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000003079 138.0
TLS3_k127_2950642_5 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000005526 138.0
TLS3_k127_2950642_6 Belongs to the BolA IbaG family - - - 0.000000000000000000503 89.0
TLS3_k127_2950642_7 PFAM Glutaredoxin - - - 0.0000000000000008993 81.0
TLS3_k127_2950642_8 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.000000000001033 71.0
TLS3_k127_2955248_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 364.0
TLS3_k127_2955248_1 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000001173 177.0
TLS3_k127_2955248_2 Tetratricopeptide repeat - - - 0.000000000000000004671 98.0
TLS3_k127_2958321_0 carnitine dehydratase K07749 - 2.8.3.16 0.0000000000000000000007112 97.0
TLS3_k127_2958321_1 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.000000000000007354 83.0
TLS3_k127_2958321_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000005308 65.0
TLS3_k127_2960729_0 Enoyl-(Acyl carrier protein) reductase K07124 - - 0.000000000000000000000000000000000000000000000000000007325 201.0
TLS3_k127_2960729_1 PFAM DUF218 domain K03748 - - 0.0000000000000000000000000000000000000000007323 162.0
TLS3_k127_2960729_2 protein-disulfide reductase activity K05807,K08309 - - 0.00006729 48.0
TLS3_k127_2970983_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 340.0
TLS3_k127_2978409_0 COG0514 Superfamily II DNA helicase K03654 - 3.6.4.12 3.947e-211 672.0
TLS3_k127_298286_0 Lipase maturation factor - - - 0.000000000000000000000000000000000000000000553 175.0
TLS3_k127_299827_0 Psort location Extracellular, score 9.64 - - - 0.0000001667 64.0
TLS3_k127_299827_1 PAS fold - - - 0.00000228 51.0
TLS3_k127_3010653_0 Component of the core of the flagella K02406 GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 327.0
TLS3_k127_3010653_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003453 287.0
TLS3_k127_3010653_2 Uncharacterized protein family UPF0016 - - - 0.0000000000000000000000007696 106.0
TLS3_k127_3013593_0 PFAM C-5 cytosine-specific DNA methylase K00558 - 2.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 540.0
TLS3_k127_3013593_1 Fic/DOC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001205 265.0
TLS3_k127_3013593_2 May nick specific sequences that contain T G mispairs resulting from m5C-deamination K07458 - - 0.000000000000000000000000000000000000000000000000000000000001175 213.0
TLS3_k127_3014875_0 Glutathione S-Transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000004242 227.0
TLS3_k127_303163_0 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000004491 134.0
TLS3_k127_3034868_0 6-phosphogluconolactonase activity - - - 0.00000000000002799 82.0
TLS3_k127_3038635_0 alcohol dehydrogenase K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000172 259.0
TLS3_k127_3038635_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000004156 250.0
TLS3_k127_3038635_2 spectrin binding K15502,K15503 - - 0.0000000000000000000000001096 119.0
TLS3_k127_3038635_3 CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.000000000001323 81.0
TLS3_k127_3055082_0 NADH-quinone oxidoreductase chain L K00341 - 1.6.5.3 0.0000000000000000000000000000003397 131.0
TLS3_k127_3055082_1 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000008584 102.0
TLS3_k127_3055082_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000001659 97.0
TLS3_k127_3056078_0 Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 324.0
TLS3_k127_3061561_0 Ppx GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000001144 239.0
TLS3_k127_3061561_1 Metalloenzyme superfamily - - - 0.00000000000000000000000000004792 123.0
TLS3_k127_3074365_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002919 280.0
TLS3_k127_3074365_1 Glycosyl hydrolase family 1 K05350 - 3.2.1.21 0.000000000000000000000000007398 109.0
TLS3_k127_3082961_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 415.0
TLS3_k127_3082961_1 helix_turn_helix, arabinose operon control protein - - - 0.0001242 52.0
TLS3_k127_3085383_0 PFAM Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000009098 91.0
TLS3_k127_3086676_0 NHL repeat containing protein - - - 0.00000001559 65.0
TLS3_k127_3087705_0 TIGRFAM Drug resistance transporter Bcr CflA subfamily K03446,K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 426.0
TLS3_k127_3092095_0 PFAM Acetyltransferase (GNAT) family K00619 - 2.3.1.1 0.000000000000000000000005872 106.0
TLS3_k127_3092095_1 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000006107 94.0
TLS3_k127_3092095_2 Cell envelope-related transcriptional attenuator domain - - - 0.00002211 56.0
TLS3_k127_3094130_0 Insecticide toxin TcdB middle/N-terminal region - - - 0.0000000000000000000172 103.0
TLS3_k127_3099688_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 375.0
TLS3_k127_3099688_1 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000000000000000000000000000001259 194.0
TLS3_k127_3099688_2 Alpha-2-macroglobulin family K06894 - - 0.000000000000000000000000000000000000000000597 181.0
TLS3_k127_3107279_0 Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits K14572 - - 0.000000002463 69.0
TLS3_k127_31190_0 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002575 272.0
TLS3_k127_313082_0 Protein of unknown function (DUF1207) - - - 0.00003515 55.0
TLS3_k127_3132401_0 PFAM Acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 422.0
TLS3_k127_3140405_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 398.0
TLS3_k127_3140405_1 COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000001758 226.0
TLS3_k127_3140405_2 cyclic nucleotide binding K01420,K10716,K10914 - - 0.00000000000000000000000000000000000000000002328 169.0
TLS3_k127_3140405_3 Protein of unknown function (DUF2892) - - - 0.000000000000000001126 87.0
TLS3_k127_3140405_4 SMART AAA ATPase K02315 - - 0.000000000000000005705 94.0
TLS3_k127_3140405_5 GumN family K09973 - - 0.00000000000000003704 92.0
TLS3_k127_3144001_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009844 428.0
TLS3_k127_3144001_1 Carbonic anhydrase K01673 - 4.2.1.1 0.00000002739 65.0
TLS3_k127_3145438_0 - - - - 0.000000000000000000000000000000000000000000000000001511 203.0
TLS3_k127_3145438_1 Sigma-70, region 4 - - - 0.00000004149 62.0
TLS3_k127_3165358_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 477.0
TLS3_k127_3167778_0 PFAM Glycosyl transferase family 2 K12990 - - 0.00000000000000000000000002106 121.0
TLS3_k127_3167778_1 - - - - 0.00000001459 61.0
TLS3_k127_3172962_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000002298 236.0
TLS3_k127_3172962_1 self proteolysis - - - 0.000000000001798 78.0
TLS3_k127_3173534_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008546 285.0
TLS3_k127_3173534_1 peptidase inhibitor activity K04771 - 3.4.21.107 0.000002515 51.0
TLS3_k127_3173534_2 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000007195 53.0
TLS3_k127_3185172_0 Metallopeptidase family M24 - - - 0.0000000000000000000000000000000000000000000000000000000002471 213.0
TLS3_k127_3185172_1 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000001719 220.0
TLS3_k127_3185172_2 Predicted metal-dependent hydrolase K07044 - - 0.000000000000000000000000000000000000000000000001239 186.0
TLS3_k127_3195081_0 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000000000000000001784 222.0
TLS3_k127_3216294_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000004839 110.0
TLS3_k127_3226177_0 amidohydrolase K20810 - 3.5.4.40 0.0001486 49.0
TLS3_k127_3231256_0 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.0000000000000000000000000000000000000007428 155.0
TLS3_k127_3231256_1 photosystem II stabilization - - - 0.0003126 53.0
TLS3_k127_3236831_0 - - - - 0.0000003506 60.0
TLS3_k127_3257168_0 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000001754 148.0
TLS3_k127_3257168_1 DNA-templated transcription, initiation K03088 - - 0.0000001453 59.0
TLS3_k127_3270130_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000001193 224.0
TLS3_k127_3270130_1 domain, Protein K20276 - - 0.000000000003826 78.0
TLS3_k127_3281309_0 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005857 330.0
TLS3_k127_3281309_1 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000000000000002706 117.0
TLS3_k127_3283345_0 Acts as a magnesium transporter - - - 0.000000000000000000000000000006987 133.0
TLS3_k127_3289139_0 - - - - 0.00000006368 64.0
TLS3_k127_3289139_1 COG0790 FOG TPR repeat, SEL1 subfamily - - - 0.000004083 57.0
TLS3_k127_3289591_0 Glycosyl transferase, family 2 K12984 - - 0.000000000000000000000000000000000000000000000000000000000007178 215.0
TLS3_k127_3289591_1 Peptidase, M23 family - - - 0.0000000000000000000000000000000002367 142.0
TLS3_k127_3294857_0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000001237 64.0
TLS3_k127_3294857_1 Outer membrane lipoprotein-sorting protein - - - 0.0002344 52.0
TLS3_k127_3297909_0 iron ion binding - - - 0.0000000000000000000000000000000000000001339 160.0
TLS3_k127_3297909_1 PFAM Hemerythrin HHE cation binding domain K07216 - - 0.00000004046 63.0
TLS3_k127_3300485_0 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000006524 157.0
TLS3_k127_3300485_1 - - - - 0.0000000000000000000000000000004057 130.0
TLS3_k127_3300485_2 Lipopolysaccharide-assembly, LptC-related - - - 0.00003033 53.0
TLS3_k127_3307773_0 SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556 K00239 - 1.3.5.1,1.3.5.4 2.617e-207 648.0
TLS3_k127_3314825_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.0000000000007571 71.0
TLS3_k127_3317217_0 with the alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 486.0
TLS3_k127_3322532_0 Belongs to the glutamate synthase family K22083 - 2.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000001576 229.0
TLS3_k127_3322532_1 SNARE associated Golgi protein K01077 - 3.1.3.1 0.0000000000000000000000000000005257 129.0
TLS3_k127_3324345_0 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 494.0
TLS3_k127_3324345_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.00000001634 57.0
TLS3_k127_3360404_0 SMART protein phosphatase 2C domain protein K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000003214 172.0
TLS3_k127_3360404_1 Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) K15256 - - 0.000000000000000000005414 96.0
TLS3_k127_3361531_0 Molybdenum cofactor biosynthesis protein K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 333.0
TLS3_k127_3361531_1 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.00000000000000000000000000000007997 134.0
TLS3_k127_3369882_0 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007265 420.0
TLS3_k127_3374039_0 Aldehyde dehydrogenase family K00140,K22187 - 1.2.1.18,1.2.1.27 3.106e-226 709.0
TLS3_k127_3374039_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 340.0
TLS3_k127_3374039_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000006773 123.0
TLS3_k127_3374321_0 PFAM YicC domain protein - - - 0.00000001456 65.0
TLS3_k127_3389223_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009104 462.0
TLS3_k127_3404548_0 peptidase - - - 0.000000000000000004555 96.0
TLS3_k127_3404548_1 ATP-independent chaperone mediated protein folding - - - 0.000000000000008445 81.0
TLS3_k127_3404899_0 PFAM Nickel transport complex, NikM subunit, transmembrane - - - 0.00000000000000000000000000000000000000000000000006826 185.0
TLS3_k127_3404899_1 Iron-regulated membrane protein K09939 - - 0.0000000000000000000000000000000006705 140.0
TLS3_k127_3404899_2 TonB-dependent Receptor Plug Domain K02014 - - 0.000000000000000000000000000001022 127.0
TLS3_k127_3406_0 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000003348 157.0
TLS3_k127_3406_1 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.00000002049 64.0
TLS3_k127_3407739_0 TonB-dependent Receptor Plug Domain - - - 0.0000000003047 69.0
TLS3_k127_3407739_1 HAMP domain - - - 0.0006958 50.0
TLS3_k127_3407739_2 ABC transporter substrate binding protein K01989 - - 0.0008858 51.0
TLS3_k127_3412648_0 Type II secretion system (T2SS), protein J K02459 - - 0.00002742 54.0
TLS3_k127_3415708_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004577 338.0
TLS3_k127_3415708_1 COGs COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.00000000000000000000000000000000002883 139.0
TLS3_k127_3420474_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005901 272.0
TLS3_k127_3420474_1 FIST N domain - - - 0.000000000000000000000000000000000000000000000000000000000000001864 222.0
TLS3_k127_3420474_2 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000008957 200.0
TLS3_k127_3420474_3 response regulator K07667 - - 0.0000000001499 71.0
TLS3_k127_3425137_0 recombinase activity - - - 0.000000000000000000000006591 116.0
TLS3_k127_343601_0 COG2366 Protein related to penicillin acylase K01434,K07116 - 3.5.1.11,3.5.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 491.0
TLS3_k127_3437253_0 PFAM MotA TolQ ExbB proton channel K02556 - - 0.000000000000000000000000000000000000000000000000000000000000001022 227.0
TLS3_k127_3437253_1 Flagellar motor protein K02557 - - 0.00000000000000000000000000000000000000442 156.0
TLS3_k127_3437284_0 response regulator - - - 0.000000000000000000000000000000003445 136.0
TLS3_k127_3437284_1 7TMR-DISM extracellular 2 - - - 0.000000000002263 79.0
TLS3_k127_3437284_2 PFAM FecR protein - - - 0.0000005024 59.0
TLS3_k127_3440323_0 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001612 264.0
TLS3_k127_3440323_1 Single-stranded DNA-binding protein K03111 - - 0.000000000000000000000000000006443 123.0
TLS3_k127_3440323_2 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000179 51.0
TLS3_k127_3451031_0 Belongs to the DEAD box helicase family K03732 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000007047 249.0
TLS3_k127_3459367_0 PFAM Orn Lys Arg decarboxylase major region K01584 - 4.1.1.19 1.361e-256 797.0
TLS3_k127_3459367_1 Neutral/alkaline non-lysosomal ceramidase, C-terminal K12349 - 3.5.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009501 602.0
TLS3_k127_3459734_0 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000000114 194.0
TLS3_k127_3466966_0 Phosphoenolpyruvate phosphomutase K01841 - 5.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 572.0
TLS3_k127_3466966_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K09459 - 4.1.1.82 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 402.0
TLS3_k127_3466966_2 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 331.0
TLS3_k127_3466966_3 MobA-like NTP transferase domain - - - 0.0000000002215 70.0
TLS3_k127_3468386_0 helix_turn_helix, Lux Regulon - - - 0.000000000000004009 80.0
TLS3_k127_3468386_1 Hemerythrin HHE cation binding domain protein K07216 - - 0.00000000000003212 79.0
TLS3_k127_348307_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009624 526.0
TLS3_k127_348307_1 anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000001744 256.0
TLS3_k127_3495266_0 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001236 290.0
TLS3_k127_3495266_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000003192 247.0
TLS3_k127_3495266_2 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000007825 169.0
TLS3_k127_3495266_3 - - - - 0.0000000000000000000000000000000005523 145.0
TLS3_k127_3495266_4 Protein of unknown function (DUF3365) - - - 0.0000000000000741 78.0
TLS3_k127_3497469_0 cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000561 255.0
TLS3_k127_3501227_0 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000471 486.0
TLS3_k127_3501227_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000006109 233.0
TLS3_k127_3501227_2 PFAM Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.00000000000000000000000000000000000000008843 157.0
TLS3_k127_3504827_0 Adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 341.0
TLS3_k127_3504827_1 Acid phosphatase homologues - - - 0.000000003589 66.0
TLS3_k127_3509246_0 GTP-binding protein TypA K06207 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002576 303.0
TLS3_k127_3509246_1 PFAM SCO1 SenC K07152 - - 0.000000000000000000000000000007535 129.0
TLS3_k127_3509246_2 MORN repeat variant - - - 0.0000000000002581 77.0
TLS3_k127_3509246_3 - - - - 0.0001122 52.0
TLS3_k127_3509519_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001738 233.0
TLS3_k127_3509519_1 DUF218 domain - - - 0.0000000000000000000000000000000000005025 150.0
TLS3_k127_3509519_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000001313 108.0
TLS3_k127_3509519_3 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000881 60.0
TLS3_k127_3511933_0 Adenylate cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000077 237.0
TLS3_k127_3511933_1 Beta-lactamase K01286 - 3.4.16.4 0.0003215 45.0
TLS3_k127_3515943_0 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406,K03776 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 303.0
TLS3_k127_3515943_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000001505 258.0
TLS3_k127_3515943_2 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - 0.000000000000000000035 95.0
TLS3_k127_3516100_0 dextransucrase activity - - - 0.000000000001146 82.0
TLS3_k127_3517750_0 limonene-1,2-epoxide hydrolase K10533 GO:0003674,GO:0003824,GO:0004301,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016801,GO:0016803,GO:0018904,GO:0033963,GO:0044237,GO:0044281,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0097176,GO:1901360 3.3.2.8 0.00000000000000000000000203 108.0
TLS3_k127_3517750_1 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.000000000001482 68.0
TLS3_k127_3525514_0 Protein of unknown function (DUF1566) - - - 0.0000008954 63.0
TLS3_k127_3525514_1 amine dehydrogenase activity K19668,K20276 - 3.2.1.91 0.000008145 59.0
TLS3_k127_3526610_0 PFAM DUF218 domain K03748 - - 0.00000000000000000000000000000000000000003179 161.0
TLS3_k127_3526610_1 PFAM Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000003912 129.0
TLS3_k127_3526610_2 Membrane - - - 0.00000000000000000000001162 104.0
TLS3_k127_3526610_3 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.000000000000000000003896 105.0
TLS3_k127_3539559_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000002601 213.0
TLS3_k127_3539559_1 Kelch motif - - - 0.0000000004869 71.0
TLS3_k127_3573813_0 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005828 252.0
TLS3_k127_3573813_1 Periplasmic protein TonB links inner and outer membranes - - - 0.00000000000000000000001056 117.0
TLS3_k127_3575345_0 Reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008176 292.0
TLS3_k127_3575345_1 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009492 259.0
TLS3_k127_3575345_2 diguanylate cyclase - - - 0.00000000000000000000000000000000005183 149.0
TLS3_k127_3575345_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000137 112.0
TLS3_k127_3576232_0 Glycosyltransferase Family 4 - - - 5.402e-263 820.0
TLS3_k127_3583635_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006472 505.0
TLS3_k127_3583635_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002941 251.0
TLS3_k127_3583635_2 Belongs to the glycosyl hydrolase 28 family - - - 0.000000000000000007452 84.0
TLS3_k127_3583635_3 tetraacyldisaccharide 4'-kinase activity K09791 - - 0.00000000004256 66.0
TLS3_k127_3583652_0 PFAM Peptidase M23 - - - 0.0000000000000000000000000000001045 130.0
TLS3_k127_3583652_1 COGs COG4741 secreted endonuclease distantly related to Holliday junction resolvase - - - 0.0000000000000000000000000006644 119.0
TLS3_k127_3590879_0 NAD(P)-binding Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 497.0
TLS3_k127_3590879_1 PFAM Transglutaminase-like - - - 0.00000004187 64.0
TLS3_k127_3590879_2 Wd-40 repeat - - - 0.00001097 56.0
TLS3_k127_3594236_0 Glycosyl transferase, family 9 K02843 - - 0.000000000000000000000000000000000000000000000000001258 195.0
TLS3_k127_3594236_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000002297 188.0
TLS3_k127_3594236_2 thymidylate kinase K00943 - 2.7.4.9 0.000000000000005211 80.0
TLS3_k127_3594572_0 PUA domain containing protein K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007012 325.0
TLS3_k127_3594572_1 Surface antigen - - - 0.0000000000000000000000000000000000000000000495 175.0
TLS3_k127_3605100_0 of the alpha beta superfamily K06889 - - 0.00000000000000000000000000000000000000000000003726 182.0
TLS3_k127_3605100_1 Domain of unknown function (DUF3332) - - - 0.0000000000000000000000000004451 120.0
TLS3_k127_3607180_0 Cholesterol oxidase K03333 - 1.1.3.6 2.545e-198 631.0
TLS3_k127_3607180_1 4-hydroxy-tetrahydrodipicolinate synthase K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000133 166.0
TLS3_k127_3607180_2 Lactonase, 7-bladed beta-propeller - - - 0.0000000000414 73.0
TLS3_k127_3616387_0 Alpha/beta hydrolase family K03928 - 3.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 391.0
TLS3_k127_3616387_1 FtsJ-like methyltransferase K06968 - 2.1.1.186 0.000000000000000000000000000000000000000000000000000000009574 200.0
TLS3_k127_3620370_0 PFAM Response regulator receiver domain K03413 - - 0.0000000000000000000000007207 108.0
TLS3_k127_3620370_1 Glycerophosphoryl diester phosphodiesterase family - - - 0.000000031 57.0
TLS3_k127_3622574_0 Alpha amylase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 504.0
TLS3_k127_3622574_1 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000003123 107.0
TLS3_k127_3622574_2 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.00000002635 55.0
TLS3_k127_363844_0 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000387 474.0
TLS3_k127_363844_1 KR domain - - - 0.0000000000000000000000000000000000000000003223 168.0
TLS3_k127_3640643_0 Domain of unknown function (DUF3362) - - - 3.447e-282 878.0
TLS3_k127_3658528_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 332.0
TLS3_k127_3658528_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000015 218.0
TLS3_k127_3658528_2 AI-2E family transporter - - - 0.000000000000000000000000000000000001179 153.0
TLS3_k127_3658528_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000002352 100.0
TLS3_k127_3658528_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000003467 63.0
TLS3_k127_3666472_0 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001283 286.0
TLS3_k127_3666472_1 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.000002971 55.0
TLS3_k127_3674504_0 WD40-like Beta Propeller Repeat - - - 0.00000000000000000002949 104.0
TLS3_k127_3680046_0 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000002396 212.0
TLS3_k127_3680046_1 amine dehydrogenase activity - - - 0.0000000000002845 83.0
TLS3_k127_3680046_2 FecR protein - - - 0.00001048 57.0
TLS3_k127_3683523_0 COG0784 FOG CheY-like receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008668 254.0
TLS3_k127_3683523_1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.0000000000000000000004966 105.0
TLS3_k127_3694744_0 His Kinase A (phosphoacceptor) domain K11527 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000004561 249.0
TLS3_k127_3694744_1 PFAM Protein kinase domain K00384,K03407,K11527 - 1.8.1.9,2.7.13.3 0.0000000000000000001156 105.0
TLS3_k127_3697651_0 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000004474 190.0
TLS3_k127_3697651_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.0000005099 54.0
TLS3_k127_3700335_0 Bacterial regulatory proteins, tetR family - - - 0.0000000000000003752 86.0
TLS3_k127_3706259_0 Amino acid permease K16238 - - 0.00000000000000000000000000000000000000000000000000000007158 200.0
TLS3_k127_3711466_0 the B subunit is part of the catalytic core of the ATP synthase complex K02118 - - 1.19e-218 685.0
TLS3_k127_3711466_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 5.608e-218 685.0
TLS3_k127_3711466_2 ATP hydrolysis coupled proton transport K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 334.0
TLS3_k127_3711466_3 ATP hydrolysis coupled proton transport K02110,K02124 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000001223 190.0
TLS3_k127_3711466_4 ATPase activity, coupled to transmembrane movement of substances K02120 - - 0.00000000000000000000000000000000000007494 151.0
TLS3_k127_3711466_5 HAMP domain - - - 0.00000001073 60.0
TLS3_k127_3719890_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000376 273.0
TLS3_k127_3719890_1 Oxidoreductase family, C-terminal alpha beta domain - - - 0.0000000000000000000000000000000000000000004069 163.0
TLS3_k127_3723809_0 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 392.0
TLS3_k127_3728362_0 Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000000000000005688 189.0
TLS3_k127_3731851_0 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007462 285.0
TLS3_k127_3731851_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000009608 191.0
TLS3_k127_3736703_0 DNA replication proofreading K02336,K06877 - 2.7.7.7 0.000000000000000000000000000000000000000000000003658 183.0
TLS3_k127_3747394_0 sterol desaturase - - - 0.0000000000000000000000000000000000000000000000000000000000000000003134 233.0
TLS3_k127_3747394_1 PFAM FecR protein - - - 0.0000000000000000000000000000000000009348 147.0
TLS3_k127_3756396_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.000000000000001584 86.0
TLS3_k127_3756396_1 Alpha beta hydrolase - - - 0.0004972 46.0
TLS3_k127_3760718_0 COG1454 Alcohol dehydrogenase, class IV K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 457.0
TLS3_k127_3760718_1 WG containing repeat - - - 0.00000000000000000000000005248 113.0
TLS3_k127_3772575_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 503.0
TLS3_k127_3781352_0 Ankyrin repeat domain protein - - - 0.0000000000000000000000002533 122.0
TLS3_k127_3786006_0 Autotransporter beta-domain - - - 0.0003759 55.0
TLS3_k127_379352_0 Bile acid K03453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002156 250.0
TLS3_k127_379352_1 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. - GO:0000003,GO:0005575,GO:0005576,GO:0008150,GO:0032501,GO:0032504 - 0.000000000000000000000000000000000000000002924 162.0
TLS3_k127_379352_2 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - 0.000005708 55.0
TLS3_k127_3796683_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000002293 167.0
TLS3_k127_3796683_1 PFAM Glutamine amidotransferase class-I - - - 0.000000000000000000000000000539 122.0
TLS3_k127_3796683_2 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000009479 88.0
TLS3_k127_3801572_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 518.0
TLS3_k127_3801572_1 Starch synthase catalytic domain protein K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008194,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.000000000000000000000000000000000000000000000000000001086 214.0
TLS3_k127_3801572_3 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000003728 104.0
TLS3_k127_380164_0 Psort location Cytoplasmic, score 9.97 K01665 - 2.6.1.85 0.00000000000000000000000000000000000000237 150.0
TLS3_k127_380164_1 Amino-transferase class IV K02619 - 4.1.3.38 0.000000000000000000000000000000003884 136.0
TLS3_k127_3807734_0 Domain of unknown function (DUF4143) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 349.0
TLS3_k127_3807734_1 spore germination - - - 0.0000000000000000000000000000000000000000000004052 177.0
TLS3_k127_3807734_2 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000002981 145.0
TLS3_k127_3811622_0 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 319.0
TLS3_k127_3811622_1 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.0000000000000000000000000000000000000000000000000000002151 206.0
TLS3_k127_3811622_2 PFAM Multi antimicrobial extrusion protein MatE K03327 - - 0.00000000000007088 79.0
TLS3_k127_3816079_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007137 568.0
TLS3_k127_3816079_1 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000009177 227.0
TLS3_k127_3817668_0 Penicillin amidase K01434,K07116 - 3.5.1.11,3.5.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 406.0
TLS3_k127_3818099_0 Saccharopine dehydrogenase C-terminal domain K00808 - 2.5.1.44 0.0000000000000000000000000000000000000000000000000000000001933 220.0
TLS3_k127_3818099_1 Cysteine-rich motif following a subset of SET domains - - - 0.00000000000003223 81.0
TLS3_k127_3818099_2 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000003233 84.0
TLS3_k127_384611_0 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000005968 170.0
TLS3_k127_384611_1 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.0000000000000000000000002628 110.0
TLS3_k127_384611_2 histidine kinase, dimerisation and phosphoacceptor region - - - 0.000000000000000000000004653 110.0
TLS3_k127_3864455_0 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005969 346.0
TLS3_k127_3867717_0 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000564 98.0
TLS3_k127_3867717_1 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000002147 66.0
TLS3_k127_3867717_2 Protein tyrosine kinase - - - 0.000000009228 66.0
TLS3_k127_3897640_0 response regulator, receiver K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000002764 178.0
TLS3_k127_3904614_0 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 0.00000000000000000000000003022 113.0
TLS3_k127_3904614_1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000001336 81.0
TLS3_k127_3904614_2 Bacterial regulatory proteins TetR family - - - 0.00000000006536 71.0
TLS3_k127_3927840_0 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000001467 169.0
TLS3_k127_3935068_0 Histidine kinase K20971,K20974 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000227 215.0
TLS3_k127_3935068_1 protein with SCP PR1 domains - - - 0.00000000000000000000000000116 116.0
TLS3_k127_3943684_0 Cellulase (glycosyl hydrolase family 5) K19355 - 3.2.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008717 393.0
TLS3_k127_3943684_1 - - - - 0.0000000000000000006917 94.0
TLS3_k127_3943684_2 Flavin containing amine oxidoreductase - - - 0.00000000000002202 76.0
TLS3_k127_3943684_3 Helix-turn-helix domain - - - 0.000000000008915 74.0
TLS3_k127_3947615_0 MMPL family K07003 - - 0.000000000000000000000000000000000000000000000000008902 194.0
TLS3_k127_394920_0 Putative modulator of DNA gyrase K03592 - - 0.000000001623 69.0
TLS3_k127_3949885_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004731,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009066,GO:0009067,GO:0009084,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071265,GO:0071267,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 307.0
TLS3_k127_3949885_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 298.0
TLS3_k127_3958142_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000005812 177.0
TLS3_k127_3958142_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000004387 148.0
TLS3_k127_3958142_2 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.0000000000000000000000000642 117.0
TLS3_k127_3958142_3 Domain of unknown function (DUF4436) - - - 0.0000000000001592 81.0
TLS3_k127_3958142_4 Histidine kinase - - - 0.0000000000005533 82.0
TLS3_k127_3958142_5 - - - - 0.0000002617 59.0
TLS3_k127_3958423_0 Outer membrane lipoprotein-sorting protein - - - 0.0000000000000000000000000000002752 133.0
TLS3_k127_3958423_1 ABC transporter permease K02004 - - 0.000000000000000000002718 109.0
TLS3_k127_3958423_2 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000004537 50.0
TLS3_k127_397595_0 SufE protein probably involved in Fe-S center assembly K02426 - - 0.00000000000000000000000000000000001574 140.0
TLS3_k127_397724_0 PFAM Diacylglycerol kinase catalytic domain - - - 0.000000000000000000000000000000000000000002592 162.0
TLS3_k127_3979770_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 516.0
TLS3_k127_3979770_1 transcription factor binding - - - 0.0000000000000000000000000000000000000000000000005779 191.0
TLS3_k127_3979770_2 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000007989 169.0
TLS3_k127_3979770_3 PFAM Hemerythrin HHE cation binding domain K07216 - - 0.000000001023 70.0
TLS3_k127_3979770_4 Hemerythrin HHE cation binding domain K07216 - - 0.00008471 54.0
TLS3_k127_398138_0 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000001126 191.0
TLS3_k127_3981671_1 Psort location Cytoplasmic, score - - - 0.00000000009452 72.0
TLS3_k127_3981671_2 Ankyrin repeat domain protein - - - 0.0000000009776 70.0
TLS3_k127_4004228_0 phosphate-selective porin O and P - - - 0.0000000000000000000000000000004651 136.0
TLS3_k127_4006306_0 peptidase K02236,K02654 - 3.4.23.43 0.000000000000000161 89.0
TLS3_k127_4013608_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000007187 205.0
TLS3_k127_4013608_1 methyltransferase activity K07011,K19620 - - 0.000000000000000000000000000000003191 139.0
TLS3_k127_4018409_0 sporulation resulting in formation of a cellular spore - - - 0.0007424 52.0
TLS3_k127_4018625_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 338.0
TLS3_k127_4022765_0 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000001119 227.0
TLS3_k127_4033023_0 Transketolase K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009582 273.0
TLS3_k127_4033023_1 TonB C terminal K03832 - - 0.00003146 52.0
TLS3_k127_4041274_0 dna polymerase iii K10857 - - 0.000000000000000000000000000000000000000000000000006934 190.0
TLS3_k127_4041274_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000001643 81.0
TLS3_k127_4041274_2 Protein of unknown function (DUF433) - - - 0.000000000000001103 79.0
TLS3_k127_4041274_3 Uncharacterized protein conserved in bacteria (DUF2130) - - - 0.00003529 49.0
TLS3_k127_4044091_0 Putative amidoligase enzyme (DUF2126) - - - 6.942e-207 662.0
TLS3_k127_4048133_0 Predicted metal-dependent hydrolase K07044 - - 0.00000000000000000000000000000000000000000217 166.0
TLS3_k127_4048133_1 PFAM Methylenetetrahydrofolate reductase - - - 0.00000000000000000000000000000000000000004227 154.0
TLS3_k127_4048133_2 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.0000000000000000000000000000000000005563 147.0
TLS3_k127_4048133_3 region 4 type 2 - - - 0.0000000000000000000000000000000001716 138.0
TLS3_k127_4048133_4 hydroperoxide reductase activity - - - 0.0000000000000000000000000001346 122.0
TLS3_k127_4048133_5 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000002763 118.0
TLS3_k127_4048133_6 - - - - 0.00000000000000000002575 94.0
TLS3_k127_4048639_0 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006706 415.0
TLS3_k127_4048639_1 G5 domain protein - - - 0.0000000000000000000000002822 117.0
TLS3_k127_4049574_0 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000008509 209.0
TLS3_k127_4049574_1 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000009821 70.0
TLS3_k127_4056458_0 PFAM Acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 391.0
TLS3_k127_4056458_1 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000002664 123.0
TLS3_k127_4057506_0 ABC transporter substrate binding protein K01989 - - 0.00000000023 69.0
TLS3_k127_4057506_1 organic phosphonate transport K02044 - - 0.00000006927 63.0
TLS3_k127_4057506_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00262 GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.4 0.000002392 52.0
TLS3_k127_407300_0 D-aminopeptidase K16203 - - 0.00000000000000000000000000000000000000000000000000000000000000000001243 248.0
TLS3_k127_407300_1 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.00000000000000000000000000000000000000000000000000000000000001726 222.0
TLS3_k127_407300_2 PhoD-like phosphatase K01113 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000003244 227.0
TLS3_k127_407300_3 Transcriptional regulator - - - 0.000000000000000000000000000000001757 136.0
TLS3_k127_407300_4 domain protein - - - 0.00000000000000000000009049 107.0
TLS3_k127_407300_5 Integral membrane protein CcmA involved in cell shape determination - - - 0.00001996 51.0
TLS3_k127_4073864_0 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 GO:0000003,GO:0003006,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0007275,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009507,GO:0009526,GO:0009536,GO:0009790,GO:0009791,GO:0009793,GO:0009941,GO:0009987,GO:0010154,GO:0019637,GO:0022414,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0061458,GO:0071704,GO:0090407,GO:1901576 2.3.1.51 0.000000001594 70.0
TLS3_k127_407921_0 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001583 259.0
TLS3_k127_407921_1 Transport of potassium into the cell K03549 - - 0.0000000000000000000000000000000000000000000000000000000004679 204.0
TLS3_k127_407921_2 ABC-type uncharacterized transport system - - - 0.0000000000000000000000000000000117 143.0
TLS3_k127_407921_3 Thioredoxin-like - - - 0.00000002432 64.0
TLS3_k127_4082028_0 MMPL family K07003 - - 0.0000000000000000000000000000000000000000000000000001261 211.0
TLS3_k127_4082028_1 COG0457 FOG TPR repeat - - - 0.0001227 51.0
TLS3_k127_4082028_2 Protein of unknown function DUF115 - - - 0.0002984 50.0
TLS3_k127_4083062_0 dipeptidase activity K14358 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004261 317.0
TLS3_k127_4083062_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004077 298.0
TLS3_k127_4083062_2 Lactonase, 7-bladed beta-propeller - - - 0.00001857 51.0
TLS3_k127_408446_0 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001923 287.0
TLS3_k127_408446_1 Flavin-nucleotide-binding protein K07005 - - 0.000000000000000000000000000000000000000000000000000000000000000002016 233.0
TLS3_k127_4093875_0 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.000000000000000000000000000000000000000000000000000002465 205.0
TLS3_k127_4093875_1 Bacterial protein of unknown function (DUF937) - - - 0.0000000000000000006254 94.0
TLS3_k127_410348_0 RmlD substrate binding domain K21271,K22320 - 1.1.1.394,1.1.1.412 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 330.0
TLS3_k127_410348_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000001493 214.0
TLS3_k127_4105118_0 MltA specific insert domain K08304 - - 4.292e-196 616.0
TLS3_k127_4105118_1 ubiE/COQ5 methyltransferase family K00570 - 2.1.1.17,2.1.1.71 0.0000000000000000000000000000000000000000000000000000000000001772 216.0
TLS3_k127_4105296_0 Phosphate acyltransferases K00655 - 2.3.1.51 0.000001413 59.0
TLS3_k127_4109273_0 Integrin alpha (beta-propellor repeats). - - - 0.000000000000000000000000000000000000000000000000000000000000000002741 248.0
TLS3_k127_4110142_0 ATPase (AAA superfamily K07133 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006879 298.0
TLS3_k127_4110142_1 helicase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000001881 233.0
TLS3_k127_4110142_2 Phosphohydrolase - - - 0.000000000000000000000000000000000000000004485 158.0
TLS3_k127_4128185_0 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 383.0
TLS3_k127_4128185_1 Calcineurin-like phosphoesterase - - - 0.00000000000000000009725 94.0
TLS3_k127_4133876_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 297.0
TLS3_k127_4133876_1 carboxypeptidase K14054 - - 0.00000000000000000000000000000000000000000000006277 177.0
TLS3_k127_4143540_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007673 265.0
TLS3_k127_4143540_1 Orotidine 5'-phosphate decarboxylase / HUMPS family K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.0000000000000000000000000000000000000000000002896 175.0
TLS3_k127_4143540_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.6.5,3.1.7.2 0.0000007086 54.0
TLS3_k127_4145600_0 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000001115 189.0
TLS3_k127_4145600_1 Belongs to the ParB family K03497 - - 0.000000000000000000000000000009669 128.0
TLS3_k127_4146274_0 Predicted metal-dependent hydrolase K07044 - - 0.00000000000000000000000000000000005842 143.0
TLS3_k127_4146274_1 Di-iron-containing protein involved in the repair of iron-sulfur clusters K07322 - - 0.0000000005755 66.0
TLS3_k127_4153257_0 Transglutaminase/protease-like homologues - - - 0.0002561 53.0
TLS3_k127_4153793_0 FIST C domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003078 251.0
TLS3_k127_4153793_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000925 260.0
TLS3_k127_4153793_2 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000477 99.0
TLS3_k127_4153793_3 Histidine kinase A domain protein - - - 0.000000000000001307 88.0
TLS3_k127_4176434_0 FAD linked oxidases, C-terminal domain K00102,K00104 - 1.1.2.4,1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000009988 257.0
TLS3_k127_4176434_1 inositol monophosphate 1-phosphatase activity K01092 - 3.1.3.25 0.0000000000000000000000000000000000000006635 160.0
TLS3_k127_4176434_2 Belongs to the glycosyltransferase 26 family K05946 - 2.4.1.187 0.0000000000000000000000000000000000199 146.0
TLS3_k127_4176434_3 TIGRFAM MazG family protein K02428,K02499,K04765 - 3.6.1.66,3.6.1.9 0.0000001626 53.0
TLS3_k127_4178684_0 PFAM AMP-dependent synthetase and ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002357 280.0
TLS3_k127_4183409_0 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000001703 218.0
TLS3_k127_4183409_1 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000006969 85.0
TLS3_k127_4190350_0 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000001295 145.0
TLS3_k127_4194118_0 COG NOG06100 non supervised orthologous group - - - 0.00000000000000000000000003584 117.0
TLS3_k127_4194118_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000003699 68.0
TLS3_k127_4210003_0 Alginate export - - - 0.00000000000009874 83.0
TLS3_k127_4214939_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 5.385e-194 617.0
TLS3_k127_4215630_0 low molecular weight K01104 - 3.1.3.48 0.000000000000000000000000000000000000001245 151.0
TLS3_k127_4215630_1 phosphoribosyl-AMP cyclohydrolase activity K01496,K11755 - 3.5.4.19,3.6.1.31 0.00000008941 58.0
TLS3_k127_4221816_0 RHS repeat-associated core domain protein - - - 0.00000000000002871 87.0
TLS3_k127_4224817_0 Mycolic acid cyclopropane synthetase - - - 0.000000000000000102 87.0
TLS3_k127_4233380_0 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000009051 220.0
TLS3_k127_4233380_1 Belongs to the ParB family K03497 GO:0005575,GO:0005622,GO:0005623,GO:0007059,GO:0008150,GO:0009295,GO:0009987,GO:0022603,GO:0042173,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0043937,GO:0043938,GO:0044424,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000002214 214.0
TLS3_k127_4233380_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000009527 214.0
TLS3_k127_4233380_3 Mediates influx of magnesium ions K03284 - - 0.00001187 54.0
TLS3_k127_4239358_0 Flagellar hook-associated protein, FlgK K02396 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001745 266.0
TLS3_k127_4242748_0 Flagellar hook protein flgE K02390 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000483 378.0
TLS3_k127_4245442_0 Glutamine amidotransferases class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000068 330.0
TLS3_k127_4245442_1 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K20866 - 3.1.3.10 0.00000000000000000000000000000000000002714 151.0
TLS3_k127_4245442_2 structural constituent of ribosome K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000003908 110.0
TLS3_k127_4245442_3 Belongs to the UPF0109 family K06960 - - 0.0000000000000871 75.0
TLS3_k127_4248740_0 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000472 176.0
TLS3_k127_4248740_1 Permease, YjgP YjgQ family K11720 - - 0.00000000000002434 85.0
TLS3_k127_4256157_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 2.399e-287 901.0
TLS3_k127_4256157_1 of poly-gamma-glutamate biosynthesis (Capsule K07282 - - 0.000000000000000000000000000000000005076 139.0
TLS3_k127_4258970_0 PFAM Hemolysin-type calcium-binding K01406 - 3.4.24.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002529 307.0
TLS3_k127_4258970_1 Protein conserved in bacteria - - - 0.0000000000000000000002913 114.0
TLS3_k127_4259364_0 FusA NodT family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003248 258.0
TLS3_k127_4259364_1 acetyltransferase - - - 0.000000000005767 72.0
TLS3_k127_4259364_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0003497 47.0
TLS3_k127_4260899_0 Insecticidal toxin complex protein TcaC - - - 0.00000000000000000000000108 119.0
TLS3_k127_4260899_1 Psort location CytoplasmicMembrane, score K12132 - 2.7.11.1 0.0000001491 63.0
TLS3_k127_4283379_0 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.00000001701 69.0
TLS3_k127_4283379_1 Chitobiase/beta-hexosaminidase C-terminal domain - - - 0.000007183 61.0
TLS3_k127_4286202_0 histidine kinase A domain protein - - - 0.0000000000000000000000000000007035 134.0
TLS3_k127_4286202_1 phosphorelay signal transduction system - - - 0.00002911 49.0
TLS3_k127_428946_0 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 310.0
TLS3_k127_428946_1 tetR family K16137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003081 245.0
TLS3_k127_428946_2 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000001691 144.0
TLS3_k127_428946_3 Protein of unknown function (DUF1761) - - - 0.00000001334 62.0
TLS3_k127_4291725_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 331.0
TLS3_k127_4308894_0 MMPL family K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007704 406.0
TLS3_k127_4312467_0 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000253 216.0
TLS3_k127_4312467_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000009388 219.0
TLS3_k127_4312467_2 endo-1,4-beta-xylanase activity - GO:0005575,GO:0005576 - 0.00000000000000000417 96.0
TLS3_k127_4316772_0 Major Facilitator - - - 2.428e-266 829.0
TLS3_k127_4316772_1 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000005724 75.0
TLS3_k127_4316772_2 Putative lumazine-binding - - - 0.000000000001081 74.0
TLS3_k127_4331070_0 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.00000000000000000000000000000000000000000000001802 187.0
TLS3_k127_4338365_0 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000008087 139.0
TLS3_k127_4339617_0 hmm pf04305 - - - 0.000000000000000000000000000000000000000000000000000000000005494 219.0
TLS3_k127_4339617_1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000001561 164.0
TLS3_k127_4339617_2 Belongs to the CinA family K03742 - 3.5.1.42 0.0000000000003926 77.0
TLS3_k127_4347305_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 528.0
TLS3_k127_4347305_1 PFAM Outer membrane efflux protein K15725 - - 0.0001196 53.0
TLS3_k127_4347780_0 Transmits chemoreceptor signals to flagelllar motor components K03413 - - 0.000000000000000000000000000004016 123.0
TLS3_k127_4347780_1 response regulator K02479,K07684 - - 0.00000000000000008204 83.0
TLS3_k127_4347780_2 helix_turn_helix, Lux Regulon - - - 0.000000114 55.0
TLS3_k127_4353387_0 Formate--tetrahydrofolate ligase K01938 GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.3 4.758e-197 629.0
TLS3_k127_4353387_1 - - - - 0.0000000000001817 79.0
TLS3_k127_4353893_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000009425 238.0
TLS3_k127_4353893_1 Glycosyl transferase - - - 0.0000000000003866 81.0
TLS3_k127_4353893_2 SPTR Surface antigen variable number repeat - - - 0.000000000003914 75.0
TLS3_k127_4358555_0 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 490.0
TLS3_k127_4358555_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 436.0
TLS3_k127_4358555_2 PFAM Glucose Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000009723 213.0
TLS3_k127_4358555_3 MORN repeat variant - - - 0.0000000000000000007383 100.0
TLS3_k127_4358555_4 - - - - 0.000002003 55.0
TLS3_k127_4359102_0 Belongs to the sigma-70 factor family K02405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 315.0
TLS3_k127_4359102_1 NAD(P)-binding Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000001932 177.0
TLS3_k127_4364813_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000203 288.0
TLS3_k127_436502_0 - - - - 0.00000000000000003182 89.0
TLS3_k127_436502_1 HDOD domain - - - 0.00000001015 64.0
TLS3_k127_4372072_0 PFAM Cys Met metabolism K01740 - 2.5.1.49 1.036e-199 629.0
TLS3_k127_4372072_1 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000009408 250.0
TLS3_k127_4372072_2 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.00000000000000000000000000000000000001504 158.0
TLS3_k127_4372072_3 Transcriptional regulator, BadM Rrf2 family - - - 0.00000000000000000000000001964 114.0
TLS3_k127_4372072_4 Belongs to the phospholipase D family. Cardiolipin synthase subfamily K06131 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0032502,GO:0043934,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 - 0.0000000000002632 78.0
TLS3_k127_4372072_5 Zn-dependent protease - - - 0.000007889 54.0
TLS3_k127_4380605_0 tetratricopeptide repeat - - - 0.0000000000002913 83.0
TLS3_k127_4393966_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006815 351.0
TLS3_k127_4393966_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.0000000000000000000000000000000000007469 149.0
TLS3_k127_4393966_2 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.000000000000000000000001711 109.0
TLS3_k127_4393966_3 nuclear ribonuclease K00784 - 3.1.26.11 0.0000000000000000000000387 104.0
TLS3_k127_4393966_4 Protein of unknown function DUF45 K07043 - - 0.00000000000000006846 91.0
TLS3_k127_4400254_0 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000007486 114.0
TLS3_k127_4400254_1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain K07696 - - 0.00000000001482 66.0
TLS3_k127_440040_0 Putative Na+/H+ antiporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006405 433.0
TLS3_k127_440040_1 Belongs to the DapB family K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 334.0
TLS3_k127_440040_2 unsaturated fatty acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006072 338.0
TLS3_k127_440040_3 protein conserved in bacteria K09766 - - 0.00000000000000000000000000000000000000000000000000000001019 209.0
TLS3_k127_440040_4 positive regulation of type IV pilus biogenesis K07343 - - 0.000000000000000000000009697 106.0
TLS3_k127_440040_5 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000008798 87.0
TLS3_k127_4401133_0 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000009723 213.0
TLS3_k127_4402372_0 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000001613 211.0
TLS3_k127_4402372_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000008305 59.0
TLS3_k127_441177_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000449 181.0
TLS3_k127_441177_1 Belongs to the UPF0296 family K09777 - - 0.00000000000000007292 83.0
TLS3_k127_441177_2 stress-induced protein - - - 0.00000000009775 63.0
TLS3_k127_441177_3 Predicted membrane protein (DUF2339) - - - 0.0000005406 63.0
TLS3_k127_4412999_0 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000001115 169.0
TLS3_k127_4412999_1 radical SAM domain protein K03716 - 4.1.99.14 0.00000000000000000000002972 102.0
TLS3_k127_4412999_2 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 0.000000001136 70.0
TLS3_k127_4416682_0 ATP-binding region, ATPase domain protein domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000003317 222.0
TLS3_k127_4416682_1 KR domain - - - 0.00000000000000008033 84.0
TLS3_k127_4418384_0 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000002743 261.0
TLS3_k127_4418384_1 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000002458 209.0
TLS3_k127_4418384_2 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000003251 53.0
TLS3_k127_4425913_0 Peptidase family M3 K01414 - 3.4.24.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006314 389.0
TLS3_k127_4425913_1 - - - - 0.000000000006412 74.0
TLS3_k127_4436916_0 PFAM conserved - - - 0.00000000000000000000000000003608 121.0
TLS3_k127_4436916_1 - - - - 0.000000000000000000002526 96.0
TLS3_k127_4438507_0 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003918 450.0
TLS3_k127_4438507_1 gamma-glutamyltransferase K00681 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000001394 267.0
TLS3_k127_4438507_2 stage II sporulation K07315 - 3.1.3.3 0.00000000000000000000000000000000000000006192 173.0
TLS3_k127_4438943_0 Phosphatidylglycerophosphatase A K01095 - 3.1.3.27 0.00000000000000000000000002959 116.0
TLS3_k127_4438943_1 Stage II sporulation D domain protein K06381 - - 0.0000000000001901 72.0
TLS3_k127_4439666_0 ribonucleoside-diphosphate reductase activity K00525 - 1.17.4.1 1.639e-212 673.0
TLS3_k127_4439666_1 Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions K09913 GO:0003674,GO:0003824,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016154,GO:0016740,GO:0016757,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.1,2.4.2.2 0.000000000000000000000000000002461 122.0
TLS3_k127_4442426_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 488.0
TLS3_k127_4442426_1 Ion transport 2 domain protein K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000002319 246.0
TLS3_k127_4442426_2 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.000000002646 64.0
TLS3_k127_4443509_0 Nitric oxide reductase large subunit K04561 - 1.7.2.5 8.829e-216 676.0
TLS3_k127_4443509_1 CbbQ/NirQ/NorQ C-terminal K04748 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003702 250.0
TLS3_k127_4453529_0 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 307.0
TLS3_k127_4453529_1 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.00000002486 56.0
TLS3_k127_4454402_0 Endonuclease I K01150 - 3.1.21.1 0.00000000000000000000000000000000000000000000000000000000000000000008578 239.0
TLS3_k127_4454402_1 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000002301 175.0
TLS3_k127_4455602_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.000000000000000000007946 104.0
TLS3_k127_4467396_0 TIGRFAM penicillin-binding protein, 1A family K05366,K21464 - 2.4.1.129,3.4.16.4 0.00000000000001055 81.0
TLS3_k127_4467741_0 Bacterial sugar transferase K00996,K16566 - 2.7.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000002427 254.0
TLS3_k127_4467741_1 Belongs to the mannose-6-phosphate isomerase type 2 family K00971,K16011 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000001317 206.0
TLS3_k127_4479696_0 MerC mercury resistance protein - - - 0.000001059 58.0
TLS3_k127_4479696_1 General secretion pathway protein C K02452 - - 0.0003668 51.0
TLS3_k127_4481192_0 PFAM Mammalian cell entry related domain protein K02067 - - 0.00000000000000000000000000000000004871 139.0
TLS3_k127_4481192_1 PFAM ABC transporter K02065 - - 0.0000000000000000000000000000003087 125.0
TLS3_k127_4481192_2 CBS domain K03699 - - 0.00000000000000000000000000006769 131.0
TLS3_k127_4481192_3 Transporter associated domain - - - 0.000000000000000000000000001213 126.0
TLS3_k127_4481192_4 belongs to the PRA-CH family K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000002239 97.0
TLS3_k127_4481192_5 PBS lyase HEAT-like repeat - - - 0.0001334 54.0
TLS3_k127_4482927_0 Histidine kinase K07641,K14980 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000001036 226.0
TLS3_k127_4482927_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00002538 57.0
TLS3_k127_4488268_0 pfam abc1 K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004437 293.0
TLS3_k127_449183_0 Histidine kinase K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 293.0
TLS3_k127_449183_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000003336 123.0
TLS3_k127_4498918_0 DAHP synthetase I family K01626 - 2.5.1.54 0.0000000000000000000000000003386 116.0
TLS3_k127_4498918_1 Amidohydrolase family K20810 - 3.5.4.40 0.00000000007652 72.0
TLS3_k127_4501168_0 e3 binding domain K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 334.0
TLS3_k127_4501168_1 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000003374 191.0
TLS3_k127_4501168_2 nitric oxide dioxygenase activity - - - 0.0000000000000005139 83.0
TLS3_k127_4501168_3 Phosphopantetheine attachment site - - - 0.00001675 50.0
TLS3_k127_4501177_0 Isocitrate dehydrogenase NADP-dependent, monomeric type K00031 - 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 349.0
TLS3_k127_4501953_0 Transmembrane protein of unknown function (DUF3556) - - - 9.371e-205 651.0
TLS3_k127_4501953_1 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000004069 154.0
TLS3_k127_4521172_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000002635 271.0
TLS3_k127_4521172_1 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000006755 121.0
TLS3_k127_4521172_2 PFAM MaoC domain protein dehydratase - - - 0.0000000000000000000000000002605 120.0
TLS3_k127_4521172_3 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749 - - 0.000000000001173 72.0
TLS3_k127_4521172_4 diguanylate cyclase - - - 0.000000001405 61.0
TLS3_k127_4524815_0 transport protein CorA K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000001699 231.0
TLS3_k127_4524815_1 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000000000000000000000000000000018 143.0
TLS3_k127_4524815_2 Domain of unknown function (DUF4399) - - - 0.000000000000000000000000000002555 124.0
TLS3_k127_4536090_0 Uncharacterized protein family (UPF0051) K09014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 545.0
TLS3_k127_4536090_1 ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000002889 241.0
TLS3_k127_4538729_0 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000001353 248.0
TLS3_k127_453926_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001782 286.0
TLS3_k127_4542421_0 COGs COG0659 Sulfate permease and related transporter (MFS superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 421.0
TLS3_k127_4542882_0 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005298 273.0
TLS3_k127_4542882_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000007932 132.0
TLS3_k127_4542882_2 Group 2 truncated hemoglobin - GO:0001666,GO:0003674,GO:0005344,GO:0006810,GO:0006950,GO:0008150,GO:0009628,GO:0009719,GO:0009725,GO:0009733,GO:0010033,GO:0015669,GO:0015671,GO:0015893,GO:0036293,GO:0042221,GO:0042493,GO:0050896,GO:0051179,GO:0051234,GO:0070482,GO:0140104 - 0.0000000001173 63.0
TLS3_k127_4544522_0 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.0 1141.0
TLS3_k127_455032_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 2.404e-301 941.0
TLS3_k127_455032_1 4Fe-4S dicluster domain K07307 - - 0.000000784 53.0
TLS3_k127_455032_2 positive regulation of growth - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000007034 51.0
TLS3_k127_4550957_0 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 486.0
TLS3_k127_4550957_1 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000004617 186.0
TLS3_k127_4550957_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.000000000000000000000000001264 112.0
TLS3_k127_4558457_0 Histidine Phosphotransfer domain K03407 - 2.7.13.3 0.00000000000000000000000000000008745 134.0
TLS3_k127_4558457_1 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 0.000000000001558 68.0
TLS3_k127_4558457_2 ECF sigma factor K03088 - - 0.000002085 57.0
TLS3_k127_4558721_0 GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 576.0
TLS3_k127_4558721_1 ATP-binding region, ATPase domain protein domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003178 441.0
TLS3_k127_4558721_2 Response regulator, receiver K11443 - - 0.00000000000000000000000000000000000000000003407 165.0
TLS3_k127_4558721_3 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000047 168.0
TLS3_k127_4558721_4 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 0.0000000000000316 75.0
TLS3_k127_4558721_5 Transcriptional regulator - - - 0.00003947 48.0
TLS3_k127_4565205_0 phosphate ion binding K02040 - - 0.0000000000000000000000000000007431 131.0
TLS3_k127_4567077_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 348.0
TLS3_k127_4567077_1 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000659 191.0
TLS3_k127_4567077_2 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000004941 159.0
TLS3_k127_4567077_3 protein-glutamate methylesterase K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000002421 93.0
TLS3_k127_456786_0 Diacylglycerol kinase - - - 0.0000000001746 64.0
TLS3_k127_4569447_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 432.0
TLS3_k127_4569447_1 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 302.0
TLS3_k127_4573926_0 ABC transporter, ATP-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001624 287.0
TLS3_k127_4573926_1 ABC transporter - - - 0.00000000000000000000000000000000004235 151.0
TLS3_k127_4579426_0 peptidase activity K01286 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000001027 234.0
TLS3_k127_4581134_0 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000001866 175.0
TLS3_k127_4581134_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000005146 86.0
TLS3_k127_4581134_3 PFAM DUF218 domain K03748 - - 0.000002772 51.0
TLS3_k127_4582786_0 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000002823 162.0
TLS3_k127_4583496_0 Beta-lactamase - - - 0.000000000000000000000000001917 119.0
TLS3_k127_4583496_1 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000005258 92.0
TLS3_k127_4584197_0 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000004652 226.0
TLS3_k127_4584197_1 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000004584 62.0
TLS3_k127_4584692_0 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 495.0
TLS3_k127_4584692_1 'Kef-type K transport systems K10716 - - 0.0000000000000000000000000000000000002336 153.0
TLS3_k127_4584692_2 - - - - 0.00003948 52.0
TLS3_k127_4586233_0 Zinc-dependent metalloprotease - - - 0.0000000000000000000000000000000000000000000000000000000000000000001151 257.0
TLS3_k127_4586233_1 - - - - 0.0000008154 56.0
TLS3_k127_4586233_2 Lamin Tail Domain - - - 0.000001624 58.0
TLS3_k127_4587090_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 327.0
TLS3_k127_459297_0 Psort location CytoplasmicMembrane, score 10.00 K02238 - - 0.000000007103 68.0
TLS3_k127_4593642_0 acyl-CoA dehydrogenase K20035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002089 262.0
TLS3_k127_4593642_1 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000005048 153.0
TLS3_k127_4593642_2 Glutamate synthase K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.00000000000000000003779 92.0
TLS3_k127_4602246_0 Asparagine synthase K01953 - 6.3.5.4 1.051e-202 641.0
TLS3_k127_4602246_1 DNA topoisomerase VI subunit A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007398 297.0
TLS3_k127_4603929_0 Amidase, hydantoinase carbamoylase family K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 548.0
TLS3_k127_4603929_1 Flavin-binding monooxygenase-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001573 281.0
TLS3_k127_4603929_2 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000002851 102.0
TLS3_k127_4604201_0 transferase activity, transferring glycosyl groups K00694,K00786 - 2.4.1.12 0.00000000000000000189 89.0
TLS3_k127_4604201_1 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000002063 55.0
TLS3_k127_4616599_0 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 502.0
TLS3_k127_4616599_1 dTDP-glucose 4,6-dehydratase activity - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000003072 220.0
TLS3_k127_4639401_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 9.737e-241 769.0
TLS3_k127_464836_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 421.0
TLS3_k127_464836_1 PFAM Glycosyl transferases group 1 K19002 - 2.4.1.337 0.00000000000000000000004658 104.0
TLS3_k127_4651480_0 Transport and Golgi organisation 2 - - - 0.000000000000000000000000000000000000000000000000000006914 199.0
TLS3_k127_4658952_0 SPTR Cell surface protein - - - 0.000000000000000000000000001347 129.0
TLS3_k127_4658952_1 cellulose binding - - - 0.00000000000000001307 94.0
TLS3_k127_4658952_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000002481 63.0
TLS3_k127_466_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 358.0
TLS3_k127_466_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 284.0
TLS3_k127_466_2 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000535 269.0
TLS3_k127_466_3 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000001396 117.0
TLS3_k127_466_4 PFAM Uncharacterised BCR, COG1937 K21600 - - 0.00002219 50.0
TLS3_k127_4668550_0 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002409 271.0
TLS3_k127_4668550_1 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000005572 196.0
TLS3_k127_4676564_0 Belongs to the aldehyde dehydrogenase family K00128,K00154 - 1.2.1.3,1.2.1.68 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005846 469.0
TLS3_k127_4676564_1 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000756 153.0
TLS3_k127_4676564_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000003533 105.0
TLS3_k127_4676564_3 Tetratricopeptide repeat - - - 0.0000000002473 70.0
TLS3_k127_4683516_0 Mannose-1-phosphate guanylyltransferase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000002266 226.0
TLS3_k127_4683516_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000001657 103.0
TLS3_k127_4683516_2 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000573 92.0
TLS3_k127_4683516_3 Sigma-70, region 4 K03088 - - 0.0000000052 65.0
TLS3_k127_4717165_0 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000003716 180.0
TLS3_k127_4717165_1 ATP-binding cassette protein, ChvD family K15738 - - 0.00000000000000000003462 89.0
TLS3_k127_4717561_0 START domain - - - 0.000000000000000000000000000001924 129.0
TLS3_k127_4717561_1 Histidine kinase K07315 - 3.1.3.3 0.000000000000000000000001678 107.0
TLS3_k127_4726224_0 ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - 0.000000000000000000209 100.0
TLS3_k127_4726224_1 Domain of unknown function (DUF1731) K07071 GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 - 0.000003911 50.0
TLS3_k127_4738792_0 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00002513 57.0
TLS3_k127_474133_0 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000002381 216.0
TLS3_k127_474133_1 Thiol-disulfide oxidoreductase DCC - - - 0.00000000000000000000000000000000001386 140.0
TLS3_k127_474149_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 604.0
TLS3_k127_4743500_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 438.0
TLS3_k127_4743500_1 Signal transducing histidine kinase, homodimeric domain K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 374.0
TLS3_k127_4743500_2 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000003759 244.0
TLS3_k127_4743500_3 response regulator receiver K03413 - - 0.0000000000000000000000000001121 120.0
TLS3_k127_4743500_4 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.4.23.36 0.0000000000000000000000001061 113.0
TLS3_k127_4743500_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000001494 89.0
TLS3_k127_4743500_6 Belongs to the glycosyl hydrolase 18 family K01183 - 3.2.1.14 0.0007422 51.0
TLS3_k127_4745198_0 Biotin carboxylase C-terminal domain K01968 - 6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 390.0
TLS3_k127_4745198_1 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000001537 190.0
TLS3_k127_4745198_2 ABC1 family - - - 0.0000000000000000000000000000000000000000000000009619 192.0
TLS3_k127_4745198_3 PFAM Tetratricopeptide repeat - - - 0.000148 51.0
TLS3_k127_4748232_0 self proteolysis - - - 0.0007508 51.0
TLS3_k127_4755011_0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K03496 GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - 0.00000000000000000000000000000000000000000000001934 180.0
TLS3_k127_4755011_1 WD40-like Beta Propeller Repeat - - - 0.00000001571 68.0
TLS3_k127_47573_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000002874 87.0
TLS3_k127_4757385_0 PFAM ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000002101 191.0
TLS3_k127_4757385_1 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000001139 75.0
TLS3_k127_4758269_0 ATPases associated with a variety of cellular activities K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 384.0
TLS3_k127_4758269_1 self proteolysis - - - 0.000000000000000000000000000000000000000000006333 186.0
TLS3_k127_4758269_2 alpha beta - - - 0.00003348 57.0
TLS3_k127_4758269_3 S-layer homology domain - - - 0.00004415 57.0
TLS3_k127_4760673_0 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000001487 203.0
TLS3_k127_4760673_1 Protein of unknown function (DUF1428) - - - 0.000000000000000000000000000000000000000000004314 167.0
TLS3_k127_4762040_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004926 408.0
TLS3_k127_4763101_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000007505 141.0
TLS3_k127_4763101_1 alpha beta - - - 0.0000000000000000009785 96.0
TLS3_k127_4766010_0 - - - - 0.0000000000000000000000002532 115.0
TLS3_k127_4766010_1 Plasmid stabilization system - - - 0.000000261 53.0
TLS3_k127_47695_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000421 331.0
TLS3_k127_47695_1 cyclic nucleotide-binding - - - 0.0000000000000000000000004361 108.0
TLS3_k127_4771889_0 Domain of unknown function (DUF4153) - - - 0.000000000000000000000003741 114.0
TLS3_k127_4771889_1 Removes 5-oxoproline from various penultimate amino acid residues except L-proline K01304 GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564 3.4.19.3 0.00000000000139 76.0
TLS3_k127_477320_0 cellulase activity - - - 0.000000000000000000000000000000000008247 148.0
TLS3_k127_4791448_0 Circularly permuted ATP-grasp type 2 - - - 5.566e-194 617.0
TLS3_k127_4791448_1 Passenger-associated-transport-repeat - - - 0.000000000008718 71.0
TLS3_k127_4792319_0 Aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006103 546.0
TLS3_k127_480847_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain K19694 - - 0.000000000000000000000000000000000000000000000000000000003128 210.0
TLS3_k127_480847_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000614 109.0
TLS3_k127_480952_0 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000001556 147.0
TLS3_k127_4818235_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000001146 59.0
TLS3_k127_482384_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000002573 132.0
TLS3_k127_482384_2 SnoaL-like domain - - - 0.0006436 46.0
TLS3_k127_4830661_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 479.0
TLS3_k127_4835880_0 Uncharacterized protein conserved in bacteria (DUF2252) K13730 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000529 456.0
TLS3_k127_4835880_1 Cellulose biosynthesis protein BcsQ - - - 0.00000000000000000000000000000000000000000000000000000005283 202.0
TLS3_k127_4835880_2 Protein of unknown function (DUF2845) - - - 0.0003659 50.0
TLS3_k127_4839248_0 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001888 265.0
TLS3_k127_4839248_1 PFAM FecR protein - - - 0.000000000006978 78.0
TLS3_k127_4841673_0 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 425.0
TLS3_k127_4841673_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01153 - 3.1.21.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008495 278.0
TLS3_k127_4841673_2 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.00000000000000000000000000000000000000000000000000000000000000000003988 239.0
TLS3_k127_4858345_0 Methyltransferase - - - 0.000000002408 64.0
TLS3_k127_4858345_1 belongs to the aldehyde dehydrogenase family K00154 - 1.2.1.68 0.0009222 42.0
TLS3_k127_4864765_0 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 382.0
TLS3_k127_4864765_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K01539 - 3.6.3.8,3.6.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 308.0
TLS3_k127_4865154_0 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.0000000000000000001569 94.0
TLS3_k127_4865159_0 NAD(P)-binding Rossmann-like domain - - - 0.0000000000000000000000000000001797 128.0
TLS3_k127_4865159_1 Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins. K15383 - - 0.000000000000000004033 86.0
TLS3_k127_4865159_2 HNH endonuclease - - - 0.000001468 55.0
TLS3_k127_4873752_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000002678 202.0
TLS3_k127_4873752_1 - - - - 0.00000000000000000000000000000000007712 143.0
TLS3_k127_4873752_2 Tricorn protease homolog - - - 0.00006777 50.0
TLS3_k127_4880259_0 Alpha-2-Macroglobulin K06894 - - 0.0000000000000000000000000000000000000000002511 179.0
TLS3_k127_4881612_0 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000002233 177.0
TLS3_k127_4881612_1 PFAM phospholipid glycerol acyltransferase - - - 0.0000000001329 64.0
TLS3_k127_4881612_2 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000002724 61.0
TLS3_k127_4881612_3 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0005692 43.0
TLS3_k127_4888597_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006708 354.0
TLS3_k127_4905806_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005375 480.0
TLS3_k127_4905806_1 Urea transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007731 323.0
TLS3_k127_4905806_2 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000237 281.0
TLS3_k127_4905806_3 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000000005845 154.0
TLS3_k127_4905806_4 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.0000000000000126 79.0
TLS3_k127_4905806_5 Belongs to the anti-sigma-factor antagonist family - - - 0.000000001371 63.0
TLS3_k127_4907951_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000005189 229.0
TLS3_k127_4907951_1 It is involved in the biological process described with response to metal ion K03926 GO:0003674,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0008104,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0019899,GO:0022607,GO:0033036,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046872,GO:0046914,GO:0051179,GO:0051259,GO:0051260,GO:0065003,GO:0071840 - 0.000000000000000008983 88.0
TLS3_k127_4911867_0 His Kinase A (phosphoacceptor) domain K13587 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000001947 213.0
TLS3_k127_4911867_1 TIGRFAM Diguanylate cyclase - - - 0.0000000000000005472 81.0
TLS3_k127_4913441_0 - - - - 0.0000000000000003854 85.0
TLS3_k127_4913441_1 Protein of unknown function (DUF1566) - - - 0.00000000000000131 83.0
TLS3_k127_4913441_2 DNA-templated transcription, initiation K03088 - - 0.0002535 46.0
TLS3_k127_4938034_0 - - - - 0.000000000000000006567 94.0
TLS3_k127_4938034_1 Thioesterase superfamily - - - 0.00000000000001639 78.0
TLS3_k127_4938160_0 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 304.0
TLS3_k127_4938160_1 Peptidogalycan biosysnthesis/recognition K09919 - - 0.0000000000000000000000000000000000000000000003734 173.0
TLS3_k127_4941915_0 PilZ domain - - - 0.0005129 52.0
TLS3_k127_4949470_0 ABC transporter C-terminal domain K15738 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004427 349.0
TLS3_k127_4953125_0 Lipid A biosynthesis K02517 - 2.3.1.241 0.000000000000000000000000009513 121.0
TLS3_k127_4953279_0 ATP-dependent Clp protease ATP-binding subunit ClpA K03694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 517.0
TLS3_k127_4953279_1 Metallophosphoesterase K07098 - - 0.000000000000000000000002051 116.0
TLS3_k127_4966473_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004707 572.0
TLS3_k127_4966473_1 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000003753 159.0
TLS3_k127_4966473_2 Erythromycin esterase - - - 0.00000000000000000000000000000000000001201 147.0
TLS3_k127_4996375_0 7TM diverse intracellular signalling K00694,K07315,K20977 - 2.4.1.12,3.1.3.3 0.00000000000000000000000000000002602 134.0
TLS3_k127_4996375_1 Conserved repeat domain - - - 0.0000000000000211 87.0
TLS3_k127_5022324_0 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02849 - - 0.000000000000000000002494 103.0
TLS3_k127_5026717_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000006361 217.0
TLS3_k127_5026717_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000001046 115.0
TLS3_k127_5041409_0 STAS domain - - - 0.000002847 57.0
TLS3_k127_5051235_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008325 365.0
TLS3_k127_5051235_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000006106 94.0
TLS3_k127_5051843_0 HD domain K07814,K13815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 396.0
TLS3_k127_5051843_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001201 294.0
TLS3_k127_5051843_2 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000001579 153.0
TLS3_k127_5051843_3 Histidine kinase - - - 0.000000000000000000002479 98.0
TLS3_k127_5051843_4 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657,K07658 - - 0.00000000001408 70.0
TLS3_k127_5062416_0 protein conserved in cyanobacteria - - - 0.0000009485 55.0
TLS3_k127_5070229_0 peptidase M24B, X-Pro dipeptidase aminopeptidase K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 317.0
TLS3_k127_5074212_0 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.0000000000000000000000000000000000000000000000000000001353 211.0
TLS3_k127_5074212_1 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000002766 132.0
TLS3_k127_5074212_2 FtsK SpoIIIE family protein K03466 - - 0.0000000000000000000000277 114.0
TLS3_k127_5079431_0 Flavin containing amine oxidoreductase K09835,K10027 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016119,GO:0016120,GO:0016491,GO:0016627,GO:0036094,GO:0042214,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046246,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,5.2.1.13 0.00000000000000000000000000000000000000000000000004762 194.0
TLS3_k127_5083257_0 Protein of unknown function (DUF454) K09790 - - 0.00000000000000000000002128 108.0
TLS3_k127_5083257_1 Anti-anti-sigma regulatory factor K20978 - - 0.0000003609 56.0
TLS3_k127_5089696_0 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon K03524 GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 0.0000000000001082 78.0
TLS3_k127_5090292_0 RsgA GTPase K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 382.0
TLS3_k127_5090292_1 - - - - 0.0008826 50.0
TLS3_k127_509200_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003849 312.0
TLS3_k127_509200_1 Domain of unknown function (DUF3817) - - - 0.0000000000000000002914 90.0
TLS3_k127_509200_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000004115 70.0
TLS3_k127_5095094_0 ATP-dependent helicase K03579 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 574.0
TLS3_k127_5095094_1 cyclic nucleotide binding K03885,K10716 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 332.0
TLS3_k127_5095094_2 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00014 53.0
TLS3_k127_5097145_0 Predicted metal-dependent hydrolase K07044 - - 0.000000000000000000000000000000000000000000005056 174.0
TLS3_k127_5097145_2 contains PIN domain - - - 0.00000132 56.0
TLS3_k127_5099576_0 Domain of unknown function (DUF1794) - - - 0.0000000000000000000000000000000000000000000000004462 182.0
TLS3_k127_5099576_1 Chemotaxis phosphatase CheX K03409 - - 0.00000000000000000000000000000000000000003365 156.0
TLS3_k127_5099576_2 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000001106 151.0
TLS3_k127_5099576_3 PFAM Response regulator receiver domain K03413 - - 0.0000000000000000000000000000000000004446 143.0
TLS3_k127_5099576_4 Chemotaxis phosphatase CheX K03409 - - 0.00000000000000000000000001486 114.0
TLS3_k127_5099576_5 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000002199 79.0
TLS3_k127_5102839_0 Belongs to the malate synthase family K01638 - 2.3.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 426.0
TLS3_k127_5102839_1 DTW K05812 - - 0.000000000000000000000000000000000000000000000000000000002901 208.0
TLS3_k127_5102839_2 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.000000000000000000000000001689 115.0
TLS3_k127_5102839_3 Belongs to the ompA family - - - 0.0004557 49.0
TLS3_k127_5112191_0 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0001224 52.0
TLS3_k127_5118169_0 COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain K09749 - - 0.000000000000000000000000000000000000001351 161.0
TLS3_k127_5118169_1 ABC-2 type transporter K01992 - - 0.00000000000000222 77.0
TLS3_k127_512549_0 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1990778 - 0.00000000000000000000000000000000000000000000000000000000000002209 222.0
TLS3_k127_512549_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000194 175.0
TLS3_k127_512549_2 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000004305 94.0
TLS3_k127_512549_3 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000007699 56.0
TLS3_k127_5129902_0 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 302.0
TLS3_k127_5129902_1 Dienelactone hydrolase family - - - 0.000000000000000000000001371 108.0
TLS3_k127_5132774_0 tRNA nucleotidyltransferase domain 2 putative K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000678 199.0
TLS3_k127_5134004_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000001073 205.0
TLS3_k127_5134004_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000003908 134.0
TLS3_k127_5134004_2 Histidine kinase - - - 0.0000000004954 60.0
TLS3_k127_5137518_0 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000003859 139.0
TLS3_k127_5137518_1 Thiol disulfide interchange protein dsbA - - - 0.000000000000000000000000012 121.0
TLS3_k127_5140315_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000002328 225.0
TLS3_k127_5140435_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000358 226.0
TLS3_k127_5140435_1 Permease, YjgP YjgQ family K11720 - - 0.0005731 50.0
TLS3_k127_5145290_0 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000001825 268.0
TLS3_k127_5145290_1 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000005801 247.0
TLS3_k127_5145290_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000007524 212.0
TLS3_k127_5145290_3 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.0000000000241 70.0
TLS3_k127_5145290_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 0.000000002258 64.0
TLS3_k127_515130_0 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006869 420.0
TLS3_k127_515130_1 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000006826 221.0
TLS3_k127_515130_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000003006 206.0
TLS3_k127_515130_3 Cytochrome C assembly protein K02195 - - 0.000000000000000000000000000000000000003128 155.0
TLS3_k127_515130_4 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000005147 77.0
TLS3_k127_5151816_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000003363 71.0
TLS3_k127_5154312_0 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006642 351.0
TLS3_k127_5154312_1 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000004587 188.0
TLS3_k127_5156318_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003401 323.0
TLS3_k127_5171864_0 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000785 246.0
TLS3_k127_5171864_1 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000003995 206.0
TLS3_k127_5171864_2 ABC transporter, ATP-binding protein - - - 0.00000000000000000000000000000000206 135.0
TLS3_k127_5180415_0 Pas domain s-box - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009699 389.0
TLS3_k127_5180415_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000005928 163.0
TLS3_k127_5180415_2 - - - - 0.00002461 49.0
TLS3_k127_5190126_0 ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000000003435 142.0
TLS3_k127_5192931_0 PFAM Bacterial domain of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 293.0
TLS3_k127_5195363_0 PFAM permease YjgP YjgQ family protein K07091 - - 0.000000000000000000000003712 116.0
TLS3_k127_5198726_0 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008574 302.0
TLS3_k127_5198726_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000002111 147.0
TLS3_k127_5198726_2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.0000000000000000000000000003053 115.0
TLS3_k127_5198726_3 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.0000000000000000000000000965 109.0
TLS3_k127_5198726_4 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000001541 81.0
TLS3_k127_5208453_0 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000009608 191.0
TLS3_k127_5208453_1 COGs COG1392 Phosphate transport regulator (distant homolog of PhoU) K07220 - - 0.0000000000000000000000000000000000000156 150.0
TLS3_k127_5211293_0 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01537 - 3.6.3.8 8.372e-239 764.0
TLS3_k127_5211293_1 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate - - - 0.0000000002776 72.0
TLS3_k127_522097_0 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000944 267.0
TLS3_k127_522097_1 LPP20 lipoprotein - - - 0.00000000000000000000000002447 122.0
TLS3_k127_522097_2 Curli production assembly/transport component CsgG - - - 0.00000002337 61.0
TLS3_k127_5224834_0 - - - - 0.00000000000000000000000000000000000000000000000000000000003183 213.0
TLS3_k127_5224834_1 COG1073 Hydrolases of the alpha beta superfamily - - - 0.0000000000000000000000000000000000000000000000000000009672 203.0
TLS3_k127_5224834_2 FeS cluster assembly scaffold protein NifU K04488 - - 0.00000000000000002202 93.0
TLS3_k127_5224834_3 PFAM Pentapeptide repeats (8 copies) - - - 0.00000001669 66.0
TLS3_k127_5233054_0 Uncharacterized protein family (UPF0051) K09014 - - 0.000000000000000000000000000000000000000000000000009342 184.0
TLS3_k127_5233531_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000003183 249.0
TLS3_k127_5233531_1 response regulator receiver - - - 0.00000000000000000000000000000000000000000000000002966 190.0
TLS3_k127_5233531_2 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000008947 140.0
TLS3_k127_5234289_0 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 535.0
TLS3_k127_5234289_1 KaiC K08482 - - 0.0007427 42.0
TLS3_k127_5241075_0 trans-aconitate 2-methyltransferase activity K02169 - 2.1.1.197 0.000000000000000000000000000000000000000000000000000000000000000000000001555 249.0
TLS3_k127_5241075_1 Domain of unknown function (DUF4180) - - - 0.00000000000000000000000001935 113.0
TLS3_k127_5241075_2 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.00000000000000000000005937 108.0
TLS3_k127_5241075_3 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000002283 95.0
TLS3_k127_5241075_4 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000002352 66.0
TLS3_k127_5241075_5 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000007649 56.0
TLS3_k127_5242584_0 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000005654 76.0
TLS3_k127_5247384_0 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000002096 84.0
TLS3_k127_5247384_1 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 K15461 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004808,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363 2.1.1.61 0.00007233 49.0
TLS3_k127_5256285_0 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000006776 181.0
TLS3_k127_5256285_1 Protein of unknown function (DUF3299) K09950 - - 0.00000000000000000000000000001716 123.0
TLS3_k127_5256285_2 ABC transporter permease K02004 - - 0.0000000000000000000000006156 107.0
TLS3_k127_527133_0 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001225 285.0
TLS3_k127_527133_1 Predicted metal-dependent hydrolase K07044 - - 0.00000000000000000000000000000000000000000000001783 181.0
TLS3_k127_527133_2 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000241 151.0
TLS3_k127_527133_3 Acyl-CoA dehydrogenase, C-terminal domain K00248,K00252,K18244 - 1.3.8.1,1.3.8.6 0.000005772 51.0
TLS3_k127_527133_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0001516 48.0
TLS3_k127_5275398_0 COG0843 Heme copper-type cytochrome quinol oxidases, subunit 1 K02274 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009496 567.0
TLS3_k127_5275398_1 cytochrome c oxidase (Subunit II) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000006431 166.0
TLS3_k127_5275398_2 Alginate export - - - 0.0000000000000002126 88.0
TLS3_k127_5275398_3 - - - - 0.0003485 46.0
TLS3_k127_527632_0 dehydrogenase E1 component K00164 GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 5.859e-198 634.0
TLS3_k127_5278983_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000008993 195.0
TLS3_k127_5279308_0 Tetratricopeptide repeat - - - 0.000002355 56.0
TLS3_k127_5281974_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 574.0
TLS3_k127_5281974_1 Protein of unknown function (DUF2804) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000284 264.0
TLS3_k127_5281974_2 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000381 241.0
TLS3_k127_5281974_3 Protein of unknown function (DUF1175) K09934 - - 0.00000000004808 72.0
TLS3_k127_528775_0 Lactonase, 7-bladed beta-propeller - - - 0.0000004997 61.0
TLS3_k127_5293311_0 PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004995 276.0
TLS3_k127_529742_0 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 402.0
TLS3_k127_529742_1 Amino acid permease K16238 - - 0.0000000000000000000000000000000002467 136.0
TLS3_k127_5299914_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000317 246.0
TLS3_k127_5299914_1 hydrolase, TatD family K03424 - - 0.000000000000000000000000000000000000000000000007006 176.0
TLS3_k127_5307518_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 5.089e-259 807.0
TLS3_k127_5312580_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K00106,K13482 - 1.17.1.4,1.17.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001218 284.0
TLS3_k127_5312580_1 peptidylprolyl isomerase, FKBP-type K01802,K03772,K03773 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000008933 231.0
TLS3_k127_5312580_2 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000005382 231.0
TLS3_k127_5312580_3 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000009285 155.0
TLS3_k127_5312580_4 hmm pf03781 - - - 0.000000000000000000000000000000008149 140.0
TLS3_k127_5312580_5 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.0000000000000006303 87.0
TLS3_k127_531455_0 Transglycosylase SLT domain protein K08309 - - 0.000000000000000000000000000007635 129.0
TLS3_k127_531455_1 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000006447 112.0
TLS3_k127_531536_0 Protein involved in outer membrane biogenesis - - - 0.000000001145 69.0
TLS3_k127_531631_0 transcription regulator containing HTH domain K18831 - - 0.0000000000000000000000000000000002257 135.0
TLS3_k127_531631_1 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system K19166 - - 0.0000000000000000000000000000001195 126.0
TLS3_k127_5330334_0 ThiF family K21029 - 2.7.7.80 0.00000000000000000000000002374 114.0
TLS3_k127_5330334_1 Patatin-like phospholipase K07001 - - 0.0000000000000000005312 95.0
TLS3_k127_5331615_0 Glyoxalase K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000003847 256.0
TLS3_k127_5331615_1 - - - - 0.0000000004355 67.0
TLS3_k127_5333947_0 TIGRFAM Diguanylate cyclase - - - 0.0000000000000000000000000214 125.0
TLS3_k127_5334869_0 PFAM Sodium Bile acid symporter family K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004441 412.0
TLS3_k127_5334869_1 Protein-tyrosine phosphatase, low molecular weight K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000000000000000000001449 233.0
TLS3_k127_5340675_0 Bacterial transglutaminase-like N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009088 318.0
TLS3_k127_5340675_1 PFAM Bacterial domain of - - - 0.000000000000000000000000000000000000000009292 164.0
TLS3_k127_5346698_0 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000003733 250.0
TLS3_k127_5352969_0 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.0000000000000000000000000000000000000000000000000005704 198.0
TLS3_k127_5352969_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.00000000000001215 76.0
TLS3_k127_5357179_0 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000006239 120.0
TLS3_k127_5369152_0 succinyl-diaminopimelate desuccinylase activity K02083,K06016 - 3.5.1.6,3.5.1.87,3.5.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004549 318.0
TLS3_k127_5369152_1 Belongs to the glycosyl hydrolase 1 family K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000303 237.0
TLS3_k127_5383239_0 Signal transducing histidine kinase, homodimeric domain K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 372.0
TLS3_k127_5383239_1 Chemotaxis sensory transducer K03776 - - 0.00000000000000000000000000000000000000000000000000002625 203.0
TLS3_k127_5383239_2 Two component signalling adaptor domain K03408 - - 0.0000000000000000009851 94.0
TLS3_k127_538707_1 Acid phosphatase homologues - - - 0.000000000000000000000000000001045 131.0
TLS3_k127_538707_2 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000002527 119.0
TLS3_k127_538707_3 Belongs to the UPF0312 family - - - 0.0000000000000000000005675 103.0
TLS3_k127_5387322_0 Sigma factor PP2C-like phosphatases - - - 0.0000000000000000000000000000000000001774 160.0
TLS3_k127_5388531_0 Flagellar hook-associated protein 3 K02397 - - 0.00000000000000000000000000000000000000000000000000000004667 206.0
TLS3_k127_5388531_1 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000004007 83.0
TLS3_k127_5392987_0 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides - - - 0.00000000000000000000000000000000000000000002508 176.0
TLS3_k127_5405377_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 1.469e-298 954.0
TLS3_k127_5405377_1 Belongs to the ClpA ClpB family K03696 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004897 615.0
TLS3_k127_5405377_2 Clan AA aspartic protease, AF_0612 family - - - 0.00000000000000000000000000000000000000000000003781 172.0
TLS3_k127_5405377_3 - - - - 0.000000000000000004886 94.0
TLS3_k127_5405377_4 Cupin 2, conserved barrel domain protein K19547 - 5.3.3.19 0.00000000000000222 81.0
TLS3_k127_5405377_5 metal-binding protein - - - 0.000001957 55.0
TLS3_k127_5405377_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0002404 53.0
TLS3_k127_5407470_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002523 259.0
TLS3_k127_5407470_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000002314 188.0
TLS3_k127_5407470_2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000009435 99.0
TLS3_k127_5407470_3 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000003354 55.0
TLS3_k127_54151_0 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02396 - - 0.0000000000000000000000000000000000002041 155.0
TLS3_k127_54151_1 Phosphoglycerol transferase family protein, alkaline phosphatase superfamily - - - 0.00000000000000000000000000000000001704 152.0
TLS3_k127_541605_0 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008925 295.0
TLS3_k127_541605_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000002773 214.0
TLS3_k127_541605_2 Eco57I restriction-modification methylase - - - 0.000000000000000000000000000000002271 139.0
TLS3_k127_541605_3 - - - - 0.000000000000009145 76.0
TLS3_k127_541605_5 FOG Ankyrin repeat K06867 - - 0.0004918 50.0
TLS3_k127_5416996_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 335.0
TLS3_k127_5419204_0 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000008148 161.0
TLS3_k127_5419204_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 GO:0008150,GO:0040007 2.7.4.16 0.0000000000000003513 90.0
TLS3_k127_5421181_0 Protein of unknown function (DUF1826) - - - 0.00000000000000000001572 102.0
TLS3_k127_5422313_0 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 483.0
TLS3_k127_5425014_0 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000003703 238.0
TLS3_k127_5425014_1 Lumazine binding domain K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.00000000000000000000000000000000000000000000005596 176.0
TLS3_k127_5425014_2 TIGRFAM DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000001862 162.0
TLS3_k127_5425014_3 Protein of unknown function (DUF3341) - - - 0.0000000000000000000000000007444 119.0
TLS3_k127_5425014_4 PFAM Cytochrome C - - - 0.0000000000000005391 85.0
TLS3_k127_5425014_5 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00004165 46.0
TLS3_k127_5435347_0 PFAM Peptidase M22, glycoprotease K01409 - 2.3.1.234 0.0001563 52.0
TLS3_k127_5438432_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000001559 247.0
TLS3_k127_5439861_0 cyclic nucleotide-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002453 287.0
TLS3_k127_5440044_0 Nitrilase cyanide hydratase - - - 0.00000000000000000000000000000000007616 141.0
TLS3_k127_5440044_1 PFAM Class I peptide chain release factor - - - 0.00000000000000001153 88.0
TLS3_k127_5440044_2 sh3 domain protein - - - 0.0000000003381 68.0
TLS3_k127_5444222_0 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.0000000000000000000001949 107.0
TLS3_k127_5444222_1 Protein of unknown function (DUF2752) - - - 0.00000000000000000000282 98.0
TLS3_k127_5444222_2 Interferon-induced transmembrane protein - - - 0.00000000000000001749 86.0
TLS3_k127_5445015_0 PFAM Glycosyl hydrolase family 1 K01223,K05350 - 3.2.1.21,3.2.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 409.0
TLS3_k127_544595_0 Peptidase family S41 - - - 0.00000004056 64.0
TLS3_k127_5447084_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000001287 150.0
TLS3_k127_5447084_1 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000007735 130.0
TLS3_k127_5447084_2 Domain of unknown function (DUF3413) K07014 - - 0.0000000000000000003829 102.0
TLS3_k127_544870_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 469.0
TLS3_k127_544870_1 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000001983 188.0
TLS3_k127_5449765_0 Non-essential cell division protein that could be required for efficient cell constriction K20276 - - 0.000000000001173 82.0
TLS3_k127_5449765_1 amine dehydrogenase activity K01218 - 3.2.1.78 0.000000000002036 81.0
TLS3_k127_5449765_2 Ankyrin repeat - - - 0.0000000000323 74.0
TLS3_k127_5449929_0 Histidine kinase-like ATPases K03407 - 2.7.13.3 0.00000000000000000000000000000003934 134.0
TLS3_k127_5449929_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0004424 53.0
TLS3_k127_5454446_0 Putative restriction endonuclease - - - 0.000000000000000000245 91.0
TLS3_k127_5454446_1 spectrin binding - - - 0.0000003186 61.0
TLS3_k127_5455938_0 Belongs to the aldehyde dehydrogenase family K00128,K06447 - 1.2.1.3,1.2.1.71 1.74e-206 652.0
TLS3_k127_5455938_1 Beta-lactamase - - - 0.00000000000000000007727 91.0
TLS3_k127_5455938_2 Domain of unknown function (DUF1905) - - - 0.0000000000000000002721 91.0
TLS3_k127_5461995_0 PFAM CoA-binding domain protein K06929 - - 0.00000000000000000000000000002746 121.0
TLS3_k127_5461995_1 Outer membrane efflux protein K12340 - - 0.0000000000005054 79.0
TLS3_k127_5461995_2 PFAM Ig domain protein group 2 domain protein - - - 0.00001186 58.0
TLS3_k127_5461995_3 - - - - 0.0004279 51.0
TLS3_k127_5470939_0 SMART Tetratricopeptide domain protein - - - 0.000009172 57.0
TLS3_k127_547640_0 NorD protein K02448 - - 0.00000000000000000000000000000000000000000000000001583 185.0
TLS3_k127_547640_1 von Willebrand factor (vWF) type A domain K02448 - - 0.0000000000000000000000002334 116.0
TLS3_k127_5480405_0 DSBA-like thioredoxin domain K07396 - - 0.00000000000000000000000000000000004936 143.0
TLS3_k127_5480405_1 class II (D, K and N) K04568 - - 0.0000000000000001689 85.0
TLS3_k127_5488418_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 4.552e-252 798.0
TLS3_k127_5494827_0 - - - - 0.00000002514 65.0
TLS3_k127_5494827_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - 0.00000004266 58.0
TLS3_k127_5505698_0 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000003219 228.0
TLS3_k127_5505698_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000000000000000000000000000000000000000000001022 216.0
TLS3_k127_551619_0 Serine hydrolase (FSH1) K06999 - - 0.00000000000000000000000000000000000000003019 162.0
TLS3_k127_551619_1 signal peptide processing K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000429 157.0
TLS3_k127_551619_2 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.00000005622 55.0
TLS3_k127_5522984_0 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000788 122.0
TLS3_k127_5522984_1 Glycosyl transferase, family 2 - - - 0.000000000000000000000005966 117.0
TLS3_k127_5522984_2 Glycosyl transferase family 8 - - - 0.00000000005176 72.0
TLS3_k127_5522984_3 - - - - 0.000002674 58.0
TLS3_k127_5527118_0 Psort location Cytoplasmic, score 8.96 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003705 274.0
TLS3_k127_5527118_1 Surface antigen - - - 0.00000000000000000000001447 113.0
TLS3_k127_5528204_0 Ricin-type beta-trefoil - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 355.0
TLS3_k127_5537361_0 Exonuclease - - - 0.0000000000000000000000000000000000000000002404 164.0
TLS3_k127_5539505_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000003443 230.0
TLS3_k127_5542115_0 Alg9-like mannosyltransferase family - - - 0.0000005469 62.0
TLS3_k127_5545656_0 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000005111 145.0
TLS3_k127_5545656_1 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000002052 143.0
TLS3_k127_5545656_2 PFAM Stage II sporulation E family protein - - - 0.0000001012 56.0
TLS3_k127_5545656_3 Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins K07533 - 5.2.1.8 0.00002599 56.0
TLS3_k127_5545656_4 PFAM CheW-like K03408 - - 0.00007671 46.0
TLS3_k127_5547411_0 Sugar nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000003579 177.0
TLS3_k127_555304_0 translation initiation factor activity - - - 0.000000000000000005359 98.0
TLS3_k127_555304_1 FecR protein - - - 0.0000000001614 70.0
TLS3_k127_5559528_0 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000004603 178.0
TLS3_k127_5559528_1 Transcriptional regulator - GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000001808 139.0
TLS3_k127_5566717_0 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000001959 125.0
TLS3_k127_5571884_0 unsaturated fatty acid biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006131 264.0
TLS3_k127_5571884_1 methylenetetrahydrofolate reductase (NAD(P)H) activity - - - 0.00000000000000000000000000000000000000000000000000000000000002892 219.0
TLS3_k127_5571884_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000001497 106.0
TLS3_k127_5571884_3 Protein of unknown function, DUF255 - - - 0.0003875 52.0
TLS3_k127_5572699_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 494.0
TLS3_k127_5572699_1 PAP2 superfamily C-terminal - - - 0.00000000000000000000000000000003354 131.0
TLS3_k127_5572699_2 Tetratricopeptide repeats - - - 0.0007577 52.0
TLS3_k127_5577430_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004502 409.0
TLS3_k127_5577430_1 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000003212 109.0
TLS3_k127_5586600_0 domain protein - - - 0.000000000000001907 84.0
TLS3_k127_5587609_0 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.000000000000000000001182 103.0
TLS3_k127_5587609_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000002118 71.0
TLS3_k127_5587609_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K09698 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0009986,GO:0030246,GO:0030247,GO:0044464,GO:2001065 6.1.1.24 0.00000000004918 65.0
TLS3_k127_5587609_3 Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B) K04757 GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 2.7.11.1 0.0009359 48.0
TLS3_k127_5591356_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 340.0
TLS3_k127_5597875_0 Saccharopine dehydrogenase NADP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 531.0
TLS3_k127_5597875_1 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related K18151 - 3.5.1.116 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 293.0
TLS3_k127_5597875_2 ketosteroid isomerase - - - 0.00000000000000000003306 102.0
TLS3_k127_5597875_3 Peptidase family M23 - - - 0.0000000001722 64.0
TLS3_k127_5600229_0 Belongs to the heme-copper respiratory oxidase family K15862 - 1.9.3.1 0.0 1017.0
TLS3_k127_5600229_1 PFAM Cytochrome c, class I K00406 - - 0.0000000000000000000000000000000000000000004426 163.0
TLS3_k127_5600229_2 Cbb3-type cytochrome oxidase component FixQ - - - 0.0001228 47.0
TLS3_k127_5601585_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 535.0
TLS3_k127_5601585_1 Cytidylyltransferase K07257 - - 0.00000000000000000000000424 112.0
TLS3_k127_5601585_2 - - - - 0.0000000001804 71.0
TLS3_k127_5601585_3 COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) - - - 0.0000000135 62.0
TLS3_k127_5602259_0 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004512 389.0
TLS3_k127_5602259_1 cytochrome P450 - - - 0.0003341 44.0
TLS3_k127_5604680_0 AlkA N-terminal domain K13529 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 506.0
TLS3_k127_5604680_1 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63 0.0000000000000000000000000000000002953 135.0
TLS3_k127_561078_0 Protein of unknown function DUF115 - - - 0.00000000006032 74.0
TLS3_k127_5612624_0 of the major facilitator superfamily K08151 - - 0.000000000000000000000000000000000009601 149.0
TLS3_k127_5612624_1 Protein of unknown function (DUF423) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000116 110.0
TLS3_k127_5612624_2 TIGRFAM maf protein K06287 - - 0.000000001351 63.0
TLS3_k127_5621406_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000003346 243.0
TLS3_k127_5621406_1 TetR family transcriptional regulator - - - 0.000000000002212 78.0
TLS3_k127_5625354_0 Isocitrate dehydrogenase NADP-dependent, monomeric type K00031 - 1.1.1.42 5.753e-261 810.0
TLS3_k127_5625354_1 Domain of unknown function (DUF4178) - - - 0.000000000000000000000000000000000006433 143.0
TLS3_k127_5628251_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000647 346.0
TLS3_k127_5628251_1 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000681 172.0
TLS3_k127_5639923_0 Helicase C-terminal domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005284 555.0
TLS3_k127_5639923_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000005563 147.0
TLS3_k127_5639923_2 Psort location Cytoplasmic, score 8.96 - - - 0.00002156 51.0
TLS3_k127_5640156_0 DEAD DEAH box helicase K03724 - - 1.48e-266 847.0
TLS3_k127_5643136_0 Small GTP-binding protein - - - 0.000000000000004507 82.0
TLS3_k127_5643136_1 Methyltransferase domain - - - 0.00000001949 63.0
TLS3_k127_565716_0 Belongs to the UbiD family K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 553.0
TLS3_k127_565716_1 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000008801 244.0
TLS3_k127_565716_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000000001895 78.0
TLS3_k127_565716_3 YbbR-like protein - - - 0.00000000000001812 85.0
TLS3_k127_5661054_0 Modulates RecA activity K03565 - - 0.00000000004715 71.0
TLS3_k127_5663123_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000001424 249.0
TLS3_k127_5663123_1 Sigma factor PP2C-like phosphatases - - - 0.0001407 48.0
TLS3_k127_566533_0 Phosphate-selective porin O and P - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 345.0
TLS3_k127_566533_1 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000001886 106.0
TLS3_k127_5666385_0 PFAM Inward rectifier potassium channel K08715 - - 0.00000000000000000000000000000000000000000000000000000000000000005196 232.0
TLS3_k127_5666385_1 STAS domain K04749 - - 0.000000000008799 69.0
TLS3_k127_5666385_2 Sulfatase-modifying factor enzyme 1 K18912 - 1.14.99.50 0.0009021 50.0
TLS3_k127_5680468_0 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002784 255.0
TLS3_k127_5680468_1 PFAM Ankyrin K06867 - - 0.000000000000005817 88.0
TLS3_k127_56809_0 Beta-lactamase - - - 0.000000000000000000000000000007953 123.0
TLS3_k127_56809_1 Belongs to the P-Pant transferase superfamily K06133 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.00000000000000000000004002 108.0
TLS3_k127_56809_2 PFAM CHAD domain containing protein - - - 0.0002148 51.0
TLS3_k127_5690040_0 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000004148 185.0
TLS3_k127_5690040_1 HD domain K07814 - - 0.00000000000000000000000000000000000000000000494 166.0
TLS3_k127_570203_0 methyltransferase - - - 0.0000000000006846 74.0
TLS3_k127_570203_1 LicD family K07271 - - 0.000000004556 69.0
TLS3_k127_5705758_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 3.622e-234 736.0
TLS3_k127_5708180_0 fatty acid desaturase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000233 292.0
TLS3_k127_5740327_0 malic protein domain protein K00027,K00029 - 1.1.1.38,1.1.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 492.0
TLS3_k127_5740497_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000361 308.0
TLS3_k127_5740497_1 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000003423 109.0
TLS3_k127_5753912_0 Belongs to the MlaE permease family K02066 - - 0.0000000000000000000000000000000000000000000000000000000000003092 221.0
TLS3_k127_5753912_1 Tim44 - - - 0.000000000000000000000000000000000000000004328 169.0
TLS3_k127_5761003_0 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009867 298.0
TLS3_k127_5761003_1 Leucine-rich repeat K13730 - - 0.000000000000000001675 93.0
TLS3_k127_5761003_2 NADPH-dependent FMN reductase - - - 0.00000008851 56.0
TLS3_k127_5767227_0 It is involved in the biological process described with DNA repair K20813 GO:0000122,GO:0000166,GO:0000287,GO:0000700,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003712,GO:0003824,GO:0004844,GO:0005080,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005886,GO:0006139,GO:0006220,GO:0006244,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006298,GO:0006304,GO:0006355,GO:0006357,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008263,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0017076,GO:0018130,GO:0019104,GO:0019219,GO:0019222,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0030554,GO:0030983,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031402,GO:0031404,GO:0031420,GO:0031974,GO:0031981,GO:0032091,GO:0032182,GO:0032183,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035510,GO:0035511,GO:0035561,GO:0035562,GO:0035639,GO:0036094,GO:0040029,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043393,GO:0043412,GO:0043621,GO:0043739,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044728,GO:0045008,GO:0045892,GO:0045934,GO:0045995,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051098,GO:0051100,GO:0051171,GO:0051172,GO:0051239,GO:0051252,GO:0051253,GO:0051336,GO:0051716,GO:0055086,GO:0055114,GO:0060255,GO:0065007,GO:0065009,GO:0070013,GO:0070988,GO:0070989,GO:0071704,GO:0071944,GO:0072527,GO:0072529,GO:0080090,GO:0080111,GO:0090304,GO:0097159,GO:0097367,GO:0097506,GO:0140097,GO:0140110,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1902544,GO:1902679,GO:1903506,GO:1903507,GO:2000026,GO:2000112,GO:2000113,GO:2001141 3.2.2.29 0.000000000000000000000000000000000000005717 152.0
TLS3_k127_5767297_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008516 604.0
TLS3_k127_5767297_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007535 303.0
TLS3_k127_5767297_2 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002364 256.0
TLS3_k127_5767297_3 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000007603 199.0
TLS3_k127_5767297_4 Phosphate-selective porin O and P - - - 0.00000006157 55.0
TLS3_k127_5792401_0 - - - - 0.00000000000000000000000000000006099 140.0
TLS3_k127_5792401_1 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000004817 96.0
TLS3_k127_5792401_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000002601 81.0
TLS3_k127_5792401_3 Metallo-beta-lactamase superfamily - - - 0.00000183 58.0
TLS3_k127_580476_0 Zinc-uptake complex component A periplasmic K09815 - - 0.0000000000000000000000000000000000000000000000000000000001585 214.0
TLS3_k127_580476_1 AAA domain, putative AbiEii toxin, Type IV TA system K02074,K09817 - - 0.00000000000000000000000000001806 127.0
TLS3_k127_5810898_0 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 312.0
TLS3_k127_5810898_1 7TM diverse intracellular signalling - - - 0.000000000000000000000000000000000000002448 161.0
TLS3_k127_5810898_2 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000001825 146.0
TLS3_k127_5832225_0 Inositol-3-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000002902 97.0
TLS3_k127_5832225_1 Glycosyl transferase 4-like domain K08256 GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 0.000000000007223 70.0
TLS3_k127_5832225_2 PFAM permease YjgP YjgQ family protein K11720 - - 0.0000002853 62.0
TLS3_k127_5857078_0 Integral membrane protein (intg_mem_TP0381) - - - 0.00000000000006689 79.0
TLS3_k127_5857078_1 Hemerythrin HHE cation binding domain K07216 - - 0.00000002218 63.0
TLS3_k127_5875595_0 BFD-like [2Fe-2S] binding domain K00360 - - 0.00008185 48.0
TLS3_k127_5876942_0 Serine aminopeptidase, S33 K03928 - 3.1.1.1 0.0000000000000000000000000000000000000000000006194 178.0
TLS3_k127_5876942_1 methylglyoxal synthase K01734 - 4.2.3.3 0.0000000000005317 70.0
TLS3_k127_5881130_0 Belongs to the CarA family K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005847 315.0
TLS3_k127_5881130_1 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000003767 169.0
TLS3_k127_5883946_0 Sulfatase-modifying factor enzyme 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002473 284.0
TLS3_k127_5883946_1 adenosine K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009156,GO:0009161,GO:0009163,GO:0009164,GO:0009165,GO:0009167,GO:0009168,GO:0009987,GO:0015949,GO:0015950,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0032261,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.00000000000000000000000000000003153 130.0
TLS3_k127_590136_0 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000004293 148.0
TLS3_k127_590136_1 - - - - 0.000000001529 66.0
TLS3_k127_590136_2 EF hand - - - 0.000001146 56.0
TLS3_k127_590249_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000001769 247.0
TLS3_k127_590249_1 PFAM Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000001126 82.0
TLS3_k127_5906207_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 1.607e-212 695.0
TLS3_k127_5906207_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000004433 207.0
TLS3_k127_5906207_2 DinB family - - - 0.000000000000000000000000000000001676 137.0
TLS3_k127_5919810_0 PFAM ROK family K00845 - 2.7.1.2 0.00000000000000001329 87.0
TLS3_k127_5919810_1 NfeD-like C-terminal, partner-binding - - - 0.00000000000005512 79.0
TLS3_k127_5923439_0 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000009767 136.0
TLS3_k127_5923439_1 Sulfatase-modifying factor enzyme 1 - - - 0.00005964 49.0
TLS3_k127_5926992_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 455.0
TLS3_k127_5936056_0 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000002093 172.0
TLS3_k127_5937519_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007096 509.0
TLS3_k127_5937519_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000003398 97.0
TLS3_k127_593910_0 GMC oxidoreductase K00108 - 1.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005227 550.0
TLS3_k127_593910_1 - - - - 0.0000000000000000000000000000000000000003605 158.0
TLS3_k127_593910_2 - - - - 0.00000000000000000002906 93.0
TLS3_k127_5941044_0 domain protein - - - 0.0000000000000008962 86.0
TLS3_k127_5951874_0 - - - - 0.0000000000002346 76.0
TLS3_k127_5951874_1 photosynthesis - - - 0.000000000003539 71.0
TLS3_k127_59528_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 1.492e-215 684.0
TLS3_k127_59528_1 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835 - 5.4.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006201 332.0
TLS3_k127_59528_2 Cation efflux family K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 307.0
TLS3_k127_59528_3 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000001624 228.0
TLS3_k127_59528_4 PIN domain - - - 0.00000000000000007349 86.0
TLS3_k127_59528_5 PAP2 superfamily - - - 0.0000000002792 69.0
TLS3_k127_59528_6 Ribbon-helix-helix protein, copG family - - - 0.000000007226 61.0
TLS3_k127_5964379_0 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000001811 138.0
TLS3_k127_5964379_1 Lamin Tail Domain - - - 0.0001952 52.0
TLS3_k127_5965676_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000005427 186.0
TLS3_k127_5965676_1 TonB dependent receptor K02014 - - 0.000000000000000000000000003715 127.0
TLS3_k127_5965676_2 Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units - - - 0.0000000000000000000009399 108.0
TLS3_k127_5965676_3 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.000000000007807 69.0
TLS3_k127_5971152_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086,K03087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006771 262.0
TLS3_k127_5980113_0 C-5 cytosine-specific DNA methylase K00558 - 2.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 449.0
TLS3_k127_5980113_1 PFAM Restriction endonuclease, type II, SinI - - - 0.0000000000000000000000000000000000000000000000000000002077 202.0
TLS3_k127_5980113_2 Protein conserved in bacteria K09984 - - 0.0000000000000000000000000000000000000000000001758 169.0
TLS3_k127_5980113_3 - - - - 0.00000000000000000000000000000002304 131.0
TLS3_k127_5980113_4 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000004509 102.0
TLS3_k127_5980113_5 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.0000000000000006957 84.0
TLS3_k127_5980113_6 Cytochrome c - - - 0.0000001764 57.0
TLS3_k127_5985332_0 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000003351 219.0
TLS3_k127_5985332_1 COG0534 Na -driven multidrug efflux pump K03327 - - 0.00000000000000000000000000000000000000000003224 168.0
TLS3_k127_5986132_0 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000008227 55.0
TLS3_k127_6000814_0 PFAM Aminotransferase class I and II K00812,K10907 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001712 275.0
TLS3_k127_6000980_0 epimerase dehydratase K01709,K01710 - 4.2.1.45,4.2.1.46 0.00000002267 61.0
TLS3_k127_6000980_1 Serine aminopeptidase, S33 K06889 - - 0.00003033 53.0
TLS3_k127_600223_0 Uncharacterized ACR, COG1678 K07735 - - 0.000000000000000000000000000989 118.0
TLS3_k127_600223_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.000001267 53.0
TLS3_k127_6008851_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 494.0
TLS3_k127_6008851_1 Cys Met metabolism K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 337.0
TLS3_k127_6016356_0 Dehydratase family K01687 - 4.2.1.9 0.0 1134.0
TLS3_k127_6016356_1 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000557 284.0
TLS3_k127_6016356_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000001126 148.0
TLS3_k127_6016356_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000002375 144.0
TLS3_k127_6017149_0 4 iron, 4 sulfur cluster binding - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000002316 94.0
TLS3_k127_6017149_1 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.0000000000000002246 82.0
TLS3_k127_6017149_2 cytochrome cbb3 oxidase maturation protein CcoH - - - 0.0000000003357 66.0
TLS3_k127_6022145_0 Belongs to the peptidase S8 family - - - 0.00000000000000000000000003646 117.0
TLS3_k127_6022145_1 - - - - 0.0000000006779 64.0
TLS3_k127_6033751_0 NADH:flavin oxidoreductase / NADH oxidase family K00219 - 1.3.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000005558 267.0
TLS3_k127_6033751_1 coproporphyrinogen III oxidase K02495 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 0.0000000000000000000000001656 109.0
TLS3_k127_604611_0 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000001003 63.0
TLS3_k127_604611_1 COG3209 Rhs family protein - - - 0.0008813 49.0
TLS3_k127_6054696_0 Pyridoxal-dependent decarboxylase conserved domain K01593,K01634 - 4.1.1.105,4.1.1.28,4.1.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 588.0
TLS3_k127_6056756_0 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000832 164.0
TLS3_k127_6056756_1 PFAM RNP-1 like RNA-binding protein - - - 0.000000000000000000000000003104 114.0
TLS3_k127_6062242_0 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009721 311.0
TLS3_k127_606591_0 PFAM peptidase S45 penicillin amidase K01434,K07116 - 3.5.1.11,3.5.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 435.0
TLS3_k127_606591_1 alpha beta K06889 - - 0.000000000000000000000000001182 117.0
TLS3_k127_6086134_0 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000002113 203.0
TLS3_k127_6086134_1 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity K00111 - 1.1.5.3 0.000001381 54.0
TLS3_k127_6101194_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 5.271e-219 687.0
TLS3_k127_6101194_1 ATP synthase K02114 - - 0.0000000001837 65.0
TLS3_k127_6106842_0 Including yeast histone deacetylase and acetoin utilization protein K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008572 348.0
TLS3_k127_6106842_1 PGAP1-like protein - - - 0.00000000000000000000000000000002082 136.0
TLS3_k127_6106842_2 PGAP1-like protein - - - 0.0000000000000000000000006731 111.0
TLS3_k127_6106842_3 Serine aminopeptidase, S33 - GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008474,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019752,GO:0032787,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704,GO:0098599,GO:0098732,GO:0098734,GO:0140096 - 0.0000136 56.0
TLS3_k127_6115901_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 2.035e-211 688.0
TLS3_k127_6115901_1 Belongs to the glycosyl hydrolase 13 family K01200 - 3.2.1.41 0.0000000000000000000005209 110.0
TLS3_k127_611625_0 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 439.0
TLS3_k127_6126428_0 Methionine aminopeptidase K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001957 279.0
TLS3_k127_6126428_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000001466 173.0
TLS3_k127_6126428_2 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000002281 169.0
TLS3_k127_6126428_3 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000001017 166.0
TLS3_k127_6126428_4 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000001124 109.0
TLS3_k127_6126428_5 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000001757 96.0
TLS3_k127_6126428_6 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000006031 66.0
TLS3_k127_61312_0 Protein of unknown function, DUF547 - - - 0.0000000000000000000000003117 107.0
TLS3_k127_6136550_0 - - - - 6.482e-299 935.0
TLS3_k127_6136550_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000007376 189.0
TLS3_k127_6146280_0 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000002351 251.0
TLS3_k127_6153802_0 Belongs to the UPF0176 family K07146 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003888 362.0
TLS3_k127_6153802_1 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000002006 170.0
TLS3_k127_6153802_2 - - - - 0.000000000000000000000000000000000000000003536 172.0
TLS3_k127_6153802_3 SRPBCC domain-containing protein - - - 0.00000000000000000000000000000002934 135.0
TLS3_k127_6153802_4 sodium metabolite cotransporter BASS1 K03453 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009526,GO:0009536,GO:0009941,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464 - 0.00000000000000000000000391 105.0
TLS3_k127_6153802_5 BFD-like [2Fe-2S] binding domain K02192 - - 0.000002392 52.0
TLS3_k127_6165600_0 NlpC P60 family protein K19303 - - 0.000000000003659 68.0
TLS3_k127_6192340_0 membrane K08994 - - 0.000000000000000000000000000000000000000000000000000000000788 206.0
TLS3_k127_6192340_1 ABC transporter transmembrane region K11085 - - 0.00000000000000000000000000000000000000000000000000000008095 211.0
TLS3_k127_6193728_0 Zinc-dependent metalloprotease - - - 0.0000000000000000000000000000000000000000000000000000000000000000005756 238.0
TLS3_k127_6193728_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000293 157.0
TLS3_k127_6193728_2 Lactonase, 7-bladed beta-propeller - - - 0.000000000005241 76.0
TLS3_k127_6218675_0 - K01278,K03561,K12287 - 3.4.14.5 0.0000000000000000000000005784 122.0
TLS3_k127_6218675_1 NHL repeat - - - 0.000000000000002684 90.0
TLS3_k127_6219415_0 ABC transporter K15738 - - 0.00000000000000000000000000000000000000000005273 166.0
TLS3_k127_6219415_1 metallopeptidase activity K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000004086 107.0
TLS3_k127_6239944_0 Methyltransferase type 11 K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 484.0
TLS3_k127_6239944_1 Protein of unknown function (DUF3641) - - - 0.000000000000000000000000000000000000000000000000000000004675 201.0
TLS3_k127_6239944_2 Protein of unknown function, DUF547 - - - 0.0000000000000000000000000000000000000000000000000000001324 204.0
TLS3_k127_6239944_3 AhpC/TSA family - - - 0.00000000000000000000000000000000000000000001507 167.0
TLS3_k127_6239944_4 heavy metal translocating P-type ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.0000000000000000000000005055 104.0
TLS3_k127_6255711_0 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006625 276.0
TLS3_k127_6255711_1 endonuclease III K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000003654 198.0
TLS3_k127_6255711_2 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000003814 173.0
TLS3_k127_6255711_3 OmpA family - - - 0.0000000000000000000000000000695 131.0
TLS3_k127_6255711_4 heme binding K08642 - - 0.00000000000000001754 94.0
TLS3_k127_6255711_5 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000006295 55.0
TLS3_k127_6256906_0 bifunctional deaminase-reductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 313.0
TLS3_k127_6256906_1 Activator of Hsp90 ATPase - - - 0.0000000000000000000000000000000000000000000000000000000002096 206.0
TLS3_k127_6256906_2 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000000000006816 179.0
TLS3_k127_6256906_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000002861 168.0
TLS3_k127_6256906_4 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000009191 162.0
TLS3_k127_6256906_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000002412 151.0
TLS3_k127_6256906_6 PD-(D/E)XK nuclease superfamily - - - 0.0000000001101 63.0
TLS3_k127_6256906_7 translation initiation factor activity - - - 0.0009772 47.0
TLS3_k127_6258340_0 OmpA family - - - 0.00000000000000000000000000000000000000009903 172.0
TLS3_k127_6264719_0 SNF2 family N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000001987 203.0
TLS3_k127_6267007_0 Phytanoyl-CoA dioxygenase (PhyH) K21195 - 1.14.11.46 0.00000000000000000000000000000000000000000000000000029 192.0
TLS3_k127_6267007_1 acetyltransferase - - - 0.00000000000000000000000000000000000915 143.0
TLS3_k127_6268587_0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006422 405.0
TLS3_k127_6271169_0 COG3209 Rhs family protein K20276 - - 0.00000000000000000000000000000004445 147.0
TLS3_k127_6271169_1 domain, Protein - - - 0.00000000000000006432 97.0
TLS3_k127_6275833_0 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 290.0
TLS3_k127_6275833_1 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.0000000000000000000000000000000000000000003264 160.0
TLS3_k127_6278219_0 FMN binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 307.0
TLS3_k127_6278219_1 PFAM Biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.0000000000000000000008861 101.0
TLS3_k127_6278219_2 Belongs to the BolA IbaG family K05527,K22066 GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564 - 0.0000003906 55.0
TLS3_k127_6286421_0 Chemotaxis phosphatase CheX K03409 - - 0.00000000000000000000000000000000000004117 147.0
TLS3_k127_6286421_1 PFAM Response regulator receiver domain K03413 - - 0.00000000000000000000000000000003238 128.0
TLS3_k127_6286421_2 Hemerythrin HHE cation binding domain protein K07216 - - 0.00000000000000000000000001901 113.0
TLS3_k127_6286421_3 transmembrane signaling receptor activity - - - 0.000000000000009649 84.0
TLS3_k127_6315475_0 FlhB HrpN YscU SpaS Family K04061 - - 0.00003046 49.0
TLS3_k127_6315475_1 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.00003745 46.0
TLS3_k127_6315475_2 HD domain protein - - - 0.0001 51.0
TLS3_k127_631631_0 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000003391 165.0
TLS3_k127_631631_1 Metallo-beta-lactamase - - - 0.000000000000000000000000000000000000006426 152.0
TLS3_k127_631631_2 Protein of unknown function (DUF1648) - - - 0.000000000000001401 84.0
TLS3_k127_631631_3 Glucose / Sorbosone dehydrogenase - - - 0.00000005346 60.0
TLS3_k127_63188_0 Cupin - - - 0.0000000000000000000000000000000000000000000002161 179.0
TLS3_k127_63188_1 Cyclic nucleotide-monophosphate binding domain K21563 - - 0.00000000000002583 81.0
TLS3_k127_63188_2 NAD(P)H-binding - - - 0.000000061 58.0
TLS3_k127_632334_0 - - - - 0.0009561 52.0
TLS3_k127_6326379_0 Glutamate synthase central domain K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1098.0
TLS3_k127_6329746_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639,K20967 - 4.1.99.22,4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000001821 243.0
TLS3_k127_6330630_0 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000247 127.0
TLS3_k127_6330630_1 COG0784 FOG CheY-like receiver K07315 - 3.1.3.3 0.000000003183 64.0
TLS3_k127_6332603_0 mercury ion transmembrane transporter activity K01533,K17686 GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.4,3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004693 300.0
TLS3_k127_6334162_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 1.026e-261 826.0
TLS3_k127_6337530_0 peptidyl-tyrosine sulfation - - - 0.0004698 53.0
TLS3_k127_6340198_0 - - - - 0.0000000000000000000000000000000000000000000000000002433 187.0
TLS3_k127_6340198_1 nitric oxide dioxygenase activity - - - 0.000000000000000000002496 104.0
TLS3_k127_6363305_0 phenazine biosynthesis protein PhzF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000006099 244.0
TLS3_k127_6363305_1 PFAM Carbamoyl-phosphate synthase L chain K01955 GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000006293 230.0
TLS3_k127_6363305_2 PAP2 superfamily C-terminal - - - 0.0000000000000000000000000000000000000001079 158.0
TLS3_k127_6363305_4 Histidine kinase K07648 - 2.7.13.3 0.0000000001219 64.0
TLS3_k127_6372499_0 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007587 288.0
TLS3_k127_6372499_1 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000009226 233.0
TLS3_k127_6372499_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000003434 181.0
TLS3_k127_6372499_3 Thioredoxin-like - - - 0.00000000000000000004452 96.0
TLS3_k127_6372499_4 protein secretion - - - 0.00000000001013 76.0
TLS3_k127_6372499_5 curli production assembly transport component CsgG - - - 0.0000000396 66.0
TLS3_k127_6372499_6 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000009629 57.0
TLS3_k127_6372499_7 Molydopterin dinucleotide binding domain K07812 - 1.7.2.3 0.00006946 49.0
TLS3_k127_6376769_0 phosphorelay sensor kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 573.0
TLS3_k127_6376769_1 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000004047 73.0
TLS3_k127_6377160_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 5.861e-234 739.0
TLS3_k127_6377160_1 Belongs to the MtfA family K09933 - - 0.0000000000000006933 77.0
TLS3_k127_6380484_0 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000001047 186.0
TLS3_k127_6380484_1 PFAM Cyclic nucleotide-binding - - - 0.00000000000000000000000003822 113.0
TLS3_k127_6380484_2 SMART Tetratricopeptide domain protein - - - 0.0001347 54.0
TLS3_k127_6400875_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain K19694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 304.0
TLS3_k127_6405103_0 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000000000002487 207.0
TLS3_k127_6405103_1 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000007614 196.0
TLS3_k127_6405103_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000003042 115.0
TLS3_k127_6405103_3 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000004619 82.0
TLS3_k127_6410817_0 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000003398 216.0
TLS3_k127_6417580_0 pfkB family carbohydrate kinase - - - 0.00000000000000000000000000000000000000000000000000000381 197.0
TLS3_k127_6426582_0 Aspartyl asparaginyl beta-hydroxylase K12979 - - 0.00000000000000000000000000000583 126.0
TLS3_k127_6426582_1 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000412 118.0
TLS3_k127_6426582_2 JmjC domain-containing protein K10277 - 1.14.11.27 0.00000000000000002936 91.0
TLS3_k127_6429692_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002393 285.0
TLS3_k127_6429692_1 Belongs to the bacterial ribosomal protein bL17 family K02879 GO:0000002,GO:0000313,GO:0000315,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0071840,GO:0098798,GO:0140053,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000002801 67.0
TLS3_k127_6429692_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000007448 61.0
TLS3_k127_6446107_0 Rhamnan synthesis protein F K07272 - - 0.000000000000000000000000000000004907 139.0
TLS3_k127_6446107_1 ABC transporter transmembrane region K06159,K06160 - - 0.000000000007307 74.0
TLS3_k127_6449487_0 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003883 286.0
TLS3_k127_6449487_1 PFAM N-acetylneuraminic acid synthase domain K01654,K18430 - 2.5.1.101,2.5.1.56 0.000000000000000000000001211 108.0
TLS3_k127_6449487_2 phosphocarrier K11184,K11189 - - 0.000000000000000000000007059 103.0
TLS3_k127_6449487_3 Sigma 54 modulation protein / S30EA ribosomal protein K05808 - - 0.00000000007384 72.0
TLS3_k127_6452156_0 Spermidine synthase K00797 - 2.5.1.16 0.00000004734 59.0
TLS3_k127_6452156_1 membrane organization K03641 - - 0.0000001098 65.0
TLS3_k127_6455518_0 Ankyrin repeat - - - 0.00000000000000000000009436 110.0
TLS3_k127_6455518_1 spectrin binding - - - 0.0000000000354 75.0
TLS3_k127_6457760_0 Amp-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000001085 158.0
TLS3_k127_6457760_1 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000008461 91.0
TLS3_k127_6474284_0 outer membrane autotransporter barrel domain - - - 0.000000000000000000000000000000000000002625 170.0
TLS3_k127_6481000_0 - - - - 0.0000000000000000000000000000000000000000000004992 177.0
TLS3_k127_6481000_1 Histidine kinase K07315 - 3.1.3.3 0.000000003767 59.0
TLS3_k127_6482797_1 Tetratricopeptide repeat - - - 0.0005459 51.0
TLS3_k127_6487177_0 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 364.0
TLS3_k127_6487177_1 Domain of unknown function (DUF4153) - - - 0.0000000000000000000000000000001179 133.0
TLS3_k127_6495944_0 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000005714 224.0
TLS3_k127_6495944_1 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.00000000000000000000004851 108.0
TLS3_k127_6495944_2 Involved in resistance toward heavy metals K03926 GO:0003674,GO:0005488,GO:0005507,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840 - 0.0000000003245 65.0
TLS3_k127_6497722_0 Helicase conserved C-terminal domain - - - 0.0000000000000000000000000879 119.0
TLS3_k127_6517157_0 A-macroglobulin complement component - - - 0.0000000000000000000000000000000000000000000000000000000000001019 237.0
TLS3_k127_6544874_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 5.859e-284 882.0
TLS3_k127_6547356_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.00000000000000000000000000000000000000000000000000002197 203.0
TLS3_k127_6550047_0 Met-10+ like-protein - - - 0.0000000000000000000000000000000000008029 146.0
TLS3_k127_6550047_1 - - - - 0.0000007305 54.0
TLS3_k127_6550047_2 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0001622 48.0
TLS3_k127_6553768_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001698 258.0
TLS3_k127_6556119_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000002453 188.0
TLS3_k127_6556119_1 DMT(Drug metabolite transporter) superfamily permease - - - 0.000000000000000000000000000000000008494 148.0
TLS3_k127_6556119_2 Phosphoribosyl transferase domain K00762 - 2.4.2.10 0.00000000000000000000000000000006924 133.0
TLS3_k127_6556119_3 4-oxalocrotonate tautomerase family K01821 - 5.3.2.6 0.00000000000000000000000000005204 117.0
TLS3_k127_6556119_4 Belongs to the Glu Leu Phe Val dehydrogenases family K00262 GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.4 0.000000000000000000009227 93.0
TLS3_k127_6556119_5 PFAM YceI-like domain - - - 0.000000000008495 73.0
TLS3_k127_6556119_6 Protein of unknown function (DUF4199) - - - 0.00003798 54.0
TLS3_k127_6561334_0 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000000004107 213.0
TLS3_k127_6561334_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000003751 115.0
TLS3_k127_6571274_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000148 257.0
TLS3_k127_6571274_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000001169 81.0
TLS3_k127_6571274_2 Transcriptional regulatory protein, C terminal K07658 - - 0.00001629 48.0
TLS3_k127_6575456_0 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000005563 241.0
TLS3_k127_6575456_1 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000006708 126.0
TLS3_k127_6575456_2 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000002845 102.0
TLS3_k127_6578301_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 5.411e-312 979.0
TLS3_k127_6578301_1 glutamate:sodium symporter activity K03312 - - 0.0000000000000000000000000000000000000000001425 175.0
TLS3_k127_6578301_2 Protein of unknown function (DUF1566) - - - 0.00000000001493 72.0
TLS3_k127_6578301_3 metallopeptidase activity - - - 0.000000421 64.0
TLS3_k127_6578301_4 Cellulase (glycosyl hydrolase family 5) K01218 - 3.2.1.78 0.00002001 58.0
TLS3_k127_6579024_0 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 2.572e-252 785.0
TLS3_k127_6579024_1 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000008762 167.0
TLS3_k127_6579024_2 PIN domain - - - 0.00000000000001639 78.0
TLS3_k127_6579024_3 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0000002747 55.0
TLS3_k127_6581765_0 Surface antigen - - - 0.00000000000000000000000000000001873 141.0
TLS3_k127_6584614_0 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 314.0
TLS3_k127_6584614_1 ThiJ/PfpI family-like K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009309 271.0
TLS3_k127_6584614_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000001616 142.0
TLS3_k127_6584614_3 - - - - 0.000000006923 60.0
TLS3_k127_6584614_4 Protein of unknown function (DUF642) - - - 0.00000001025 66.0
TLS3_k127_6584614_5 Plasmid stability protein K21495 - - 0.0000008943 55.0
TLS3_k127_6585455_0 GGDEF domain - - - 0.00000000000000000000000000000000000000000000000001696 195.0
TLS3_k127_6585455_1 Peptidase M50B-like - - - 0.0000000000000009786 87.0
TLS3_k127_6588556_0 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.000000000000000000000000000000000000000000000000000000000000000004572 231.0
TLS3_k127_6588556_1 Reverse transcriptase-like K03469 - 3.1.26.4 0.0000000000000000006631 94.0
TLS3_k127_6596740_0 DNA primase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 457.0
TLS3_k127_6596740_1 Phage integrase, N-terminal SAM-like domain K04763 - - 0.000000000000000000000000000000000000000000000000000000000000001852 229.0
TLS3_k127_6596740_2 Belongs to the 'phage' integrase family. XerC subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000004557 228.0
TLS3_k127_6596740_3 TIGRFAM RHS repeat-associated core - - - 0.000000000000000000000000000000000000000000000000000000146 224.0
TLS3_k127_6596740_4 nucleic acid-binding protein contains PIN domain K07065 - - 0.0000000000000000000000000009599 117.0
TLS3_k127_6596740_5 sequence-specific DNA binding - - - 0.00000000000000000000000001937 112.0
TLS3_k127_6596740_6 Super-infection exclusion protein B - - - 0.00000000000000001742 90.0
TLS3_k127_66090_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000002717 200.0
TLS3_k127_66090_1 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.0000000000000000000000000000000000000002462 156.0
TLS3_k127_66090_2 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000003383 91.0
TLS3_k127_6609856_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 GO:0003674,GO:0003682,GO:0003824,GO:0003938,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002034 273.0
TLS3_k127_6609856_1 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000002366 165.0
TLS3_k127_6609856_2 voltage-gated potassium channel activity K21867 - - 0.0000000006067 65.0
TLS3_k127_6612393_0 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000008668 239.0
TLS3_k127_6612393_1 response regulator, receiver K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000002256 194.0
TLS3_k127_6612393_2 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.0000000000000000000000000000008903 138.0
TLS3_k127_6612393_3 Addiction module toxin, RelE StbE - - - 0.00000000000000000000008889 100.0
TLS3_k127_6612393_4 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.00000000008852 65.0
TLS3_k127_661365_0 phosphogluconate dehydrogenase (decarboxylating) activity K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003729 286.0
TLS3_k127_6630651_0 MazG nucleotide pyrophosphohydrolase domain K02499,K04765 - 3.6.1.9 0.00000000000000000000000000000000000000000000000000001867 199.0
TLS3_k127_6630651_1 Polysaccharide biosynthesis protein CapD - - - 0.0000000000000000000000000000000154 141.0
TLS3_k127_6636983_0 SNF2 Helicase protein K08282 - 2.7.11.1 0.00000000000000000000000000000000000654 152.0
TLS3_k127_6638109_0 PFAM band 7 protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 373.0
TLS3_k127_6638109_1 PFAM band 7 protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 351.0
TLS3_k127_6638109_2 PFAM Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000002113 209.0
TLS3_k127_6642831_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 404.0
TLS3_k127_6642831_1 phenylalanine-tRNA ligase activity K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000874 394.0
TLS3_k127_6642831_2 Beta-lactamase class C and other penicillin binding - - - 0.000000000000000000000001208 119.0
TLS3_k127_6642831_3 BON domain - - - 0.000000000000000000009533 97.0
TLS3_k127_6642831_4 PFAM Lytic K08309 - - 0.00001114 53.0
TLS3_k127_6660326_0 DSBA oxidoreductase - - - 0.0000000000000000000000000000000000000000003971 168.0
TLS3_k127_6660326_1 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.0000000000000000000000000000000000008692 145.0
TLS3_k127_6661717_0 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005403 311.0
TLS3_k127_6661717_1 glycerophosphoryl diester phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001265 268.0
TLS3_k127_6661717_2 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001729 265.0
TLS3_k127_6661717_3 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon - - - 0.00000001835 55.0
TLS3_k127_666729_0 DNA helicase K03656,K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000001983 205.0
TLS3_k127_6677111_0 COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain K09749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 322.0
TLS3_k127_6677111_1 Peptidase, M23 - - - 0.000000000000000000000000000000001007 134.0
TLS3_k127_6677111_2 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000319 128.0
TLS3_k127_6685101_0 Multicopper oxidase - - - 0.0007626 51.0
TLS3_k127_6706576_0 Predicted membrane protein (DUF2157) - - - 0.0000000000000000000000000009682 126.0
TLS3_k127_6708386_0 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00226,K00254 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.3.5.2,1.3.98.1 0.0000000000000000000000000000000000000000000000000000000004229 215.0
TLS3_k127_6708386_1 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000001282 114.0
TLS3_k127_6711268_0 Adenylate cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004135 603.0
TLS3_k127_6711268_1 Alpha beta hydrolase - - - 0.0000000000000000000000000001121 120.0
TLS3_k127_6712125_0 Beta-lactamase superfamily domain - - - 0.00000000000000000000000008114 111.0
TLS3_k127_671227_0 Hydrolase K21471 - - 0.000000000000000000000001627 117.0
TLS3_k127_671227_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000008197 98.0
TLS3_k127_6712288_0 Flagellar filament outer layer protein Flaa - - - 0.00000000000000000003156 101.0
TLS3_k127_6712288_1 Flagellar filament outer layer protein FlaA - - - 0.00000000000002867 76.0
TLS3_k127_6712288_2 Domain present in PSD-95, Dlg, and ZO-1/2. K02452 - - 0.0000000001673 72.0
TLS3_k127_6715645_0 cyclic nucleotide-binding K10914 - - 0.000000000000000000000000000001312 128.0
TLS3_k127_6715662_0 TonB-dependent receptor K16092 - - 0.0000121 57.0
TLS3_k127_673322_0 Ribonuclease z K00784 - 3.1.26.11 0.0000000000000000002031 91.0
TLS3_k127_6741110_0 - - - - 0.000000000000000000000000000000002157 132.0
TLS3_k127_6741110_1 Ndr family - - - 0.0000000000000000000008823 96.0
TLS3_k127_6741110_2 Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell - - - 0.00000000007836 68.0
TLS3_k127_6746499_0 Obg-like ATPase - - - 0.00000000000002182 76.0
TLS3_k127_6746499_1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance - - - 0.00000000003963 70.0
TLS3_k127_6751000_0 Helicase K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000003826 223.0
TLS3_k127_6752476_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 505.0
TLS3_k127_6752476_1 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 361.0
TLS3_k127_6752476_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 343.0
TLS3_k127_6755998_0 DNA primase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 450.0
TLS3_k127_6755998_1 Phage integrase, N-terminal SAM-like domain K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000004351 253.0
TLS3_k127_6755998_2 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.000000000000000000000000000000000005319 158.0
TLS3_k127_6755998_3 Helix-turn-helix - - - 0.0000000000000000000000002353 109.0
TLS3_k127_6755998_4 - - - - 0.00000001116 63.0
TLS3_k127_6771097_0 - - - - 0.00000000000000000000000000000001352 136.0
TLS3_k127_6772239_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000008467 172.0
TLS3_k127_6772239_1 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000002762 89.0
TLS3_k127_6772239_2 PFAM Forkhead-associated protein - - - 0.0002773 49.0
TLS3_k127_6772863_0 ATP-binding cassette protein, ChvD family - - - 7.648e-244 760.0
TLS3_k127_6772863_1 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000001588 169.0
TLS3_k127_6783156_0 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000001267 180.0
TLS3_k127_6792139_0 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582 GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0099046,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.1.11.5 0.0000000000000000000000000000000000001188 163.0
TLS3_k127_6792139_1 Helix-hairpin-helix containing domain K03581 - 3.1.11.5 0.0007364 48.0
TLS3_k127_679249_0 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004183 273.0
TLS3_k127_679249_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000164 227.0
TLS3_k127_679249_2 MerT mercuric transport protein - - - 0.00000000000000000000000000000000000000000000000000000000000004812 221.0
TLS3_k127_679249_3 RelA SpoT domain protein - - - 0.0000000000000000000000000000002545 137.0
TLS3_k127_679249_4 manually curated - - - 0.000000000000000000000000001826 113.0
TLS3_k127_679249_5 - - - - 0.000000000000000000009221 103.0
TLS3_k127_679249_6 - - - - 0.00000000000000000003323 93.0
TLS3_k127_6793949_0 succinate-CoA ligase activity K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 396.0
TLS3_k127_6793949_1 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000001149 148.0
TLS3_k127_6799608_0 Lactonase, 7-bladed beta-propeller - - - 0.0000007673 59.0
TLS3_k127_6803218_0 MMPL family K07003 - - 0.0000000000000000000000000000000000000000000000000000000000004375 229.0
TLS3_k127_6803218_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000004006 61.0
TLS3_k127_6804880_0 ABC transporter, ATP-binding protein K02003 - - 0.000000000000000000000000000000000000000000008848 171.0
TLS3_k127_6806409_1 C-terminal domain of CHU protein family - - - 0.0000000000068 76.0
TLS3_k127_6821538_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 364.0
TLS3_k127_682412_0 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 329.0
TLS3_k127_682412_1 FtsX-like permease family K02004 - - 0.0000000000000000000001261 102.0
TLS3_k127_6834583_0 aldo keto reductase K05275 - 1.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006246 499.0
TLS3_k127_6834583_1 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007687 281.0
TLS3_k127_6834583_2 Predicted metal-dependent hydrolase K07044 - - 0.000000000000000000000000000000000000009425 155.0
TLS3_k127_6834583_3 Protein tyrosine kinase - - - 0.0000000000000005907 86.0
TLS3_k127_6834583_4 Protein of unknown function (DUF2628) - - - 0.00000007287 60.0
TLS3_k127_6835667_0 Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 333.0
TLS3_k127_686093_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 441.0
TLS3_k127_686093_1 protein conserved in bacteria - - - 0.00000000000000000000000000000004445 141.0
TLS3_k127_686093_2 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000001079 126.0
TLS3_k127_686093_3 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000002091 60.0
TLS3_k127_6861552_0 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000001232 116.0
TLS3_k127_6861552_1 - - - - 0.0000000000000000000006581 100.0
TLS3_k127_6862601_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001012 283.0
TLS3_k127_686517_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000003705 265.0
TLS3_k127_6869495_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 471.0
TLS3_k127_6875783_0 PAS domain - - - 2.887e-197 636.0
TLS3_k127_6875783_1 KaiC K08482 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 465.0
TLS3_k127_6875783_2 cheY-homologous receiver domain K02657 - - 0.0000000000000000000002871 102.0
TLS3_k127_6875783_3 KaiB K08481 - - 0.000000001595 63.0
TLS3_k127_6878177_0 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 302.0
TLS3_k127_6878177_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000006821 92.0
TLS3_k127_6890509_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 0.00000000000000000000000000000000006087 137.0
TLS3_k127_6890887_0 PFAM Bacterial regulatory helix-turn-helix proteins, AraC family - - - 0.000000000000002271 88.0
TLS3_k127_6890887_1 Belongs to the peptidase M50B family - - - 0.00000000000141 72.0
TLS3_k127_6891421_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 544.0
TLS3_k127_6891421_1 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000004322 234.0
TLS3_k127_6891421_2 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain K19694 - - 0.000000000000000000000000000000000000000000000000000000000000000172 239.0
TLS3_k127_6891421_3 Protein of unknown function (DUF2937) - - - 0.000000008055 63.0
TLS3_k127_6891421_4 PIN domain - - - 0.0000001182 59.0
TLS3_k127_6891421_5 ApaG domain K06195 - - 0.0002962 43.0
TLS3_k127_6893414_0 protein conserved in bacteria K09778 - - 0.00000000000000000000000006683 118.0
TLS3_k127_6893414_1 domain protein - - - 0.00000000000003688 81.0
TLS3_k127_6899329_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000009273 184.0
TLS3_k127_6908242_0 M18 family aminopeptidase K01267 - 3.4.11.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 293.0
TLS3_k127_6908242_1 TIGRFAM phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000005307 233.0
TLS3_k127_6908242_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000026 86.0
TLS3_k127_6908242_3 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000009817 75.0
TLS3_k127_6911794_0 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 368.0
TLS3_k127_6911794_1 cellulase activity K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000004829 263.0
TLS3_k127_6911794_2 NmrA-like family K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000004072 185.0
TLS3_k127_6911794_3 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000326 156.0
TLS3_k127_69177_0 ankyrin repeat K06867,K21440 - - 0.00002653 56.0
TLS3_k127_693283_0 Phosphate acyltransferases - - - 0.00000000000000000000000000000000009741 149.0
TLS3_k127_693283_2 Serine aminopeptidase, S33 - - - 0.00000000000751 70.0
TLS3_k127_693283_3 Divergent 4Fe-4S mono-cluster K05337 - - 0.0000000001164 64.0
TLS3_k127_6932896_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000015 150.0
TLS3_k127_6932896_1 FtsX-like permease family - - - 0.0000000000009206 75.0
TLS3_k127_6933535_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009848 362.0
TLS3_k127_6941052_0 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 341.0
TLS3_k127_6941052_1 SelR domain K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000009086 203.0
TLS3_k127_6941052_2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000002651 185.0
TLS3_k127_6941052_3 PFAM NUDIX hydrolase K01515 - 3.6.1.13 0.000000000000000326 86.0
TLS3_k127_6943829_0 Polymer-forming cytoskeletal - - - 0.000000000000000002234 89.0
TLS3_k127_6943829_1 Peptidase, M23 family - - - 0.000000000000000004604 91.0
TLS3_k127_6944161_0 TOBE-like domain K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 399.0
TLS3_k127_6944161_1 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000004333 285.0
TLS3_k127_6947946_0 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.0000000000000000000000000000001333 132.0
TLS3_k127_6947946_1 Protein of unknown function (DUF3467) - - - 0.000000000000000001717 89.0
TLS3_k127_6947946_2 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.000000002132 65.0
TLS3_k127_6951596_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006274 452.0
TLS3_k127_6951596_1 PFAM OmpA MotB domain protein K02557 - - 0.0000000000000000000000000000003757 131.0
TLS3_k127_6952550_0 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000002462 214.0
TLS3_k127_6952550_1 ABC transporter K02065 - - 0.0000000000000000000000000000000006627 134.0
TLS3_k127_6972649_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000008383 223.0
TLS3_k127_6972649_1 Helix-turn-helix domain - - - 0.000000000000000000002202 107.0
TLS3_k127_6972649_2 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.00004217 53.0
TLS3_k127_697483_0 - - - - 0.000000000000000000000005495 108.0
TLS3_k127_6979029_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.443e-210 665.0
TLS3_k127_6979029_1 Thioesterase superfamily - - - 0.0000000000000001194 85.0
TLS3_k127_6979029_2 NAD(P)H-binding - - - 0.00006664 48.0
TLS3_k127_6981483_0 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000005502 224.0
TLS3_k127_6981774_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 5.188e-202 642.0
TLS3_k127_6981774_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 304.0
TLS3_k127_6981774_2 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K17223 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000166 214.0
TLS3_k127_6981774_3 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000001622 157.0
TLS3_k127_6981774_4 protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.000000000000002728 78.0
TLS3_k127_6981774_5 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.00000001412 60.0
TLS3_k127_6988963_0 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000398 279.0
TLS3_k127_7005933_0 CDGSH-type zinc finger. Function unknown. - - - 0.000000000000000000000000001653 114.0
TLS3_k127_7005933_1 Adenylate cyclase K01768 - 4.6.1.1 0.000000000000007354 83.0
TLS3_k127_7009776_0 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate K00381 GO:0003674,GO:0003824,GO:0004783,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016673,GO:0019419,GO:0020037,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0097159,GO:1901363 1.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 452.0
TLS3_k127_7009776_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000003155 185.0
TLS3_k127_7009776_2 Siroheme synthase K02304 GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016741,GO:0016829,GO:0018130,GO:0019354,GO:0019438,GO:0019752,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042084,GO:0042168,GO:0042440,GO:0043115,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046156,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.76,4.99.1.4 0.000000000009902 69.0
TLS3_k127_7026097_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006656 322.0
TLS3_k127_7026097_1 tetratricopeptide repeat - - - 0.000000001715 70.0
TLS3_k127_7026114_0 Belongs to the glycosyl hydrolase family 6 K19668 - 3.2.1.91 0.0000000000000000000002651 113.0
TLS3_k127_7026114_1 Alpha beta hydrolase K00433,K01055 - 1.11.1.10,3.1.1.24 0.0000000002574 64.0
TLS3_k127_7043990_0 PspA/IM30 family K03969 - - 0.0000000000000000000000000005564 116.0
TLS3_k127_7043990_1 Tetratricopeptide repeat - - - 0.00000000000008717 80.0
TLS3_k127_7047746_0 adhesin AidA-related - - - 0.000001976 58.0
TLS3_k127_7051028_0 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 301.0
TLS3_k127_7068151_0 Periplasmic binding protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004749 650.0
TLS3_k127_7068151_1 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 643.0
TLS3_k127_7068151_2 hydrolase of the alpha beta-hydrolase fold K07019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 291.0
TLS3_k127_7068151_3 ubiquinone biosynthetic process - - - 0.0000000000000000000000000000000000000000000000005546 184.0
TLS3_k127_7068151_4 Arylesterase - - - 0.00000000000000000000000000000000000000000003346 175.0
TLS3_k127_7068151_5 Methyltransferase - - - 0.00000000000000007799 91.0
TLS3_k127_7068151_6 conserved protein, contains double-stranded beta-helix domain - - - 0.00000000000002006 78.0
TLS3_k127_7068151_7 Acts as a magnesium transporter - - - 0.0000000008015 68.0
TLS3_k127_7073042_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.875e-228 721.0
TLS3_k127_7073042_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000003198 228.0
TLS3_k127_7073937_0 PFAM phospholipase D Transphosphatidylase - - - 0.000000000000000000000002269 119.0
TLS3_k127_7073937_1 FMN-dependent dehydrogenase K11517 - 1.1.3.15 0.00001884 48.0
TLS3_k127_7078544_0 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000006685 179.0
TLS3_k127_7078544_1 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000001254 90.0
TLS3_k127_7078544_2 ORF located using Glimmer GeneMark Blastx COG0697 - - - 0.000000000000008505 77.0
TLS3_k127_7078544_3 protein, possibly involved in aromatic compounds catabolism - - - 0.000006375 54.0
TLS3_k127_7078544_4 Putative beta-lactamase-inhibitor-like, PepSY-like - - - 0.00007225 51.0
TLS3_k127_7081563_0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000000000000002391 233.0
TLS3_k127_7081563_1 LexA-binding, inner membrane-associated putative hydrolase K07038 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000003134 167.0
TLS3_k127_7081563_2 - - - - 0.000000000000000000000000002479 113.0
TLS3_k127_7081563_3 Protein conserved in bacteria K09859 - - 0.0000003512 61.0
TLS3_k127_708202_0 PFAM N-6 DNA methylase K03427 - 2.1.1.72 1.791e-271 840.0
TLS3_k127_708202_1 AAA domain - - - 0.000000000000000000000009275 103.0
TLS3_k127_7090509_0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000003367 270.0
TLS3_k127_7090509_1 Hydroxymethylglutaryl-CoA lyase K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000001196 208.0
TLS3_k127_7090509_2 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000000000000000001287 158.0
TLS3_k127_7090509_3 Beta-lactamase superfamily domain K06167 - 3.1.4.55 0.00006198 49.0
TLS3_k127_7090931_0 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000001328 216.0
TLS3_k127_7090931_1 fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000002366 146.0
TLS3_k127_7091929_0 beta-lactamase - - - 0.000006419 57.0
TLS3_k127_7098473_0 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 409.0
TLS3_k127_7098473_1 sodium hydrogen exchanger - - - 0.0000001182 65.0
TLS3_k127_7098651_0 May be involved in recombinational repair of damaged DNA K03631,K07459,K20345 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 346.0
TLS3_k127_7098651_1 PFAM Cytochrome C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008697 251.0
TLS3_k127_7103542_0 TIGRFAM RHS repeat-associated core - - - 0.0000000000000000000000000000000000000000000000000005048 213.0
TLS3_k127_7105211_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 392.0
TLS3_k127_7105211_1 Serine phosphatase RsbU regulator of sigma subunit - - - 0.00000000000000000001752 103.0
TLS3_k127_7109716_0 Aspartate carbamoyltransferase K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000003005 225.0
TLS3_k127_7110010_0 (ABC) transporter K02021,K06147,K06148,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 362.0
TLS3_k127_7110010_1 Chemotaxis phosphatase CheX K03409 - - 0.000000000000000000000000000000000001461 143.0
TLS3_k127_7110010_2 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000001604 149.0
TLS3_k127_7114821_0 FAD linked oxidase domain protein K11472 - - 0.0000000000000000000000000000000000000000000001663 177.0
TLS3_k127_7114821_1 cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000001267 115.0
TLS3_k127_7115020_0 COG0642 Signal transduction histidine kinase K07678 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000079 231.0
TLS3_k127_7115020_1 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000000006091 193.0
TLS3_k127_7115020_2 EamA-like transporter family K15268 - - 0.0000000000008283 71.0
TLS3_k127_712022_0 Sigma factor PP2C-like phosphatases K01768,K07315 - 3.1.3.3,4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000008274 244.0
TLS3_k127_7126889_0 Appr-1'-p processing enzyme - GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231 - 0.000000000000000000000000000000000000000004905 157.0
TLS3_k127_7126889_1 NHL repeat containing protein - - - 0.0000000000000003071 92.0
TLS3_k127_7126889_2 cellulase activity - - - 0.0000000006782 65.0
TLS3_k127_712813_0 acetyltransferase K00661 - 2.3.1.79 0.00000000000001403 85.0
TLS3_k127_7130535_0 PFAM acyl-CoA dehydrogenase domain protein K00253 - 1.3.8.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 389.0
TLS3_k127_7130535_1 carboxypeptidase K14054 - - 0.00000000000000000087 97.0
TLS3_k127_7130535_2 PFAM General secretion pathway protein K K02460 - - 0.0000000000000006771 88.0
TLS3_k127_7133298_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007299 344.0
TLS3_k127_7133298_1 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007227 291.0
TLS3_k127_7133298_2 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000003562 216.0
TLS3_k127_7137062_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 561.0
TLS3_k127_7137062_1 Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene) K09880 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019509,GO:0019752,GO:0042578,GO:0043094,GO:0043102,GO:0043436,GO:0043874,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.77 0.0000000000000000000000000000000000000000000000000009786 190.0
TLS3_k127_7137062_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000004844 133.0
TLS3_k127_7138992_0 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000008909 226.0
TLS3_k127_7138992_1 TrkA-C domain K10716 - - 0.000000000000000000000000005332 119.0
TLS3_k127_7138992_2 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000001253 108.0
TLS3_k127_71423_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 398.0
TLS3_k127_71423_1 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.0000000000000000000000000000000000000000000004283 181.0
TLS3_k127_71423_2 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000002357 91.0
TLS3_k127_71423_3 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000001508 81.0
TLS3_k127_7150404_0 PFAM Coenzyme A transferase K01029,K01032 - 2.8.3.5,2.8.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 373.0
TLS3_k127_7150404_1 PFAM Coenzyme A transferase K01027,K01028,K01031,K01034 - 2.8.3.5,2.8.3.6,2.8.3.8,2.8.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009426 324.0
TLS3_k127_7151687_0 Haemolysin-III related K11068 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000001118 190.0
TLS3_k127_7151687_1 8-amino-7-oxononanoate synthase - - - 0.000000000000000000000000000782 130.0
TLS3_k127_7151687_2 PFAM membrane-bound metal-dependent hydrolase K07038 - - 0.000000000000000000001276 108.0
TLS3_k127_7151687_3 SNARE associated Golgi protein - - - 0.000000000000007266 88.0
TLS3_k127_7152423_0 Major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 442.0
TLS3_k127_7152423_1 PFAM CBS domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009767 357.0
TLS3_k127_7152423_2 PFAM Bacterial transcription activator, effector binding domain K13653 - - 0.000000000000000000000000000000000000000008723 159.0
TLS3_k127_7152423_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000001797 128.0
TLS3_k127_7156264_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 411.0
TLS3_k127_7156264_1 Molybdopterin converting factor K03635 - 2.8.1.12 0.00000000000000000000000000000000000003047 147.0
TLS3_k127_7156264_2 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000002929 116.0
TLS3_k127_7159666_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00322 - 1.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008712 566.0
TLS3_k127_7169065_0 Outer membrane lipoprotein - - - 0.000129 54.0
TLS3_k127_7177482_0 Sodium:neurotransmitter symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 539.0
TLS3_k127_717938_0 COG0859 ADP-heptose LPS heptosyltransferase - - - 0.00000000000000001083 96.0
TLS3_k127_717938_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 GO:0008150,GO:0040007 1.2.1.70 0.00000000000001022 82.0
TLS3_k127_7181998_0 COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain) K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 294.0
TLS3_k127_7185275_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K10912 GO:0000156,GO:0000160,GO:0003674,GO:0003700,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000008146 81.0
TLS3_k127_7185275_1 HDOD domain - - - 0.00000000000002049 83.0
TLS3_k127_7187346_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1233.0
TLS3_k127_7194097_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 366.0
TLS3_k127_7194097_1 - - - - 0.0000000000003878 79.0
TLS3_k127_7200820_0 Oxidoreductase FAD-binding domain K00523 - 1.17.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008123 322.0
TLS3_k127_7200820_1 Flavin containing amine oxidoreductase K00231,K14266 - 1.14.19.9,1.3.3.15,1.3.3.4 0.00000000000000000000000000000000003172 148.0
TLS3_k127_7200820_2 Bifunctional nuclease K08999 - - 0.00000000000000000000000009053 116.0
TLS3_k127_7200820_3 Patatin-like phospholipase K07001 - - 0.0004646 47.0
TLS3_k127_7214824_0 repeat-containing protein - - - 0.00000000008143 74.0
TLS3_k127_7214824_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00001262 49.0
TLS3_k127_72179_0 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 327.0
TLS3_k127_72179_1 acid phosphatase activity - - - 0.000000000000000000000000000000000000000000000000000000001744 212.0
TLS3_k127_72179_2 KR domain - - - 0.000000000000001496 78.0
TLS3_k127_72190_0 GTP-binding protein K06207 - - 0.00000000000000000000000000000000000000000000000894 174.0
TLS3_k127_72190_1 COG0668 Small-conductance mechanosensitive channel - - - 0.0000000000000000000000000000000000000000595 162.0
TLS3_k127_72190_2 Histidine kinase - - - 0.0000002078 64.0
TLS3_k127_7219741_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000394 273.0
TLS3_k127_7219741_1 Histidine kinase - - - 0.0000000000000000000000000000477 123.0
TLS3_k127_7232166_0 COG1055 Na H antiporter NhaD and related arsenite - - - 0.000000000000000000000000000000000001374 147.0
TLS3_k127_7232166_1 chlorophyll binding K03286 - - 0.000000000000000003984 95.0
TLS3_k127_7232166_2 Belongs to the ompA family K03286 - - 0.0000000000000003473 89.0
TLS3_k127_7239531_0 TonB-dependent Receptor Plug Domain - - - 0.0000000000000000004253 101.0
TLS3_k127_7239531_1 ABC transporter substrate binding protein K01989 - - 0.000002653 55.0
TLS3_k127_7239531_2 Histidine kinase - - - 0.00003308 57.0
TLS3_k127_7239531_3 response regulator K07315 - 3.1.3.3 0.0009238 52.0
TLS3_k127_7249052_0 Belongs to the UPF0061 (SELO) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 598.0
TLS3_k127_7268228_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003176 281.0
TLS3_k127_7268228_1 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.0000000000000000000000001736 113.0
TLS3_k127_7268228_2 PFAM Bacterial regulatory proteins, tetR family K09017 - - 0.000000001141 67.0
TLS3_k127_7279479_0 arylsulfatase activity - - - 0.000000000000000000004474 105.0
TLS3_k127_7283391_0 Belongs to the 5'-nucleotidase family K01081,K07004,K08693,K11751 - 3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45 0.00000001673 67.0
TLS3_k127_7303194_0 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007226 287.0
TLS3_k127_7303194_1 R3H domain protein K06346 - - 0.00000000000000000000000000000000002309 144.0
TLS3_k127_7322799_0 stress-induced mitochondrial fusion - - - 0.000000000000000000000000000000000000000000000000000000000000000000002116 243.0
TLS3_k127_7322799_1 Putative restriction endonuclease - - - 0.00003153 47.0
TLS3_k127_7322799_2 TIGRFAM Polymorphic membrane protein, Chlamydia - - - 0.0001364 55.0
TLS3_k127_7322799_3 hydrolase family 5 K01218 - 3.2.1.78 0.0005434 53.0
TLS3_k127_7323681_0 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007979 304.0
TLS3_k127_7356882_0 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - - 0.0000000000000000000000000000000000000005674 159.0
TLS3_k127_7361056_0 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000001238 243.0
TLS3_k127_7365621_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003205 279.0
TLS3_k127_7365621_2 - - - - 0.0009424 46.0
TLS3_k127_7379330_0 Phosphorylase superfamily K00772,K03783 - 2.4.2.1,2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 311.0
TLS3_k127_7379330_1 oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor K00283 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.4.4.2 0.000003349 51.0
TLS3_k127_7382709_0 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008788 377.0
TLS3_k127_7382709_1 Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00334,K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000001115 175.0
TLS3_k127_7382709_2 PFAM FecR protein - - - 0.000000003942 66.0
TLS3_k127_7392480_0 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 451.0
TLS3_k127_7397731_0 Tellurite resistance protein TehB - - - 0.0000000000000000000000000000000000000000000000000000000000000001663 226.0
TLS3_k127_7397731_1 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000005604 210.0
TLS3_k127_7397731_2 DNA topoisomerase (ATP-hydrolyzing) inhibitor activity K13652 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000001188 72.0
TLS3_k127_7399463_0 Nitrite and sulphite reductase 4Fe-4S domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 608.0
TLS3_k127_7399463_1 oxidoreductase FAD NAD(P)-binding domain protein K00380 - 1.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000999 455.0
TLS3_k127_7421972_0 NAD(P)H-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 346.0
TLS3_k127_7421972_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000009073 194.0
TLS3_k127_7421972_2 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.0000000000000000000000000000000000000000000001066 172.0
TLS3_k127_7421972_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000002696 158.0
TLS3_k127_7427879_0 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 335.0
TLS3_k127_7439708_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000008917 202.0
TLS3_k127_7439708_1 cyclopropane-fatty-acyl-phospholipid synthase K20444 - - 0.000000006403 64.0
TLS3_k127_7440247_0 Transglycosylase K05366 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 316.0
TLS3_k127_7440247_1 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000002851 162.0
TLS3_k127_7451267_0 - - - - 0.000000000000000000000000000000000000003459 151.0
TLS3_k127_7451763_0 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000012 291.0
TLS3_k127_7451763_1 Carboxylesterase family - - - 0.00000000000000000000000000000000000000000000000000000000000000003769 234.0
TLS3_k127_7451763_2 Peptidase, U32 family K08303 - - 0.000000000000000000000000000000363 129.0
TLS3_k127_7451763_3 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000006089 109.0
TLS3_k127_7451763_4 3-demethylubiquinone-9 3-O-methyltransferase activity K07011 - - 0.00001376 51.0
TLS3_k127_7451885_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000004231 63.0
TLS3_k127_7462794_0 PFAM ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001758 261.0
TLS3_k127_7462794_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00065 - 1.1.1.127 0.0000000000000000000000000000000000000000000008536 175.0
TLS3_k127_7462794_2 Phosphoglycerate mutase - - - 0.000000000000000000006354 102.0
TLS3_k127_7465904_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 516.0
TLS3_k127_7465904_1 ClpX C4-type zinc finger K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 505.0
TLS3_k127_7465904_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006361 277.0
TLS3_k127_7465904_3 transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000185 95.0
TLS3_k127_7466818_0 Cytochrome c-type biogenesis protein K02198 - - 0.000000000000000009133 89.0
TLS3_k127_746798_0 D-glycerate 3-kinase K15918 - 2.7.1.31 0.00000000000000000000000000000000000000000000000001944 186.0
TLS3_k127_7468073_0 Response regulator receiver domain - - - 0.00000000000000000000000000001943 124.0
TLS3_k127_7468073_1 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.000000000000000002678 91.0
TLS3_k127_7474353_0 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07659 - - 0.000000000000000000001731 102.0
TLS3_k127_7474353_1 Sensor protein basS K07643,K07645 GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0042221,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 0.000000000832 68.0
TLS3_k127_7474615_0 phosphorelay sensor kinase activity K07673 - 2.7.13.3 0.000000001032 72.0
TLS3_k127_7490760_0 TIGRFAM RHS repeat-associated core - - - 0.0000000000000000000000000000439 134.0
TLS3_k127_7492081_0 Shikimate kinase K00891 - 2.7.1.71 0.00000000000000000000223 102.0
TLS3_k127_7492081_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000002465 49.0
TLS3_k127_7496583_0 translation initiation factor activity - - - 0.00000000000000006928 94.0
TLS3_k127_7496583_1 FecR protein - - - 0.00000003001 66.0
TLS3_k127_7501344_0 D-isomer specific 2-hydroxyacid dehydrogenase K03778 - 1.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 415.0
TLS3_k127_7508042_0 PFAM Sodium sulphate symporter K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003732 465.0
TLS3_k127_7508042_1 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 440.0
TLS3_k127_7508042_2 Protein of unknown function (DUF2490) - - - 0.000000000000000000000000000000000000000000000000000000004108 208.0
TLS3_k127_7516779_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 521.0
TLS3_k127_7516779_1 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007116 247.0
TLS3_k127_7516779_2 hemolysin - - - 0.0000000000000000000000000000000000000000000000000000002736 202.0
TLS3_k127_7516779_3 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000004556 182.0
TLS3_k127_7516779_4 Transport and Golgi organisation 2 - - - 0.0000000000000000000000000000000187 138.0
TLS3_k127_7516779_5 DinB family - - - 0.000000000000000000000000005064 118.0
TLS3_k127_7525291_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 441.0
TLS3_k127_7532223_0 GHMP kinases C terminal K07031 - 2.7.1.168 0.00000000000000000000000000000000000000000000000000006084 194.0
TLS3_k127_7532223_1 Lysin motif - - - 0.0006493 49.0
TLS3_k127_7533742_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K18824 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 0.000000000000000000000000000000000000000000000000000000001267 210.0
TLS3_k127_7533742_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 2.7.7.85 0.00000000000000000000000000000009322 130.0
TLS3_k127_7534477_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 366.0
TLS3_k127_7534477_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000005864 70.0
TLS3_k127_7542752_0 Beta-propeller repeat - - - 0.00001775 57.0
TLS3_k127_7551525_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.00002032 48.0
TLS3_k127_7567966_0 Transfers the fatty acyl group on membrane lipoproteins - - - 0.000000000008679 77.0
TLS3_k127_756803_0 HD domain - - - 0.000000000000000000000000000000001276 148.0
TLS3_k127_7573370_0 PFAM Fatty acid desaturase K04712 - 1.14.18.5,1.14.19.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 337.0
TLS3_k127_7573370_1 iron ion binding - - - 0.00000000000000000000000000000000000004214 149.0
TLS3_k127_7574875_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000009742 230.0
TLS3_k127_7574875_1 Urate oxidase N-terminal - - - 0.000000000000000000000000000000000000004833 154.0
TLS3_k127_75753_0 Dienelactone hydrolase family - - - 0.0000000000000000000000000008457 118.0
TLS3_k127_7577443_0 CHASE2 K10715 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000305 279.0
TLS3_k127_7583925_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 615.0
TLS3_k127_7583925_1 LysM domain - - - 0.00000000001378 73.0
TLS3_k127_7587493_0 membrane organization K03641,K07277 - - 0.0000000000000000000000000000000000000000000000000000000001208 214.0
TLS3_k127_7587493_1 Inner membrane protein involved in colicin E2 resistance K06143 - - 0.000000000000000000000000000000000000000000000000009401 196.0
TLS3_k127_7588411_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 359.0
TLS3_k127_7588411_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000005954 229.0
TLS3_k127_7588411_2 Sigma-70 region 2 K03088 - - 0.0003111 52.0
TLS3_k127_7591480_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 468.0
TLS3_k127_7591480_1 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000002403 96.0
TLS3_k127_7593820_0 pseudouridine synthase activity K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.000000000000000000000000000000000000000000000000002645 203.0
TLS3_k127_7593820_1 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.0000000000000002649 83.0
TLS3_k127_7593820_2 Bacterial SH3 domain - - - 0.000003977 57.0
TLS3_k127_7596440_0 EAL domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 343.0
TLS3_k127_7596482_0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 497.0
TLS3_k127_7596482_1 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 454.0
TLS3_k127_7596482_2 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000004563 167.0
TLS3_k127_7596518_0 cyclic nucleotide-binding - - - 0.0000000000000000000000000000003534 126.0
TLS3_k127_7596518_1 cyclic nucleotide-binding - - - 0.00000000008211 72.0
TLS3_k127_760518_0 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000004249 186.0
TLS3_k127_760518_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.000000000000000000000000000000000000000001545 162.0
TLS3_k127_760518_2 M23 M37 peptidase domain protein - - - 0.00000000000000000000000000000000000002088 156.0
TLS3_k127_7615535_0 peptidyl-tyrosine sulfation - - - 0.00004003 57.0
TLS3_k127_7615535_1 EstX protein - - - 0.0005631 49.0
TLS3_k127_7615771_0 Zinc-dependent metalloprotease - - - 0.00000000000000000000000000000000000000000000000000000000000000005511 233.0
TLS3_k127_7617839_0 domain, Protein - - - 0.00000000000008049 83.0
TLS3_k127_7617839_1 beta-lactamase activity K07126 - - 0.00000000001071 73.0
TLS3_k127_7627953_0 iron ion binding - - - 0.00000000000000000000000000000000000000000000000002459 185.0
TLS3_k127_7640414_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001449 233.0
TLS3_k127_7640414_1 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000006813 79.0
TLS3_k127_7644156_0 response regulator, receiver - - - 0.0000007077 60.0
TLS3_k127_764701_0 COGs COG1253 Hemolysins and related protein containing CBS domains - - - 0.00000000000000000000000000000000000186 148.0
TLS3_k127_764701_1 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K01489,K03474,K03595,K07042 GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 0.00000000000000007718 87.0
TLS3_k127_7649589_0 Sulfatase K01138 - - 0.000000000000000000000000000000000000000000000000000000006571 221.0
TLS3_k127_7649950_0 Aldolase K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009798 562.0
TLS3_k127_7649950_1 - - - - 0.0000000000000000000000000001964 119.0
TLS3_k127_7649950_2 Alpha/beta hydrolase family - - - 0.00000000000000000285 96.0
TLS3_k127_7657196_0 Glyoxalase - - - 0.000000000000000000000000000009164 121.0
TLS3_k127_7657196_1 Ankyrin repeat and protein kinase domain-containing protein 1 K16289 - 2.7.11.1 0.000001508 59.0
TLS3_k127_7661886_0 Elongation factor P--(R)-beta-lysine ligase K04568 - - 0.000000000000989 76.0
TLS3_k127_7662092_0 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000001442 184.0
TLS3_k127_7665461_0 Guanine deaminase K01487 - 3.5.4.3 0.000000000000000000000000000000000000000000000000000000000000000000001281 252.0
TLS3_k127_7665461_1 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.000000000000000000000000000000000000000000000000000000000000000003774 243.0
TLS3_k127_7665461_2 Adenine glycosylase K03575 - - 0.00000000000000000000000000000000000000000000007309 185.0
TLS3_k127_7665461_3 Putative restriction endonuclease - - - 0.000000000000000000002784 100.0
TLS3_k127_7665461_5 ATPases associated with a variety of cellular activities K02065 - - 0.00000001887 58.0
TLS3_k127_7665461_7 - - - - 0.00003019 51.0
TLS3_k127_7665991_0 glycyl-tRNA synthetase, tetrameric type, beta subunit K01879 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 349.0
TLS3_k127_7665991_1 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.000000001048 70.0
TLS3_k127_7666667_0 von Willebrand factor type A domain K07114 - - 0.000000002816 68.0
TLS3_k127_7666667_1 Belongs to the peptidase S26 family K03100 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.4.21.89 0.0001531 49.0
TLS3_k127_7667459_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000001315 264.0
TLS3_k127_7667459_1 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000006685 148.0
TLS3_k127_7679298_0 Enoyl-(Acyl carrier protein) reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000002232 254.0
TLS3_k127_7679298_1 Nitroreductase family - - - 0.00000000000000000000000000000000000001352 151.0
TLS3_k127_7679298_2 Cupin superfamily (DUF985) K09705 - - 0.00000000000000000000000000000001207 133.0
TLS3_k127_7679298_3 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000000000006397 101.0
TLS3_k127_7679298_4 PFAM YcfA-like protein - - - 0.0000000000000000000006735 97.0
TLS3_k127_7694836_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 432.0
TLS3_k127_7694836_1 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.000000000000543 70.0
TLS3_k127_76960_0 oxidoreductase FAD NAD(P)-binding K21832 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 325.0
TLS3_k127_76960_1 Bacterial protein of unknown function (DUF898) - - - 0.00000000000000000000000000000000000000000001731 175.0
TLS3_k127_76960_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000008994 126.0
TLS3_k127_76960_3 cyclic nucleotide-binding domain - - - 0.0000000006756 61.0
TLS3_k127_7704021_0 recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000001716 225.0
TLS3_k127_7704021_1 ATPase with chaperone activity K07391 - - 0.0000000000000000000000000000000000000000000003961 175.0
TLS3_k127_7704051_0 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 323.0
TLS3_k127_7704051_1 NmrA-like family - - - 0.000000000000000000000000000004316 123.0
TLS3_k127_7707840_0 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000001905 105.0
TLS3_k127_7707840_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0003264 50.0
TLS3_k127_7708952_0 Alginate export - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 409.0
TLS3_k127_7710217_0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000001753 57.0
TLS3_k127_7715571_0 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 415.0
TLS3_k127_7715571_1 7TM diverse intracellular signalling K00694,K07315,K20977 - 2.4.1.12,3.1.3.3 0.0000000000000000000000000000000000000000000000000008601 209.0
TLS3_k127_7715692_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000009503 250.0
TLS3_k127_7715692_1 protein ubiquitination K10454,K10457 - - 0.0000000000000000000000004964 121.0
TLS3_k127_7715692_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000128 73.0
TLS3_k127_7722378_0 Esterase PHB depolymerase K03932 - - 0.0000000000000000000000000000000000000000000000000000000000000005061 232.0
TLS3_k127_7722378_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000001953 171.0
TLS3_k127_7722378_2 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000008983 128.0
TLS3_k127_7722378_3 MerC mercury resistance protein - - - 0.00003759 52.0
TLS3_k127_7726368_0 TIGRFAM RHS repeat-associated core - - - 0.000000000000000000000000000000000001178 162.0
TLS3_k127_7727198_1 Pyruvate kinase, barrel domain - - - 0.000000000001088 72.0
TLS3_k127_7728506_0 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 346.0
TLS3_k127_7728506_1 diaminopimelate decarboxylase activity K01581 - 4.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000003276 259.0
TLS3_k127_7728506_2 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.00000000000000000000000000000000000000004406 162.0
TLS3_k127_7728506_3 protein conserved in cyanobacteria - - - 0.000000000000000000000000000000000001144 145.0
TLS3_k127_7728506_4 regulation of translation K03530 - - 0.0000000000000000004888 91.0
TLS3_k127_7728506_5 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000001179 89.0
TLS3_k127_7728506_6 Alpha beta hydrolase - - - 0.00000000005989 74.0
TLS3_k127_7728574_0 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004112 364.0
TLS3_k127_7728574_1 Protein of unknown function (DUF1295) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008893 321.0
TLS3_k127_7744453_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000005852 63.0
TLS3_k127_7750792_0 COG0666 FOG Ankyrin repeat K06867 - - 0.000000000000000000000000002913 120.0
TLS3_k127_775534_0 Diacylglycerol kinase catalytic domain - - - 0.00000000002686 72.0
TLS3_k127_7756109_0 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000000000000000000000000000000000000006553 158.0
TLS3_k127_7756109_1 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00956 - 2.7.7.4 0.00000003094 61.0
TLS3_k127_7760495_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003587 379.0
TLS3_k127_7760495_1 Psort location CytoplasmicMembrane, score - - - 0.0000000000000003345 88.0
TLS3_k127_7760495_2 Hemerythrin HHE cation binding domain protein K07216 - - 0.000000002539 66.0
TLS3_k127_7760495_3 - - - - 0.000000006274 58.0
TLS3_k127_7761198_0 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 355.0
TLS3_k127_7761198_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000001046 251.0
TLS3_k127_7771036_0 Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway K08967 GO:0000096,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0010309,GO:0016491,GO:0016701,GO:0016702,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0051213,GO:0055114,GO:0071704,GO:1901564,GO:1901605 1.13.11.53,1.13.11.54 0.0000000000000000000000000000000000000000000000000000000000002904 215.0
TLS3_k127_7771036_1 Class ii aldolase K01628,K08964,K08966 - 3.1.3.87,4.1.2.17,4.2.1.109 0.0000000000000000000000000000000000002722 148.0
TLS3_k127_7771425_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877 - 0.00000000000000000000000000000000000000000000000000000000001516 215.0
TLS3_k127_7771425_1 Enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000001648 147.0
TLS3_k127_7775726_0 exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 353.0
TLS3_k127_7776131_0 Belongs to the MIP aquaporin (TC 1.A.8) family K02440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005921 325.0
TLS3_k127_7776131_1 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related K18151 - 3.5.1.116 0.00000000000000000000000000000000000000000000005062 174.0
TLS3_k127_7776131_2 Haem-degrading - - - 0.00000000000000000000000000000000006264 139.0
TLS3_k127_7776131_3 Signal peptidase I K03100 - 3.4.21.89 0.0000000000000001301 91.0
TLS3_k127_7776131_4 iron ion binding - - - 0.0000000000000003374 79.0
TLS3_k127_7781969_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 475.0
TLS3_k127_7782645_0 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000004443 159.0
TLS3_k127_7782645_1 Protein conserved in bacteria - - - 0.00000001816 66.0
TLS3_k127_77832_0 Cyclic peptide transporter K06160 - - 0.000000000000000000000000000000000000000000000000000000000000000004381 236.0
TLS3_k127_77832_1 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000003982 163.0
TLS3_k127_7791528_0 Acts as a magnesium transporter - - - 0.0000009533 56.0
TLS3_k127_7802711_0 transcriptional - - - 0.0000000000000004004 89.0
TLS3_k127_7805852_0 NADH:flavin oxidoreductase / NADH oxidase family K00219 - 1.3.1.34 0.00000000000000000000000000000000001041 138.0
TLS3_k127_7808105_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 411.0
TLS3_k127_7808105_1 Sphingolipid Delta4-desaturase (DES) K04712 - 1.14.18.5,1.14.19.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 332.0
TLS3_k127_7819959_0 in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine K15777 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 307.0
TLS3_k127_7819959_1 protein conserved in bacteria K09919 - - 0.00000000000000000000000000000000000000000000000003298 184.0
TLS3_k127_7830572_0 Belongs to the DEAD box helicase family - GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000727 473.0
TLS3_k127_7853567_0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000009314 174.0
TLS3_k127_7853567_1 Putative glycosyl hydrolase domain - - - 0.0000209 51.0
TLS3_k127_7853602_0 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000006548 174.0
TLS3_k127_7853602_1 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000000000004255 78.0
TLS3_k127_7857709_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000861 196.0
TLS3_k127_7858289_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 559.0
TLS3_k127_7859157_0 Alpha-2-Macroglobulin K06894 - - 0.00000000000000000000000000007008 134.0
TLS3_k127_786410_0 signal peptide peptidase SppA, 67K type K04773 - - 0.000000000000000000000000000000000001477 149.0
TLS3_k127_786410_1 - - - - 0.00001294 58.0
TLS3_k127_7866513_0 converts alpha-aldose to the beta-anomer - - - 0.00000000000000000000000000000000000000000000000000000000000000000004045 245.0
TLS3_k127_7866513_1 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.00000000000000000000000000000000000000000000000000000000001015 216.0
TLS3_k127_7866513_2 - - - - 0.000000000000000000000004023 115.0
TLS3_k127_7866513_3 adenosylhomocysteine nucleosidase activity K01243,K03784,K11783 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.4.2.1,3.2.2.26,3.2.2.9 0.00000006912 61.0
TLS3_k127_7867858_0 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000008014 151.0
TLS3_k127_7867858_1 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000005348 124.0
TLS3_k127_7867858_2 Serine aminopeptidase, S33 - - - 0.000000000000000000002649 99.0
TLS3_k127_7869040_0 acyl-CoA dehydrogenase K00249,K00255 - 1.3.8.7,1.3.8.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000003702 264.0
TLS3_k127_7885164_0 ferrous iron transmembrane transporter activity K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 568.0
TLS3_k127_7885164_1 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000003909 253.0
TLS3_k127_7885164_2 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.0000000000000001562 90.0
TLS3_k127_7885164_3 COG1918 Fe2 transport system protein A K04758 - - 0.0008324 47.0
TLS3_k127_7889580_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.639e-264 829.0
TLS3_k127_7889580_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 5.667e-213 675.0
TLS3_k127_7889580_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.0000008514 52.0
TLS3_k127_7890439_0 PFAM Borrelia P83 100 protein - - - 0.000000000000000000000000000000000004731 152.0
TLS3_k127_7904097_0 - - - - 0.00000000000000000004518 98.0
TLS3_k127_7904097_1 protein related to plant photosystem II stability assembly factor - - - 0.0000000000115 77.0
TLS3_k127_7904097_2 membrane K07058 - - 0.000000001026 71.0
TLS3_k127_7924508_0 Psort location Cytoplasmic, score 8.87 K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000002211 196.0
TLS3_k127_7924508_1 - - - - 0.00003167 49.0
TLS3_k127_7924762_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 482.0
TLS3_k127_7924762_1 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.00000000000000000000000000000000000003445 149.0
TLS3_k127_7924762_2 B-1 B cell differentiation - - - 0.00000000000000000000000000000000002413 149.0
TLS3_k127_7924762_3 haloacid dehalogenase-like hydrolase K01243 - 3.2.2.9 0.000000000000385 76.0
TLS3_k127_7932628_0 Domain of unknown function (DUF1731) K07071 - - 0.0000000000000000000000000000000000001366 151.0
TLS3_k127_7932628_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000003986 141.0
TLS3_k127_7932628_2 RDD family - - - 0.000000000000000000000000002088 117.0
TLS3_k127_7932628_3 Phosphohistidine phosphatase SixA K08296 - - 0.0000000000000000001184 95.0
TLS3_k127_793981_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000001303 120.0
TLS3_k127_793981_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000003626 76.0
TLS3_k127_7941927_0 PFAM response regulator receiver K03413 - - 0.00000000000000000000000000000000872 130.0
TLS3_k127_7941927_1 Histidine kinase - - - 0.00000000000000000000000000000001448 136.0
TLS3_k127_7941927_2 helix_turn_helix, Lux Regulon - - - 0.0000000004463 62.0
TLS3_k127_7955215_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001794 277.0
TLS3_k127_7962512_0 PFAM DNA RNA helicase, DEAD DEAH box type, N-terminal K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 440.0
TLS3_k127_7962512_1 Component of the core of the flagella K02406 GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 307.0
TLS3_k127_7962512_2 - - - - 0.000000000000000000000000000001557 124.0
TLS3_k127_7962512_3 protein conserved in bacteria K01768 - 4.6.1.1 0.0000000000001549 70.0
TLS3_k127_7967016_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002277 249.0
TLS3_k127_7967016_1 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000007658 160.0
TLS3_k127_7967016_2 HDOD domain - - - 0.00000000000003007 78.0
TLS3_k127_7967016_3 - - - - 0.0000009244 56.0
TLS3_k127_7969408_0 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.0000000000000000000000000000008727 135.0
TLS3_k127_7969408_1 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.00000005473 53.0
TLS3_k127_7969408_2 Oxidoreductase NAD-binding domain - - - 0.0000005681 59.0
TLS3_k127_7969408_3 - - - - 0.0000009989 58.0
TLS3_k127_7969803_0 Neutral/alkaline non-lysosomal ceramidase, C-terminal K12349 - 3.5.1.23 1.397e-295 920.0
TLS3_k127_7969803_1 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000000000000000000000000000005219 216.0
TLS3_k127_7972778_0 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000000000000000000009164 121.0
TLS3_k127_7972778_1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.000000000000000002485 95.0
TLS3_k127_7972778_2 Sigma factor PP2C-like phosphatases - - - 0.0000001788 62.0
TLS3_k127_7974767_0 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000001549 183.0
TLS3_k127_7974767_1 MAPEG family - - - 0.000000000000000000000001104 106.0
TLS3_k127_7974767_2 Thioredoxin-like domain K03671 - - 0.000000000000000000002753 95.0
TLS3_k127_7989995_0 NADH dehydrogenase K03885 - 1.6.99.3 0.00000000000001898 78.0
TLS3_k127_799234_0 NADH:flavin oxidoreductase / NADH oxidase family K00219 - 1.3.1.34 0.00000000000000000000000000000000000000000000000000000000001718 217.0
TLS3_k127_799234_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0000000000000000000000002064 109.0
TLS3_k127_7995588_0 PFAM NHL repeat containing protein - - - 0.0002972 50.0
TLS3_k127_7999292_0 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 492.0
TLS3_k127_7999292_1 epimerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000445 263.0
TLS3_k127_7999292_2 Radical SAM domain protein - - - 0.000000000000000000000000000000008322 139.0
TLS3_k127_800260_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000452 167.0
TLS3_k127_800260_1 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000003586 148.0
TLS3_k127_8011455_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03320 - - 0.0000000000000000000000000000000000000000000000000000000001582 220.0
TLS3_k127_8012302_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 475.0
TLS3_k127_8012302_1 PFAM secretion protein HlyD family protein - - - 0.0001208 53.0
TLS3_k127_8015755_0 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000009365 247.0
TLS3_k127_8015755_1 Phosphoribosyl transferase domain K07100 - - 0.00000000000000000000000000000000000000000000000000000005506 202.0
TLS3_k127_8015755_2 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000003602 141.0
TLS3_k127_8015755_3 Dienelactone hydrolase family - - - 0.0000000000000000000000000702 109.0
TLS3_k127_8015755_5 family 18 - - - 0.0000000000002049 81.0
TLS3_k127_8024477_0 SAICAR synthetase K01923,K01945,K03566 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 288.0
TLS3_k127_8024477_1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K00332 - 1.6.5.3 0.00000000000000000000000000002741 126.0
TLS3_k127_8030759_0 Sh3 type 3 domain protein - - - 0.000001546 60.0
TLS3_k127_8033224_0 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 347.0
TLS3_k127_8033224_2 His Kinase A (phosphoacceptor) domain K02482 - 2.7.13.3 0.000009878 53.0
TLS3_k127_803365_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000005951 188.0
TLS3_k127_8033928_0 - - - - 0.000001148 61.0
TLS3_k127_8039687_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000001629 256.0
TLS3_k127_8043862_0 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000108 210.0
TLS3_k127_8043862_1 drug transmembrane transporter activity K03327 - - 0.00000000000000000000000000000000000000000000000001049 191.0
TLS3_k127_8044432_0 Peptidase S15 K06978 - - 0.00000000000000000000000000000000000001302 151.0
TLS3_k127_8046739_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 318.0
TLS3_k127_8046739_1 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000002979 186.0
TLS3_k127_8046739_2 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360 - 0.00000000000000000000000000007527 128.0
TLS3_k127_8046739_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000009513 113.0
TLS3_k127_8048324_0 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006672 253.0
TLS3_k127_8048324_1 - - - - 0.000000000000000006024 89.0
TLS3_k127_8048324_2 transcriptional regulator K09017 - - 0.000000000001345 75.0
TLS3_k127_8061588_0 Penicillin-binding Protein K05515 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005666 307.0
TLS3_k127_8061588_1 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000003827 210.0
TLS3_k127_8061588_2 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000001792 119.0
TLS3_k127_8061588_3 Psort location CytoplasmicMembrane, score 9.99 K03571 - - 0.00000002308 63.0
TLS3_k127_8069493_0 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000001874 275.0
TLS3_k127_8069493_1 PFAM Response regulator receiver domain K07667 - - 0.00000000000000000000000000000000000002387 148.0
TLS3_k127_8071874_0 Fatty acid desaturase K00496 - 1.14.15.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 295.0
TLS3_k127_8071874_1 O-acyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000007647 234.0
TLS3_k127_8071874_2 PFAM AMP-dependent synthetase and ligase - - - 0.00000000000000000000000000000000000003717 146.0
TLS3_k127_8076655_0 phytol kinase activity K16368 GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0098827,GO:1901576 2.7.1.174 0.0000000000005427 75.0
TLS3_k127_8076655_1 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000001551 58.0
TLS3_k127_8077094_0 Cell shape determining protein, MreB Mrl family K03569 - - 0.0000000009888 59.0
TLS3_k127_8092761_0 Flavin-binding monooxygenase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008788 349.0
TLS3_k127_8092761_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000002869 108.0
TLS3_k127_8092761_2 epimerase - - - 0.00000000003119 71.0
TLS3_k127_8103737_0 Domain of unknown function (DUF4178) - - - 0.000000000000000000000000000000000000000005946 174.0
TLS3_k127_8103737_1 Transmembrane secretion effector - - - 0.0000000000000000002011 89.0
TLS3_k127_8103737_2 Domain of Unknown Function (DUF350) - - - 0.0000000005772 64.0
TLS3_k127_8103737_3 PFAM AsmA family K07289 - - 0.000006079 59.0
TLS3_k127_8107501_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007188 530.0
TLS3_k127_8107501_1 Belongs to the ParA family K04562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002381 269.0
TLS3_k127_8107501_2 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.00000000000000000000000000000000000000000000000000000000000000005053 239.0
TLS3_k127_8107501_3 flagellar biosynthesis protein FlhF K02404 - - 0.00000000000000000000000000000000001139 151.0
TLS3_k127_8107501_4 nuclease activity - - - 0.000004244 53.0
TLS3_k127_8109256_0 aconitate hydratase K01681,K20455 - 4.2.1.117,4.2.1.3 0.0 1037.0
TLS3_k127_8109256_1 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - 0.000000000000000000000000000000000000000000005226 169.0
TLS3_k127_810968_0 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003947 259.0
TLS3_k127_810968_1 - K01992 - - 0.00000000000000000000000000000000000000003355 162.0
TLS3_k127_8111277_0 Cytidylyltransferase family K00981 - 2.7.7.41 0.000000000000000000000007229 113.0
TLS3_k127_8129275_0 Molecular chaperone. Has ATPase activity K04079 GO:0000302,GO:0000303,GO:0000305,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0010035,GO:0016020,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071450,GO:0071451,GO:0071944,GO:1901700,GO:1901701 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 494.0
TLS3_k127_8135725_1 inhibitor of MCP methylation, homolog of CheC K03409 - - 0.0000000000000000000000000000001259 129.0
TLS3_k127_8135725_2 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000001573 77.0
TLS3_k127_8150719_0 EVE domain - - - 0.000000000000000000000000000000000453 136.0
TLS3_k127_8150719_1 peptidylprolyl isomerase K03769,K07533 - 5.2.1.8 0.0002295 53.0
TLS3_k127_8155331_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002124 246.0
TLS3_k127_8183754_0 Uncharacterized protein conserved in bacteria (DUF2309) K09822 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 607.0
TLS3_k127_8183754_1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 391.0
TLS3_k127_8183754_2 PFAM Sulphate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000935 213.0
TLS3_k127_819998_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000000000000000000000000000000001008 153.0
TLS3_k127_819998_1 Fatty acid desaturase K00508 - 1.14.19.3 0.000000000000000000000000000000008954 132.0
TLS3_k127_8203832_0 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000007223 224.0
TLS3_k127_8206192_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000278 512.0
TLS3_k127_8206192_1 COGs COG0659 Sulfate permease and related transporter (MFS superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 420.0
TLS3_k127_8206192_2 PFAM sodium calcium exchanger membrane region K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000296 278.0
TLS3_k127_8206192_3 COGs COG0659 Sulfate permease and related transporter (MFS superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001309 276.0
TLS3_k127_8207028_0 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000005741 154.0
TLS3_k127_8207028_1 Agenet domain - - - 0.000000000000000000000000000003054 132.0
TLS3_k127_8212046_0 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000004633 137.0
TLS3_k127_8212046_1 Belongs to the GPI family K01810,K13810 - 2.2.1.2,5.3.1.9 0.000001276 57.0
TLS3_k127_8213661_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 369.0
TLS3_k127_8213661_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 335.0
TLS3_k127_8233663_0 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005317 252.0
TLS3_k127_8233663_1 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 0.00000000000000000000000000001966 134.0
TLS3_k127_8233663_2 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.0000000006801 60.0
TLS3_k127_8234356_0 Phosphohydrolase-associated domain K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 338.0
TLS3_k127_8234356_1 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000001802 217.0
TLS3_k127_8234356_2 - - - - 0.000000000000000000000009019 107.0
TLS3_k127_8234356_4 - - - - 0.00008985 55.0
TLS3_k127_8241016_0 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008646 376.0
TLS3_k127_8241016_1 spermidine synthase activity K00797 - 2.5.1.16 0.0000000000000000000000001575 116.0
TLS3_k127_8241016_2 MFS_1 like family - - - 0.0000000000000000000001714 97.0
TLS3_k127_8241327_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005349 309.0
TLS3_k127_8241327_1 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000001059 131.0
TLS3_k127_8242665_0 NAD(P)-binding Rossmann-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 379.0
TLS3_k127_8242665_1 Alginate export K16081 - - 0.0005654 52.0
TLS3_k127_8245050_0 GGDEF domain - GO:0003674,GO:0003824,GO:0008081,GO:0016787,GO:0016788,GO:0042578,GO:0071111 - 0.00000000000000000000000000000000000000000000000000000000001753 217.0
TLS3_k127_8245050_1 Diguanylate cyclase - - - 0.000000000000000000000000000000000006685 143.0
TLS3_k127_825732_0 lyase activity - - - 0.0000000000000000000000000000000000000000004645 165.0
TLS3_k127_825732_1 DNA helicase K03657 - 3.6.4.12 0.00000005854 55.0
TLS3_k127_8267340_0 secondary active sulfate transmembrane transporter activity K06901 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 496.0
TLS3_k127_8267340_1 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004534 293.0
TLS3_k127_8273723_0 Domain of unknown function (DUF4143) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 396.0
TLS3_k127_8273723_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000003348 177.0
TLS3_k127_8273723_2 Rhodanese Homology Domain - - - 0.0000000000000000000000002748 109.0
TLS3_k127_8273723_3 geranylgeranyl reductase activity - GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0008152,GO:0009404,GO:0009987,GO:0019748,GO:0030153,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050660,GO:0050662,GO:0097159,GO:1901265,GO:1901363 - 0.0001542 50.0
TLS3_k127_8273935_0 Histidine kinase - - - 0.0000000000000000000000000000000000005663 156.0
TLS3_k127_8274668_0 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000008971 132.0
TLS3_k127_8274668_1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00002136 56.0
TLS3_k127_8278920_0 PolyA polymerase K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000241 170.0
TLS3_k127_8278920_1 Methyltransferase domain - - - 0.0000000000000000000000002193 116.0
TLS3_k127_8279198_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000009907 190.0
TLS3_k127_828921_0 Cytochrome p450 - - - 0.000000000000000000000000000000000000000000000000003793 192.0
TLS3_k127_8291897_0 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000001918 73.0
TLS3_k127_8291897_1 Helicase conserved C-terminal domain - - - 0.0008297 52.0
TLS3_k127_8304461_0 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009601 297.0
TLS3_k127_8304461_1 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000339 220.0
TLS3_k127_8304461_2 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000000000002858 151.0
TLS3_k127_8304461_3 - - - - 0.0000000000000000001242 97.0
TLS3_k127_8305049_0 TIGRFAM isocitrate dehydrogenase, NADP-dependent K00031 - 1.1.1.42 6.079e-195 614.0
TLS3_k127_8305049_1 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001383 281.0
TLS3_k127_8305049_2 Belongs to the enoyl-CoA hydratase isomerase family - GO:0001666,GO:0003008,GO:0006950,GO:0007600,GO:0008150,GO:0009628,GO:0009987,GO:0019233,GO:0032501,GO:0033554,GO:0036293,GO:0036294,GO:0042221,GO:0050877,GO:0050896,GO:0051716,GO:0070482,GO:0070887,GO:0071453,GO:0071456 - 0.0000000000000000000000000000000000000000000000000003248 197.0
TLS3_k127_8305493_0 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.0000000000000000000000000009595 128.0
TLS3_k127_8305718_0 COGs COG4299 conserved - - - 0.00000000000000000000000000000000000000000006524 175.0
TLS3_k127_8305718_1 Alpha/beta hydrolase family K08726,K10089 GO:0000287,GO:0001676,GO:0002532,GO:0002538,GO:0002539,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004301,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006633,GO:0006690,GO:0006725,GO:0006793,GO:0006796,GO:0006805,GO:0006810,GO:0006873,GO:0006874,GO:0006875,GO:0006886,GO:0006950,GO:0006952,GO:0006954,GO:0006996,GO:0007031,GO:0007600,GO:0008015,GO:0008104,GO:0008150,GO:0008152,GO:0008217,GO:0008610,GO:0009056,GO:0009058,GO:0009410,GO:0009636,GO:0009810,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0015031,GO:0015643,GO:0015833,GO:0016043,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016801,GO:0016803,GO:0017144,GO:0018904,GO:0019216,GO:0019218,GO:0019222,GO:0019233,GO:0019369,GO:0019373,GO:0019439,GO:0019725,GO:0019752,GO:0030003,GO:0030258,GO:0031907,GO:0031974,GO:0032501,GO:0032787,GO:0033036,GO:0033365,GO:0033559,GO:0034613,GO:0035150,GO:0035296,GO:0042221,GO:0042577,GO:0042578,GO:0042579,GO:0042592,GO:0042632,GO:0042759,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043651,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045777,GO:0046272,GO:0046394,GO:0046483,GO:0046839,GO:0046872,GO:0046907,GO:0046983,GO:0048518,GO:0048878,GO:0050789,GO:0050801,GO:0050877,GO:0050880,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055088,GO:0055092,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070727,GO:0070887,GO:0071466,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072330,GO:0072503,GO:0072507,GO:0072593,GO:0072594,GO:0072662,GO:0072663,GO:0080090,GO:0090066,GO:0090181,GO:0097176,GO:0097746,GO:0097755,GO:0098771,GO:1900673,GO:1901360,GO:1901361,GO:1901568,GO:1901575,GO:1901576 3.1.3.76,3.3.2.10 0.000000000000000000000000000007044 120.0
TLS3_k127_8305718_2 Hemerythrin-like metal-binding protein K07216 - - 0.000000000000000000005024 99.0
TLS3_k127_8310762_0 glucose sorbosone K00117 - 1.1.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 299.0
TLS3_k127_8310762_1 PFAM Phosphomethylpyrimidine kinase type-1 K00868,K00941,K14153 - 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001291 279.0
TLS3_k127_8311080_0 Belongs to the SpoVG family K06412 - - 0.00000000000002273 78.0
TLS3_k127_8311080_1 membrane - - - 0.0000000000002563 78.0
TLS3_k127_8316441_0 phosphorelay sensor kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004829 488.0
TLS3_k127_8316441_1 7TM diverse intracellular signalling K00694,K07315,K20977 - 2.4.1.12,3.1.3.3 0.0000000000000000000000000001623 121.0
TLS3_k127_8316441_2 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.00000000000000251 80.0
TLS3_k127_8323569_0 site-specific DNA-methyltransferase (adenine-specific) activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 444.0
TLS3_k127_8323569_1 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006964 419.0
TLS3_k127_8323569_2 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000742 296.0
TLS3_k127_8323569_3 Protein of unknown function (DUF1698) - - - 0.0000000000000000000000000000000000006272 148.0
TLS3_k127_8323569_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000001873 130.0
TLS3_k127_8323569_5 Thioredoxin domain - - - 0.00000000000000000003606 92.0
TLS3_k127_8323569_6 arsenical-resistance protein K03325 - - 0.00000000000000004601 81.0
TLS3_k127_8323569_7 Sulfate transporter antisigma-factor antagonist STAS - - - 0.00000436 52.0
TLS3_k127_8324959_0 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.00000000000000000000000000001733 126.0
TLS3_k127_8324959_1 Belongs to the flagella basal body rod proteins family K02392 - - 0.0000000000000000000001148 98.0
TLS3_k127_8327241_0 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004548 267.0
TLS3_k127_8328010_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 499.0
TLS3_k127_8328010_1 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.0000000000000000000000003884 108.0
TLS3_k127_8328642_0 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002172 263.0
TLS3_k127_8328642_1 chaperone-mediated protein folding - - - 0.000000001038 70.0
TLS3_k127_83299_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 352.0
TLS3_k127_83299_1 methyltransferase activity - - - 0.0000000000000000009377 93.0
TLS3_k127_83299_2 Methyltransferase type 11 - - - 0.0000000000006278 80.0
TLS3_k127_83299_3 YhhN family - - - 0.00000000001337 65.0
TLS3_k127_8330292_0 Psort location CytoplasmicMembrane, score - - - 0.000000000000000028 91.0
TLS3_k127_8330292_1 protein conserved in bacteria - - - 0.0000000000003022 79.0
TLS3_k127_8351442_0 (Lipo)protein K04754 - - 0.00000000000000000000000000001839 122.0
TLS3_k127_8351442_1 - - - - 0.00000000000000000000000000009967 119.0
TLS3_k127_8351442_2 PFAM toluene tolerance family protein K07323 - - 0.000000000000004375 82.0
TLS3_k127_8351743_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 471.0
TLS3_k127_8351743_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000001988 146.0
TLS3_k127_8351743_2 Protein tyrosine kinase - - - 0.0000000001614 62.0
TLS3_k127_8353035_0 SPFH domain-Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001358 241.0
TLS3_k127_8353035_1 Belongs to the FPP GGPP synthase family K02523 GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 0.00000000000000000000000000000000000006332 151.0
TLS3_k127_8354175_0 PFAM AMP-dependent synthetase and ligase K08295 - 6.2.1.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 310.0
TLS3_k127_8354175_1 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005036 303.0
TLS3_k127_8355475_0 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005423 314.0
TLS3_k127_8363533_0 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000001694 165.0
TLS3_k127_8363533_1 cyclic nucleotide-binding - - - 0.0000000000000000000022 96.0
TLS3_k127_836538_0 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis K13010 - 2.6.1.102 0.00000000000000000000000000000004333 139.0
TLS3_k127_8366770_0 Haemolysin-III related K11068 - - 0.0000000000000000000000000000000000000000000000000000000000000000008162 235.0
TLS3_k127_8366770_1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha-like K03989,K13509 GO:0001817,GO:0001819,GO:0001959,GO:0001961,GO:0003674,GO:0003824,GO:0003841,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010646,GO:0010647,GO:0012505,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019222,GO:0019637,GO:0023051,GO:0023056,GO:0031323,GO:0031325,GO:0031984,GO:0042171,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0051239,GO:0051240,GO:0060759,GO:0060760,GO:0065007,GO:0071617,GO:0071704,GO:0090407,GO:0098827,GO:1901576 2.3.1.51 0.0000000000000000000000000000000000003742 151.0
TLS3_k127_8366770_2 MotA TolQ ExbB proton channel family K03561 - - 0.00000001996 60.0
TLS3_k127_8372_0 PFAM CheB methylesterase - - - 6.895e-315 984.0
TLS3_k127_8372_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 7.661e-235 734.0
TLS3_k127_8372_2 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 522.0
TLS3_k127_8372_3 PFAM Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 312.0
TLS3_k127_8372_4 PFAM Bacterial capsule synthesis protein PGA_cap K07282 - - 0.00000000000000000000000003158 122.0
TLS3_k127_8372_5 Mammalian cell entry related domain protein K02067 - - 0.0000000000000004074 86.0
TLS3_k127_8372_6 subunit of a heme lyase K02200 - - 0.0000657 53.0
TLS3_k127_8372_7 MlaD protein K02067 - - 0.0007228 51.0
TLS3_k127_837650_0 FGGY family of carbohydrate kinases, N-terminal domain K00854 - 2.7.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 477.0
TLS3_k127_8380323_0 Putative glycosyl hydrolase domain - - - 0.000000000000000000000000000000000000000000000000004226 192.0
TLS3_k127_8380323_1 PFAM Rhomboid family protein - - - 0.00000000000000000000000001764 119.0
TLS3_k127_8381180_0 Belongs to the DegT DnrJ EryC1 family K02805 - 2.6.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000292 248.0
TLS3_k127_8381180_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.000000000000000000000000001827 121.0
TLS3_k127_8382406_0 Belongs to the thiolase family K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 0.000000000000000000000000000000000000000000000000000000004532 216.0
TLS3_k127_8383470_0 Lipase (class 2) K01046 GO:0003674,GO:0003824,GO:0004806,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0052689,GO:0071704,GO:1901575 3.1.1.3 0.00000000000000003185 91.0
TLS3_k127_8397527_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 341.0
TLS3_k127_8397527_1 Phosphate transport system permease protein PstA K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000001058 235.0
TLS3_k127_8397527_2 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000127 117.0
TLS3_k127_8405944_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 8.834e-214 687.0
TLS3_k127_8405944_1 - - - - 0.0000000000000001583 84.0
TLS3_k127_8413093_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000592 229.0
TLS3_k127_8415088_0 Type I restriction and modification enzyme - subunit R C terminal K01153 - 3.1.21.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 482.0
TLS3_k127_8415088_1 - - - - 0.000000000000000000000000000000225 131.0
TLS3_k127_8415088_2 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000000000000001468 85.0
TLS3_k127_8415088_3 STAS-like domain of unknown function (DUF4325) - - - 0.00000000003788 67.0
TLS3_k127_8420804_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000005067 213.0
TLS3_k127_8420804_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000002324 71.0
TLS3_k127_8420804_2 Ankyrin repeat K06867 - - 0.0000000002476 67.0
TLS3_k127_8427797_0 TIGRFAM lysine 2,3-aminomutase YodO family protein K01843,K19810 - 5.4.3.2 0.0000000000000000000000000000000000000000000000122 183.0
TLS3_k127_8427797_1 Patatin-like phospholipase K07001 - - 0.000000000000000000009139 100.0
TLS3_k127_8427797_2 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.000000000001172 77.0
TLS3_k127_8429465_0 Pfam:KaiC K08482 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000542 364.0
TLS3_k127_8429465_1 HWE histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000007967 221.0
TLS3_k127_8429465_2 histidine kinase A domain protein - - - 0.0000000000000000008093 90.0
TLS3_k127_8429465_3 KaiB K08481 - - 0.0000000000000004051 81.0
TLS3_k127_8429465_4 His Kinase A (phosphoacceptor) domain - - - 0.0001595 51.0
TLS3_k127_8434272_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.000000000000000000000000000000003 133.0
TLS3_k127_8434272_1 COG0208 Ribonucleotide reductase, beta subunit - - - 0.00000001437 66.0
TLS3_k127_8434272_2 - - - - 0.00000006091 59.0
TLS3_k127_8436501_0 protein localization to T-tubule K10380,K15503,K21440 - - 0.00000000000000000000000000000000000000004411 174.0
TLS3_k127_8436501_1 spectrin binding - - - 0.000000000001279 74.0
TLS3_k127_8440095_0 Chemotaxis protein cheY K03413 - - 0.000000000000000000000000000009213 123.0
TLS3_k127_8440095_1 Phage tail tube, TTP, lambda-like - - - 0.0000000001167 76.0
TLS3_k127_8440095_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000114 47.0
TLS3_k127_8440095_3 epimerase K00491,K21572 - 1.14.14.47 0.00004951 57.0
TLS3_k127_8442793_0 Transport of potassium into the cell K03549 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 553.0
TLS3_k127_8442793_1 Transport of potassium into the cell K03549 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003844 291.0
TLS3_k127_8442987_0 Phosphomannose isomerase type I K01809 - 5.3.1.8 0.0000000000000000000000000085 121.0
TLS3_k127_8442987_1 PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000006109 78.0
TLS3_k127_8447404_0 belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.00000000000000000004218 91.0
TLS3_k127_8447404_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000002615 54.0
TLS3_k127_8447404_2 Adenylyl- / guanylyl cyclase, catalytic domain K01768 GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.000003284 58.0
TLS3_k127_8450696_0 COG3209 Rhs family protein K20276 - - 0.0000000000000000000000000000000000000000001324 184.0
TLS3_k127_8455653_0 RimP N-terminal domain - - - 0.000000007785 61.0
TLS3_k127_8459999_0 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 309.0
TLS3_k127_8459999_1 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006054 299.0
TLS3_k127_8459999_2 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000002155 231.0
TLS3_k127_8459999_3 AAA domain K07028 - - 0.00000000000000000000000000000000000000000000000000000000001365 224.0
TLS3_k127_8459999_4 Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs K15257 - - 0.00000000000000000000000000000000000000000000000000000003674 208.0
TLS3_k127_8459999_5 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000001704 179.0
TLS3_k127_8459999_6 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000002469 134.0
TLS3_k127_8459999_7 Domain of unknown function (DUF4349) - - - 0.0000000000000000000000000000175 127.0
TLS3_k127_8471277_0 helix_turn_helix, Lux Regulon K02282 - - 0.000000000000000000000000000000000000000000002265 173.0
TLS3_k127_8471277_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000004623 130.0
TLS3_k127_8471277_2 metal-dependent phosphohydrolase HD region - - - 0.0000000003732 64.0
TLS3_k127_8472346_0 Carbamoyltransferase C-terminus K00612 - - 4.883e-254 796.0
TLS3_k127_8472346_1 Nucleotidyl transferase K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 364.0
TLS3_k127_8472346_2 Stealth protein CR2, conserved region 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004699 255.0
TLS3_k127_8472346_3 - - - - 0.00000089 51.0
TLS3_k127_8472346_4 Nucleotide-diphospho-sugar transferase K20784 - - 0.00004345 54.0
TLS3_k127_8472346_5 - - - - 0.0001275 51.0
TLS3_k127_8472346_6 lipolytic protein G-D-S-L family - - - 0.0001817 53.0
TLS3_k127_8476526_0 metallopeptidase activity K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 443.0
TLS3_k127_8476526_1 metallopeptidase activity K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004843 289.0
TLS3_k127_8476841_0 GIY-YIG type nucleases (URI domain) K02342 - 2.7.7.7 0.0000000000000000000001198 108.0
TLS3_k127_8476841_1 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000004347 63.0
TLS3_k127_8479311_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000005148 229.0
TLS3_k127_8484118_0 TAP-like protein - - - 0.000000000000000000000000002958 119.0
TLS3_k127_8484118_1 Protein of unknown function (DUF1761) - - - 0.0000008881 55.0
TLS3_k127_8487482_0 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003853 254.0
TLS3_k127_8487482_1 Electron transfer flavoprotein domain K03521 - - 0.00000000000000000000000000000000000000000000000000000000001633 214.0
TLS3_k127_8497541_0 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000001195 132.0
TLS3_k127_8497541_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold K01046 - 3.1.1.3 0.00000000000000000000000000007962 127.0
TLS3_k127_8497541_2 ATPase activity K02065 - - 0.0000000000000000000003555 106.0
TLS3_k127_8497541_3 Transmembrane family 220, helix - - - 0.000000000000000006256 87.0
TLS3_k127_8497541_4 MlaD protein K02067 - - 0.0000003453 60.0
TLS3_k127_8497823_0 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000001404 194.0
TLS3_k127_8498013_1 OmpA family - - - 0.00000000000000000133 91.0
TLS3_k127_8498633_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 488.0
TLS3_k127_8498633_1 domain protein - - - 0.00000000000000000001069 99.0
TLS3_k127_8498633_2 PFAM Rhodanese-like domain - - - 0.000000001086 63.0
TLS3_k127_8498633_3 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000001132 60.0
TLS3_k127_8498633_4 protein conserved in bacteria - - - 0.0007338 47.0
TLS3_k127_850282_0 - K12065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008543 314.0
TLS3_k127_850282_1 FMN binding K03612 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000004585 89.0
TLS3_k127_8505689_0 PFAM TRAP dicarboxylate transporter- DctP subunit - - - 0.00000000000000000000000000000000000000000000000008774 190.0
TLS3_k127_8507424_0 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000005729 219.0
TLS3_k127_8507424_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000003623 178.0
TLS3_k127_8507424_2 Domain of unknown function (DUF4287) - - - 0.00000000000000000000000000000004552 126.0
TLS3_k127_8507424_3 YjbR - - - 0.0000000000000000000000008372 108.0
TLS3_k127_8507424_4 COG0202 DNA-directed RNA polymerase, alpha subunit 40 kD subunit - - - 0.00000000000000002122 86.0
TLS3_k127_8507424_5 DoxX-like family - - - 0.00000000007634 64.0
TLS3_k127_8507424_6 Alpha/beta hydrolase family - - - 0.0000000002082 62.0
TLS3_k127_8508050_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 2.793e-255 803.0
TLS3_k127_8508050_1 Diguanylate cyclase - - - 0.0000000000000000000000000000000000001807 153.0
TLS3_k127_8508246_0 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000003577 108.0
TLS3_k127_8508602_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000367 78.0
TLS3_k127_8508602_1 - - - - 0.0000000000111 76.0
TLS3_k127_8512171_0 haloacid dehalogenase-like hydrolase K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000006672 179.0
TLS3_k127_8512171_1 Outer membrane protein assembly complex, YaeT protein K07277 - - 0.0000007759 60.0
TLS3_k127_8512685_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005423 403.0
TLS3_k127_8512685_1 Pyruvate dehydrogenase K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 355.0
TLS3_k127_8512685_2 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000002089 141.0
TLS3_k127_8512685_3 Belongs to the pseudouridine synthase RsuA family K06181 - 5.4.99.20 0.0000002252 56.0
TLS3_k127_8518743_0 Catalase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004703 265.0
TLS3_k127_8518743_1 OmpA family - - - 0.0000000000000000000000000000000000004047 156.0
TLS3_k127_8518743_2 terminase - - - 0.000000002863 61.0
TLS3_k127_8522136_0 Sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006035 271.0
TLS3_k127_8522136_1 PFAM Alpha beta hydrolase fold-3 domain protein K01066,K14731 - 3.1.1.83 0.0000000000000000000000000000000000000000000000000003538 196.0
TLS3_k127_8528741_0 Catalyzes the formation of 5-methyl-uridine at position equivalent to 747 (m5U747) in 23S rRNA K03212 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070041,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.189 0.000000002478 64.0
TLS3_k127_8528741_1 PGAP1-like protein K01046 - 3.1.1.3 0.00000003424 64.0
TLS3_k127_8532344_0 Domain of unknown function (DUF389) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 319.0
TLS3_k127_8540327_0 ATPases associated with a variety of cellular activities K05776 - - 0.0000000000000000000000000687 123.0
TLS3_k127_854712_0 Protein of unknown function (DUF559) - - - 0.00000000000000000000000007357 109.0
TLS3_k127_854712_1 Cysteine rich repeat - - - 0.000002216 54.0
TLS3_k127_854712_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0002771 51.0
TLS3_k127_854736_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008606 316.0
TLS3_k127_854736_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000531 63.0
TLS3_k127_8554181_0 Alpha beta hydrolase - - - 0.00000000000000000000000000000006017 133.0
TLS3_k127_8557357_0 phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000001295 96.0
TLS3_k127_8562668_0 Bacterial regulatory proteins, tetR family K09017 - - 0.000000000000000004109 94.0
TLS3_k127_8564669_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 383.0
TLS3_k127_8564669_1 N-terminal domain of galactosyltransferase - - - 0.0000000000000000000000000000000000001203 153.0
TLS3_k127_8564669_2 methyltransferase - - - 0.000000000000000000005851 104.0
TLS3_k127_856513_0 sterol desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004823 249.0
TLS3_k127_8582063_0 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000005742 145.0
TLS3_k127_8582063_1 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate K03473 - 1.1.1.290 0.000000000000000000000000000145 127.0
TLS3_k127_8584293_0 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 528.0
TLS3_k127_8584293_1 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 328.0
TLS3_k127_8584293_2 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001563 276.0
TLS3_k127_8584293_3 OHCU decarboxylase K16840 - 4.1.1.97 0.00000000000000000000000000000000000000000000000007052 184.0
TLS3_k127_8584293_4 Sulfite exporter TauE/SafE - - - 0.0000000000000000000000000000000000000000004279 161.0
TLS3_k127_8584293_5 histidine kinase A domain protein - - - 0.000000000000000000000000000000001674 136.0
TLS3_k127_8585964_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 302.0
TLS3_k127_8585964_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000008919 159.0
TLS3_k127_8585964_2 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.000000000000000002551 85.0
TLS3_k127_8587082_0 NAD-dependent K08678 - 4.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 344.0
TLS3_k127_8587082_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003332 326.0
TLS3_k127_8588188_0 Histidine kinase K20974 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009367 486.0
TLS3_k127_8588188_1 COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain K07814,K13815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 449.0
TLS3_k127_8588188_2 phosphorelay signal transduction system - - - 0.000000000000000000000008611 105.0
TLS3_k127_8588188_3 Methionine synthase K00548 - 2.1.1.13 0.0000000000000000000001714 97.0
TLS3_k127_8589047_0 Acetoacetate decarboxylase (ADC) - - - 0.00000000000000000000000000000000004545 142.0
TLS3_k127_8589047_1 PFAM ROK family K00845 - 2.7.1.2 0.00000000000000000002873 95.0
TLS3_k127_864524_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K01539 - 3.6.3.8,3.6.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009066 422.0
TLS3_k127_864524_1 HipA-like C-terminal domain - - - 0.0000000000000000000000000000006781 132.0
TLS3_k127_867886_0 SMART PDZ DHR GLGF domain protein K11749 - - 0.00000000000000000000000000000000000000000000001014 190.0
TLS3_k127_867886_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0001582 52.0
TLS3_k127_884806_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001397 276.0
TLS3_k127_884806_1 Nucleotidyl transferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000003525 235.0
TLS3_k127_884806_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000001126 225.0
TLS3_k127_884806_3 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000003341 205.0
TLS3_k127_884806_4 - - - - 0.00000000000000000000000000000000000000000000000000007326 205.0
TLS3_k127_884806_5 Protein of unknown function (DUF433) - - - 0.00000000000000000000000000001871 118.0
TLS3_k127_884806_6 - - - - 0.00000000000000000000000006366 110.0
TLS3_k127_884806_7 Transposase IS200 like - - - 0.000000000000001182 82.0
TLS3_k127_884806_8 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.0000004209 55.0
TLS3_k127_909667_0 START domain - - - 0.00000000000000001123 91.0
TLS3_k127_909667_1 Glycosyltransferase like family 2 - - - 0.00000000000003405 80.0
TLS3_k127_913619_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 344.0
TLS3_k127_913619_1 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 297.0
TLS3_k127_913735_0 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007347 434.0
TLS3_k127_913735_1 dihydroorotase K01466 - 3.5.2.5 0.000000000000000000000000000000000000000000000000000000000000000000008571 239.0
TLS3_k127_913735_2 protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain K01179 - 3.2.1.4 0.000000000003081 77.0
TLS3_k127_913735_3 Subtilase family - - - 0.00008826 53.0
TLS3_k127_918731_0 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000001886 175.0
TLS3_k127_918731_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000003721 81.0
TLS3_k127_929786_0 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000108 54.0
TLS3_k127_935968_0 uridine kinase K00876 - 2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 394.0
TLS3_k127_935968_1 DegT/DnrJ/EryC1/StrS aminotransferase family K04487 - 2.8.1.7 0.000000000000000000000000000000000002659 150.0
TLS3_k127_936871_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain K19694 - - 0.00000000000000000000000000000000000000000000000000000000000000002081 236.0
TLS3_k127_939402_0 PFAM SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000001909 240.0
TLS3_k127_939402_1 transcriptional regulator K22105 - - 0.00000000000000000000000007295 114.0
TLS3_k127_939402_2 protein conserved in bacteria K09859 - - 0.0000000000000005639 85.0
TLS3_k127_940546_0 cGMP-dependent protein kinase K19477 - 2.7.11.12 0.000000000629 72.0
TLS3_k127_940546_1 of the beta-lactamase superfamily III - - - 0.0002247 54.0
TLS3_k127_946215_0 NmrA-like family - - - 0.00000000000000000000000000000000000000008843 157.0
TLS3_k127_946215_1 membrane transporter protein K07090 - - 0.00000000000000000000000000006781 120.0
TLS3_k127_947999_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004092 361.0
TLS3_k127_947999_1 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000002326 214.0
TLS3_k127_947999_2 Putative aminopeptidase - - - 0.0000000000000000000000000000000002993 140.0
TLS3_k127_947999_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000003079 86.0
TLS3_k127_954282_0 COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit K01847,K14447 - 5.4.99.2,5.4.99.63 6.434e-308 958.0
TLS3_k127_954282_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000001382 172.0
TLS3_k127_954282_2 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000001596 162.0
TLS3_k127_955873_0 Penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000002103 188.0
TLS3_k127_955873_1 Histidine Phosphotransfer domain K20976 - - 0.0004295 47.0
TLS3_k127_956728_0 Lactonase, 7-bladed beta-propeller - - - 0.0000003422 58.0
TLS3_k127_956767_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K07004 - - 0.000000000000000000000000000000000000000000000000000000000000000001773 252.0
TLS3_k127_956767_1 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.0000000000000000000000000000000000000000000005899 173.0
TLS3_k127_956767_2 Domain of unknown function (DUF4347) - - - 0.0000000000000000000000000000001523 143.0
TLS3_k127_956767_3 chitinase K01183 - 3.2.1.14 0.0000001763 64.0
TLS3_k127_956767_4 Sh3 type 3 domain protein - - - 0.00001748 50.0
TLS3_k127_961710_0 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001241 255.0
TLS3_k127_961710_1 ankyrin 3, node of Ranvier (ankyrin G) - - - 0.00000000000000006251 89.0
TLS3_k127_963790_0 COG2885 Outer membrane protein and related peptidoglycan-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 406.0
TLS3_k127_963790_1 MotA TolQ ExbB proton channel family K03561 - - 0.000000000000000000000000001101 123.0
TLS3_k127_963790_2 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.000000000000000003466 89.0
TLS3_k127_963790_3 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.00000000000008457 73.0
TLS3_k127_967381_0 Predicted nucleotide-binding protein containing TIR-like domain - - - 0.0000000000000000000000000001389 121.0
TLS3_k127_967381_1 Belongs to the MtfA family K09933 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0006807,GO:0008134,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0043170,GO:0043433,GO:0044092,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000002798 113.0
TLS3_k127_969822_0 Glycoside hydrolase family 3 K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000003604 258.0
TLS3_k127_969822_1 PIN domain - - - 0.000000000001458 71.0
TLS3_k127_971323_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 496.0
TLS3_k127_971323_1 Predicted metal-dependent hydrolase K07044 - - 0.00000000000000000000000000000000000042 150.0
TLS3_k127_971323_2 TIGRFAM Methylglyoxal synthase K01734 - 4.2.3.3 0.00000000000000000000000000000000001433 136.0
TLS3_k127_974494_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 - 2.7.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000004948 264.0
TLS3_k127_974494_1 HI0933-like protein K07007 - - 0.0000000000000000000000059 104.0
TLS3_k127_976072_0 Glutathione S-transferase K00799,K11209 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000001593 226.0
TLS3_k127_978796_0 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000008538 233.0
TLS3_k127_982711_0 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 330.0
TLS3_k127_982711_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000002192 213.0
TLS3_k127_983921_0 Catalyzes the conversion of dihydroorotate to orotate K00226,K17723 - 1.3.1.1,1.3.98.1 1.097e-214 672.0
TLS3_k127_983921_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00266,K17722 - 1.3.1.1,1.4.1.13,1.4.1.14 0.00000000000000000000000000000000323 131.0
TLS3_k127_985257_0 Nitrite and sulphite reductase 4Fe-4S K00362 - 1.7.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 584.0
TLS3_k127_985257_1 TIGRFAM nitrite reductase NAD(P)H , small subunit K00363 - 1.7.1.15 0.0000000000000000000000000000001024 134.0
TLS3_k127_985257_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.0000000001344 63.0
TLS3_k127_985751_0 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000001266 170.0
TLS3_k127_985751_1 START domain - - - 0.0000000000000000000000000000004886 129.0
TLS3_k127_99193_0 Histidine kinase K07636 - 2.7.13.3 0.00000007703 64.0
TLS3_k127_99624_0 ammonium transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 593.0
TLS3_k127_99624_1 ammonium transporteR K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005183 342.0
TLS3_k127_99624_2 Belongs to the P(II) protein family K04752 - - 0.00000000000000000000000000000000000000000000002811 171.0
TLS3_k127_99624_3 Belongs to the P(II) protein family K04752 - - 0.0000000000000000000000000000000000002838 141.0